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Dental Update 2015Recurrent oral ulceration is common and may present in childhood. Causes of recurrent oral ulceration are numerous and there may be an association with underlying...
Recurrent oral ulceration is common and may present in childhood. Causes of recurrent oral ulceration are numerous and there may be an association with underlying systemic disease. Recurrent aphthous stomatitis (RAS) is the most common underlying diagnosis in children. The discomfort of oral ulcers can impact negatively on quality of life of a child, interfering with eating, speaking and may result in missed school days. The role of the general dental practitioner is to identify patients who can be treated with simple measures in primary dental care and those who require assessment and treatment in secondary care. Management may include topical agents for symptomatic relief, topical corticosteroids and, in severe recalcitrant cases, systemic agents may be necessary.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Immunosuppressive Agents; Male; Quality of Life; Stomatitis, Aphthous; Stomatitis, Herpetic; Young Adult
PubMed: 26506812
DOI: 10.12968/denu.2015.42.6.564 -
Clinical Oral Investigations Nov 2014This study analyzed the oxidative stress status in patients with recurrent aphthous stomatitis (RAS) in the presence and absence of active ulceration.
OBJECTIVES
This study analyzed the oxidative stress status in patients with recurrent aphthous stomatitis (RAS) in the presence and absence of active ulceration.
MATERIAL AND METHODS
Oxidative stress was analyzed in peripheral mononuclear cells of 28 RAS patients with active ulceration and 29 controls. A further blood sample was collected from nine subjects randomly selected from the 28 RAS cases, during the period in which the patients did not have active oral ulceration. The reduced glutathione (GSH), malondialdehyde (MDA), and oxidized glutathione (GSSG) levels were measured in these samples.
RESULTS
The mean MDA and GSSG levels were significantly higher in patients with active RAS than in the controls, while GSH was lower in the RAS group (pā<ā0.01). There was a nonsignificant tendency toward higher MDA and GSSG levels in patients with major RAS compared with minor RAS. On comparing the serum findings in the nine RAS patients in the presence and absence of lesions, the presence of ulceration was associated with even higher MDA and GSSG levels and lower GSH concentrations (pā<ā0.05) CONCLUSIONS: Oxidative stress was detected in our RAS patients.
Topics: Female; Humans; Male; Oral Ulcer; Oxidative Stress; Recurrence; Stomatitis
PubMed: 24407552
DOI: 10.1007/s00784-013-1181-2 -
Seminars in Dermatology Mar 1992The oral mucous membranes may manifest a vast array of disease states. Pediatric patients with oral diseases pose unique challenges in diagnosis and management. An... (Review)
Review
The oral mucous membranes may manifest a vast array of disease states. Pediatric patients with oral diseases pose unique challenges in diagnosis and management. An overview of mucositis and xerostomia are presented along with helpful diagnostic features to differentiate recurrent aphthous stomatitis from recurrent herpes simplex infection.
Topics: Child; Diagnosis, Differential; Humans; Mouth Mucosa; Mouthwashes; Mucous Membrane; Oral Hygiene; Recurrence; Stomatitis; Stomatitis, Aphthous; Stomatitis, Herpetic; Xerostomia
PubMed: 1550719
DOI: No ID Found -
Dental Clinics of North America Jan 2005Oral mucositis refers to erythematous, erosive, and ulcerative lesions of the oral mucosa seen in two patient populations: (1) head and neck cancer patients undergoing... (Review)
Review
Oral mucositis refers to erythematous, erosive, and ulcerative lesions of the oral mucosa seen in two patient populations: (1) head and neck cancer patients undergoing radiation therapy to fields involving the oral cavity, and (2) patients receiving high-dose chemotherapy for cancer. Oral mucositis is a significant and dose-limiting toxicity of cancer therapy, with important clinical and economic implications. This article reviews the current knowledge on the pathogenesis, clinical presentation, diagnosis, and management of oral mucositis.
Topics: Humans; Mouth Mucosa; Stomatitis
PubMed: 15567367
DOI: 10.1016/j.cden.2004.07.009 -
Seminars in Oncology Nursing Feb 2004To review the management of radiotherapy- and chemotherapy-induced gastrointestinal mucositis. (Review)
Review
OBJECTIVE
To review the management of radiotherapy- and chemotherapy-induced gastrointestinal mucositis.
DATA SOURCE
Articles and research studies.
CONCLUSION
Gastrointestinal damage is becoming a common dose-limiting toxicity. However, there is only limited research into the mechanism and possible treatment of this toxicity.
IMPLICATIONS FOR NURSING PRACTICE
It is important to document the frequency and severity of gastrointestinal mucositis, and to alleviate symptoms wherever possible.
Topics: Antineoplastic Agents; Gastrointestinal Diseases; Humans; Mouth Mucosa; Neoplasms; Nurse's Role; Nursing Assessment; Oncology Nursing; Radiotherapy; Stomatitis
PubMed: 15038516
DOI: 10.1053/j.soncn.2003.10.007 -
Annals of Emergency Medicine Jun 1989
Topics: Adult; Diagnosis, Differential; Humans; Male; Mouthwashes; Stomatitis
PubMed: 2729704
DOI: 10.1016/s0196-0644(89)80540-2 -
Journal of Periodontology May 1977This case report discusses a 42-year-old male patient who presented with migratory stomatitis located on the labial and buccal mucosa and the lateral tongue border. The...
This case report discusses a 42-year-old male patient who presented with migratory stomatitis located on the labial and buccal mucosa and the lateral tongue border. The lesions were circumscribed, flat, smooth, and red in color with a slightly raised white border varying in size from 3 mm to over 1 cm. Duration was between 7 and 14 days and healing transpired without scarring. Follow-up continued for approximately 1 year and at each visit several lesions were seen. The possibility of stress and heredity as positive factors was considered, but with so few reported cases conclusions would be purely speculative. The absence of dermatologic pathology does not aid in establishing a relationship with psoriasis, however there is a microscopic similarity. An almost total lack of clinical symptoms may contribute to this sparse documentation, therefore dental practitioners should be articularly observant when examining oral soft tissues. Further recognition and investigation is necessary before a cause can be discovered.
Topics: Adult; Glossitis, Benign Migratory; Humans; Male; Mouth Mucosa; Stomatitis
PubMed: 266077
DOI: 10.1902/jop.1977.48.5.298 -
Pediatric Dermatology Sep 2017Noma is an opportunistic infection characterized by devastating gangrenous stomatitis leading to severe tissue destruction that predominantly affects malnourished...
Noma is an opportunistic infection characterized by devastating gangrenous stomatitis leading to severe tissue destruction that predominantly affects malnourished children in sub-Saharan Africa. Only a few cases have been reported in immunocompromised patients from developed countries. We present an unusual case of nomalike necrotizing stomatitis in a previously healthy child with Crohn's disease in Korea.
Topics: Anti-Bacterial Agents; Child; Crohn Disease; Diagnosis, Differential; Female; Humans; Immunosuppressive Agents; Noma; Republic of Korea; Skin; Stomatitis
PubMed: 28783211
DOI: 10.1111/pde.13212 -
Postgraduate Medicine Mar 1966
Topics: Humans; Stomatitis, Aphthous
PubMed: 5905849
DOI: 10.1080/00325481.1966.11695718 -
Clinical and Experimental Dermatology Jan 2004Pyostomatitis vegetans is a rare oral disorder often associated with gastrointestinal and/or cutaneous diseases and sometimes with other disorders. The association of... (Review)
Review
Pyostomatitis vegetans is a rare oral disorder often associated with gastrointestinal and/or cutaneous diseases and sometimes with other disorders. The association of pyostomatitis vegetans with inflammatory bowel disease, particularly ulcerative colitis, is well known and in most cases bowel disease precedes the onset of oral lesions by months or years. A peripheral eosinophilia has been observed in most reported cases. Pyostomatitis vegetans is characterized by erythematous, thickened oral mucosa with multiple pustules and superficial erosions. Histopathologically, it is characterized by intraepithelial and/or subepithelial abscesses containing large numbers of eosinophils. The pathogenesis is as yet unknown although immunological and microbial factors have been suggested as possible aetiological factors. Management of pyostomatitis vegetans consists mainly of immunosuppression using topical or systemic corticosteroids with medical and/or surgical treatment of any underlying inflammatory bowel disease.
Topics: Diagnosis, Differential; Humans; Irritable Bowel Syndrome; Liver Diseases; Mouth Mucosa; Skin Diseases; Stomatitis
PubMed: 14723710
DOI: 10.1111/j.1365-2230.2004.01438.x