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JAAD Case Reports Jul 2023
PubMed: 37332362
DOI: 10.1016/j.jdcr.2023.04.028 -
Journal of the European Academy of... Nov 2023
Topics: Infant, Newborn; Female; Humans; Meconium; Amniotic Fluid; Miliaria; Pregnancy Complications; Infant, Newborn, Diseases
PubMed: 37328926
DOI: 10.1111/jdv.19275 -
The New England Journal of Medicine May 2023
Topics: Humans; Miliaria
PubMed: 37195944
DOI: 10.1056/NEJMicm2210388 -
Jornal de Pediatria 2023Determine the frequency of dermatological diagnoses in preterm newborns up to 28 days of life and associated perinatal factors.
OBJECTIVES
Determine the frequency of dermatological diagnoses in preterm newborns up to 28 days of life and associated perinatal factors.
METHOD
a cross-sectional analytical study with a convenience sample and prospective data collection, was conducted between November 2017 and August 2019. Overall, 341 preterm newborns who had been admitted to a University hospital - including those admitted to the Neonatal Intensive Care Unit - were evaluated.
RESULTS
61 (17.9%) had less than 32 weeks gestational age (GA), with a mean GA and birth weight of 33.9 ± 2.8 weeks and 2107.8 ± 679.8g (465 to 4230g), respectively. The median age at the time of evaluation was 2.9 days (4 h to 27 days). The frequency of dermatological diagnoses was 100% and 98.5% of the sample had two or more, with an average of 4.67+1.53 dermatoses for each newborn. The 10 most frequent diagnoses were lanugo (85.9%), salmon patch (72.4%), sebaceous hyperplasia (68.6%), physiological desquamation (54.8%), dermal melanocytosis (38.7%), Epstein pearls (37.2%), milia (32.2%), traumatic skin lesions (24%), toxic erythema (16.7%), and contact dermatitis (5%). Those with GA< 28 weeks showed more traumatic injuries and abrasions, whereas those with ≥ 28 weeks had physiological changes more frequently, and those with GA between 34-36 weeks, had transient changes.
CONCLUSION
Dermatological diagnoses were frequent in our sample and those with higher GA showed a higher frequency of physiological (lanugo and salmon patch) and transient changes (toxic erythema and miliaria). Traumatic lesions and contact dermatitis were among the 10 most frequent injuries, reinforcing the need to effectively implement neonatal skin care protocols, especially in preterm.
Topics: Pregnancy; Female; Humans; Infant, Newborn; Cross-Sectional Studies; Infant, Newborn, Diseases; Birth Weight; Erythema; Gestational Age; Dermatitis, Contact; Intensive Care Units, Neonatal
PubMed: 37172615
DOI: 10.1016/j.jped.2023.04.005 -
Scientific Reports Mar 2023Batik, a resist-dyeing technique to decorate a special cotton fabric, has been practiced for centuries in Indonesia. Unfortunately, as an informal enterprise, batik...
Batik, a resist-dyeing technique to decorate a special cotton fabric, has been practiced for centuries in Indonesia. Unfortunately, as an informal enterprise, batik industry activities lack work safety and health regulations. This study aimed to identify potential health hazards, including inventorying the chemicals to which the workers are exposed, the PPE profile, and investigating the prevalence of occupational skin diseases (OSD) in the batik industry. A cross-sectional study and an inventory of exposure to the chemicals were done in traditional batik workplaces in 5 districts in Yogyakarta province, Indonesia. The chemicals were classified as potential sensitizers/irritants, and the workers were examined and interviewed using the Nordic Occupational Skin Questionnaire-2002/LONG. Of 222 traditional batik workers, OSD were diagnosed in 61 (27.5%) workers, with occupational contact dermatitis was the most common OSD encountered (n = 23/61; 37.7%) (allergic contact dermatitis n = 7/23; irritant contact dermatitis n = 16/23). A smaller portion of other OSD was also encountered including callus, miliaria, and nail disorder (9%, 6.3%, and 5.9%, respectively). During each step of the traditional batik manufacturing process, the workers are exposed to substances that act as irritants and/or as potential contact allergens. However, only one-fourth of the workers used PPE regularly, particularly during the coloring process and wax removal (wet processes). Traditional batik manufacturing process exposes the worker to various physical and chemical hazards, resulting in a high prevalence of occupational skin diseases, especially contact dermatitis among the employees.
Topics: Humans; Indonesia; Irritants; Prevalence; Cross-Sectional Studies; Dermatitis, Allergic Contact; Dermatitis, Occupational; Dermatitis, Irritant; Occupational Exposure
PubMed: 36997563
DOI: 10.1038/s41598-022-17890-w -
Cureus Jan 2023In this case report, we discuss the diagnostic dilemma presented by a patient admitted for elevated liver enzymes and rash, who had a history of recent amoxicillin use....
In this case report, we discuss the diagnostic dilemma presented by a patient admitted for elevated liver enzymes and rash, who had a history of recent amoxicillin use. This presentation initially appeared to fit the criteria for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome. However, histologic evaluation determined the rash was consistent with Miliaria rubra rather than the lymphocytic infiltrate of DRESS. This necessitated broad diagnostic testing to determine the underlying etiology of the patient's syndrome. Serology subsequently demonstrated primary Epstein-Barr Virus (EBV) infection, which explained her acute liver injury. Her eosinophilia was potentially related to an allergic reaction to surgical tape but was never definitely diagnosed. This case demonstrates the importance of maintaining a wide differential even when clinical diagnostic criteria are apparently met.
PubMed: 36819351
DOI: 10.7759/cureus.33782 -
Clinical and Experimental Dermatology Apr 2023Miliaria crystallina (MC) is an uncommon form of a sweat retention syndrome that chiefly affects neonates. It is more common in hot and humid conditions, such as in... (Review)
Review
Miliaria crystallina (MC) is an uncommon form of a sweat retention syndrome that chiefly affects neonates. It is more common in hot and humid conditions, such as in tropical regions. It commonly presents as clusters of dewdrop-like vesicles on a nonerythematous base that heals with furfuraceous scaling. A clinical diagnosis is often sufficient. The differential diagnosis is wide and varying. One of the hallmarks of MC is its self-limiting nature. The purpose of this review is to increase awareness of this condition among physicians and dermatologists.
Topics: Infant, Newborn; Humans; Miliaria; Hypohidrosis; Diagnosis, Differential
PubMed: 36692206
DOI: 10.1093/ced/llad032 -
Nederlands Tijdschrift Voor Geneeskunde Dec 2022This case concerns a newborn with many small transparent vesicles on the forehead, trunk and face. Miliaria crystallina was diagnosed based on the typical presentation....
This case concerns a newborn with many small transparent vesicles on the forehead, trunk and face. Miliaria crystallina was diagnosed based on the typical presentation. Miliaria crystalline is a transient obstruction of sweat glands resulting in non-inflammatory vesicles. The treatment is simple: cool down.
Topics: Infant, Newborn; Humans; Blister; Miliaria
PubMed: 36633068
DOI: No ID Found -
Infectious Diseases (London, England) Mar 2023The spreading of the SARS-CoV-2 Omicron variant is probably due to its increased transmissibility and ability to escape from neutralising antibodies. Cutaneous...
BACKGROUND
The spreading of the SARS-CoV-2 Omicron variant is probably due to its increased transmissibility and ability to escape from neutralising antibodies. Cutaneous manifestations have been reported after infection with the Omicron strain, consisting mainly of generalised urticarial eruption and prickly heat rash, also known as miliaria, that can persist for several days. Here the impact of Omicron SARS-CoV-2 on skin was investigated.
METHODS
The case series of 10 patients with SARS-CoV-2 Omicron variant-related cutaneous manifestations were described; moreover, skin derived cells were challenged with SARS-CoV-2 Omicron variant.
RESULTS
The main clinical cutaneous features observed were urticarial lesions lasting more than 24 h, mainly involving the trunk and sometimes extending to the extremities, and miliaria presenting with clusters of small sweat-filled vesicles, sometimes surrounded by slight erythema. HaCaT keratinocytes, BJ fibroblast cell lines and outer root sheath (ORS) keratinocytes were not susceptible to SARS-CoV-2 Omicron variant infection; they also did not present any evident cytopathic effect or modification of cells viability.
CONCLUSION
Our findings suggests that, despite the high number of nucleotide mutations in the spike protein of SARS-CoV-2 Omicron variant, responsible to the higher transmissibility of this virus, and the increased reports of cutaneous manifestation in COVID-19 affected patients, the virus is not able to directly infect and damage the keratinocytes and fibroblasts, thus suggesting an indirect virus-induced activation of the immune system as the major pathogenetic driver.
Topics: Humans; SARS-CoV-2; COVID-19; Skin; Miliaria
PubMed: 36494183
DOI: 10.1080/23744235.2022.2153913