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Pleura and Peritoneum Jun 2024There are few data on Pressurized IntraPeritoneal Aerosol Chemotherapy with cisplatin and doxorubicin (PIPAC C/D) in women with primary unresectable or recurrent...
OBJECTIVES
There are few data on Pressurized IntraPeritoneal Aerosol Chemotherapy with cisplatin and doxorubicin (PIPAC C/D) in women with primary unresectable or recurrent platinum-resistant peritoneal metastasis (PM) from ovarian cancer (OC). We evaluated survival, histological and cytological response, Quality of Life (QoL) and toxicity after PIPAC C/D in these patients.
METHODS
Retrospective analysis of patients from the prospective PIPAC-OPC1 and -OPC2 studies. The histological response was evaluated by the Peritoneal Regression Grading Score (PRGS). QoL questionnaires were collected at baseline and after third PIPAC or 60 days. Adverse events were collected until 30 days after the last PIPAC. Demographic and survival data were analysed based on intention to treat. Response, QoL and toxicity were analysed per protocol (≥1 PIPAC).
RESULTS
Twenty-nine patients were included. Five patients (17 %) were non-accessible at PIPAC 1. One patient was excluded due to liver metastases at PIPAC 1. Thus, 23 patients had 76 PIPACs (median 2, range 1-12). Median overall survival was 8.2 months (95 % CI 4.4-10.3) from PIPAC 1. Biopsy data were available for 22 patients, and seven (32 %) patients had a major/complete histological response (PRGS≤2) at PIPAC 3. No cytological conversions were registered. Symptoms and function scores worsened, while emotional scores improved. Three patients had severe adverse reactions (two ileus, one pulmonary embolism); no life-threatening reactions or treatment-related mortality was observed.
CONCLUSIONS
PIPAC C/D was feasible and induced histological regression in a substantial proportion of patients with platinum-resistant PM from OC. Larger studies are needed to evaluate impact on survival.
PubMed: 38948328
DOI: 10.1515/pp-2023-0049 -
ACS Omega Jun 2024The durability of Pt nanoparticle catalysts is currently the most important factor limiting the widespread use of polymer electrolyte fuel cells (PEFCs). Specifically,...
The durability of Pt nanoparticle catalysts is currently the most important factor limiting the widespread use of polymer electrolyte fuel cells (PEFCs). Specifically, the Pt nanoparticles in standard carbon black-supported Pt nanoparticle (Pt/CB) catalysts repeatedly aggregate on the CB surfaces during PEFC operation, thus, reducing the performance of the cell. Therefore, PEFCs must contain large quantities of Pt to maintain sufficient service lifetimes. This is the main factor hindering the reduction of the cost of PEFCs. The present research demonstrates that ultrafine Pt particles (Pt) having diameters of approximately 0.5 nm can be formed in situ from a platinum chloride complex (PtCl ) on a carbon-based material doped with Fe and N via the dissolution and reprecipitation of Pt in the PtCl during potential cycling in a 0.1 M HClO solution. The Pt are immobilized by both Fe and N in the support material. The mass-based catalytic activity of this material during the oxygen reduction reaction is eight times higher than that of a standard Pt/CB catalyst and is maintained even after 100,000 potential step cycles (0.6 ↔ 1.0 V). The present results provide guidelines for the development of highly durable yet active membrane electrode assemblies that minimize the use of Pt.
PubMed: 38947817
DOI: 10.1021/acsomega.4c02723 -
Cureus May 2024Brain metastasis is a rare complication of ovarian cancer, always found at the advanced stage. Even though different multimodal approaches are available, including...
Niraparib Maintenance Therapy for Brain Metastasis in Ovarian Endometrioid Adenocarcinoma With Peritoneal Carcinomatosis: A Comprehensive Case Study and Literature Review.
Brain metastasis is a rare complication of ovarian cancer, always found at the advanced stage. Even though different multimodal approaches are available, including surgical intervention and radiotherapy, there are no official guidelines for handling this serious complication. Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors are a group of medications initially used for maintenance therapy in platinum-sensitive recurrent ovarian cancer. Niraparib has shown some efficacy in patients with brain metastasis due to its unique properties of penetrating the blood-brain barrier. Here, we present the case of a 51-year-old patient with advanced ovarian cancer with no germline breast cancer susceptibility gene (BRCA) mutations. Despite undergoing surgery and multiple rounds of chemotherapy, the patient's condition worsened, culminating in brain metastasis. Given her neurological issues, radiotherapy was not an option, prompting the initiation of a 300 mg dose of niraparib. To date, only sporadic case reports in the literature have described patients with ovarian cancer treated with niraparib and complicated by brain metastasis. Our case is unique because it is the first case of a patient with the endometrioid type of ovarian cancer.
PubMed: 38947662
DOI: 10.7759/cureus.61355 -
Heliyon Jun 2024During the measurement of multiphase flow in low yield oil wells, the liquid volume will vary with the operating characteristics of the pumping unit. Using the pulsating...
During the measurement of multiphase flow in low yield oil wells, the liquid volume will vary with the operating characteristics of the pumping unit. Using the pulsating characteristics of the up and down strokes of a pumping unit, the flow rate is measured when there is a flow rate on the up stroke, and the water content is measured when the fluid is stationary on the down stroke. In this paper, the heat transfer method is used to measure the water content of the oil water mixture during the down stroke process. At this time, the water content can be expressed as the instantaneous water content of the oil well. Firstly, the feasibility of measuring water content using heat transfer method is demonstrated theoretically, and then the temperature change of the heating probe PT300 is simulated. Finally, the actual temperature of PT300 is measured experimentally. Comparing the experimental value with the simulation value, the calculated measurement error is within 1.27 %, which indicates that the heat transfer method is feasible for measuring water content. Using the same single sensor to measure oil water two-phase flow using the pulsation characteristics of the up and down strokes of a pumping unit is a major innovation in this paper. And lays a foundation for the detection of multiphase flow using heat transfer methods. The successful implementation of the text heat transfer method for measuring water content has broken the previous situation of multiple sensor detection, simplified the structure of multiphase flow instruments, and extended the life of the instrument.
PubMed: 38947454
DOI: 10.1016/j.heliyon.2024.e31835 -
Journal of Cancer 2024As a chemotherapy agent, cisplatin (DDP) is often associated with drug resistance and gastrointestinal toxicity, factors that severely limit therapeutic efficacy in...
As a chemotherapy agent, cisplatin (DDP) is often associated with drug resistance and gastrointestinal toxicity, factors that severely limit therapeutic efficacy in patients with ovarian cancer (OC). Naringin has been shown to increase sensitivity to cisplatin, but whether the intestinal microbiota is associated with this effect has not been reported so far. In this study, we applied a humanized mouse model for the first time to evaluate the reversal of cisplatin resistance by naringin, as well as naringin combined with the microbiota in ovarian cancer. The results showed that naringin combined with subsp. NCU-01 had an inhibitory effect on the tumor, significantly reducing tumor size (<0.05), as well as the concentrations of serum tumor markers CA125 and HE4, increased the relative abundance of and , inhibit Toll-like receptor 4 (TLR4)/nuclear factor κB (NF-κB)-induced intestinal inflammation and increase the expression of intestinal permeability-associated proteins ZO-1 (<0.001) and occludin (<0.01). In conclusion, the above data demonstrate how naringin combined with subsp. NCU-01 reverses cisplatin resistance in ovarian cancer by modulating the intestinal microbiota, inhibiting the TLR4/NF-κB signaling pathway and modulating the p38MAPK signaling pathway.
PubMed: 38947385
DOI: 10.7150/jca.96448 -
Health Care Science Jun 2024The exploration of newer antibacterial strategies is driven by antibiotic-resistant microbes that cause serious public health issues. In recent years, nanoscale... (Review)
Review
The exploration of newer antibacterial strategies is driven by antibiotic-resistant microbes that cause serious public health issues. In recent years, nanoscale materials have developed as an alternative method to fight infections. Despite the fact that many nanomaterials have been discovered to be harmful, numerous researchers have shown a keen interest in nanoparticles (NPs) made of noble metals like silver, gold and platinum. To make environmentally safe NPs from plants, green chemistry and nanotechnology have been combined to address the issue of toxicity. The study of bimetallic nanoparticles (BNPs) has increased tremendously in the past 10 years. The production of BNPs mediated by natural extracts is straightforward, low cost and environmentally friendly. Due to their low toxicity, safety and biological stability, noble BNPs with silver, gold, platinum and palladium have the potential to be used in biomedical applications. They have a significant impact on human health and are used in medicine and pharmacy due to their biological characteristics, which include catalytic, antioxidant, antibacterial, antidiabetic, anticancer, hepatoprotective and regenerative activity.
PubMed: 38947365
DOI: 10.1002/hcs2.96 -
Inorganic Chemistry Jul 2024The first fully inorganic Pt(IV) carbonato-complex -[Pt(CO)(OH)] with a {PtO} coordination sphere was isolated as the (MeN)[Pt(CO)(OH)] () salt. The compound was...
The first fully inorganic Pt(IV) carbonato-complex -[Pt(CO)(OH)] with a {PtO} coordination sphere was isolated as the (MeN)[Pt(CO)(OH)] () salt. The compound was characterized using single-crystal and powder X-ray diffraction, Raman spectroscopy, infrared spectroscopy (FTIR), electrospray ionization mass spectrometry (ESI-MS), nuclear magnetic resonance spectroscopy (NMR), and thermogravimetric analysis (TG). Density functional theory (DFT) calculations were also performed to analyze the spectral features of the complex. crystallizes in the triclinic system (P-1) with a Z of 1. The -[Pt(CO)(OH)] anion has axial hydroxo ligands and κ-CO ligands, which form an equatorial plane. This anionic complex exhibits notable stability in aqueous solutions, while the axial hydroxo ligand can be readily modified, as exemplified by the acylation of the -[Pt(CO)(OH)] into -[Pt(CO)(OAc)] anion. Furthermore, it has been shown that rigid and glittering platinum coatings can be electrochemically deposited from an aqueous solution of without the addition of surfactants.
PubMed: 38946343
DOI: 10.1021/acs.inorgchem.4c00909 -
Clinical Lung Cancer Jun 2024Third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have significant antitumor activity to advanced non-small-cell lung cancer...
The Design for a Phase II, Randomized, Multicenter Study of CtDNA-Guided Treatment With Furmonertinib Combined Therapy or Furmonertinib Alone for Untreated Advanced EGFR Mutant Non-small-cell Lung Cancer Patients: The FOCUS-C Study.
BACKGROUND
Third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have significant antitumor activity to advanced non-small-cell lung cancer (NSCLC) patients with classic EGFR mutations. However, EGFR-TKI monotherapy shows poor efficacy in patients whose circulating tumor cell DNA (ctDNA) of EGFR mutations cannot be rapidly cleared.
MATERIALS AND METHODS
As a third-generation TKI, furmonertinib has shown superior antitumor activity and minor toxicity. The FOCUS-C study is a prospective, multicenter, randomized controlled trial (NCT05334277) to explore the efficacy and safety of furmonertinib plus pemetrexed-platinum doublet chemotherapy with or without bevacizumab versus furmonertinib monotherapy in untreated advanced EGFR mutant NSCLC patients without EGFR clearance after the induction therapy of furmonertinib. Patients with EGFR clearance will still receive furmonertinib as Arm A. Patients without ctDNA clearance will be randomized in a 2:2:1 ratio as Arm B1 (furmonertinib), Arm B2 (furmonertinib combined with carboplatin and pemetrexed for 4 cycles, and then furmonertinib and pemetrexed as maintenance therapy) and Arm B3 (Arm B2 regimen plus bevacizumab). The primary endpoint is progression-free survival (PFS) in Arm B2/B1. Secondary endpoints include PFS in Arm B3/B1, PFS in Arm A/B1, PFS in Arm B3/B2, objective response and disease control rate, overall survival and safety in all Arms. Exploratory endpoints are focused on the efficacy based on plasma NGS at different timepoints.
CONCLUSION
This study will evaluate the efficacy and tolerability of furmonertinib plus carboplatin and pemetrexed with or without bevacizumab verses furmonertinib alone in untreated patients with advanced EGFR mutant NSCLC without EGFR clearance.
PubMed: 38945800
DOI: 10.1016/j.cllc.2024.06.002 -
The Science of the Total Environment Jun 2024The energy consumption of up to 90 % of the total power input in the anodic oxygen evolution reaction (OER) slows down the implementation of electrochemical CO...
The energy consumption of up to 90 % of the total power input in the anodic oxygen evolution reaction (OER) slows down the implementation of electrochemical CO reduction reaction (CORR) to generate valuable chemicals. Herein, we present an alternative strategy that utilizes methanol oxidation reaction (MOR) to replace OER. The iron single atom anchored on nitrogen-doped carbon support (Fe-N-C) use as the cathode catalyst (CORR), low-loading platinum supported on the composites of tungsten phosphide and multiwalled carbon nanotube (Pt-WP/MWCNT) use as the anode catalyst (MOR). Our results show that the Fe-N-C exhibits a Faradaic selectivity as high as 94.93 % towards CORR to CO, and Pt-WP/MWCNT exhibits a peak mass activity of 544.24 mA mg, which is 5.58 times greater than that of PtC (97.50 mA mg). The well-established MOR||CORR reduces the electricity consumption up to 52.4 % compared to conventional OER||CORR. Moreover, a CO emission analysis shows that this strategy not only saves energy but also achieves carbon neutrality without changing the existing power grid structure. Our findings have crucial implications for advancing CO utilization and lay the foundation for developing more efficient and sustainable technologies to address the rising atmospheric CO levels.
PubMed: 38945233
DOI: 10.1016/j.scitotenv.2024.174288 -
Oral Oncology Jun 2024Neoadjuvant chemotherapy for induction selection of definitive treatment (IS) protocols have shown excellent outcomes for organ preservation and survival in patients...
BACKGROUND
Neoadjuvant chemotherapy for induction selection of definitive treatment (IS) protocols have shown excellent outcomes for organ preservation and survival in patients with T3 laryngeal squamous cell carcinoma (LSCC). We seek to evaluate survival and organ preservation outcomes in T4 LSCC patients treated with IS protocols.
METHODS
Retrospective cohort of advanced T3 and T4 LSCC patients who underwent IS protocols based upon potential for preserving a functional larynx. Patients received one neoadjuvant cycle of platinum-based chemotherapy with either 5-fluorouracil or docetaxel or with two cycles of platinum-based chemotherapy with docetaxel and a Bcl-2 inhibitor. Patients who achieved ≥ 50 % response as determined by radiographic review and/or endoscopic evaluation received definitive chemoradiation. Patients who had < 50 % response after IS underwent total laryngectomy (TL) followed by post-operative radiation +/- chemotherapy.
RESULTS
Amongst T4 patients, 114 met inclusion criteria including 89 who underwent IS protocols and 25 who received an upfront TL. In total, 76.0 % of T3 patients and 71.9 % of T4 patients responded to IS and underwent definitive chemoradiation. There was no significant difference in hazard of death between T4 IS and T4 TL patients (HR: 0.9, p = 0.86). Among responders, there was no significant difference in 5-year laryngectomy-free survival (T3 - 59.6 %, T4 44.3 %, p = 0.15) or laryngeal preservation by T stage (T3 - 72.8 %, T4 - 73.0 %, p = 0.84).
CONCLUSIONS
Select T4 patients may benefit from organ preservation using IS protocols with similar response rates to patients with T3 tumors, without compromising survival when compared to upfront TL.
PubMed: 38945011
DOI: 10.1016/j.oraloncology.2024.106917