-
Journal of the American Society For... Dec 2020Imaging mass spectrometry has become a mature molecular mapping technology that is used for molecular discovery in many medical and biological systems. While powerful by... (Review)
Review
Imaging mass spectrometry has become a mature molecular mapping technology that is used for molecular discovery in many medical and biological systems. While powerful by itself, imaging mass spectrometry can be complemented by the addition of other orthogonal, chemically informative imaging technologies to maximize the information gained from a single experiment and enable deeper understanding of biological processes. Within this review, we describe MALDI, SIMS, and DESI imaging mass spectrometric technologies and how these have been integrated with other analytical modalities such as microscopy, transcriptomics, spectroscopy, and electrochemistry in a field termed multimodal imaging. We explore the future of this field and discuss forthcoming developments that will bring new insights to help unravel the molecular complexities of biological systems, from single cells to functional tissue structures and organs.
Topics: Animals; Electrochemical Techniques; Gene Expression Profiling; Humans; Mass Spectrometry; Microscopy; Multimodal Imaging; Spectrophotometry, Infrared; Spectrum Analysis, Raman; Transcriptome
PubMed: 32886506
DOI: 10.1021/jasms.0c00232 -
Analytical Chemistry Jun 1994
Review
Topics: Electron Probe Microanalysis; Image Processing, Computer-Assisted; Spectrometry, Fluorescence; Spectrometry, X-Ray Emission; Spectrum Analysis; X-Rays
PubMed: 8092465
DOI: 10.1021/ac00084a009 -
Analytical Chemistry Jun 1994
-
Analytical Chemistry Dec 1990
-
Analytical Chemistry Jun 2004
Review
Topics: Electron Probe Microanalysis; Fluorescence; Holography; Spectrum Analysis; Tomography; X-Rays
PubMed: 15193119
DOI: 10.1021/ac0400820 -
Talanta Jun 2022Chemical vapor or hydride generation (CVG/HG) still plays a significant role in continuous flow sample introduction system. The development and higher accessibility of... (Review)
Review
Chemical vapor or hydride generation (CVG/HG) still plays a significant role in continuous flow sample introduction system. The development and higher accessibility of new commercial CVG/HG accessories (especially modified spray chambers and nebulizers) improves the analytical possibilities of plasma-based optical emission spectrometry for determination of hydride forming analytes. These systems are still designed and widely applied despite the better availability of its alternatives. The commercialization of the first nitrogen microwave induced plasma optical emission spectrometry instrument (MIP OES) also contributes to the increase in popularity of these solutions. The latest achievements in commercial and laboratory-made generators and instruments, as well as new strategies in sample preparation for total content and speciation analysis, are discussed in the review.
Topics: Gases; Microwaves; Spectrum Analysis
PubMed: 35287019
DOI: 10.1016/j.talanta.2022.123372 -
Radiation Protection Dosimetry 2004The various instruments used for neutron spectrometry can be divided into four categories. Within each of these categories, the underlying measurement principle for all... (Comparative Study)
Comparative Study Review
The various instruments used for neutron spectrometry can be divided into four categories. Within each of these categories, the underlying measurement principle for all devices is essentially the same. The applications of the instruments within each group to spectrometry for radiation protection are reviewed.
Topics: Equipment Design; Neutrons; Radiation Dosage; Radiation Protection; Radiometry; Spectrum Analysis; Technology Assessment, Biomedical
PubMed: 15353637
DOI: 10.1093/rpd/nch204 -
Applied Spectroscopy Jan 2003
Review
Topics: Algorithms; Chemistry Techniques, Analytical; Models, Molecular; Spectrum Analysis; Spectrum Analysis, Raman; Stochastic Processes
PubMed: 14610929
DOI: 10.1366/000370203321165133 -
Applied Radiation and Isotopes :... 2006This paper describes the status of alpha-particle spectrometry. Some of the main contributions made to this field in the last years are reviewed. Topics covered include... (Review)
Review
This paper describes the status of alpha-particle spectrometry. Some of the main contributions made to this field in the last years are reviewed. Topics covered include instrumentation, source characterization, numerical analysis, Monte Carlo simulations and applications.
Topics: Algorithms; Alpha Particles; Equipment Design; Equipment Failure Analysis; Radiation Dosage; Radiation Monitoring; Software; Spectrum Analysis; Technology Assessment, Biomedical; Transducers
PubMed: 16554165
DOI: 10.1016/j.apradiso.2006.02.034 -
Radiation Protection Dosimetry 2003
Review
Topics: Calibration; Environmental Monitoring; Equipment Failure Analysis; Europe; Guidelines as Topic; Occupational Exposure; Protons; Radiation Dosage; Radiation Protection; Radiometry; Spectrum Analysis; Technology Assessment, Biomedical
PubMed: 14756172
DOI: 10.1093/oxfordjournals.rpd.a006381