-
Angewandte Chemie (International Ed. in... Dec 2023Multianionic metal hydrides, which exhibit a wide variety of physical properties and complex structures, have recently attracted growing interest. Here we present Sr...
Multianionic metal hydrides, which exhibit a wide variety of physical properties and complex structures, have recently attracted growing interest. Here we present Sr N[BN ] H , prepared in a solid-state ampoule reaction at 800 °C, as the first combination of nitridoborate, nitride and hydride anions within a single compound. The crystal structure was solved from single-crystal X-ray and neutron powder diffraction data in space group P2 /c (no. 14), revealing a three-dimensional network of undulated layers of nitridoborate units, strontium atoms and hydride together with nitride anions. Magic angle spinning (MAS) NMR and vibrational spectroscopy in combination with quantum chemical calculations further confirm the structure model. Electrochemical measurements suggest the existence of hydride ion conductivity, allowing the hydrides to migrate along the layers.
PubMed: 37905748
DOI: 10.1002/anie.202313564 -
Annales Pharmaceutiques Francaises Mar 2024To determine whether hospital computerised physician order entry (CPOE) systems contribute to securing intravenous potassium chloride (KCl) prescriptions with reference...
OBJECTIVES
To determine whether hospital computerised physician order entry (CPOE) systems contribute to securing intravenous potassium chloride (KCl) prescriptions with reference to the recommendations issued by French healthcare agencies.
METHODS
We sent a questionnaire to the members of the Association pour le Digital et l'Information en Pharmacie.
RESULTS
More than three quarters of the 84 responses received involving 23 CPOE systems indicate that it is possible to: prescribe an ampoule of concentrated potassium chloride 10% 10mL intravenously without any diluents (80%); prescribe 4g of KCl in a bag of 500mL of NaCl 0,9% (98%); prescribe a solution that contains 6 grams of KCl per liter (94%); prescribe the administration of an injectable ampoule orally by means of a free text comment (83%). Nearly half of the responses indicate that it is possible to prescribe: concentrated KCl ampoules as administration solvent (50%); an injectable vial to be administered by oral route (52%).
CONCLUSION
At least 23 hospital CPOE systems are unable to secure the prescriptions of injectable KCl. This finding lifts the veil on an unthought, namely the role of CPOE systems in securing high-risk medications. In order to solve this problem, it should be mandatory that health information technology vendors pay particular attention to these drugs. With regard to injectable KCl, the utilisation of a dilution vehicle, maximum concentration and maximum infusion flow rate are the first four constraints to be satisfied.
Topics: Humans; Potassium; Potassium Chloride; Medical Order Entry Systems; Medication Errors; Hospitals
PubMed: 37879563
DOI: 10.1016/j.pharma.2023.06.007 -
Health Science Reports Oct 2023Melasma is a common skin condition. Microneedling acts as a dermal delivery system that facilitates the penetration of lightening agents such as vitamin C and tranexamic...
Evaluation of the effectiveness of microneedling with tranexamic acid in comparison with microneedling with vitamin C in the treatment of melasma: A prospective and single-blind clinical trial.
BACKGROUND AND AIMS
Melasma is a common skin condition. Microneedling acts as a dermal delivery system that facilitates the penetration of lightening agents such as vitamin C and tranexamic acid (TXA) into the deeper layers of the skin. Therefore, this study aimed to compare the effectiveness of microneedling with TXA with microneedling and vitamin C in treating melasma.
METHODS
In patients with melasma, microneedling was performed at 2-3 mm depth. During that, TXA and vitamin C were poured on the skin of each side of the face, and then each ampoule was soaked for 15 min. This method was performed three times in 2-week intervals, and the results were compared by measuring the Melasma Area and Severity Index (MASI) score before, during, and 2 months after the completion of the treatment.
RESULTS
The average MASI score in the baseline in the TXA group was 4.61, and in the vitamin C group was 4.58. The average MASI score in the patients treated with TXA in the last treatment session was 2.40, and the group treated with vitamin C was 2.44. The study results showed that the treatment was effective in both groups based on MASI score. Although there was a difference between the responses of the two groups, it was not significant.
CONCLUSION
Microneedling with vitamin C and TXA is a safe and effective treatment option without side effects for treating melasma.
PubMed: 37867785
DOI: 10.1002/hsr2.1636 -
Spectrochimica Acta. Part A, Molecular... Jan 2024A unique spectrofluorimetric protocol has been conceived for octreotide (a synthetic peptide drug) quantitation in both its authentic form and its application to dosage...
A unique spectrofluorimetric protocol has been conceived for octreotide (a synthetic peptide drug) quantitation in both its authentic form and its application to dosage form. The protocol has been established simply upon condensation of octreotide by ninhydrin / phenyl acetaldehyde reagent in buffered media (pH 6.2). An intense fluorescence product has been formed and quantified at 463 nm (390 nm for excitation). After optimization for various experimental conditions, a wide linear interval (0.2-4.0 µg/ml) has been used to construct the calibration curve with a determination coefficient (r) of 0.9994, a slope ± SD of 81.147 ± 0.7985, and a highly sensitive detection and quantitation limits nearly equal to 0.066 and 0.2 µg/ml, respectively. A proposed protocol has been checked in accordance with ICH validation guidelines, which indicate good accuracy and high precision of the proposed method. Furthermore, this protocol could be perfectly applied for the quantitative estimation of octreotide in its ampoules with a high degree of accuracy and precision. As a result, a developed protocol is ideally appropriate for fast and simple octreotide quantitative estimation in quality control laboratories.
Topics: Octreotide; Spectrometry, Fluorescence; Indicators and Reagents; Ninhydrin
PubMed: 37864971
DOI: 10.1016/j.saa.2023.123546 -
European Journal of Medical Research Oct 2023This study aims to illustrate the impact of applying the tranexamic acid impregnated in a gelatin sponge between the anterior rectus sheath and the Rectus Abdominis... (Randomized Controlled Trial)
Randomized Controlled Trial
Role of tranexamic acid-soaked gelatin sponge in minimizing rectus sheath hematoma after cesarean section in women treated with warfarin, a simple tool for high-risk cases, a randomized controlled trial.
BACKGROUND
This study aims to illustrate the impact of applying the tranexamic acid impregnated in a gelatin sponge between the anterior rectus sheath and the Rectus Abdominis muscle during Cesarean section (CS) in minimizing rectus sheath hematoma (RHS) in women treated with Warfarin.
METHODS
A clinical trial was carried out on 63 pregnant women attended for elective CS, who on antenatal warfarin anticoagulation started from 13 weeks gestation to 36 weeks then shifted to low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH), and with an indication for postnatal warfarin anticoagulation. They were randomly assigned on the day of the scheduled CS into three equal groups (21 women for each). Group 1 had two pieces of gelatin sponges soaked with one ampoule of tranexamic acid. Group 2 had two pieces of gelatin sponges not soaked with tranexamic acid. Group 3 (control group) had no gelatin sponge applied. All patients underwent postoperative assessment done for hemoglobin (Hb), hematocrit (HCT), estimated blood loss (EBL), amount and nature of discharge collected from the sub-rectus drain, complications (RHS, wound infection, thromboembolism), need for re-operation, and need for blood transfusion.
RESULTS
Statistically significant differences were found between Group 1 and Group 2 regarding the postoperative Hb (10.66 ± 1.13 vs. 9.77 ± 0.69, P = 0.009), between Group 1 and Group 2 regarding the postoperative HCT (31.87 ± 3.59 vs. 28.54 ± 1.85, P = 0.001), between Group 1 and Group 2 regarding EBL (442.19 ± 244.46 vs. 744.38 ± 267.05, P = 0.003), between Group 1 and Group 3 regarding EBL (442.19 ± 244.46 vs. 664.29 ± 343.97, P = 0.040), and between Group 1 and Group 3 regarding the discharge amount from the sub rectus drain (190.48 ± 100.77 vs. 307.14 ± 127.76, P = 0.004).
CONCLUSION
Tranexamic acid-soaked gelatin sponges are safe and effective in reducing postoperative drainage and EBL.
CLINICAL TRIAL REGISTRATION
At ClinicalTrials.gov in June 2022 (NCT05439694).
Topics: Humans; Female; Pregnancy; Tranexamic Acid; Gelatin; Warfarin; Heparin; Heparin, Low-Molecular-Weight; Cesarean Section; Anticoagulants; Hematoma
PubMed: 37864195
DOI: 10.1186/s40001-023-01434-7 -
Acta Crystallographica. Section E,... Oct 2023A new solid-state inorganic compound, indium dilead penta-chloride, InPbCl, was synthesized by melting InCl and PbCl in a vacuum-sealed quartz ampoule. The ampoule was...
A new solid-state inorganic compound, indium dilead penta-chloride, InPbCl, was synthesized by melting InCl and PbCl in a vacuum-sealed quartz ampoule. The ampoule was heated to 793 K and then slowly cooled to room temperature to induce crystallization of InPbCl. InPbCl crystallizes in the monoclinic crystal system adopting a space group of type 2/, which is isostructural with other metal halides such as RbPbCl, KPbCl and TlPbCl. The bulk InPbCl exhibits a metallic black/grey colour, allowing it to be separated from white/yellow PbCl crystals. Due to the incongruent nature of the compound, the pure bulk InPbCl was not obtained. The black/grey InPbCl crystals were characterized by powder and single-crystal X-ray diffraction. InPbCl was also explored, however the growth was unsuccessful.
PubMed: 37817955
DOI: 10.1107/S2056989023007892 -
Beilstein Journal of Nanotechnology 2023This article describes an approach for synthesizing silicon phosphide nanoparticles with a defective zinc blende structure under mild conditions through thermal...
This article describes an approach for synthesizing silicon phosphide nanoparticles with a defective zinc blende structure under mild conditions through thermal annealing of hydrogenated silicon nanoparticles with red phosphorus. The synthesized SiP nanoparticles were analyzed using FTIR, XRD, electron diffraction, EDX, TEM, Raman spectroscopy, X-ray fluorescence spectrometry, and UV-vis spectrophotometry. For the isolated cubic SiP phase, a cell parameter of = 5.04 Å was determined, and the bandgap was estimated to be equal to 1.25 eV. Because of the nanoscale dimensions of the obtained SiP nanoparticles, the product may exhibit several exceptional properties as a precursor for diffusion doping of wafers and as anode material for Li-ion batteries. A similar method with a hydrogenation step offers the possibility to obtain other compounds, such as silicon selenides, arsenides, and sulfides.
PubMed: 37800121
DOI: 10.3762/bjnano.14.80 -
Journal of AOAC International Nov 2023In response to the growing global need for pesticide residue testing, laboratories must develop versatile analytical methods and workflows to produce scientifically...
BACKGROUND
In response to the growing global need for pesticide residue testing, laboratories must develop versatile analytical methods and workflows to produce scientifically sound results. One of the many challenges faced by food chemists is acquiring suitable pesticide certified reference materials (CRMs) to calibrate analytical equipment, monitor method performance, and confirm the identity and concentration of hundreds of pesticide residues in food samples. CRM producers invest considerable resources to ensure the stability of their products.
OBJECTIVE
To present proper CRM handling and storage practices as guidance to ensure stability based on the results of several multiresidue pesticide stability studies.
METHODS
The open ampoule and combined multiresidue mix studies were conducted under controlled conditions. New ampoules containing multiresidue pesticide CRM mixtures were opened and compared to previously opened ampoules at multiple intervals while stored under freezing and refrigerated temperatures. Both LC- and GC-amenable pesticides (>200 residues) were combined and stored under typical laboratory conditions. Studies were performed with and without celery matrix.
RESULTS
The open ampoule study showed high levels of stability for all mixtures. All GC residues remained stable over the duration of the experiment. A week after opening LC multiresidue pesticide mixtures showed minor degradation. After combination of the multiresidue pesticide mixtures, degradation occurred rapidly for both the GC and LC mixtures.
CONCLUSION
Multiresidue pesticide mixtures are stable as ampullated until they are opened. Once the contents of a kit were opened and combined, decreasing stability was observed over time. This was true for both the LC and GC kits. Working mixtures of CRMs for instrument calibration should be made daily.
HIGHLIGHTS
This article shows a novel approach for measuring stability of CRM mixes. In-depth analysis of multiresidue pesticide mixtures and the stability that can be expected before and after mixing under typical storage conditions is described.
Topics: Tandem Mass Spectrometry; Pesticides; Gas Chromatography-Mass Spectrometry; Chromatography, Liquid; Pesticide Residues
PubMed: 37701991
DOI: 10.1093/jaoacint/qsad096 -
IUCrData Aug 2023The title compound, digadolinium(III) oxidodisilicate, Gd[SiO], was obtained in its -type crystal structure after attempts to synthesize GdBr[AsO] as a by-product from...
The title compound, digadolinium(III) oxidodisilicate, Gd[SiO], was obtained in its -type crystal structure after attempts to synthesize GdBr[AsO] as a by-product from fused silica ampoules. It crystallizes isotypically with -type Eu[SiO]. This structure consists of layers of ecliptically arranged oxidodisilicate [SiO] units separated from each other by bilayers consisting of Gd cations.
PubMed: 37693777
DOI: 10.1107/S2414314623006545 -
International Journal of Clinical... Feb 2024Look-alike medications, where ampoules or vials of intravenous medications look similar, may increase the risk of medication errors in the perioperative setting. (Review)
Review
BACKGROUND
Look-alike medications, where ampoules or vials of intravenous medications look similar, may increase the risk of medication errors in the perioperative setting.
AIM
This scoping review aimed to identify and explore the issues related to look-alike medication incidents in the perioperative setting and the reported risk reduction interventions.
METHOD
Eight databases were searched including: CINAHL Complete, Embase, OVID Emcare, Pubmed, Scopus, Informit, Cochrane and Prospero and reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews (PRISMA-ScR). Key search terms included anaesthesia, adverse drug event, drug error or medication error, look alike sound alike, operating theatres and pharmacy. Title and abstracts were screened independently and findings were extracted using validated tools in collaboration and consensus with co-authors.
RESULTS
A total of 2567 records were identified to 4th July 2022; however only 18 publications met the inclusion criteria. Publication types consisted of case reports, letters to the editor, multimodal quality improvement activities or survey/audits, a controlled simulation study and one randomised clinical trial. Risk reduction intervention themes identified included regulation, procurement, standardisation of storage, labelling, environmental factors, teamwork factors and the safe administration.
CONCLUSION
This review highlighted challenges with look-alike medications in the perioperative setting and identified interventions for risk reduction. Key interventions did not involve technology-based solutions and further research is required to assess their effectiveness in preventing patient harm.
Topics: Humans; Medication Errors; Drug-Related Side Effects and Adverse Reactions; Risk Reduction Behavior; Randomized Controlled Trials as Topic
PubMed: 37688737
DOI: 10.1007/s11096-023-01629-2