-
Skin Therapy LetterPrednicarbate is a nonhalogenated corticosteroid that is used in the treatment of inflammatory skin diseases, for example atopic dermatitis. It has a favorable... (Review)
Review
Prednicarbate is a nonhalogenated corticosteroid that is used in the treatment of inflammatory skin diseases, for example atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. Thus, prednicarbate may be a consideration in the treatment of atopic dermatitis in children, and other inflammatory disorders in children and adults.
Topics: Glucocorticoids; Humans; Prednisolone; Skin Diseases
PubMed: 15657633
DOI: No ID Found -
Journal of Clinical Neuroscience :... Jun 2024Corticosteroids are a potential treatment to combat Complex Regional Pain Syndrome, however the adverse effect profile far outweighs the benefits of using them....
Corticosteroids are a potential treatment to combat Complex Regional Pain Syndrome, however the adverse effect profile far outweighs the benefits of using them. Avascular necrosis and Osteonecrosis are among well defined adverse effects. Postmenopausal women are especially affected by corticosteroids due to loss of estrogen. Diabetics are an interesting study as their pain perception is altered due to either high cortisol levels or the development of peripheral neuropathy.
Topics: Humans; Reflex Sympathetic Dystrophy; Prednisolone; Female
PubMed: 38705026
DOI: 10.1016/j.jocn.2024.04.034 -
Journal of Oral Medicine 1986
Comparative Study
Topics: Absorption; Adult; Female; Humans; Male; Mouth Mucosa; Mouthwashes; Prednisolone; Saliva; Spectrophotometry, Ultraviolet; Time Factors; Water
PubMed: 3459831
DOI: No ID Found -
Drug and Therapeutics Bulletin Oct 1977
Topics: Humans; Prednisolone; Tablets, Enteric-Coated
PubMed: 923431
DOI: No ID Found -
Food Additives & Contaminants. Part A,... 2013Prednisolone is a steroid belonging to the corticosteroid group. The results obtained in the application of the 2008 and 2009 Italian Residue Control Plans show the...
Prednisolone is a steroid belonging to the corticosteroid group. The results obtained in the application of the 2008 and 2009 Italian Residue Control Plans show the frequent detection of prednisolone traces in cow's urine. Since most of the positive samples were detected at the slaughterhouse, the researchers hypothesised that, together with an increase of cortisol concentration, traces of prednisolone could be produced endogenously during stressful situations due to transport and handling before slaughter. In the present trial, 52 lactating cows housed in seven different farms in Lombardy, Italy, were studied. Urine samples were collected at the farm (after urethral catheterisation) and immediately after slaughter (from urinary bladder) together with 40 adrenal gland samples belonging to the same animals. All the samples were analysed for the determination of prednisolone and cortisol by LC/MS(n). The results demonstrated that prednisolone can be endogenously produced in dairy cows and, furthermore, its endogenous presence in bovine urine seems to be strongly related to a state of stress in the animals (at the farm and at the slaughterhouse). The data from adrenal glands do not, however, clarify if the endogenous production occurs, partially or totally, in this organ.
Topics: Adrenal Glands; Animals; Cattle; Chromatography, Liquid; Female; Mass Spectrometry; Prednisolone
PubMed: 23566227
DOI: 10.1080/19440049.2013.781273 -
Eye (London, England) 1989Gas Chromatography with Mass Spectrometry (GCMS) was utilised to determine the penetration of prednisolone sodium phosphate into the aqueous humour of human volunteers...
Gas Chromatography with Mass Spectrometry (GCMS) was utilised to determine the penetration of prednisolone sodium phosphate into the aqueous humour of human volunteers undergoing routine cataract extraction. Detectable levels of prednisolone were measured in the aqueous humour within 15 minutes. Peak concentrations occurred between 90 and 240 minutes, and the steroid could not be detected in samples taken 10 hours or more after topical administration.
Topics: Administration, Topical; Aged; Aged, 80 and over; Aqueous Humor; Cataract Extraction; Humans; Middle Aged; Prednisolone; Time Factors
PubMed: 2606222
DOI: 10.1038/eye.1989.69 -
PloS One 2014To assess the efficacy of a biodegradable, prednisolone acetate implant in a rabbit uveitis model.
AIM
To assess the efficacy of a biodegradable, prednisolone acetate implant in a rabbit uveitis model.
METHODS
Randomized, controlled study of biodegradable microfilms preloaded with prednisolone acetate (PA) in a rabbit uveitis model. Experimental uveitis was induced by unilateral intravitreal injection of Mycobacterium tuberculosis H37Ra antigen (50 ug; 1 ug/uL) in preimmunized rabbits. PA-loaded poly[d,l-lactide-co-ε-caprolactone] (PLC) microfilms (n = 10) and blank microfilms (n = 6) were implanted subconjunctivally. An estimate of PA release in vivo was calculated from measured residual PA amounts in microfilms after the rabbits were sacrificed. The eyes were clinically monitored for ocular inflammation for 28 days. Histopathological examination of the enucleated eyes was performed at the end of the study period.
RESULTS
In vitro studies revealed that sandwich PA-loaded microfilm formulations exhibited higher release kinetic compared to homogenous PA-loaded microfilms. The 60-40-60% microfilm released an average of 0.034 mg/day of PA over the period of 60 days in vitro; and we found that approximately 0.12 mg/day PA was released in vivo. Animals implanted with the PA-loaded microfilms exhibited significantly lowered median inflammatory scores when compared against the control group in this model for recurrent uveitis (P<0.001). The implants were clinically well tolerated by all the animals. Histology results showed no significant scarring or inflammation around the PA-loaded microfilms.
CONCLUSION
Our pilot study demonstrated that a subconjunctival PA-loaded implant is effective in suppressing inflammation in the rabbit model of uveitis, by providing therapeutic levels of PA that attenuated the inflammatory response even after a rechallenge. Longer term studies are now needed to establish the therapeutic potential of such a delivery system for treatment of ocular inflammation.
Topics: Animals; Conjunctiva; Drug Administration Routes; Inflammation; Male; Prednisolone; Prostheses and Implants; Rabbits; Uveitis
PubMed: 24842851
DOI: 10.1371/journal.pone.0097555 -
Kokuritsu Iyakuhin Shokuhin Eisei... 1998The raw material of prednisolone was examined for the preparation of the "Prednisolone Reference Standard (Control 971)". Analytical data obtained were as follows:...
The raw material of prednisolone was examined for the preparation of the "Prednisolone Reference Standard (Control 971)". Analytical data obtained were as follows: melting point, 238.4 degrees C (decomposition); infrared spectrum, the same as that of the Prednisolone Reference Standard (Control 911); UV spectrum, lambda max = 243 nm; specific absorbance, E1 cm 1% (243 nm) = 414.8; loss on drying, 0.06%; thin-layer chromatography, one impurity was detected; high-performance liquid chromatography (HPLC), 4 to 5 impurities were detected and the total amount was estimated to be about 0.51%; assay by HPLC, 100.6%. Based on the above results, the raw material was authorized as the Prednisolone Reference Standard (Control 971) of National Institute of Health Sciences.
Topics: Government Agencies; Japan; Prednisolone; Reference Standards
PubMed: 10097537
DOI: No ID Found -
Allergie Und Asthma Feb 1959
Topics: Asthma; Prednisolone
PubMed: 13649528
DOI: No ID Found -
Zeitschrift Fur Rheumaforschung Apr 1957
Topics: Arthritis; Arthritis, Rheumatoid; Disease; Hip; Humans; Osteoarthritis; Phenylbutazone; Prednisolone; Spondylitis, Ankylosing
PubMed: 13456917
DOI: No ID Found