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Acta Ophthalmologica Mar 2012A large number of methods have been developed for assessing glaucomatous visual field progression, but their properties have not yet been systematically evaluated. In... (Review)
Review
A large number of methods have been developed for assessing glaucomatous visual field progression, but their properties have not yet been systematically evaluated. In this systematic literature review, we summarize the evidence base for selecting a method by providing answers to ten relevant questions on the variety, validity and reproducibility of methods. In total, we found 301 different methods in 412 articles. The majority of studies (54%) used the Humphrey Field Analyzer. No data have been published about the reproducibility of methods. Although there is no gold standard to assess glaucomatous visual field progression, we found evidence on validity for 48 different methods. Some methods were less capable of distinguishing between progressive and nonprogressive patients. Choosing among twelve methods is supported by some evidence of their validity. These methods still differ in sensitivity, specificity and predictive values of test results within studies comparing several methods. In conclusion, the current evidence base is not perfect. A selection should be made from a limited number of methods, according to the clinical purpose of progression assessment. Methods that quantify the rate of visual field progression seem to be the most appropriate for guiding subsequent medical actions in individual patients. Future studies should investigate whether using one method to monitor patients is superior to another method in preventing loss of quality of life.
Topics: Diagnostic Techniques, Ophthalmological; Disease Progression; Evidence-Based Medicine; False Positive Reactions; Glaucoma, Open-Angle; Humans; Optic Disk; Optic Nerve Diseases; Predictive Value of Tests; Reproducibility of Results; Sensitivity and Specificity; Validation Studies as Topic; Vision Disorders; Visual Field Tests; Visual Fields
PubMed: 21812943
DOI: 10.1111/j.1755-3768.2011.02206.x -
Canadian Journal of Ophthalmology.... Feb 2011
Review
Topics: Cost-Benefit Analysis; Databases, Factual; Diagnostic Techniques, Ophthalmological; Glaucoma; Humans; Optic Disk
PubMed: 21283168
DOI: 10.3129/i10-101 -
Ophthalmology Jan 2010To determine (1) the extent to which the definition of success of glaucoma surgery varies in the literature and (2) the degree to which the reported outcome after... (Review)
Review
PURPOSE
To determine (1) the extent to which the definition of success of glaucoma surgery varies in the literature and (2) the degree to which the reported outcome after trabeculectomy is affected by the criteria used to define success.
DESIGN
A systematic review of the literature and application of definitions to a retrospective cohort.
PARTICIPANTS
A cohort of 100 patients who previously underwent trabeculectomy.
METHODS
A literature search was performed of PubMed using the search term trabeculectomy for a 5-year period. Studies presenting original data relating to longitudinal intraocular pressure (IOP) control after glaucoma surgery were included. The definitions of success and failure used were documented for each publication. Each IOP-related definition of success was applied to a cohort of patients who previously underwent trabeculectomy. Success rates were derived for each published definition up to 36 months after surgery.
MAIN OUTCOME MEASURES
Intraocular pressure measured by Goldmann applanation tonometry.
RESULTS
From 100 publications meeting the inclusion criteria, 92 distinct IOP-related definitions of success were identified. Using these definitions, success rates for this series of 100 trabeculectomies varied between 36.0% and 98.0% after 3 years of follow-up.
CONCLUSIONS
Over a recent 5-year period, there were nearly as many different definitions of success after glaucoma surgery as publications on the subject. The definition used markedly affects the quoted success rate after trabeculectomy, making interpretation of and comparison between published results extremely difficult. Standardization of published outcome parameters after glaucoma surgery is essential to allow meaningful comparisons between different study reports.
FINANCIAL DISCLOSURE(S)
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Topics: Controlled Clinical Trials as Topic; Glaucoma; Humans; Intraocular Pressure; Optic Disk; Outcome Assessment, Health Care; Prospective Studies; Retrospective Studies; Tonometry, Ocular; Trabeculectomy; Visual Acuity; Visual Fields
PubMed: 19896196
DOI: 10.1016/j.ophtha.2009.06.014 -
Medical Science Monitor : International... Jul 2008The aim was to review all published studies that investigated the association between MYOC.mt1 polymorphism and the risk of primary open-angle glaucoma (POAG). (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
The aim was to review all published studies that investigated the association between MYOC.mt1 polymorphism and the risk of primary open-angle glaucoma (POAG).
MATERIAL/METHODS
Electronic databases were searched for relevant articles in English. Inclusion and exclusion criteria were established according to the criteria of the Cochrane Methods Group. Studies were included if participants were patients with POAG (adult- or juvenile-onset), had extractable data on both genotypes of MYOC.mt1, phenotypes of severity, and reasonable controls. Statistical analysis was performed using SPSS 13.0 for Windows and RevMan 4.2. Four case-control studies of 835 cases and 530 controls were included in the meta-analysis.
RESULTS
The pooled odds ratio (OR) to develop POAG with and without MYOC.mt1 from a fixed-effects model was 1.06 (95%CI: 0.81-1.38, P=0.67), i.e. MYOC.mt1 carriers did not have significantly higher risk of developing POAG than non-carriers. There was also no significant association between the -1000G allele and increased risk (OR=1.05, 95%CI: 0.83-1.32, P=0.71). Comprehensive summarization was done to determine the influence of MYOC.mt1 on the severity of optic disk changes and visual function loss in POAG cases. There was evidence of publication bias from funnel-plot asymmetry and Egger's test.
CONCLUSIONS
Evidence for an association between MYOC.mt1 and the risk of POAG is limited. These results suggest that MYOC.mt1 polymorphism does not have significant influence on the risk of POAG development or its severity. However, the evidence of publication bias suggests that more large prospective cohort studies with precise design are required to confirm an association between MYOC.mt1 and POAG.
Topics: Alleles; Cytoskeletal Proteins; Eye Proteins; Genetic Predisposition to Disease; Glaucoma, Open-Angle; Glycoproteins; Humans; Polymorphism, Genetic; Promoter Regions, Genetic
PubMed: 18591929
DOI: No ID Found -
Journal of Glaucoma Dec 2006To examine the variability and to evaluate the influence of the Ocular Hypertension Treatment Study (OHTS) on the criteria for published definition of ocular... (Review)
Review
PURPOSE
To examine the variability and to evaluate the influence of the Ocular Hypertension Treatment Study (OHTS) on the criteria for published definition of ocular hypertension (OH).
DESIGN
Systematic literature review.
METHODS
All articles about OH published between January 1995 and July 2005 from the 3 clinical journals of ophthalmology were identified by a literature search. They were reviewed to determine the criteria used to define OH, including intraocular pressure and central corneal thickness, visual field and optic disc assessment.
RESULTS
There were 133 studies published on OH during the period under study. As a goal of the current study was to evaluate the influence of the publication of the OHTS results on the definition of OH used in the literature, all reports from the OHTS and its ancillary studies (n = 11) were excluded from the main analysis. After the exclusion of the OHTS reports, a total of 122 studies were used in the analysis. The intraocular pressure cut-off level used for OH diagnosis ranged from 18 to 26 mm Hg, with a mode of 22 mm Hg (49.2%). Only 13.1% of the articles reported central corneal thickness, and these were distributed evenly during the 10-year period under study. Visual field assessment was reported by most of the studies (110; 90.2%), but only 45% of them defined the criteria to classify a field as normal or glaucomatous. Further, only 37 of the 57 articles that reported the method of optic disc assessment described the criteria used to classify optic discs.
CONCLUSIONS
The criteria used to define OH during the past 10 years have been highly variable. This wide variation suggests the important need for a standardized definition of OH.
Topics: Humans; Intraocular Pressure; Ocular Hypertension; Optic Disk; Optic Nerve Diseases; Terminology as Topic; Tonometry, Ocular; Vision Disorders; Visual Fields
PubMed: 17106367
DOI: 10.1097/01.ijg.0000212279.03595.70