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The Australasian Journal of Dermatology May 2020
Topics: Adult; Female; Fox-Fordyce Disease; Hair Removal; Humans; Lasers, Solid-State; Low-Level Light Therapy
PubMed: 31734939
DOI: 10.1111/ajd.13194 -
Granulomatous Variant of Giant Centrifugal Miliaria Profunda in a Hypothyroid Infant: A Case Report.Indian Dermatology Online Journal 2019The miliarias are a clinically heterogeneous group of diseases which occur when the free flow of eccrine sweat to the skin surface is impeded. Miliaria profunda is a...
The miliarias are a clinically heterogeneous group of diseases which occur when the free flow of eccrine sweat to the skin surface is impeded. Miliaria profunda is a variant with obstruction of the duct at or below the level of dermoepidermal junction. The giant centrifugal variant of miliaria profunda has been described in the past at the sites of occlusive tapes and in febrile patients. Thyroid hormone has a regulatory effect on the skin and its appendages and an association of hypothyroidism with this variant of miliaria profunda has not been described in the past. We report a case of giant centrifugal miliaria profunda in an infant with congenital hypothyroidism.
PubMed: 31544077
DOI: 10.4103/idoj.IDOJ_422_18 -
JAAD Case Reports Sep 2019
PubMed: 31516988
DOI: 10.1016/j.jdcr.2019.04.024 -
Miliaria crystallina secondary to herbal remedies-induced toxic epidermal necrolysis: A case report.Dermatologic Therapy Jul 2019Miliaria crystallina is a skin disorder that often erupts in the process of febrile diseases or under hot and humid climatic conditions. Toxic epidermal necrolysis (TEN)...
Miliaria crystallina is a skin disorder that often erupts in the process of febrile diseases or under hot and humid climatic conditions. Toxic epidermal necrolysis (TEN) is a rare, acute, and life-threatening mucocutaneous disease with a mortality rate of 25-35%. There has been no inevitable connection between the two diseases among previously reported cases, but we observed a case of secondary miliaria crystallina a woman with herbal remedies-induced TEN during the therapeutic process.
Topics: Adult; Female; Humans; Miliaria; Phytotherapy; Plant Preparations; Stevens-Johnson Syndrome
PubMed: 31197923
DOI: 10.1111/dth.12995 -
Experimental Dermatology Dec 2019Sweating plays an important role in maintaining temperature homeostasis in humans. However, under certain circumstances, sweat can cause itching. For example, when... (Review)
Review
Sweating plays an important role in maintaining temperature homeostasis in humans. However, under certain circumstances, sweat can cause itching. For example, when excessive sweat accumulates on the skin surface for a long period, miliaria can develop and cause itching. Subjects with dermatoses, such as atopic dermatitis (AD), suffer from itch when exposed to heat or psychological stresses, which are also known perspiration stimuli. Recently, some mechanisms of sweat-induced itch have been revealed. For instance, attenuated sweating ability is observed in subjects with AD, causing heat retention, skin dryness, and high susceptibility to itch. Furthermore, the decreased tight junction of the sweat gland in AD leads to sweat leakage in the dermis, which could be designated as a "sweat endocrine response" and may be the cause of tingling itch during sweating. Additionally, metabolomic analysis of sweat from patients with AD revealed that glucose concentration in sweat increases according to disease severity. Sweat with elevated glucose concentration retards the recovery of the damaged skin barrier and may promote itching. This viewpoint essay outlines the relationship between sweat and itch based on recent evidence.
Topics: Dermatitis, Atopic; Humans; Pruritus; Sweat
PubMed: 31152459
DOI: 10.1111/exd.13981 -
The Pan African Medical Journal 2018We here report the case of a 58-year old patient admitted with respiratory distress, oxygen desaturation 65% while breathing ambient air and fever 38.5°C. Blood count...
We here report the case of a 58-year old patient admitted with respiratory distress, oxygen desaturation 65% while breathing ambient air and fever 38.5°C. Blood count showed pancytopenia. Ionogram objectified slight hepatic cytolysis and chest X-ray showed bilateral miliaria. BK research using sputum was negative as well as Genexpert TB test. Anatomopathological examination of the osteomedullar biopsy revealed epitheliogigantocellular granuloma without caseous necrosis and polymerase chain reaction (PCR) showed mycobacterium tuberculosis in osteomedullary biopsy. Liver biopsy showed epithelioid granuloma without caseous necrosis. The diagnosis of multifocal tuberculosis with pulmonary, hematopoietic and hepatic impairment was retained. Miliary Tuberculosis is a severe form of tuberculosis. Bacilloscopies are often negative and the diagnosis can be retained based on other sampling, including cerebrospinal fluid sampling and osteomedullary biopsy. Different kinds of biopsies enable diagnosis in rare cases. PCR, a technique used in molecular biology, has enabled to shorten the window period from disease onset to diagnosis as well as treatment implementation. Miliary tuberculosis can be life-threatening; therefore, sometimes, treatment must be administered before certain diagnosis.
Topics: Biopsy; Female; Granuloma; Humans; Middle Aged; Mycobacterium tuberculosis; Pancytopenia; Polymerase Chain Reaction; Tuberculosis, Hepatic; Tuberculosis, Miliary; Tuberculosis, Pulmonary
PubMed: 31011393
DOI: 10.11604/pamj.2018.31.92.17046 -
Molecular & Cellular Proteomics : MCP Jul 2019The eccrine sweat gland is an exocrine gland that is involved in the secretion of sweat for control of temperature. Malfunction of the sweat glands can result in...
The eccrine sweat gland is an exocrine gland that is involved in the secretion of sweat for control of temperature. Malfunction of the sweat glands can result in disorders such as miliaria, hyperhidrosis and bromhidrosis. Understanding the transcriptome and proteome of sweat glands is important for understanding their physiology and role in diseases. However, no systematic transcriptome or proteome analysis of sweat glands has yet been reported. Here, we isolated eccrine sweat glands from human skin by microdissection and performed RNA-seq and proteome analysis. In total, ∼138,000 transcripts and ∼6,100 proteins were identified. Comparison of the RNA-seq data of eccrine sweat glands to other human tissues revealed the closest resemblance to the cortex region of kidneys. The proteome data showed enrichment of proteins involved in secretion, reabsorption, and wound healing. Importantly, protein level identification of the calcium ion channel TRPV4 suggests the importance of eccrine sweat glands in re-epithelialization of wounds and prevention of dehydration. We also identified 2 previously missing proteins from our analysis. Using a proteogenomic approach, we identified 7 peptides from 5 novel genes, which we validated using synthetic peptides. Most of the novel proteins were from short open reading frames (sORFs) suggesting that many sORFs still remain to be annotated in the human genome. This study presents the first integrated analysis of the transcriptome and proteome of the human eccrine sweat gland and would become a valuable resource for studying sweat glands in physiology and disease.
Topics: Amino Acid Sequence; Eccrine Glands; Exons; Humans; Open Reading Frames; Proteome; Proteomics; Pseudogenes; RNA; Transcriptome
PubMed: 30979791
DOI: 10.1074/mcp.RA118.001101 -
Pediatric Annals Jan 2019Skin eruptions are commonly encountered in the neonatal and infant period and can be a source of concern for providers and parents alike. We present a brief, clinically... (Review)
Review
Skin eruptions are commonly encountered in the neonatal and infant period and can be a source of concern for providers and parents alike. We present a brief, clinically focused discussion on topics commonly encountered by the pediatrician with a focus on pearls of knowledge to help distinguish diseases from one another and from more serious conditions. We review miliaria, transient neonatal pustular melanosis, neonatal cephalic pustulosis, erythema toxicum neonatorum, diaper dermatitis, seborrheic dermatitis, and atopic dermatitis. Treatment strategies are also discussed. [Pediatr Ann. 2019;48(1):e16-e22.].
Topics: Diagnosis, Differential; Exanthema; Humans; Infant, Newborn; Infant, Newborn, Diseases; Skin
PubMed: 30653638
DOI: 10.3928/19382359-20181206-01 -
Biologia 2019The expansion of energy crops such as miscanthus has changed the habitat of European farmland birds. However, most studies on the subject are based in Western Europe....
The expansion of energy crops such as miscanthus has changed the habitat of European farmland birds. However, most studies on the subject are based in Western Europe. We surveyed the avian community in a sample bioenergy landscape in Poland to investigate the pattern of use of the crop by birds in Central Europe. During a year-long survey, 80 species were noted, with 32 sighted in miscanthus. The number of bird sightings was negatively correlated with the area covered by miscanthus in study plots. In contrast to results from Western Europe, most woodland-generalist bird species tended to avoid miscanthus. Farmland species (e.g. the corn bunting ; the tree sparrow ; the starling ; the yellowhammer ) were less frequently sighted in the crop than in other habitats. Only a few species were sighted more often in miscanthus than in other habitats, e.g. the marsh warbler ; the reed bunting ; the whinchat . The potential impact of expanded miscanthus cropping on bird communities in Central and Eastern Europe may diverge from predictions derived from studies based in Western Europe due to differing habitat preferences and bird densities between the regions. For a majority of farmland species, the crop may constitute only a suboptimal, supplementary habitat, with only a few birds potentially adapting to the exploitation of bioenergy plantations.
PubMed: 30636777
DOI: 10.2478/s11756-018-0143-1 -
Skin Research and Technology : Official... May 2019Many studies have revealed the importance of palpation for dermatologists; however, palpation is not always possible due to the risk of secondary infections or the risk...
BACKGROUND/PURPOSE
Many studies have revealed the importance of palpation for dermatologists; however, palpation is not always possible due to the risk of secondary infections or the risk of damaging the affected area. Thus, haptic rendering for indirect palpation using in-vivo skin images, which will enable to examine a real three-dimensional (3D) skin sample by virtual touch without directly palpating the infected skin area, could be a useful technology in dermatology.
METHODS
We propose a new method of accurate 3D skin surface reconstruction using simple gradients from a single skin image for accurate 3D roughness rendering with a haptic device. Our approach takes advantage of bilateral filtering to preserve skin roughness and image gradients in order to generate a 3D skin surface (polygonal meshes) while preserving skin wrinkles and rough surface textures.
RESULTS
Our method was evaluated using two experiments. The accuracy was tested with six 3D ground-truth surfaces and four clinical skin images (acne, miliaria, sweet syndrome, and herpes simplex). For objective evaluation, a well-known 3D roughness estimation method and the Hausdorff distance were adopted to compute errors. All results showed that the accuracy of our method is superior to that of the two existing methods.
CONCLUSION
Haptic roughness rendering for skin palpation examination requires efficient and accurate 3D surface reconstruction. In this study, we developed a new method that can be used to reconstruct a 3D skin surface accurately while preserving roughness through the use of a single skin image.
Topics: Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Palpation; Skin; Surface Properties
PubMed: 30604497
DOI: 10.1111/srt.12650