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International Journal of Cosmetic... Jun 2024To characterize the scalp microbial composition, function, and connection to dandruff severity using a metagenomics approach and to understand the impact of a Piroctone... (Randomized Controlled Trial)
Randomized Controlled Trial
OBJECTIVE
To characterize the scalp microbial composition, function, and connection to dandruff severity using a metagenomics approach and to understand the impact of a Piroctone Olamine containing anti-dandruff shampoo on the scalp microbiome.
METHODS
Shotgun metagenomics was used to characterize the composition of the scalp microbiomes from 94 subjects with and without clinically defined dandruff. Furthermore, the microbiome of the scalps of 100 dandruff sufferers before and after 3 weeks of treatment with either control or anti-dandruff shampoo containing 0.5% Piroctone Olamine (PO) was characterized and compared to identify microorganisms associated with the dandruff condition and the associated pathways and processes that may contribute to PO's effect on scalp microbiome.
RESULTS
A higher relative abundance of Malassezia restricta and Staphylococcus capitis and a lower abundance of Cutibacterium acnes were associated with the dandruff scalps relative to the no-dandruff scalps. A 3-week PO shampoo treatment reduced the relative abundance of Malassezia species and Staphylococcus capitis and increased the relative abundance of Cutibacterium acnes. This change to the scalp microbiome composition is consistent with a return to a healthy no-dandruff microbiome and improved clinical signs and symptoms as measured by adherent scalp flaking score (ASFS) compared with the control shampoo. Functional genomics analysis showed that the PO shampoo treatment reduced oxidative stress-associated genes and decreased the abundance of protease, urease, and lipase genes. These changes correlated positively to improvements in dandruff severity. PO treatment favourably shifted scalp microbiomes in dandruff subjects toward the no-dandruff state.
CONCLUSION
Our results suggest that part of the aetiology of dandruff can be attributed to dysbiosis of the scalp microbiome. PO treatment can restore a healthier microbiome, reducing oxidative stress and promoting better scalp health.
Topics: Humans; Microbiota; Scalp; Hair Preparations; Dandruff; Female; Male; Middle Aged; Adult; Drug Combinations; Ethanolamines; Pyridones
PubMed: 38196163
DOI: 10.1111/ics.12933 -
Annals of Plastic Surgery Apr 1990
Topics: Anastomosis, Surgical; Child; Female; Humans; Microsurgery; Replantation; Scalp
PubMed: 2353786
DOI: 10.1097/00000637-199004000-00010 -
Journal of Cutaneous Medicine and... 2014Lymphangiosarcoma is a rare, aggressive malignancy that originates from the endothelial cells lining lymphatic vessels and carries an extremely poor prognosis. Its...
BACKGROUND
Lymphangiosarcoma is a rare, aggressive malignancy that originates from the endothelial cells lining lymphatic vessels and carries an extremely poor prognosis. Its clinical and histologic features are often indistinguishable from angiosarcoma.
OBJECTIVE
We sought to better characterize the clinical and histologic features of lymphangiosarcoma.
METHODS
Case report and review of the literature.
RESULTS
A number of immunohistochemical markers, including Von Willebrand factor, Ulex europaeus agglutinin 1, CD31, VEGFR-3, D2-40, Prox-1, can be used to help differentiate lymphatic from vascular tissue.
CONCLUSIONS
Recent characterization of several new biologic markers has allowed greater differentiation between these tumors and may provide new therapeutic targets for treatment.
Topics: Aged; Female; Humans; Immunohistochemistry; Lymphangiosarcoma; Scalp; Tomography, X-Ray Computed
PubMed: 24636440
DOI: 10.2310/7750.2013.13025 -
Dermatologic Surgery : Official... Sep 2001The purpose of surgery is to effect functional and/or cosmetic benefit while causing as few adverse consequences as possible. At its core lies incision/excision, tissue...
BACKGROUND
The purpose of surgery is to effect functional and/or cosmetic benefit while causing as few adverse consequences as possible. At its core lies incision/excision, tissue mobilization, and reconstruction. Each body region presents its own particular surgical challenge. Scalp is made up of collagen, elastin, blood vessels, nerve fibers, and lymphatics with mucopolysaccharide ground substance and tissue fluid, together with hair follicles, sweat, and sebaceous glands. All these elements are anatomically and biologically affected by each modality of surgery.
OBJECTIVE
To establish technical guidelines for scalp surgery compatible with maximal functional/cosmetic benefit and complication-free results.
METHODS
More than 3000 scalp operations done personally were reviewed. These included the entire spectrum of plastic and reconstructive surgery and hair restoration procedures.
RESULTS
Some guidelines compatible with improved scalp surgery results were derived.
CONCLUSION
Complication-free scalp surgery is most likely to occur when incisions spare neurovascular structures; do not transect collagen or elastin; undermining is modest and discriminate; deep plane fixation is used; and hair directional orientation (drape) is preserved.
Topics: Biomechanical Phenomena; Hair; Humans; Male; Postoperative Complications; Practice Guidelines as Topic; Retrospective Studies; Scalp; Surgery, Plastic
PubMed: 11553172
DOI: 10.1046/j.1524-4725.2001.00350.x -
Pediatric Neurosurgery 2016The object of this report is to review the management of patients having the composite type of aplasia cutis congenita in the context of the relevant literature on this... (Review)
Review
BACKGROUND/AIMS
The object of this report is to review the management of patients having the composite type of aplasia cutis congenita in the context of the relevant literature on this condition.
METHODS
Clinical records, neuroimaging and photographic documentation of identified cases of composite type aplasia cutis congenita, with a comprehensive review of the literature, are the material basis of this report.
RESULTS
Two neonates with composite type aplasia cutis congenita are described as examples of this disorder, and their management, including complications, is discussed. Both had satisfactory outcomes.
CONCLUSIONS
Early aggressive surgical management with scalp rotation flaps has a low rate of complications, provides satisfactory functional and esthetic outcome, minimizes hospital stays, and should provide cost-effective care by reduction of the time to secure wound closure. Most bony defects, even large ones, commonly ossify completely. Optimal case management requires a synchronized neurosurgical and plastic surgical team. Intuitive nonsurgical and surgical approaches by the inexperienced can be hazardous.
Topics: Disease Management; Ectodermal Dysplasia; Female; Humans; Infant; Infant, Newborn; Male; Plastic Surgery Procedures; Scalp; Surgical Flaps; Triplets
PubMed: 26937970
DOI: 10.1159/000442989 -
Dermatologic Surgery : Official... Jan 2021
Topics: Adult; Chronic Disease; Female; Humans; Munchausen Syndrome; Scalp; Tomography, X-Ray Computed
PubMed: 31577567
DOI: 10.1097/DSS.0000000000002186 -
Indian Journal of Dermatology,... 2018
Topics: Aneurysm; Arteriovenous Malformations; Humans; Male; Scalp; Young Adult
PubMed: 29176252
DOI: 10.4103/ijdvl.IJDVL_270_17 -
BMJ Case Reports Sep 2017
Topics: Adult; Conservative Treatment; Humans; Male; Nevus, Pigmented; Scalp; Skin Neoplasms
PubMed: 28942417
DOI: 10.1136/bcr-2017-222402 -
Injury Jul 1989
Topics: Hair; Humans; Scalp; Suture Techniques
PubMed: 2687176
DOI: 10.1016/0020-1383(89)90131-9 -
Journal of the South Carolina Medical... Feb 1981
Topics: Accidents, Occupational; Adult; Female; Humans; Replantation; Scalp; Wound Healing
PubMed: 6937720
DOI: No ID Found