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Nihon Rinsho. Japanese Journal of... Jun 2003Mucositis is a significant dose-limiting factor associated with cancer chemotherapy and radiotherapy. For exact management, an early diagnosis and precise evaluation are... (Review)
Review
Mucositis is a significant dose-limiting factor associated with cancer chemotherapy and radiotherapy. For exact management, an early diagnosis and precise evaluation are surely required. A basis of the prevention and care of stomatitis is maintaining cleanliness and moisture in the mouth. The medical treatment plans of oral mucositis are a measure against infection, and prevention against symptoms, and are restoration of a tissue damage, and treatment to sharp pain. However, there is no still established prevention method. As for the present condition, in the clinical practice, there are many portions depending on experiential knowledge. In this paper, it outlined including Empiric therapy about measures of oral mucositis.
Topics: Antineoplastic Agents; Humans; Mucous Membrane; Neoplasms; Stomatitis
PubMed: 12806943
DOI: No ID Found -
Protein & Cell Mar 2015Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for... (Review)
Review
Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. Among cancer patients, at least 40% and up to 70%, of individuals treated with standard chemotherapy regimens or upper-body radiation, develop oral mucositis. To date, there is no FDA approved drug to treat oral mucositis in cancer patients. The key challenges for oral mucositis treatment are to repair and protect ulcerated oral mucosa without promoting cancer cell growth. Oral mucositis is the result of complex, multifaceted pathobiology, involving a series of signaling pathways and a chain of interactions between the epithelium and submucosa. Among those pathways and interactions, the activation of nuclear factor-kappa B (NF-κB) is critical to the inflammation process of oral mucositis. We recently found that activation of TGFβ (transforming growth factor β) signaling is associated with the development of oral mucositis. Smad7, the negative regulator of TGFβ signaling, inhibits both NF-κB and TGFβ activation and thus plays a pivotal role in the prevention and treatment of oral mucositis by attenuating growth inhibition, apoptosis, and inflammation while promoting epithelial migration. The major objective of this review is to evaluate the known functions of Smad7, with a particular focus on its molecular mechanisms and its function in blocking multiple pathological processes in oral mucositis.
Topics: Animals; Humans; Mouth Diseases; Smad7 Protein; Stomatitis
PubMed: 25566830
DOI: 10.1007/s13238-014-0130-4 -
Journal of Wildlife Diseases Oct 1975Necrotic stomatitis of undetermined etiology was found in an Atlantic bottlenosed dolphin, Tursiops truncatus. The case history, treatment and hematologic findings are...
Necrotic stomatitis of undetermined etiology was found in an Atlantic bottlenosed dolphin, Tursiops truncatus. The case history, treatment and hematologic findings are described. The animal remained anorectic throughout the course of the illness, and was force fed on a daily basis for approximately 5 weeks.
Topics: Animals; Dolphins; Gentamicins; Male; Mouth; Necrosis; Penicillin G Procaine; Stomatitis
PubMed: 1195485
DOI: 10.7589/0090-3558-11.4.460 -
New Zealand Veterinary Journal Oct 1966
Topics: Animals; Cattle; Cattle Diseases; Inclusion Bodies, Viral; New Zealand; Stomatitis; Virus Diseases
PubMed: 5232162
DOI: 10.1080/00480169.1966.33662 -
Medical Oncology (Northwood, London,... Apr 2023The superiority of oral cryotherapy (OC) for prevention of chemotherapy-induced oral mucositis (OM) has been demonstrated in several trials. In clinical settings,... (Randomized Controlled Trial)
Randomized Controlled Trial
The superiority of oral cryotherapy (OC) for prevention of chemotherapy-induced oral mucositis (OM) has been demonstrated in several trials. In clinical settings, cooling is usually initiated prior to the chemotherapy infusion. It then continues during the infusion, and for a period after the infusion has been completed. While the cooling period post-infusion depends on the half-life of the chemotherapeutic drug, there is no consensus on when cooling should be initiated prior to the infusion. The lowest achieved temperature in the oral mucosa is believed to provide the best condition for OM prevention. Given this, it was of interest to investigate when along the course of intraoral cooling this temperature is achieved. In total, 20 healthy volunteers participated in this randomized crossover trial. Each subject attended three separate cooling sessions of 30 min each, with ice chips (IC) and the intraoral cooling device (ICD) set to 8 and 15 °C, respectively. At baseline and following 5, 10, 15, 20 and 30 min of cooling, intraoral temperatures were registered using a thermographic camera. The greatest drop in intraoral temperature was seen after 5 min of cooling with IC, ICD and ICD, respectively. A statistically significant difference, corresponding to 1.4 °C, was seen between IC and the ICD (p < 0.05). The intraoral temperature further declined throughout the 30 min of cooling, showing an additional temperature reduction of 3.1, 2.2, and 1.7 °C for IC, ICD and ICD, respectively.
Topics: Humans; Temperature; Cryotherapy; Stomatitis; Mouth Mucosa
PubMed: 37058178
DOI: 10.1007/s12032-023-01989-9 -
Rivista Dell'infermiere 1997Mucositis are a common problem in patients undergoing active treatment: oral complications can be painful, impact on quality of life and contribute to significant... (Review)
Review
Mucositis are a common problem in patients undergoing active treatment: oral complications can be painful, impact on quality of life and contribute to significant compliance problems that may require suspension of the treatments. There is no agreement on oral care prevention and treatment protocols and on the scientific bases of the measures recommended. Seventy articles published from 1980 to 1996 were identified using the key-words mucositis, antineoplastic agents, chemotherapy and radiotherapy and 42 double-blind clinical trials were selected and analysed. The limitedness of sample sizes, the heterogeneity of patients' treatments (chemo and radiotherapy, different dosages and drugs) and oral care protocols (frequency of oral care, products used), the differences in evaluation scales used and in the outcomes selected (effect on pain, number of ulcers, severity of ulcers) did not allow to compare studies, and therefore to arrive to a consensus on the effectiveness of the treatments studied. Unfortunately, to date, there are no solutions to such a problem and, once the mucositis occurs, the best results can be obtained only on pain control.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Mouth Mucosa; Oral Hygiene; Patient Compliance; Quality of Life; Radiotherapy; Research Design; Stomatitis
PubMed: 9510823
DOI: No ID Found -
The New England Journal of Medicine Dec 2004
Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Hematopoietic Stem Cell Transplantation; Humans; Mouth Mucosa; Radiotherapy; Stomatitis
PubMed: 15602026
DOI: 10.1056/NEJMe048239 -
Wiadomosci Lekarskie (Warsaw, Poland :... 2022The aim: To make a narrative assessment of the agents currently in use, with a particular emphasis on the topical agents that we frequently utilize in our practice. (Review)
Review
OBJECTIVE
The aim: To make a narrative assessment of the agents currently in use, with a particular emphasis on the topical agents that we frequently utilize in our practice.
PATIENTS AND METHODS
Materials and methods: The main method of this work is a review of literary sources. We reviewed the literature (PubMed, Google Scholar, Web of Science, Scopus) to support and explain the interventions we use in different cases of oral mucositis patients. We decided to combine our experience with evidence-based data.
CONCLUSION
Conclusions: Topical treatments alleviate and prevent oral mucositis. Topical medicines can assist maintain oral balance and moistness by modulating oral bacteria and replacing saliva.
Topics: Humans; Neoplasms; Stomatitis; Antineoplastic Agents
PubMed: 36256939
DOI: 10.36740/WLek202209113 -
British Dental Journal Mar 1997Stomatitis glandularis is an unusual chronic inflammatory condition of the minor salivary glands, mainly affecting the lower lip. Two cases are reported, one of which...
Stomatitis glandularis is an unusual chronic inflammatory condition of the minor salivary glands, mainly affecting the lower lip. Two cases are reported, one of which was progressive and affected the glands of both the cheeks as well as the lips. After confirmation of the clinical diagnosis by histopathological appearances, treatment was by excision of the suppurating areas as staged procedures. Chronic irritation from dentures may have contributed to the condition.
Topics: Female; Humans; Male; Middle Aged; Mouth Mucosa; Salivary Gland Diseases; Salivary Glands, Minor; Stomatitis
PubMed: 9115840
DOI: 10.1038/sj.bdj.4809351 -
Advance For NPs & PAs Jun 2013
Review
Topics: Antineoplastic Agents; Humans; Neoplasms; Physician Assistants; Stomatitis
PubMed: 23795414
DOI: No ID Found