-
Terapevticheskii Arkhiv Sep 2023To establish the features of the influence of anxiety and depressive disorders on treatment adherence, as well as to clarify the factors associated with it in...
AIM
To establish the features of the influence of anxiety and depressive disorders on treatment adherence, as well as to clarify the factors associated with it in hematologic malignancies patients.
MATERIALS AND METHODS
The study included 117 patients: 51 men and 66 women, aged 19 to 67 years, with Hodgkin's lymphoma - 88, acute lymphoblastic leukemia - 16 and aplastic anemia - 13 patients. Patients were examined by psychiatrist using the Brief Psychiatric Rating Scale, as well as some psychometric methods.
RESULTS
Anxiety-depressive spectrum disorders were detected in 36 (40.9%) patients with Hodgkin's lymphoma and 8 (50%) with acute lymphoblastic leukemia, in the aplastic anemia group there were three (23.1%) of such patients. It was found that the average adherence to treatment was in 2/3 of patients, low and high - in the remaining 1/3 of patients. With medium and low adherence to treatment, the risk of adverse events increases by an average of 1.7 times. The adherence to treatment it is significantly higher in patients older than 45 years. Signs of depression that negatively correlated with adherence to treatment were pessimism and disruption of social ties. Adherence to treatment significantly positively correlates with the following types of attitudes towards the disease: anosognosic, hypochondriac and egocentric, and significantly negatively correlates with the following types of attitudes towards the disease: anxious, melancholic and dysphoric.
CONCLUSION
Anxiety/depressive disorders contribute to reduced adherence of hematologic malignancies patients to treatment. Their correction and increased adherence should be carried out jointly by hematologists and mental health professionals.
Topics: Male; Humans; Female; Depression; Hodgkin Disease; Anemia, Aplastic; Anxiety; Hematologic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma
PubMed: 38159005
DOI: 10.26442/00403660.2023.07.202291 -
Appetite Mar 2024The food price inflation in 2022 has put considerable pressure on some consumers, leading to changes in their food choice and consumption behavior. To gain a better...
The food price inflation in 2022 has put considerable pressure on some consumers, leading to changes in their food choice and consumption behavior. To gain a better understanding of consumers' responses to rising food prices, we conducted an online survey among 1000 consumers in Germany, in which they were asked to self-report the extent of their changes during a period from the beginning of 2022 to November 2022. A principal component analysis was conducted to summarize the queried items into three factors, which were subsequently used for a cluster analysis. The emerging clusters were characterized in terms of sociodemographic as well as psychographic variables, namely locus of control, life satisfaction, optimism, pessimism, human values, and food values. The segment that appears to be most affected by rising food prices consists of about 28% of the sample's respondents and is characterized by a strong engagement in saving behaviors. These consumers are less satisfied with their lives and more pessimistic, corresponding to their lower incomes and lower likelihood to be fully employed. Communication and policy measures need to be designed in a way that these consumers regain stability and become more confident about the future.
Topics: Humans; Consumer Behavior; Food; Food Preferences; Surveys and Questionnaires; Germany
PubMed: 38154572
DOI: 10.1016/j.appet.2023.107192 -
Journal of Behavior Therapy and... Jun 2024Following engagement in a social event people with heightened vulnerability to social anxiety report elevated levels of negative thinking about the event, and this...
BACKGROUND AND OBJECTIVES
Following engagement in a social event people with heightened vulnerability to social anxiety report elevated levels of negative thinking about the event, and this post-event negative thinking is implicated in the maintenance of social anxiety vulnerability. It has also been established that heightened social anxiety vulnerability is associated with disproportionately negative expectations of upcoming social events. However, contribution of social anxiety-linked pre-event negative expectancy to post-event negative thinking has not been directly investigated. The objective of the present study was to test the hypothesis that the relationship between social anxiety vulnerability and post-event negative thinking is mediated by pre-event negative expectancies that drive increased state anxiety at the time of encountering the event.
METHODS
One-hundred and ten participants who varied in social anxiety vulnerability completed a simulated job interview. Participants reported negativity of expectancies before the event, state anxiety experienced at the time of encountering the event, and post-event negative thinking across the seven days following the event.
RESULTS
Analyses revealed elevated social anxiety predicted increased negative post-event thinking. The association between social anxiety and post-event negative thinking was fully mediated by a mediation pathway involving pre-event negative expectancies and state anxiety at the time of encountering the interview event.
LIMITATIONS
The study used a laboratory-based social experience, and conclusions could usefully be tested in the context of natural social events.
CONCLUSIONS
The findings suggest that social anxiety-linked variation in pre-event negative expectancy may contribute to post-event negative thinking following a social event via its impact on state anxiety.
Topics: Humans; Pessimism; Thinking; Anxiety; Fear; Anxiety Disorders
PubMed: 38134620
DOI: 10.1016/j.jbtep.2023.101937 -
PLoS Computational Biology Dec 2023Positive and negative affective states are respectively associated with optimistic and pessimistic expectations regarding future reward. One mechanism that might...
Positive and negative affective states are respectively associated with optimistic and pessimistic expectations regarding future reward. One mechanism that might underlie these affect-related expectation biases is attention to positive- versus negative-valence features (e.g., attending to the positive reviews of a restaurant versus its expensive price). Here we tested the effects of experimentally induced positive and negative affect on feature-based attention in 120 participants completing a compound-generalization task with eye-tracking. We found that participants' reward expectations for novel compound stimuli were modulated in an affect-congruent way: positive affect induction increased reward expectations for compounds, whereas negative affect induction decreased reward expectations. Computational modelling and eye-tracking analyses each revealed that these effects were driven by affect-congruent changes in participants' allocation of attention to high- versus low-value features of compounds. These results provide mechanistic insight into a process by which affect produces biases in generalized reward expectations.
Topics: Humans; Motivation; Emotions; Pessimism; Generalization, Psychological; Reward
PubMed: 38127874
DOI: 10.1371/journal.pcbi.1011707 -
ACS Pharmacology & Translational Science Dec 2023Although the oncogenic roles of regulator of G protein signaling 20 (RGS20) and its upstream microRNAs (miRNAs) have been reported, their involvement in hepatocellular...
Although the oncogenic roles of regulator of G protein signaling 20 (RGS20) and its upstream microRNAs (miRNAs) have been reported, their involvement in hepatocellular carcinoma (HCC) remains unexplored. We utilized the starBase, miRDB, TargetScan, and mirDIP databases, along with a dual-luciferase reporter assay and cDNA chip analysis to identify miRNAs targeting RGS20. miR-204-5p was selected for further experiments to confirm its direct targeting and downregulation of the RGS20 expression. To study the miR-204-5p/RGS20 axis in HCC, RGS20 and miR-204-5p were increased in PLC/PRF/5/Hep3B cells, and the viability, hyperplasia, apoptosis, cell cycle, and invasion/migration of the cells were assessed. RGS20 exhibited optimism, while miR-204-5p exhibited pessimism in tumors. miR-204-5p directly targeted RGS20 and downregulated its expression, whereas high RGS20 expression indicated a poor prognosis. Transfection of miR-204-5p inhibited the hyperplasia, migration, and invasion of HCC cells, but promoted apoptosis and influenced the levels of cyclin-dependent kinase 2 (CDK2), cyclin E1, B-cell lymphoma-2 (Bcl-2), Bax, and cleaved caspase-3/8. These effects were reversed by overexpression of RGS20. We recognized miR-204-5p as an upstream regulator targeting RGS20, thereby inhibiting HCC progression by downregulating RGS20 expression. RGS20 may prove to be a potential target for HCC treatment, and miR-204-5p might seem like to be a potential miRNA in gene therapy.
PubMed: 38093845
DOI: 10.1021/acsptsci.3c00114 -
Gynecologic Oncology Jan 2024To identify endometrial cancer survivors' (ECS) barriers and facilitators for participation in lifestyle interventions to improve their dietary and exercise behaviors....
OBJECTIVES
To identify endometrial cancer survivors' (ECS) barriers and facilitators for participation in lifestyle interventions to improve their dietary and exercise behaviors. Our secondary objective is to determine baseline information: physical activity level, quality of life (QoL), and impact of COVID-19 on exercise, diet, and mental health.
METHODS
Obese, early-stage ECS participated in 2-part mixed-methods data collection; Part 1: survey gathering sample characteristics, QoL, exercise, and basic endometrial cancer- related knowledge. Part 2: virtual focus group or individual interviews using a brainwriting premortem protocol. Statistical analysis was performed using SAS (version 8.3). Qualitative data were analyzed using deductive thematic coding guided by the RE-AIM framework.
RESULTS
Twenty percent (70/358) of ECS from a survivorship database and clinic recruitment completed the survey; 16 ECS provided qualitative feedback. Common barriers to intervention participation included time and resource costs, meeting frequency, and pessimism about weight loss maintenance. Facilitators included an opportunity to connect with other survivors and a focus on health rather than weight loss. Most ECS could not identify exercise guidelines (60%) and 83% were not meeting these guidelines. Higher BMI was correlated with a lower confidence in completing in moderate physical activity (p-value = 0.0206). Post-COVID-19 pandemic, physical activity, nutritional decisions, and/or mental health worsened for 67% of ECS.
CONCLUSION
ECS are a disparate population, with worsening behaviors and mental health following the pandemic. The identified ECS-specific barriers and facilitators to behavioral intervention participation are being used to simultaneously improve the reach of and adherence to a lifestyle intervention aimed at improving their health and QoL.
Topics: Female; Humans; Quality of Life; Survivorship; Pandemics; Life Style; Endometrial Neoplasms; Weight Loss; COVID-19
PubMed: 38091776
DOI: 10.1016/j.ygyno.2023.11.028 -
Journal of Medical Internet Research Dec 2023Repetitive negative thinking (RNT) is a key transdiagnostic mechanism underpinning depression and anxiety. Using "just-in-time adaptive interventions" via smartphones... (Randomized Controlled Trial)
Randomized Controlled Trial
A Personalized, Transdiagnostic Smartphone Intervention (Mello) Targeting Repetitive Negative Thinking in Young People With Depression and Anxiety: Pilot Randomized Controlled Trial.
BACKGROUND
Repetitive negative thinking (RNT) is a key transdiagnostic mechanism underpinning depression and anxiety. Using "just-in-time adaptive interventions" via smartphones may disrupt RNT in real time, providing targeted and personalized intervention.
OBJECTIVE
This pilot randomized controlled trial evaluates the feasibility, acceptability, and preliminary clinical outcomes and mechanisms of Mello-a fully automated, personalized, transdiagnostic, and mechanistic smartphone intervention targeting RNT in young people with depression and anxiety.
METHODS
Participants with heightened depression, anxiety, and RNT were recruited via social media and randomized to receive Mello or a nonactive control over a 6-week intervention period. Assessments were completed via Zoom sessions at baseline and at 3 and 6 weeks after baseline.
RESULTS
The findings supported feasibility and acceptability, with high rates of recruitment (N=55), uptake (55/64, 86% of eligible participants), and retention (52/55, 95% at 6 weeks). Engagement was high, with 90% (26/29) and 59% (17/29) of the participants in the Mello condition still using the app during the third and sixth weeks, respectively. Greater reductions in depression (Cohen d=0.50), anxiety (Cohen d=0.61), and RNT (Cohen d=0.87) were observed for Mello users versus controls. Mediation analyses suggested that changes in depression and anxiety were accounted for by changes in RNT.
CONCLUSIONS
The results indicate that mechanistic, targeted, and real-time technology-based solutions may provide scalable and effective interventions that advance the treatment of youth mental ill health.
TRIAL REGISTRATION
Australian New Zealand Clinical Trials Registry ACTRN12621001701819; http://tinyurl.com/4d3jfj9f.
Topics: Adolescent; Humans; Smartphone; Depression; Pessimism; Pilot Projects; Australia; Anxiety
PubMed: 38090786
DOI: 10.2196/47860 -
Scientific Reports Dec 2023Some animal species exhibit considerable physiological and behavioural alterations in response to captivity. It has been hypothesized, but rarely tested, that such...
Some animal species exhibit considerable physiological and behavioural alterations in response to captivity. It has been hypothesized, but rarely tested, that such changes reflect a negative affective state that is associated to this specific context. In the last years, judgement bias measures have emerged as reliable indicators of animal affective state, under the assumption that individuals in a negative affective state are more likely to evaluate ambiguous stimuli as negative and display therefore pessimistic behaviours. Here, we have developed a judgement bias task for juvenile European sea bass (Dicentrarchus labrax) aiming to measure optimism/pessimism in this marine species, which have previously been reported to show important dysregulations in captive settings. Our results show that juvenile sea bass exhibit a considerable bias towards pessimistic behaviours in laboratory settings. Furthermore, juveniles that received an unexpected positive event during the judgement bias test displayed more optimistic responses toward ambiguous stimuli as compared to control fish, indicating a positive change in their affective state induced by the appetitive experience. These results reveal a direct interaction of the internal affective state with decision-making processing under ambiguity in juvenile European sea bass, highlighting therefore the potential of judgement bias tests as a tool for the advancement and improvement of our understanding of welfare in finfish aquaculture.
Topics: Animals; Bass; Aquaculture
PubMed: 38086896
DOI: 10.1038/s41598-023-49236-5 -
Animals : An Open Access Journal From... Dec 2023This study examined how separation behavior differs between dogs with and without separation-related problem behavior (SRB) and the possible risk factors. The study...
This study examined how separation behavior differs between dogs with and without separation-related problem behavior (SRB) and the possible risk factors. The study consisted of an online survey with 940 dog holders, which, in addition to demographic facts, also includes personality, emotional disposition and the attachment by the holder. Furthermore, a separation test was carried out with six non-SRB dogs over a maximum of 6 h, in which behavior and cortisol were determined. The questionnaire revealed that SRB dogs differed significantly from non-SRB dogs regarding the following factors: symptoms with at least a medium effect size such as restlessness, excitement, whining, howling, lip licking, barking and salivation, time to relax after separation, pessimism, persistence, excitability, calmness, separation frequency, greeting of holder and type of greeting. There were several other differences, but with weak effect sizes. The test showed that non-SRB dogs were mostly inactive during separation (lying resting and lying alert). Vocalization was almost non-existent. Behavior and cortisol did not change significantly over the different time periods. The data demonstrated typical symptoms and possible risk factors, some of which may be avoided or changed to improve animal welfare.
PubMed: 38067087
DOI: 10.3390/ani13233735 -
The Clinical Journal of Pain Mar 2024The understanding of the role that cognitive and emotional factors play in how an individual recovers from a whiplash injury is important. Hence, we sought to evaluate...
OBJECTIVES
The understanding of the role that cognitive and emotional factors play in how an individual recovers from a whiplash injury is important. Hence, we sought to evaluate whether pain-related cognitions (self-efficacy beliefs, expectation of recovery, pain catastrophizing, optimism, and pessimism) and emotions (kinesiophobia) are longitudinally associated with the transition to chronic whiplash-associated disorders in terms of perceived disability and perceived recovery at 6 and 12 months.
METHODS
One hundred sixty-one participants with acute or subacute whiplash-associated disorder were included. The predictors were: self-efficacy beliefs, expectation of recovery, pain catastrophizing, optimism, pessimism, pain intensity, and kinesiophobia. The 2 outcomes were the dichotomized scores of perceived disability and recovery expectations at 6 and 12 months. Stepwise regression with bootstrap resampling was performed to identify the predictors most strongly associated with the outcomes and the stability of such selection.
RESULTS
Baseline perceived disability, pain catastrophizing, and expectation of recovery were the most likely to be statistically significant, with an overage frequency of 87.2%, 84.0%, and 84.0%, respectively.
CONCLUSION
Individuals with higher expectations of recovery and lower levels of pain catastrophizing and perceived disability at baseline have higher perceived recovery and perceived disability at 6 and 12 months. These results have important clinical implications as both factors are modifiable through health education approaches.
Topics: Humans; Prospective Studies; Follow-Up Studies; Prognosis; Whiplash Injuries; Pain; Chronic Disease; Disability Evaluation
PubMed: 38031848
DOI: 10.1097/AJP.0000000000001182