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Applications of turning point analysis in behavioral medicine research: A systematic scoping review.Social Science & Medicine (1982) May 2024Turning Point Analysis (TPA) is a methodological approach that allows scholars to retrospectively capture change over time by identifying instances of critical change...
BACKGROUND
Turning Point Analysis (TPA) is a methodological approach that allows scholars to retrospectively capture change over time by identifying instances of critical change (i.e., turning points) encountered across a given time period. While TPA has been used to examine time as a variable in health and illness experiences, the use of the method in behavioral medicine scholarship may be limited by the lack of understanding of TPA procedures and applicability.
OBJECTIVE
To describe how TPA has been used and enhance its accessibility by identifying and synthesizing methods of TPA data collection and analysis.
METHODS
A systematic search of electronic databases, including Academic Source Premier, Psychology and Behavioral Sciences Collection, APA PsycInfo, and ProQuest Dissertation and Theses Database, was conducted in May 2020. In July 2020, we used hand searching to identify additional articles, including forward and back tracking seminal articles on TPA. Studies were screened in duplicate.
RESULTS
Of the 1184 studies screened for this review, we included 52. Studies used TPA to examine relational (k = 40), organizational (k = 6), and individual (k = 6) variables and included an analysis of either turning points (k = 28), the trajectories of change over time created by the turning points (k = 3), or both (k = 21). Turning points and trajectories were captured and analyzed using qualitative and quantitative analytic approaches, with most studies using either purely qualitative (k = 26) or mixed methods (k = 21).
CONCLUSIONS
The findings of this review provide insight into the varied applications of TPA and suggest the potential value of this methodological approach in better understanding health experiences across time. By synthesizing the procedural and analytic steps to conducting a TPA, this review could also increase the accessibility and use of TPA in behavioral medicine research.
PubMed: 38824697
DOI: 10.1016/j.socscimed.2024.116987 -
Cognition Jun 2024The social-contract tradition of Hobbes, Rousseau, Kant, and Rawls has been widely influential in moral philosophy but has until recently received relatively little...
The social-contract tradition of Hobbes, Rousseau, Kant, and Rawls has been widely influential in moral philosophy but has until recently received relatively little attention in moral psychology. For contractualist moral theories, ethics is a matter of forming, adhering to, and enforcing (hypothetical) agreements, and morality is fundamentally about acting according to what would be agreed by rational agents. A recent psychological theory, virtual bargaining, models social interactions in contractualist terms, suggesting that we often act as we would agree to do if we were to negotiate explicitly. However, whether such contractualist tendencies (a propensity to make typically contractualist choices) and forms of reasoning (agreement-based cognitive processes) play a role in moral cognition is still unclear. Drawing upon virtual bargaining, we develop two novel experimental paradigms designed to elicit incentivized decisions and moral judgments. We then test the descriptive relevance of contractualism in moral judgment and decision making in five preregistered online experiments (n = 4103; English-speaking Prolific participants). In the first task, we find evidence that many participants show contractualist tendencies: their choices are "characteristically" contractualist. In the second task, we find evidence consistent with contractualist reasoning influencing some participants' judgments and incentivized decisions. Our findings suggest that a propensity to act as prescribed by tacit agreements may be particularly important in understanding the moral psychology of fleeting social interactions and coordination problems. By complementing the rich literature on deontology and consequentialism in moral psychology, empirical approaches inspired by contractualism may prove fruitful to better understand moral cognition.
PubMed: 38824696
DOI: 10.1016/j.cognition.2024.105838 -
Natural Product Research Jun 2024While natural products have undeniably played a crucial role in drug discovery, challenges such as limited availability and complex synthesis methods have hindered the... (Review)
Review
While natural products have undeniably played a crucial role in drug discovery, challenges such as limited availability and complex synthesis methods have hindered the identification of lead compounds. At the core of numerous natural and synthetic compounds, each displaying distinct biological behaviours, lies the foundational structure of 2-quinolinone. Compounds with this structural motif exhibit a broad range of effects in different tissues. Furthermore, specific members showcase therapeutic potential for various disorders. Despite the significance of these compounds, the current review literature has not provided a comprehensive overview, underscoring the essential contribution of this article in exploring their biological functions. This study examines the biological activity of selected 2-quinolinone alkaloids across diverse organisms, unveiling their potential as a source of innovative bioactive natural products.
PubMed: 38824680
DOI: 10.1080/14786419.2024.2359545 -
Small Methods Jun 2024Manufacturing semiconductor devices requires advanced patterning technologies, including reactive ion etching (RIE) based on the synergistic interactions between ions...
Manufacturing semiconductor devices requires advanced patterning technologies, including reactive ion etching (RIE) based on the synergistic interactions between ions and etch gas. However, these interactions weaken as devices continuously scale down to sub-nanoscale, primarily attributed to the diminished transport of radicals and ions into the small features. This leads to a significant decrease in etch rate (ER). Here, a novel synergistic interaction involving ions, surface-adsorbed chemistries, and materials at cryogenic temperatures is found to exhibit a significant increase in the ER of SiO using CF/H plasmas. The ER increases twofold when plasma with H/(CF + H) = 33% is used and the substrate temperature is lowered from 20 to -60 °C. The adsorption of HF and HO on the SiO surface at cryogenic temperatures is confirmed using in situ Fourier transform infrared spectroscopy. The synergistic interactions of the surface-adsorbed HF/HO as etching catalysts and plasma species result in the ER enhancement. Therefore, a mechanism called "pseudo-wet plasma etching" is proposed to explain the cryogenic etching process. This synergy demonstrates that the enhanced etch process is determined by the surface interactions between ions, surface-adsorbed chemistry, and the material being etched, rather than interactions between ion and gas phase, as observed in the conventional RIE.
PubMed: 38824668
DOI: 10.1002/smtd.202400090 -
Proteomics Jun 2024RNA-dependent liquid-liquid phase separation (LLPS) proteins play critical roles in cellular processes such as stress granule formation, DNA repair, RNA metabolism, germ...
RNA-dependent liquid-liquid phase separation (LLPS) proteins play critical roles in cellular processes such as stress granule formation, DNA repair, RNA metabolism, germ cell development, and protein translation regulation. The abnormal behavior of these proteins is associated with various diseases, particularly neurodegenerative disorders like amyotrophic lateral sclerosis and frontotemporal dementia, making their identification crucial. However, conventional biochemistry-based methods for identifying these proteins are time-consuming and costly. Addressing this challenge, our study developed a robust computational model for their identification. We constructed a comprehensive dataset containing 137 RNA-dependent and 606 non-RNA-dependent LLPS protein sequences, which were then encoded using amino acid composition, composition of K-spaced amino acid pairs, Geary autocorrelation, and conjoined triad methods. Through a combination of correlation analysis, mutual information scoring, and incremental feature selection, we identified an optimal feature subset. This subset was used to train a random forest model, which achieved an accuracy of 90% when tested against an independent dataset. This study demonstrates the potential of computational methods as efficient alternatives for the identification of RNA-dependent LLPS proteins. To enhance the accessibility of the model, a user-centric web server has been established and can be accessed via the link: http://rpp.lin-group.cn.
PubMed: 38824664
DOI: 10.1002/pmic.202400044 -
International Journal of Qualitative... Dec 2024To examine the lived experiences of children and adolescents coping with mental health issues and seeking mental health services in Saskatchewan during the COVID-19...
PURPOSE
To examine the lived experiences of children and adolescents coping with mental health issues and seeking mental health services in Saskatchewan during the COVID-19 pandemic.
METHODS
In our descriptive phenomenological qualitative study, we interviewed forty-six individuals, including children aged 8-15 and their parents. Thematic analysis was applied to interpret the interview data.
RESULTS
Our analysis identified three key themes: pyscho-behavioural impact, academic impact, and social impact. The pandemic adversely affected children due to factors like changes in behaviours such as increased screen time and decreased physical activity, limited access to mental health services, and disruptions to schooling and social interactions. Coping mechanisms varied, ranging from the utilization of available mental health supports and services to individual and family-based strategies. Disparities in timely access to mental health services were evident, with financially stable families accessing private services, while others struggled, particularly in rural areas. Families demonstrated resilience through parental efforts to seek balance and prioritize safety amidst COVID-19 challenges.
CONCLUSIONS
Social connectedness served as a crucial buffer against pandemic-induced stress. Children faced difficulty in accessing timely mental health services and supports. Echoing participant experiences, our findings emphasize the urgency of targeted interventions and policy adjustments to address existing gaps in mental health service accessibility and availability.
Topics: Humans; COVID-19; Saskatchewan; Adolescent; Child; Male; Female; Adaptation, Psychological; Qualitative Research; Mental Health; Mental Health Services; SARS-CoV-2; Parents; Family; Health Services Accessibility; Adult; Pandemics
PubMed: 38824661
DOI: 10.1080/17482631.2024.2361494 -
Journal of Women & Aging Jun 2024Prior research suggests that using photo-based social media may increase body image concerns among young women. Consumption of versus contribution to social media may...
Prior research suggests that using photo-based social media may increase body image concerns among young women. Consumption of versus contribution to social media may moderate this relationship, and the type of content contributed (e.g., self-images or "selfies") may further account for variations. A critical limitation of the extant scholarship is a lack of attention to understudied groups, such as older women. Using a cross-sectional sample of 238 midlife women (M = 50.92), this study investigated the relationship between social media behavior, perceived effects of social media use, and body image indices. Results indicated that our sample of midlife women contributed mainly photos of their current setting and family, contrasting with prior work among younger women. Results suggested that the type of content contributed may be more pertinent to body image than social media behavior generally, and highlighted complex relationships. Posting photos broadly was associated only with lower drive for youthfulness. However, selfie posting specifically was associated with greater facial satisfaction as well as greater positive (e.g., connectedness) and negative (e.g., appearance concerns) perceived effects of social media, but not drive for youthfulness. Results suggest that the type of content contributed to social media may be a particularly important factor for body image, and highlight complex relationships potentially influenced by unmeasured factors such as social media use motivations. Together, these findings contribute to a fuller understanding of social media and body image and call for further theoretically-driven work in this area to guide effective prevention resources.
PubMed: 38824660
DOI: 10.1080/08952841.2024.2347712 -
STAR Protocols Jun 2024Microfluidic single-cell cultivation (MSCC) is a powerful tool for investigating the cellular behavior of various cell types at the single-cell level. Here, we present a...
Microfluidic single-cell cultivation (MSCC) is a powerful tool for investigating the cellular behavior of various cell types at the single-cell level. Here, we present a protocol specifically developed for the reliable and reproducible MSCC of industrially relevant Chinese hamster ovary (CHO) suspension cell lines. We summarize critical experimental steps from the initial seed train up to the final MSCC experiment, with a special focus on pre-culture management and medium preparation, device inoculation, and the establishment of a constant medium perfusion.
PubMed: 38824641
DOI: 10.1016/j.xpro.2024.103106 -
American Journal of Primatology Jun 2024As a central topic in Behavioral Ecology, animal space use involves dynamic responses to social and ecological factors. We collared 22 rhesus macaques (Macaca mulatta)...
As a central topic in Behavioral Ecology, animal space use involves dynamic responses to social and ecological factors. We collared 22 rhesus macaques (Macaca mulatta) from six groups on Neilingding Island, China, and collected 80,625 hourly fixes over a year. Using this high-resolution location data set, we quantified the macaques' space use at the individual level and tested the ecological constraints model while considering various environmental and human interfering factors. As predicted by the ecological constraints model, macaques in larger groups had longer daily path lengths (DPLs) and larger home ranges. We found an inverted U-shape relationship between mean daily temperatures and DPLs, indicating that macaques traveled farther on mild temperature days, while they decreased DPLs when temperatures were too high or too low. Anthropogenic food subsidies were positively correlated to DPLs, while the effect of rainfall was negative. Macaques decreased their DPLs and core areas when more flowers and less leaves were available, suggesting that macaques shifted their space use patterns to adapt to the seasonal differences in food resources. By applying GPS collars on a large number of individuals living on a small island, we gained valuable insights into within-group exploitation competition in wild rhesus macaques.
PubMed: 38824636
DOI: 10.1002/ajp.23636 -
Journal of Managed Care & Specialty... Jun 2024Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous condition with extensive psychiatric comorbidities. ADHD has been associated with substantial clinical...
BACKGROUND
Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous condition with extensive psychiatric comorbidities. ADHD has been associated with substantial clinical and economic burden; however, little is known about the incremental burden specifically attributable to psychiatric comorbidities of ADHD in adults.
OBJECTIVE
To assess the impact of psychiatric comorbidities, specifically anxiety and depression, on health care resource utilization (HRU) and costs in treated adults with ADHD in the United States.
METHODS
A retrospective case-cohort study was conducted. Adults with ADHD were identified in the IQVIA PharMetrics Plus database (10/01/2015-09/30/2021). The index date was defined as the date of initiation of a randomly selected ADHD treatment. The baseline period was defined as the 6 months prior to the index date, and the study period as the 12 months following the index date. Patients with at least 1 diagnosis for anxiety and/or depression during both the baseline and study periods were classified in the ADHD+anxiety/depression cohort, whereas those without diagnoses for anxiety or depression at any time were classified in the ADHD-only cohort. Entropy balancing was used to create reweighted cohorts with similar baseline characteristics. All-cause HRU and health care costs were assessed during the study period and compared between cohorts using regression analyses. Cost analyses were also conducted in subgroups stratified by comorbid conditions.
RESULTS
After reweighting, patients in the ADHD-only cohort (N = 276,906) and ADHD+anxiety/depression cohort (N = 217,944) had similar characteristics (mean age 34.1 years; 54.8% male). All-cause HRU was higher in the ADHD+anxiety/depression cohort than the ADHD-only cohort (incidence rate ratios for inpatient admissions: 4.5, emergency department visits: 1.8, outpatient visits: 2.0, and psychotherapy visits: 6.4; all < 0.01). All-cause health care costs were more than 2 times higher in the ADHD+anxiety/depression cohort than the ADHD-only cohort (mean per-patient per-year [PPPY] costs in ADHD-only vs ADHD+anxiety/depression cohort: $5,335 vs $11,315; < 0.01). Among the ADHD+anxiety/depression cohort, average all-cause health care costs were $9,233, $10,651, and $15,610 PPPY among subgroup of patients with ADHD and only anxiety, only depression, and both anxiety and depression, respectively.
CONCLUSIONS
Comorbid anxiety and depression is associated with additional HRU and costs burden in patients with ADHD. Comanagement of these conditions is important and has the potential to alleviate the burden experienced by patients and the health care system.
Topics: Humans; Attention Deficit Disorder with Hyperactivity; Male; Female; Retrospective Studies; Adult; Health Care Costs; Comorbidity; Patient Acceptance of Health Care; United States; Middle Aged; Health Resources; Anxiety; Young Adult; Depression; Cohort Studies; Adolescent
PubMed: 38824634
DOI: 10.18553/jmcp.2024.30.6.588