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Revista Espanola de Geriatria Y... 2019
Topics: Adie Syndrome; Aged; Anisocoria; Anti-Bacterial Agents; Bronchodilator Agents; Female; Humans; Ipratropium; Levofloxacin; Mydriasis; Nebulizers and Vaporizers; Pulmonary Disease, Chronic Obstructive
PubMed: 30598303
DOI: 10.1016/j.regg.2018.11.009 -
Journal Francais D'ophtalmologie Jan 2019To describe the ocular findings and management of Hymenoptera insect stings.
PURPOSE
To describe the ocular findings and management of Hymenoptera insect stings.
METHODS
We treated and followed 8 patients with ocular Hymenoptera stings. All patients were admitted through emergencies and hospitalized at the Hedi Rays eye institute in Tunis.
RESULTS
The site of the sting was the cornea in 5 cases, limbus in one case, conjunctiva in one case and upper lid in the last case. Retained stingers were objectified in 4 cases. Immediate surgical extraction carried out in all cases. We also followed one case of post-sting Adie's syndrome and one case of retrobulbar optic neuritis. The sting was conjunctival in one case and palpebral in the other case. Corticosteroids were ineffective in these two cases.
CONCLUSION
Ocular Hymenoptera stings are rare environmental accidents. They may cause various severe ocular complications. Early management, adapted to the clinical manifestations, is the key to a good outcome.
Topics: Adrenal Cortex Hormones; Adult; Animals; Cyclosporine; Eye Injuries, Penetrating; Female; Humans; Hymenoptera; Insect Bites and Stings; Male; Ophthalmic Solutions; Retrospective Studies; Tunisia
PubMed: 30559016
DOI: 10.1016/j.jfo.2018.04.014 -
Neurology Oct 2018
Topics: Diagnosis, Differential; Disease Progression; Female; Humans; Iridocorneal Endothelial Syndrome; Middle Aged; Pupil
PubMed: 30297503
DOI: 10.1212/WNL.0000000000006327 -
Medicina Clinica Aug 2018
Topics: Adie Syndrome; Female; Humans; Miotics; Photography; Pilocarpine; Young Adult
PubMed: 29196034
DOI: 10.1016/j.medcli.2017.10.024 -
Neurological Sciences : Official... Jan 2018Sir Gordon Morgan Holmes (1876-1965) was one of the most important founders of modern neurology and a great teacher and scientist. He was the first scientist to...
Sir Gordon Morgan Holmes (1876-1965) was one of the most important founders of modern neurology and a great teacher and scientist. He was the first scientist to challenge the theory of the unitary function of the cerebellum and described cerebellar disorders. Holmes together with Thomas Grainger Stewart (1877-1957) described 40 cases of the rebound phenomenon in cerebellar disease (Stewart-Holmes maneuver or Stewart-Holmes test). He also described the symptoms of inherited neurodegenerative spinocerebellar ataxia involving the olivary nucleus (Gordon-Holmes syndrome). Independently from the Australian neurologist William John Adie (1886-1935), he described the partial iridoplegia (Holmes-Adie pupil or Holmes-Adie syndrome). His teaching skills became clearly visible in Goulstonian and Croonian lectures dedicated to spinal cord injuries.
Topics: History, 19th Century; History, 20th Century; Neurology
PubMed: 29116546
DOI: 10.1007/s10072-017-3180-6 -
Neurophysiologie Clinique = Clinical... Dec 2017
Topics: Adie Syndrome; Adult; Female; Humans; Lower Extremity; Reflex; Reflex, Abnormal
PubMed: 28939242
DOI: 10.1016/j.neucli.2017.08.001 -
Molecular and Clinical Oncology Jun 2017Adie's syndrome (AS) and paraneoplastic sensorimotor neuropathy with cerebellar ataxia (PSN CA) are extremely rare, rapidly progressive, autoimmune diseases associated...
Synchronous Adie's syndrome and type 1 antineuronal nuclear antibody (anti-Hu)-related paraneoplastic neurological syndromes as predictors of complete response in limited-stage small-cell lung cancer: A case report.
Adie's syndrome (AS) and paraneoplastic sensorimotor neuropathy with cerebellar ataxia (PSN CA) are extremely rare, rapidly progressive, autoimmune diseases associated with the development of antibodies against neuronal-specific Hu proteins that are abnormally expressed in small-cell lung cancer (SCLC). We herein present the unique case of a 55-year-old obese woman, previous heavy smoker, who, during treatment with standard cisplatin-etoposide chemotherapy for limited-stage SCLC, developed simultaneous AS and worsening symptoms consistent with PSN CA that led to significant neurological disability and severe axonal electrophysiological pattern on nerve conduction studies. Serology confirmed the presence of low-titre type 1 antineuronal nuclear antibodies (ANNA-1), previously referred to as anti-Hu antibodies. Following plasmapheresis, immunosuppressive therapy and physical rehabilitation, the neurological symptoms progressively improved. The tumour completely regressed, with no recurrence detected on subsequent radiological examinations. The aim of this case was to highlight the importance of a multidisciplinary team approach for early recognition and rapid treatment of paraneoplastic neurological syndromes (PNS) as key to achieving significant recovery and marked improvement of the neurological deficit. This report extends the literature by confirming earlier studies showing that the presence of serum ANNA-1 in SCLC, an aggressive type of pulmonary carcinoma that is challenging to treat, may portend a more favourable prognosis and response to chemotherapy. Thus, patients with SCLC and new-onset neurological symptoms should be tested for ANNA-1. The role of a multimodality approach to treating PNS is also emphasized.
PubMed: 28588791
DOI: 10.3892/mco.2017.1248 -
Case Reports in Neurological Medicine 2017A 40-year-old woman was found to have bilateral Adie's pupils and generalized muscle stretch areflexia. She did not have orthostatic hypotension but, in an ECG strip in...
A 40-year-old woman was found to have bilateral Adie's pupils and generalized muscle stretch areflexia. She did not have orthostatic hypotension but, in an ECG strip in the office, she appeared to have an almost fixed heart rate. We thus studied the heart rate variability (HRV) and the systolic blood pressure variability (SBPV) in supine and standing position and also during rhythmic breathing. We found a decreased HRV in the time domain with very low standard deviation in supine and standing position and during rhythmic breathing. HRV in the frequency domain was low with a decrease in the absolute power of HF and LF and a decrease in the sympathovagal balance in supine and standing positions. SBPV in the time and frequency domains was found to be normal. This patient with Holmes-Adie syndrome had an asymptomatic severe loss of HRV and a preserved SBPV. The global decrease in the HRV in the time and frequency domains indicated that she had both vagal and sympathetic cardiac denervation, whereas the preserved SBPV suggested normal innervation of the blood vessels.
PubMed: 28428900
DOI: 10.1155/2017/4919758 -
Indian Journal of Dermatology 2016Ross syndrome is a rare dysautonomia characterized by a clinical complex of segmental anhidrosis or hypohidrosis, areflexia, and tonic pupils. A very few cases (≃50)...
Ross syndrome is a rare dysautonomia characterized by a clinical complex of segmental anhidrosis or hypohidrosis, areflexia, and tonic pupils. A very few cases (≃50) have been reported in literature since its original description in 1958. Here, we report the case of a middle-aged homemaker from Odisha, India, who presented with complaints of segmental hypohidrosis for the past 7 years.
PubMed: 27293279
DOI: 10.4103/0019-5154.182472 -
Journal of Pediatric Hematology/oncology Aug 2016Paraneoplastic neurological syndromes (PNS) are rare, remote effects of cancer that are usually caused by an altered immune response to the tumor and not due to the...
Paraneoplastic neurological syndromes (PNS) are rare, remote effects of cancer that are usually caused by an altered immune response to the tumor and not due to the tumor mass, metastasis, infection, ischemia, or metabolic derangements. PNSs can affect any area of the central, the peripheral, and the autonomic nervous systems. These are rare in lymphomas compared with solid tumors attributed to their presentation even in late stages and the absence of onconeural antibodies. We present a child with stage IIB Hodgkin lymphoma who presented with dual PNS, achalasia cardia, and Holmes Adie pupil occurring synchronously with the cancer.
Topics: Adie Syndrome; Child; Esophageal Achalasia; Fluorodeoxyglucose F18; Hodgkin Disease; Humans; Male; Paraneoplastic Syndromes, Nervous System; Positron-Emission Tomography
PubMed: 27164530
DOI: 10.1097/MPH.0000000000000569