-
The American Journal of Physiology Nov 1988A simple, linear, noninteractive model of the reflex control of blood pressure was developed to demonstrate that simple linear addition of the responses of the...
A simple, linear, noninteractive model of the reflex control of blood pressure was developed to demonstrate that simple linear addition of the responses of the baroreceptor reflexes can produce observations that appear to have resulted from a redundant control system. Our analysis indicated that common experimental paradigms such as hemorrhage with sequential reflex ablation, which are often used to evaluate reflex interactions, can be simply interpreted. Complex nonlinear interactions need not be postulated to explain data that appear to indicate a redundant control system.
Topics: Aorta, Thoracic; Blood Pressure; Carotid Sinus; Denervation; Feedback; Pressoreceptors
PubMed: 3189583
DOI: 10.1152/ajpheart.1988.255.5.H1244 -
Acta Medica Scandinavica. Supplementum 1956
Topics: Blood Vessels; Humans; Hypertension; Musculoskeletal Physiological Phenomena; Pressoreceptors
PubMed: 13339166
DOI: No ID Found -
Terapevticheskii Arkhiv 1996
Review
Topics: Alcoholism; Ethanol; Humans; Hypertension; Pressoreceptors
PubMed: 8771694
DOI: No ID Found -
Pflugers Archiv Fur Die Gesamte... 1953
Topics: Action Potentials; Carotid Sinus; Pressoreceptors; Veratrine; Veratrum Alkaloids
PubMed: 13073340
DOI: 10.1007/BF00364329 -
Revista Clinica Espanola Jun 1959
Topics: Hypotension; Pressoreceptors; Reflex; Vasomotor System
PubMed: 13814794
DOI: No ID Found -
Kokyu To Junkan. Respiration &... Aug 1976
Topics: Animals; Heart; Pressoreceptors; Shock, Cardiogenic; Vascular Resistance
PubMed: 1034974
DOI: No ID Found -
The American Journal of Physiology May 1992The cellular mechanisms enabling baroreceptors to transduce wall distortion into axonal discharge are unknown but might involve stretch-activated ion channels....
The cellular mechanisms enabling baroreceptors to transduce wall distortion into axonal discharge are unknown but might involve stretch-activated ion channels. Gadolinium (Gd3+, 10 microM) blocks stretch-activated channels in several preparations. Here we tested Gd3+ effects on discharge responses of 15 single-fiber baroreceptors in vitro. We simultaneously measured discharge, pressure, and aortic diameter at Gd3+ concentrations from 0.001 to 400 microM. High levels of Gd3+ added to a bicarbonate-buffered perfusate (Krebs) slightly shifted the pressure-discharge relation (less than 4 mmHg, n = 3, P = 0.01) without affecting slope or discharge frequency at threshold. Gd3+ in Krebs variably altered the pressure-diameter relation. Because 500 microM Gd3+ produced visible precipitate in Krebs, we tested Gd3+ in a simpler perfusate using N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES). Gd3+ in HEPES (n = 10) induced minor, but statistically significant, average increases in threshold (less than +5-7%) and no changes in gain. However, prolonged HEPES exposure alone (n = 2) produced similar shifts. Electron microscopy verified that Gd3+ diffused from the lumen to reach extracellular locations near baroreceptor endings. We conclude that 1) HEPES perfusate alone reversibly depresses baroreceptor discharge and 2) Gd3+ has no direct effects on baroreceptors. Thus it appears that aortic baroreceptor mechanotransduction must utilize a different class of stretch-activated ion channels.
Topics: Animals; Aorta; Differential Threshold; Gadolinium; HEPES; Isotonic Solutions; Male; Mechanoreceptors; Osmolar Concentration; Perfusion; Pressoreceptors; Pressure; Rats; Rats, Inbred Strains; Signal Transduction
PubMed: 1590446
DOI: 10.1152/ajpheart.1992.262.5.H1415 -
Nature Jul 1975
Topics: Fingers; Humans; Pressoreceptors; Touch
PubMed: 1152987
DOI: 10.1038/256203a0 -
The American Journal of Sports Medicine 1983
Topics: Heel; Humans; Pressoreceptors; Pressure
PubMed: 6829842
DOI: 10.1177/036354658301100116 -
Kaibogaku Zasshi. Journal of Anatomy Feb 1979
Topics: Animals; Aorta, Thoracic; Axons; Dogs; Pressoreceptors
PubMed: 442977
DOI: No ID Found