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Asian Journal of Surgery Jul 2023
Topics: Female; Humans; Pyometra; Endometrium; Uterus
PubMed: 36907738
DOI: 10.1016/j.asjsur.2023.01.107 -
Journal of the American Veterinary... Feb 1955
Topics: Abortion, Veterinary; Animals; Disease; Dog Diseases; Dogs; Female; Pregnancy; Pyometra; Uterine Diseases; Uterus
PubMed: 13233106
DOI: No ID Found -
Surgical Infections Jun 2014
Topics: Aged; Female; Humans; Peritonitis; Pyometra; Uterine Perforation
PubMed: 24796754
DOI: 10.1089/sur.2013.110 -
Veterinary Immunology and... Oct 2017Neutrophils are capable of releasing their DNA in response to infectious agents to form neutrophil extracellular traps (NETs) to destroy pathogens. Even though pyometra...
Neutrophils are capable of releasing their DNA in response to infectious agents to form neutrophil extracellular traps (NETs) to destroy pathogens. Even though pyometra in queens and bitches is a common disease, its pathogenesis is not fully understood. The aim of this study was to assess the presence of NETs in the endometrium of queens and bitches suffering from pyometra. Pyometra and normal uteri were obtained after ovariohysterectomy from adult queens and bitches in diestrus. Uterine contents were evaluated for bacterial isolation and identification and for NETs presence. Escherichia coli were isolated in 5/5 queens and 4/5 bitches, and Streptococcus spp in one bitch. Sterile glass coverslips were placed on the endometrium surface to obtain material for NETs that were evaluated by immunocytochemistry (histone, neutrophil elastase or myeloperoxidase), fluorescence microscopy or scanning electron microscopy. NETs in endometrium content were positively stained by DNA histone DAPI, myeloperoxidase and by neutrophil elastase. NETs were spread in all observed queen and bitch endometria of pyometra cases. Ultrastructure images of NETs depicted clusters of globular material with fine filaments deposited on or around thick filaments and trapped bacteria. To the best of our knowledge these are the first findings confirming NETs endometrial presence in queen and bitch pyometra. Nevertheless, the precise role of NETs in pyometra in the bitch and queen, either to contribute to the defeat of infection or to its persistence remains to be unraveled.
Topics: Animals; Dog Diseases; Dogs; Endometrium; Escherichia coli; Extracellular Traps; Female; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Pyometra; Streptococcus
PubMed: 29042016
DOI: 10.1016/j.vetimm.2017.09.001 -
Case Reports in Obstetrics and... 2021Pyometra is a rare condition in which purulent material becomes entrapped within the uterine cavity. If unrecognized in a timely fashion, life-threatening complications...
Pyometra is a rare condition in which purulent material becomes entrapped within the uterine cavity. If unrecognized in a timely fashion, life-threatening complications can arise. The following is a case report of a 50-year-old female who presented to the emergency department with abdominal pain and heavy vaginal bleeding. She was diagnosed with a pyometra based on imaging and treated conservatively with antibiotics. The patient ultimately had an uncomplicated hysterectomy with resolution of normal female pelvic anatomy prior to surgery. Pyometra should be considered when women present with diffuse abdominal pain or peritonitis. As demonstrated in this report, early detection and conservative management may help prevent serious complications such as uterine perforation, lead to shorter hospital stays, and result in safer operative management.
PubMed: 34745673
DOI: 10.1155/2021/7995348 -
Journal of Surgical Case Reports Aug 2022Spontaneous perforation of pyometra is a rare event associated with significant morbidity and mortality when diffuse peritonitis is present. While malignant lesions of...
Spontaneous perforation of pyometra is a rare event associated with significant morbidity and mortality when diffuse peritonitis is present. While malignant lesions of the cervical tract are the most common cause of pyometra, several benign conditions can contribute to this diagnosis. Traditionally hysterectomy has been the surgical approach of choice for this clinical entity; however, in the setting of septic shock, temporizing techniques may offer the opportunity to stabilize patients and complete a thorough work up before committing to definitive resection. This report explores a case of septic shock secondary to spontaneous perforation of pyometra that was definitively managed with peritoneal lavage and wide drainage. Intraoperative hysteroscopy and uterine biopsy were performed, and no malignancy was identified on final pathology. Intraoperative hysteroscopy along with peritoneal lavage and wide drainage may reduce the morbidity and mortality associated with sepsis from spontaneous perforation of pyometra and potentially avoid unnecessary hysterectomy.
PubMed: 36051005
DOI: 10.1093/jscr/rjac388 -
BioMed Research International 2023Canine pyometra, which is accompanied by bacterial contamination of the dog uterus, is defined as a complex disease associated with the activation of several systems,...
Canine pyometra, which is accompanied by bacterial contamination of the dog uterus, is defined as a complex disease associated with the activation of several systems, including the immune system. This study uses text mining and microarray data analysis methods to discover some existing targeted gene drugs and expand potential new drug indications. Text mining ("canine pyometra") and microarray data analysis (GSE99877) were used to obtain a common set of genes. These genes and protein-protein interaction (PPI) networks were analyzed using Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes. Then, the important genes clustered in the PPI network were selected for gene-drug interaction analysis to provide evidence for potential drug discovery. Through text mining and data analysis, we obtained 17,544 text mining genes (TMGs) and 399 differentially expressed genes (DEGs), respectively. There were 256 repeat genes between TMGs and DEGs, including 70 upregulated genes and 186 downregulated genes. Thirty-seven genes clustered in three significant gene modules. Eight of the 37 genes can target 23 existing drugs. In conclusion, the discovery of 8 immune response-related genes (, , , , , , , and ) targeting 23 existing drugs may expand the drug indications for pyometra-related diseases in dogs.
Topics: Humans; Female; Animals; Dogs; Gene Expression Profiling; Pyometra; Microarray Analysis; Gene Regulatory Networks; Protein Interaction Maps; Data Mining; Computational Biology; Gene Ontology
PubMed: 37101686
DOI: 10.1155/2023/7839568 -
Reproduction in Domestic Animals =... Dec 2010Pyometra in an inguinal hernia was diagnosed in a 10-year-old intact cross-bred bitch which had had dysorexia, depression and inguinal distension. The hernia contained...
Pyometra in an inguinal hernia was diagnosed in a 10-year-old intact cross-bred bitch which had had dysorexia, depression and inguinal distension. The hernia contained caudal portions of the two uterine horns, uterine cervix and cranial part of the vagina. As the organs were enlarged and full of pus, manual attempt to push back the uterine horns and the vagina in the abdominal cavity through the inguinal canal was unsuccessful. Herniated uterine horns were ligated and cut in their median portion, so it became possible to remove the cervix and the caudal portion of the horns through the hernial orifice, and the ovaries and the cranial part of the horns through a peritoneal midline incision. This bitch was not intended for breeding purposes and, given the presence of a huge pyometra associated with an inguinal hernia, an ovario-hysterectomy was recommended. Uterine herniation should be considered as a differential diagnosis of a caudal lateral inguinal mass. When pushing the uterus back in the abdominal cavity is impossible, a surgical procedure should be performed to detect ischemia–reperfusion injury and/or a septic risk.
Topics: Animals; Dogs; Female; Hernia, Inguinal; Pyometra
PubMed: 20088851
DOI: 10.1111/j.1439-0531.2009.01576.x -
Revista Brasileira de Ginecologia E... Dec 2016We describe a Herlyn-Werner-Wunderlich syndrome (HWWS) patient with previous history of infertility who got pregnant without treatment and presented a pyometra in the...
We describe a Herlyn-Werner-Wunderlich syndrome (HWWS) patient with previous history of infertility who got pregnant without treatment and presented a pyometra in the contralateral uterus throughout the gestational period, despite multiple antibiotic treatments. Due to the uterus' congenital anomaly and the possibility of ascending infection with subsequent abortion, this pregnancy was classified as high-risk. We believe that the partial horizontal septum in the vagina may have contributed to the closure of the gravid uterus cervix, thus ensuring that the pregnancy came to term, with an uneventful vaginal delivery.
Topics: Abnormalities, Multiple; Adult; Female; Humans; Infertility, Female; Kidney; Pregnancy; Pyometra; Syndrome; Ultrasonography, Prenatal; Urogenital Abnormalities; Uterus; Vagina
PubMed: 28002847
DOI: 10.1055/s-0036-1594304 -
Journal of the American Animal Hospital... 2019
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Dog Diseases; Dogs; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Humans; Hysterectomy; Ovariectomy; Pyometra
PubMed: 31525086
DOI: 10.5326/JAAHA-MS-6744