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Annales de Pathologie Aug 2016We report a case of vaginal adenosis in a woman of 42years. This is a rare congenital disorder since cessation of use of diethylstilbestrol (DES), usually of benign... (Review)
Review
We report a case of vaginal adenosis in a woman of 42years. This is a rare congenital disorder since cessation of use of diethylstilbestrol (DES), usually of benign course, not to ignore in its tubo-endometrial histological form which may progress to atypical adenosis precursor of vaginal clear cell adenocarcinoma in patients exposed in utero to DES.
Topics: Adult; Biopsy; Cell Differentiation; Diagnosis, Differential; Diethylstilbestrol; Exocrine Glands; Female; Humans; Infertility, Female; Leiomyomatosis; Polyps; Uterine Neoplasms; Vaginal Diseases
PubMed: 27475006
DOI: 10.1016/j.annpat.2016.06.003 -
The American Journal of Surgical... Feb 2013Papillary proliferation of the endometrium (PPE) without cytologic atypia is uncommon and has only been studied in detail by Lehman and Hart in 2001. On histologic...
Papillary proliferation of the endometrium (PPE) without cytologic atypia is uncommon and has only been studied in detail by Lehman and Hart in 2001. On histologic examination, PPE ranges from simple papillae with fibrovascular cores, often involving the surface of endometrial polyps, to complex intracystic proliferations; some consider the latter to be analogous to nonatypical complex hyperplasia. To further characterize PPE, with emphasis on the risk of and features associated with concurrent or subsequent neoplasia, the clinicopathologic features of 59 cases without cytologic atypia were studied. The cases were classified into 2 groups according to the degree of architectural complexity and extent of proliferation. Group 1 consisted of those with localized simple papillae. Simple papillae were defined as those with short, predominantly nonbranching stalks; those with occasional secondary branches and/or detached papillae were also included in this group. Localized proliferations were those with 1 or 2 foci involving the surface or the subjacent glands of polyps or nonpolypoid endometrium. Group 2 consisted of those with complex papillae and/or those with diffuse and crowded intracystic papillae. Complex papillae were those with either short or long stalks, with frequent secondary and complex branches. Diffuse proliferation was defined as presence of 3 or more foci within a specimen or involvement of >50% of the endometrial polyp by simple or complex PPE. Any coexistent or subsequent hyperplasia of conventional type (World Health Organization classification) or adenocarcinoma was recorded. The age of patients ranged from 23 to 82 years (median, 53 y); 36 (61%) were postmenopausal. The majority presented with abnormal vaginal bleeding. Sixteen patients (27%) were receiving hormonal preparations including 5 who were treated with a progestogen for preexisting endometrial hyperplasia or low-grade endometrioid adenocarcinoma. The histologic diagnosis of PPE was made in 49 biopsies and in 10 hysterectomy specimens. Thirty-six cases (61%) were classified as group 1 and 23 (39%) as group 2. In 47 cases (80%), there was a coexisting endometrial polyp, 39 (66%) of which were involved by the PPE. Fifty-three cases (90%) had coexisting epithelial metaplastic changes, 41 (77%) of which were involved by the PPE. The most common type of metaplasia was mucinous (41 of 59 cases, or 69%). Follow-up information was known for 46 patients (78%). Coexistent or subsequent nonatypical and atypical hyperplasia was found in 8 (17%) and 6 cases (13%), respectively. In 6 of the 46 cases (13%), a low-grade endometrioid adenocarcinoma was present either in the original specimen or during follow-up. In contrast to group 1 PPE, those with group 2 features were significantly associated with concurrent or subsequent premalignant lesions (nonatypical and atypical hyperplasia) or carcinoma (P<0.0001). This study indicates that localized and architecturally simple PPEs confined to a completely removed polyp are usually associated with a benign outcome and may be appropriately labeled as "benign papillary proliferation of the endometrium." Lesions with architecturally complex papillae, especially when extensive, have an increased risk of concurrent or subsequent endometrial hyperplasia and carcinoma and should probably be regarded as analogous to atypical complex hyperplasia, and the term "complex papillary hyperplasia" is appropriate. As the distinction between simple and complex PPE may be difficult in small endometrial aspirational samples, consideration for curettage should be given to ascertain whether the lesion has been completely removed.
Topics: Adult; Aged; Aged, 80 and over; Biopsy; Carcinoma, Endometrioid; Cell Proliferation; Endometrial Hyperplasia; Endometrial Neoplasms; Endometrium; Female; Humans; Hysterectomy; Metaplasia; Middle Aged; Polyps; Postmenopause; Young Adult
PubMed: 23211295
DOI: 10.1097/PAS.0b013e318272d428 -
Journal of Mid-life Health 2021Endocervical polyps are a common occurrence in the postmenopausal age group and many reports have described the presence of heterologous elements in the stroma of such...
Endocervical polyps are a common occurrence in the postmenopausal age group and many reports have described the presence of heterologous elements in the stroma of such polyps. The presence of mature adipose tissue in the stroma has been hypothesized to be arising from the perivascular fat or metaplastic transformation of the smooth muscle cells posttrauma. A 75-year-old female presented with spotting per vagina. Colposcopic examination revealed an endocervical polyp which was excised. Microscopic examination showed an ulcerated epithelium with metaplastic changes along with sheets of mature adipose tissue with focal S100 positivity conferring a diagnosis of choristomatous endocervical polyp with heterologous adipose tissue. The primary clinical concern of a malignant cause in this age group is alleviated by the diagnosis of this rare benign entity. Only three such cases have been reported in the English literature so far, and the present case accounts for the fourth such case.
PubMed: 34759708
DOI: 10.4103/jmh.JMH_96_20 -
The Journal of Reproductive Medicine Aug 1996Very large cervical polyps are rarely reported. (Review)
Review
BACKGROUND
Very large cervical polyps are rarely reported.
CASE
A giant cervical polyp, 17 x 10 x 5 cm, protruded through the vaginal introitus in a 27-year-old, sexually inactive woman.
CONCLUSION
Although carcinomatous change occurs in 1.7% of cervical polyps, malignant degeneration did not occur in the six reported cases. Thus, biopsy of these tumors before excision may not be necessary.
Topics: Adult; Biopsy; Female; Humans; Leukorrhea; Polyps; Preoperative Care; Uterine Cervical Neoplasms; Uterine Hemorrhage
PubMed: 8866393
DOI: No ID Found -
Hinyokika Kiyo. Acta Urologica Japonica Aug 1987A case of vaginal polyp in an infant girl was presented. The tumor was polypoid shape and yellow so that it resembled sarcoma botryoides. Histopathological findings...
A case of vaginal polyp in an infant girl was presented. The tumor was polypoid shape and yellow so that it resembled sarcoma botryoides. Histopathological findings showed hamartomatous appearance with hemangiomatous portions in the stroma. For 5 years after simple resection, she has been well without recurrence.
Topics: Female; Humans; Infant; Polyps; Prognosis; Rhabdomyosarcoma; Vaginal Neoplasms
PubMed: 3425530
DOI: No ID Found -
Ceska Gynekologie Jun 2015To decribe a case of rare type of vaginal polyp.
OBJECTIVE
To decribe a case of rare type of vaginal polyp.
DESIGN
Case report.
SETTING
Department of Pathological Anatomy, Regional hospital Nachod.
CONCLUSION
Tubulo-squamous polyp is rare type of vaginal polyp first described in 2007, with only up to 20 cases have been reported in the literature so far. It affects mostly postmenopausal women and presents as a polypoid mass occurring in the upper part of vagina. Histologically, it is composed of squamous and glandular component within fibrous stroma. The etiopathogenesis of this lesion remains unclear, but it may arise from mesonephric remnants or Skene glands (so-called female prostate). This theory is supported by the fact that some cases show expression of prostate specific acid phosphatase (PSAP) and/or prostate specific antigen (PSA).
Topics: Acid Phosphatase; Aged; Diagnosis, Differential; Female; Humans; Neoplasms, Complex and Mixed; Polyps; Prostate-Specific Antigen; Vaginal Neoplasms
PubMed: 26087210
DOI: No ID Found -
Canadian Association of Radiologists... Aug 2016Female gynaecologic conditions arising from the endometrium are common and depend on a woman's age, her menstrual history, and the use of medications such as hormone... (Review)
Review
Female gynaecologic conditions arising from the endometrium are common and depend on a woman's age, her menstrual history, and the use of medications such as hormone replacement and tamoxifen. Both benign and malignant conditions affect the endometrium. Benign conditions must be distinguished from malignant and premalignant conditions. The most commonly used imaging modality for evaluating the endometrium is pelvic ultrasound with transabdominal and transvaginal techniques. Additional imaging methods include hysterosonography and magnetic resonance imaging. This pictorial essay will review the normal and abnormal appearance of the endometrium and diagnostic algorithms to evaluate abnormal vaginal bleeding and abnormal endometrial thickness.
Topics: Endometrial Neoplasms; Endometrium; Endosonography; Female; Humans; Hyperplasia; Infertility, Female; Magnetic Resonance Imaging; Polyps
PubMed: 27090929
DOI: 10.1016/j.carj.2015.09.012 -
International Journal of Surgical... Aug 2021Tubulosquamous polyp (TSP) of the vagina is a rare and benign lesion, best considered along the spectrum of lesions derived from Skene's glands, the female counterpart...
Tubulosquamous polyp (TSP) of the vagina is a rare and benign lesion, best considered along the spectrum of lesions derived from Skene's glands, the female counterpart of male prostatic glands. It is likely underdiagnosed and represents a challenging diagnosis if one is unfamiliar with this entity. We present an illustrative case of TSP occurring as an upper vaginal wall nodule of a 75-year-old woman, with characteristic morphology and broad immunophenotype. It should be suspected in postmenopausal women with a polyp that demonstrates biphasic squamous and glandular components, which show a prostatic immunophenotype.
Topics: Aged; Choristoma; Exocrine Glands; Female; Humans; Polyps; Vagina; Vaginal Diseases
PubMed: 33624543
DOI: 10.1177/1066896921995944 -
Journal de Gynecologie, Obstetrique Et... Feb 2010We present herein a particular case of surprising vaginal polyps, associated with nodular lesions (epidermal cysts). Fibroepithelial polyps are rare and benign but...
We present herein a particular case of surprising vaginal polyps, associated with nodular lesions (epidermal cysts). Fibroepithelial polyps are rare and benign but pathological aspect may be similar to malignant lesions. Vaginal polyps usually appear after genito-urinary surgery, during pregnancy, or with hormonal treatment. These lesions are effectively treated by local resection, with rare recurrence.
Topics: Adult; Epidermal Cyst; Female; Humans; Polyps; Vaginal Neoplasms
PubMed: 19819648
DOI: 10.1016/j.jgyn.2009.09.003 -
Clinical Pediatrics Jun 1990
Topics: Female; Humans; Infant, Newborn; Polyps; Vaginal Neoplasms
PubMed: 2361345
DOI: 10.1177/000992289002900612