-
Frontiers in Public Health 2024Aging is one of the most important public health issues. Previous studies on the factors affecting aging focused on genetics and lifestyle, but the association between...
BACKGROUND
Aging is one of the most important public health issues. Previous studies on the factors affecting aging focused on genetics and lifestyle, but the association between polycyclic aromatic hydrocarbons (PAHs) and aging is still unclear.
METHODS
This study utilized data from the National Health and Nutrition Examination Survey (NHANES) 2003-2010. A total of 8,100 participants was used to construct the biological age predictors by using recent advanced algorithms Klemera-Doubal method (KDM) and Mahalanobis distance. Two biological aging indexes, recorded as KDM-BA acceleration and PhenoAge acceleration, were used to investigate the relationship between single PAHs and biological age using a multiple linear regression analysis, and a weighted quantile sum (WQS) model was constructed to explore the mixed effects of PAHs on biological age. Finally, we constructed the restricted cubic spline (RCS) model to assess the non-linear relationship between PAHs and biological age.
RESULTS
Exposure to PAHs was associated with PhenoAge acceleration. Each unit increase in the log10-transformed level of 1-naphthol, 2-naphthol, and 2-fluorene was associated with a 0.173 (95% CI: 0.085, 0.261), 0.310 (95% CI: 0.182, 0.438), and 0.454 (95% CI: 0.309, 0.598) -year increase in PhenoAge acceleration, respectively (all corrected < 0.05). The urinary PAH mixture was relevant to KDM-BA acceleration (β = 0.13, 95% CI: 0, 0.26, = 0.048) and PhenoAge acceleration (β = 0.59, 95% CI: 0.47, 0.70, < 0.001), and 2-naphthol had the highest weight in the weighted quantile sum (WQS) regression. The RCS analyses showed a non-linear association between 2-naphthol and 2-fluorene with KDM-BA acceleration (all < 0.05) in addition to a non-linear association between 1-naphthol, 2-naphthol, 3-fluorene, 2-fluorene, and 1-pyrene with PhenoAge acceleration (all < 0.05).
CONCLUSION
Exposure to mixed PAHs is associated with increased aging, with 2-naphthol being a key component of PAHs associated with aging. This study has identified risk factors in terms of PAH components for aging.
Topics: Humans; Polycyclic Aromatic Hydrocarbons; Male; Female; Nutrition Surveys; Middle Aged; Aging; Adult; Environmental Exposure; Fluorenes; Aged; Naphthols
PubMed: 38903587
DOI: 10.3389/fpubh.2024.1379252 -
Chemical Science Jun 2024Stepped spin crossover (SCO) complexes with three or more spin states have promising applications in high-order data storage, multi-switches and multi-sensors. Further...
Stepped spin crossover (SCO) complexes with three or more spin states have promising applications in high-order data storage, multi-switches and multi-sensors. Further synergy with other functionalities, such as luminescence and dielectric properties, will provide a good chance to develop novel multifunctional SCO materials. Here, a bent pillar ligand and luminescent pyrene guest are integrated into a three-dimensional (3D) Hofmann-type metal-organic framework (MOF) [Fe(dpoda){Au(CN)}]·pyrene (dpoda = 2,5-di-(pyridyl)-1,3,4-oxadiazole). The magnetic data show an incomplete and two-step SCO behavior with the sequence of 1 ↔ 1/2 ↔ 1/4. The rare bi-directional light-induced excited spin-state trapping (LIESST) effect and light-induced stepped thermal relaxation after LIESST are observed. The pyrene guests interact with dpoda ligands offset face-to-face π⋯π interactions to form intermolecular exciplex emissions. The competition between thermal quenching and stepped SCO properties results in a complicated and stepped exciplex fluorescence. Moreover, the stepped dielectric property with higher dielectric permittivity at lower temperature may be related to the more frustrated octahedral distortion parameters in the intermediate spin states. Hence, a 3D Hofmann-type MOF with bent pillar ligands and fluorescent guests illustrates an effective way for the development of multifunctional switching materials.
PubMed: 38903231
DOI: 10.1039/d4sc00331d -
Inflammation and Regeneration Jun 2024Tobacco smoking causes pulmonary inflammation, resulting in emphysema, an independent risk factor for lung cancer. Induction of insulin-like growth factor 2 (IGF2) in...
BACKGROUND
Tobacco smoking causes pulmonary inflammation, resulting in emphysema, an independent risk factor for lung cancer. Induction of insulin-like growth factor 2 (IGF2) in response to lung injury by tobacco carcinogens, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and polycyclic aromatic hydrocarbon benzo[a]pyrene in combination (NB), is critical for the proliferation of alveolar type 2 cells (AT2s) for lung repair. However, persistent IGF2 overexpression during NB-induced severe injury results in hyperproliferation of AT2s without coordinated AT2-to-AT1 differentiation, disrupting alveolar repair, which leads to the concurrent development of emphysema and lung cancer. The current study aims to verify the role of IGF2 signaling in the associated development of emphysema and cancer and develop effective pharmaceuticals for the diseases using animal models that recapitulate the characteristics of these chronic diseases.
METHODS
The pathogenesis of pulmonary emphysema and cancer was analyzed by lung function testing, histological evaluation, in situ zymography, dihydroethidium staining, and immunofluorescence and immunohistochemistry analyses utilizing mouse models of emphysema and cancer established by moderate exposure to NB for up to seven months.
RESULTS
Moderate NB exposure induced IGF2 expression in AT2s during the development of pulmonary emphysema and lung cancer in mice. Using AT2-specific insulin receptor knockout mice, we verified the causative role of sustained IGF2 signaling activation in AT2s in emphysema development. IGF2-targeting strategies, including voltage-dependent calcium channel blocker (CCB) and a neutralizing antibody, significantly suppressed the NB-induced development of emphysema and lung cancer. A publicly available database revealed an inverse correlation between the use of calcium channel blockers and a COPD diagnosis.
CONCLUSIONS
Our work confirms sustained IGF2 signaling activation in AT2s couples impaired lung repair to the concurrent development of emphysema and cancer in mice. Additionally, CCB and IGF2-specific neutralizing antibodies are effective pharmaceuticals for the two diseases.
PubMed: 38902841
DOI: 10.1186/s41232-024-00344-3 -
Materials (Basel, Switzerland) Jun 2024The visible-light-driven photocatalytic production of hydrogen peroxide (HO) is currently an emerging approach for transforming solar energy into chemical energy. In...
The visible-light-driven photocatalytic production of hydrogen peroxide (HO) is currently an emerging approach for transforming solar energy into chemical energy. In general, the photocatalytic process for producing HO includes two pathways: the water oxidation reaction (WOR) and the oxygen reduction reaction (ORR). However, the utilization efficiency of ORR surpasses that of WOR, leading to a discrepancy with the low oxygen levels in natural water and thereby impeding their practical application. Herein, we report a novel donor-bridge-acceptor (D-B-A) organic polymer conjugated by the Sonogashira-Hagihara coupling reaction with tetraphenylethene (TPE) units as the electron donors, acetylene (A) as the connectors and pyrene (P) moieties as the electron acceptors. Notably, the resulting TPE-A-P exhibits a remarkable solar-to-chemical conversion of 1.65% and a high BET-specific surface area (1132 m·g). Furthermore, even under anaerobic conditions, it demonstrates an impressive HO photosynthetic efficiency of 1770 μmol g h, exceeding the vast majority of previously reported photosynthetic systems of HO. The outstanding performance is attributed to the effective separation of electrons and holes, along with the presence of sufficient reaction sites facilitated by the incorporation of alkynyl electronic bridges. This protocol presents a successful method for generating HO via a water oxidation reaction, signifying a significant advancement towards practical applications in the natural environment.
PubMed: 38893973
DOI: 10.3390/ma17112709 -
Molecules (Basel, Switzerland) May 2024In aqueous and solid media, 2-HP-β/γ-CD inclusion complexes with poly aromatic hydrocarbon (PAH) Phenanthrene (PHN), Anthracene (ANT), Benz(a)pyrene (BaP), and...
In aqueous and solid media, 2-HP-β/γ-CD inclusion complexes with poly aromatic hydrocarbon (PAH) Phenanthrene (PHN), Anthracene (ANT), Benz(a)pyrene (BaP), and Fluoranthene (FLT) were investigated for the first time. The inclusion complexes were characterized and investigated using fluorescence and HNMR spectroscopy. The most prevalent complexes consisting of both guests and hosts were those with a 1:1 guest-to-host ratio. The stability constants for the complexes of PHN with 2-HP-β-CD and 2-HP-γ-CD were 85 ± 12 M and 49 ± 29 M, respectively. Moreover, the stability constants were found to be 502 ± 46 M and 289 ± 44 M for the complexes of ANT with both hosts. The stability constants for the complexes of BaP with 2-HP-β-CD and 2-HP-γ-CD were (1.5 ± 0.02) × 10 M and (9.41 ± 0.03) × 10 M, respectively. The stability constant for the complexes of FLT with 2-HP-β-CD was (1.06 ± 0.06) × 10 M. However, FLT was observed to form a weak complex with 2-HP-γ-CD. Molecular dynamic (MD) simulations were used to investigate the mechanism and mode of inclusion processes, and to monitor the atomic-level stability of these complexes. The analysis of MD trajectories demonstrated that all guests formed stable inclusion complexes with both hosts throughout the duration of the simulation time, confirming the experimental findings. However, the flexible Hydroxypropyl arms prevented the PAHs from being encapsulated within the cavity; however, a stable exclusion complex was observed. The main forces that influenced the complexation included van der Waals interactions, hydrophobic forces, and C-H⋯π interaction, which contribute to the stability of these complexes.
PubMed: 38893410
DOI: 10.3390/molecules29112535 -
ACS Omega Jun 2024Microplastics have been detected in various food types, suggesting inevitable human exposure. A major fraction may originate from aerial deposition and could be...
Microplastics have been detected in various food types, suggesting inevitable human exposure. A major fraction may originate from aerial deposition and could be contaminated by ubiquitous pollutants such as polycyclic aromatic hydrocarbons (PAHs). While data on the sorption of pollutants to microplastics are abundant, the subsequent desorption in the gastrointestinal tract (GIT) is less understood. This prompted us to systematically investigate the release of microplastics-sorbed PAHs at realistic loadings (44-95 ng/mg) utilizing a physiology-based in vitro model comprising digestion in simulated saliva, gastric, and small and large intestinal fluids. Using benzo[]pyrene as a representative PAH, desorption from different microplastics based on low density polyethylene (LDPE), thermoplastic polyurethanes (TPUs), and polyamides (PAs) was investigated consecutively in all four GIT fluid simulants. The cumulative relative desorption (CRD) of benzo[]pyrene was negligible in saliva simulant but increased from gastric (4 ± 1% - 15 ± 4%) to large intestinal fluid simulant (21 ± 1% - 29 ± 6%), depending on the polymer type. CRDs were comparable for ten different microplastics in the small intestinal fluid simulant, except for a polydisperse PA-6 variant (1-10 μm), which showed an exceptionally high release (51 ± 8%). Nevertheless, the estimated contribution of microplastics-sorbed PAHs to total human PAH dietary intake was very low (≤0.1%). Our study provides a systematic data set on the desorption of PAHs from microplastics in GIT fluid simulants.
PubMed: 38882100
DOI: 10.1021/acsomega.3c09380 -
Environment International Jul 2024In experimental studies, several polycyclic aromatic hydrocarbons (PAHs) have shown endocrine disrupting properties, but very few epidemiological studies have examined...
BACKGROUND
In experimental studies, several polycyclic aromatic hydrocarbons (PAHs) have shown endocrine disrupting properties, but very few epidemiological studies have examined their impact on pubertal development and results have been heterogenous.
OBJECTIVE
To explore if maternal PAH exposure during pregnancy was associated with the offspring's timing of pubertal onset.
METHODS
We studied 582 mother-daughter dyads originating from a population-based cohort in a rural setting in Bangladesh. Maternal urinary samples, collected in early pregnancy (on average, gestational week 8), were analyzed for monohydroxylated metabolites of phenanthrene (1-OH-Phe, Σ2-,3-OH-Phe, and 4-OH-Phe), fluorene (Σ2-,3-OH-Flu), and pyrene (1-OH-Pyr) using liquid chromatography with tandem mass spectrometry (LC-MS/MS). The girls were interviewed on two separate occasions concerning date of menarche, as well as breast and pubic hair development according to Tanner. Associations were assessed using Kaplan-Meier analysis and multivariable-adjusted Cox proportional hazards regression or ordered logistic regression.
RESULTS
In early pregnancy, the mothers' median urinary concentrations of Σ1-,2-,3-,4-OH-Phe, Σ2-,3-OH-Flu, and 1-OH-Pyr were 3.25 ng/mL, 2.0 ng/mL, and 2.3 ng/mL respectively. At the second follow-up, 78 % of the girls had reached menarche, and the median age of menarche was 12.7 ± 0.81 years. Girls whose mothers belonged to the second and third quintiles of ΣOH-Phe metabolites had a higher rate of menarche, indicating a younger menarcheal age (HR 1.39; 95 % CI 1.04, 1.86, and HR 1.41; 95 % CI 1.05, 1.88, respectively), than girls of mothers in the lowest quintile. This trend was not observed in relation to either breast or pubic hair development. None of the other maternal urinary PAH metabolites or the sum of all thereof in early pregnancy were associated with age at menarche or pubertal stage.
CONCLUSIONS
Indications of non-monotonic associations of prenatal phenanthrene exposure with the daughters' age of menarche were found, warranting further investigation.
Topics: Humans; Female; Pregnancy; Polycyclic Aromatic Hydrocarbons; Bangladesh; Maternal Exposure; Rural Population; Adult; Prenatal Exposure Delayed Effects; Adolescent; Puberty; Child; Longitudinal Studies; Environmental Pollutants; Menarche; Cohort Studies; Young Adult
PubMed: 38875814
DOI: 10.1016/j.envint.2024.108798 -
Chemical Science Jun 2024Controlling chemical functionalization and achieving stable electrode-molecule interfaces for high-performance electrochemical energy storage applications remain...
Controlling chemical functionalization and achieving stable electrode-molecule interfaces for high-performance electrochemical energy storage applications remain challenging tasks. Herein, we present a simple, controllable, scalable, and versatile electrochemical modification approach of graphite rods (GRs) extracted from low-cost Eveready cells that were covalently modified with anthracene oligomers. The anthracene oligomers with a total layer thickness of ∼24 nm on the GR electrode yield a remarkable specific capacitance of ∼670 F g with good galvanostatic charge-discharge cycling stability (10 000) recorded in 1 M HSO electrolyte. Such a boost in capacitance is attributed mainly to two contributions: (i) an electrical double-layer at the anthracene oligomer/GR/electrolyte interfaces, and (ii) the proton-coupled electron transfer (PCET) reaction, which ensures a substantial faradaic contribution to the total capacitance. Due to the higher conductivity of the anthracene films, it possesses more azo groups (-N[double bond, length as m-dash]N-) during the electrochemical growth of the oligomer films compared to pyrene and naphthalene oligomers, which is key to PCET reactions. AC-based electrical studies unravel the in-depth charge interfacial electrical behavior of anthracene-grafted electrodes. Asymmetrical solid-state supercapacitor devices were made using anthracene-modified biomass-derived porous carbon, which showed improved performance with a specific capacitance of ∼155 F g at 2 A g with an energy density of 5.8 W h kg at a high-power density of 2010 W kg and powered LED lighting for a longer period. The present work provides a promising metal-free approach in developing organic thin-film hybrid capacitors.
PubMed: 38873075
DOI: 10.1039/d4sc00611a -
RSC Advances Jun 2024The aim of this study was to develop a new method for sampling and analyzing polycyclic aromatic hydrocarbons in the air. This was achieved by utilizing a needle trap...
The aim of this study was to develop a new method for sampling and analyzing polycyclic aromatic hydrocarbons in the air. This was achieved by utilizing a needle trap device packed with a modified porous aromatic framework coated with magnetic nanoparticles (PAF-6-MNPs). The modified adsorbent underwent qualitative evaluation using Fourier-transform infrared spectroscopy and X-ray diffraction, as well as scanning and transmission electron microscopy. The optimal conditions for sampling polycyclic aromatic hydrocarbons compounds were determined using a dynamic atmosphere chamber. The method was validated by taking various samples from the standard chamber, and then analyzed under different environmental sampling conditions using a gas chromatography device. The limit of detection (LOD) and limit of quantification (LOQ) values for the analytes of interest, including naphthalene, anthracene, and pyrene, ranged from 0.0034-0.0051 and 0.010-0.015 μg L, respectively. Also, the repeatability and reproducibility of the method expressed as relative standard deviation, for the mentioned analyses were found to be in the range of 17.8-20.5% and 20-22.9%. The results indicated that over a 20 day storage period (with the needle trap device containing the analytes of interest kept in the refrigerator), there was no significant decrease in the amount of analytes compared to the initial amount. These findings suggest that, the needle trap packed with the proposed adsorbent offers a reliable, highly-sensitive, easy-to-use, and cost-effective method for sampling polycyclic aromatic hydrocarbons in the air compared to the conventional method recommended by the National Institute of Occupational Safety and Health (NIOSH), method 5515.
PubMed: 38860255
DOI: 10.1039/d4ra01651c