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JAMA Mar 1979
Topics: Cardiovascular System; History, 20th Century; Humans; Nuclear Medicine; Radionuclide Imaging; United States
PubMed: 372582
DOI: No ID Found -
Hellenic Journal of Nuclear Medicine 2005Infection imaging is a field of intense interest in medicine because, despite the great advances in our understanding of microorganisms and the development of new... (Review)
Review
Infection imaging is a field of intense interest in medicine because, despite the great advances in our understanding of microorganisms and the development of new antimicrobial agents, infection remains a major cause of patient morbidity and mortality. Nuclear Medicine for many years has an important role in this field. The significance of this role varies in different clinical situations, in some cases being complementary to other imaging modalities as in postoperative patients, and in some cases being the method of choice as in orthopaedic infections after implants have been placed. Today there are many agents in Nuclear Medicine capable in imaging infection. Each of them has its own advantages and drawbacks. In recent years there is an increased research in the field with new methods tested. Among them are labelled antibacterial agents, labelled antimicrobial peptides, monoclonal antibodies for leukocyte labelling, labelled liposomes, and (18)F-FDG-PET. In this short article there is an effort to briefly review these agents and their possible role in infection imaging.
Topics: Antibodies, Monoclonal; Bacterial Infections; Clinical Trials as Topic; Fluorodeoxyglucose F18; Humans; Practice Patterns, Physicians'; Prosthesis-Related Infections; Radionuclide Imaging; Radiopharmaceuticals
PubMed: 15886746
DOI: No ID Found -
Physics in Medicine and Biology Jun 2019When locating the sentinel lymph node (SLN), surgeons use state-of-the-art imaging devices, such as a 1D gamma probe or less widely spread a 2D gamma camera. These...
BACKGROUND
When locating the sentinel lymph node (SLN), surgeons use state-of-the-art imaging devices, such as a 1D gamma probe or less widely spread a 2D gamma camera. These devices project the 3D subspace onto a 1D respectively 2D space, hence loosing accuracy and the depth of the SLN which is very important, especially in the head and neck area with many critical structures in close vicinity. Recent methods which use a multi-pinhole collimator and a single gamma detector image try to gain a depth estimation of the SLN. The low intensity of the sources together with the computational cost of the optimization process make the reconstruction in real-time, however, very challenging.
RESULTS
In this paper, we use an optimal design approach to improve the classical pinhole design, resulting in a non-symmetric distribution of the pinholes of the collimator. This new design shows a great improvement of the accuracy when reconstructing the position and depth of the radioactive tracer. Then, we introduce our Sentinel lymph node fingerprinting (SLNF) algorithm, inspired by MR-fingerprinting, for fast and accurate reconstruction of the tracer distribution in 3D space using a single gamma detector image. As a further advantage, the method requires no pre-processing, i.e. filtering of the detector image. The method is very stable in its performance even for low exposure times. In our ex vivo experiments, we successfully located multiple Technetium 99m (Tc-99m) sources with an exposure time of only one second and still, with a very small L -error.
CONCLUSION
These promising results under short exposure time are very encouraging for SLN biopsy. Although, this device has not been tested on patients yet, we believe: that this approach will give the surgeon accurate 3D positions of the SLN and hence, can potentially reduce the trauma for the patient.
Topics: Humans; Radionuclide Imaging; Radiopharmaceuticals; Sentinel Lymph Node; Sentinel Lymph Node Biopsy; Technetium Tc 99m Sulfur Colloid
PubMed: 30965313
DOI: 10.1088/1361-6560/ab177d -
European Journal of Nuclear Medicine... Mar 2021
Topics: COVID-19; Humans; Lung; Radionuclide Imaging; SARS-CoV-2
PubMed: 33159223
DOI: 10.1007/s00259-020-05100-6 -
Physics in Medicine and Biology Apr 2002A review of medical diagnostic imaging methods utilizing x-rays or gamma rays and the application and development of inorganic scintillators is presented. (Review)
Review
A review of medical diagnostic imaging methods utilizing x-rays or gamma rays and the application and development of inorganic scintillators is presented.
Topics: Gamma Rays; Humans; Inorganic Chemicals; Radionuclide Imaging; Time Factors; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; X-Rays
PubMed: 12030568
DOI: 10.1088/0031-9155/47/8/201 -
Arquivos Brasileiros de Cardiologia Oct 2009Thoracic pain is a common symptom in emergency services, and stress radionuclide imaging represents one of the phases of risk stratification in these individuals....
Thoracic pain is a common symptom in emergency services, and stress radionuclide imaging represents one of the phases of risk stratification in these individuals. However, a group of patients with negative functional exams after physical or pharmacological stress develops myocardial ischemia during this psychological stress. Alterations in vascular tonus as a response to endogenous mechanisms are the physiopathologic basis for such alterations. We report a case that illustrates how mental stress radionuclide imaging has the potential to be used in the assessment of myocardial ischemia non-detected by conventional methods in patients with suspicion of ischemic thoracic pain.
Topics: Aged; Chest Pain; Female; Humans; Myocardial Ischemia; Radionuclide Imaging; Stress, Psychological
PubMed: 19936445
DOI: 10.1590/s0066-782x2009001000024 -
Current Opinion in Cardiology Nov 1993Imaging techniques for the noninvasive detection and evaluation of coronary artery disease continue to develop. New techniques for the quantification of myocardial blood... (Review)
Review
Imaging techniques for the noninvasive detection and evaluation of coronary artery disease continue to develop. New techniques for the quantification of myocardial blood flow by positron-emission tomography, new approaches to metabolic imaging, and new gamma camera technology have the potential to expand the scope of cardiac nuclear medicine in many facilities. Determination of the best and most cost-effective method of assessing myocardial viability in patients with advanced coronary artery disease remains of key interest with research directed at alternative 201Tl imaging protocols, fatty acid metabolism, and viability assessment with the new 99mTc-based myocardial perfusion radiopharmaceuticals. The assessment of endothelial function and determination of coronary flow reserve with 13N-ammonia positron-emission tomography may aid in the identification of preclinical atherosclerosis, and in monitoring disease progression and response to therapy. New information in radionuclide perfusion imaging in young and elderly patients and in those with interventricular conduction disturbances may allow for more accurate identification of coronary artery disease. The role of radionuclide imaging in patients with dilated cardiomyopathy continues to evolve with the development of radiolabeled chemicals of the adrenergic nervous system and their analogues, which will be helpful in the stratification of disease severity. These new imaging techniques promise to increase the accuracy of nuclear cardiology for detection of disease, assessment of function, and prognosis.
Topics: Blood Flow Velocity; Coronary Disease; Fatty Acids; Forecasting; Humans; Myocardium; Radionuclide Imaging; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed
PubMed: 10146527
DOI: 10.1097/00001573-199311000-00014 -
Clinical Nuclear Medicine Sep 2011Subclinical hyperthyroidism is defined as normal serum free thyroxine and a free triiodothyronine level, with a thyroid-stimulating hormone level suppressed below the... (Review)
Review
Subclinical hyperthyroidism is defined as normal serum free thyroxine and a free triiodothyronine level, with a thyroid-stimulating hormone level suppressed below the normal range and is usually undetectable. Although patients with this diagnosis have no or few signs and symptoms of overt thyrotoxicosis, there is sufficient evidence that it is associated with a relatively higher risk of supraventricular arrhythmias as well as the acceleration or the development of osteoporosis. Consequently, the approach to the patient with subclinical hyperthyroidism is controversial, that is, therapeutic intervention versus watchful waiting. Regardless, it is imperative for the referring physician to identify the causative thyroid disorder. This is optimally accomplished by a functional study, namely scintigraphy. Recognition of the scan findings of the various causes of subclinical hyperthyroidism enables the imaging specialist to help in diagnosing the underlying condition causing thyroid-stimulating hormone suppression thereby facilitating the workup and management of this thyroid disorder.
Topics: Humans; Hyperthyroidism; Iodine Radioisotopes; Radionuclide Imaging
PubMed: 21825836
DOI: 10.1097/RLU.0b013e3182175477 -
Journal of Nuclear Medicine : Official... Dec 1998
Topics: Aged; Artifacts; Gamma Cameras; Humans; Lacrimal Apparatus; Lacrimal Apparatus Diseases; Male; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Technetium Tc 99m Medronate
PubMed: 9867167
DOI: No ID Found -
Pediatric Radiology May 2019Technical and clinical aspects of esophageal transit scintigraphy in pediatric patients are reviewed via several illustrative cases that highlight its utility in... (Review)
Review
Technical and clinical aspects of esophageal transit scintigraphy in pediatric patients are reviewed via several illustrative cases that highlight its utility in evaluating primary and secondary esophageal motility disorders.
Topics: Child; Diagnosis, Differential; Esophageal Motility Disorders; Humans; Radionuclide Imaging
PubMed: 30535870
DOI: 10.1007/s00247-018-4301-y