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Schweizer Archiv Fur Tierheilkunde Jun 2022Aural hematoma is the most common injury of the pinna in dogs. Treatment options are various. More recently, medical therapy has been more commonly pursued than surgical...
Aural hematoma is the most common injury of the pinna in dogs. Treatment options are various. More recently, medical therapy has been more commonly pursued than surgical options. Therefore, our hypothesis was that monotherapy with oral prednisolone for one month is sufficient to successfully treat dogs diagnosed with aural hematoma. In this open prospective experimental study without control group, clinicians treated 24 privately-owned dogs suffering from aural hematoma with oral prednisolone at 1 mg / kg / day for 14 days, followed by 0,5 mg / kg / day for another 14 days. In case of strong side effects, the dose reduction was already initiated after 7 days of treatment. The success was assessed subjectively after 14 days by the owner and after 28 days by a clinician or specialist. In addition, before and after treatment the thickness of the swelling was measured. In 21 of 24 dogs, oral prednisolone treatment for 28 days lead to a subjective clinical improvement of at least 80 %. The ear thickness was reduced by at least 50 %. This study showed that treating dogs suffering from aural hematoma for four weeks with oral prednisolone used as a monotherapy leads to promising results and could be considered as an economical, non-invasive and safe treatment alternative for aural hematoma in dogs.
Topics: Animals; Dog Diseases; Dogs; Hematoma; Prednisolone; Prospective Studies
PubMed: 35652255
DOI: 10.17236/sat00358 -
BioMed Research International 2013To evaluate the plasma and aqueous humor disposition of prednisolone after oral administration in cats.
OBJECTIVE
To evaluate the plasma and aqueous humor disposition of prednisolone after oral administration in cats.
METHODS
Six cats were administered with a single oral dose of prednisolone (10 mg). Blood and aqueous humor samples were serially collected after drug administration. Prednisolone concentrations in plasma and aqueous humor were measured at 0.25, 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, and 5.0 h after administration by a high-performance liquid chromatographic analytical method developed and validated for this purpose.
RESULTS
Mean ± standard error (SE) of maximum plasma prednisolone concentration (300.8 ± 67.3 ng/mL) was reached at 1 h after administration. Prednisolone was distributed to the aqueous humor reaching a mean peak concentration of 100.9 ± 25.5 ng/mL at 1.25 h after administration. The mean ± SE systemic and aqueous humor exposure (AUC) was 553.3 ± 120.0 ng h/mL and 378.8 ± 64.9 ng h/mL, respectively. A high AUC(aqueous humor)/AUC(plasma) ratio was observed (0.68 ± 0.13). The mean half-life time of elimination in plasma and aqueous humor was 0.87 ± 0.16 h and 2.25 ± 0.44 h, respectively.
CLINICAL SIGNIFICANCE
The observed high ratio between aqueous humor and plasma prednisolone concentrations indicates that extensive penetration of prednisolone to the anterior segment of the eye may occur. This is the first step that contributes to the optimization of the pharmacological therapeutics for the clinical treatment of uveitis.
Topics: Administration, Oral; Animals; Aqueous Humor; Cats; Chromatography, High Pressure Liquid; Male; Prednisolone; Reproducibility of Results; Time Factors; Tissue Distribution
PubMed: 24069591
DOI: 10.1155/2013/209439 -
European Journal of Clinical... Jan 1981Prednisolone was measured in plasma, saliva and urine at various times after a single dose. Peak plasma prednisolone levels were observed about 1 h after the dose....
Prednisolone was measured in plasma, saliva and urine at various times after a single dose. Peak plasma prednisolone levels were observed about 1 h after the dose. Saliva prednisolone levels were measurable for at least 3 h after dosing but showed no consistent relationship to either total or free plasma prednisolone concentrations. Unchanged prednisolone in amounts up to 14% of the dose administered was found in the 24 h urine and most of it was excreted in the first 5 h.
Topics: Adult; Female; Humans; Male; Prednisolone; Radioimmunoassay; Saliva
PubMed: 7461028
DOI: 10.1007/BF00558389 -
MMW Fortschritte Der Medizin Feb 2014
Topics: Anti-Inflammatory Agents; Carpal Tunnel Syndrome; Follow-Up Studies; Humans; Injections, Intra-Articular; Prednisolone; Randomized Controlled Trials as Topic; Treatment Outcome
PubMed: 24934050
DOI: 10.1007/s15006-014-2592-y -
Current Opinion in Investigational... Nov 2004COLAL-PRED (prednisolone sodium metasulfobenzoate), which is targeted to the colon by COLAL colonic drug delivery technology, is being developed by Alizyme for the... (Review)
Review
COLAL-PRED (prednisolone sodium metasulfobenzoate), which is targeted to the colon by COLAL colonic drug delivery technology, is being developed by Alizyme for the potential treatment of inflammatory bowel disease. Alizyme expect to initiate a phase III trial in 2005.
Topics: Animals; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Inflammatory Bowel Diseases; Prednisolone; Structure-Activity Relationship
PubMed: 15573870
DOI: No ID Found -
Journal of Controlled Release :... Jun 2004The purpose of this study is to demonstrate a stable retention of prednisolone (PLS) in the unique liposomes integrated by lipophilic derivative approach and PEGylation...
The purpose of this study is to demonstrate a stable retention of prednisolone (PLS) in the unique liposomes integrated by lipophilic derivative approach and PEGylation approach. Palmitoyl prednisolone (Pal-PLS) was newly synthesized and used as a lipophilic derivative. The liposomes were composed of egg phosphatidylcholine (EggPC)/cholesterol (Chol) and L-alpha-distearoylphosphatidylcholine (DSPC)/Chol with or without L-alpha-distearoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE-PEG 2000) or -PEG 5000 (DSPE-PEG 5000). The retentions of PLS and Pal-PLS in the various liposomes were examined by ultrafiltration and gel filtration. Although PLS showed high trapping efficiency by all liposomes after ultrafiltration, low incorporation efficiency was observed in gel filtration. It indicates that PLS was released from the liposomes by a dilution with elution medium in gel filtration. Pal-PLS showed high incorporation into all liposomes after both ultrafiltration and gel filtration. The high incorporation of Pal-PLS into EggPC/Chol liposomes, however, was reduced by incubation with rat plasma in gel filtration. The reducing effect of rat plasma on drug incorporation into liposomes was inhibited by using DSPC and DSPE-PEGs. Thus, we systemically examined the drug retention in various liposomes and demonstrated the high retention of PLS in the liposomes integrated by lipophilic derivative approach and pharmaceutical approach using special lipids.
Topics: Animals; Chromatography, Gel; Drug Delivery Systems; In Vitro Techniques; Liposomes; Phosphatidylcholines; Phosphatidylethanolamines; Polyethylene Glycols; Prednisolone; Rats; Ultrafiltration
PubMed: 15196748
DOI: 10.1016/j.jconrel.2004.03.011 -
Lancet (London, England) Jan 1987
Topics: Humans; Kinetics; Prednisolone; Psychoses, Substance-Induced
PubMed: 2880083
DOI: 10.1016/s0140-6736(87)90084-5 -
Orvosi Hetilap Nov 1966
Topics: Adams-Stokes Syndrome; Adult; Aprotinin; Humans; Male; Neomycin; Pancreatitis; Prednisolone
PubMed: 5298852
DOI: No ID Found -
Der Hautarzt; Zeitschrift Fur... Jul 2018
Topics: Administration, Oral; Anti-Inflammatory Agents; Drug Compounding; Emergencies; Humans; Prednisolone
PubMed: 29869674
DOI: 10.1007/s00105-018-4208-4 -
Journal of Chromatography Apr 1991Prednisolone, prednisolone acetate and prednisolone sodium phosphate are glucocorticoids used for ocular, anti-inflammatory therapy. A reversed-phase high-performance...
Prednisolone, prednisolone acetate and prednisolone sodium phosphate are glucocorticoids used for ocular, anti-inflammatory therapy. A reversed-phase high-performance liquid chromatographic assay using ultraviolet detection has been developed that affords baseline resolution of the above analytes in balanced salt solutions and rabbit aqueous humor. The drugs can be quantified at 0.025-0.05 micrograms/ml in the above matrices; 6 alpha-methylprednisolone is used as the internal standard. Both esters of prednisolone are vulnerable to chemical and enzymatic hydrolysis giving prednisolone. Analysis of aqueous humor samples shows prednisolone acetate penetrating/metabolizing primarily to prednisolone; prednisolone sodium phosphate penetrates the cornea giving the ester and alcohol.
Topics: Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Female; Male; Prednisolone; Rabbits
PubMed: 1874907
DOI: 10.1016/0378-4347(91)80373-k