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Meditsina Truda I Promyshlennaia... 2012The ophthalmologic investigation of workers of the two metallurgical enterprises has shown that 1045 persons (55%) from 1911 observed workers suffer chronic diseases of...
The ophthalmologic investigation of workers of the two metallurgical enterprises has shown that 1045 persons (55%) from 1911 observed workers suffer chronic diseases of a forward piece of eyes. Chronic inflammatory diseases (blepharitis, conjunctivitis and blepharoconjunctivitis) are found at 28,9% of them, and dystrophic diseases (pinguecula/pterygium)--at 25,8%. Among metallurgists (1801 persons) ophthalmopathy was found in 2, 2 times more often than at persons in control group (110 observed engineers and managers). Two polymorphisms of cytochrome P450 1A1 (CYP1A1) and P-450 2E1 (CYP2E1) genes were defined in 91 workers, by the method of allele-specific polymerase chain reaction. It is revealed that CYP1A1 Ile462Val polymorphism associates with pinguecula/pterygium, raising risk of their development almost in 3 times, unlike CYP 2E1 -1293G/C polymorphism. Development of chronic inflammatory diseases is not connected with tested polymorphisms.
Topics: Adult; Chronic Disease; Conjunctival Diseases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2E1; Eyelid Diseases; Female; Humans; Male; Metallurgy; Middle Aged; Occupational Diseases; Occupational Exposure; Polymorphism, Single Nucleotide; Prevalence; Russia
PubMed: 22997752
DOI: No ID Found -
International Journal of Ophthalmology 2012To determine the influence of the dialysis time before kidney transplantation on postoperative ophthalmic complications.
AIM
To determine the influence of the dialysis time before kidney transplantation on postoperative ophthalmic complications.
METHODS
One hundred and eighty three patients who were given the follow-up after kidney transplantation were selected, including 124 males and 59 females. The dialysis time before kidney transplantation was (2.9±2.1) years. Among them, there were 93 cases having cadaveric renal transplantation and 90 cases having living relative renal transplantation. The conditions of ophthalmic complications in all the patients after kidney transplantation were investigated and the incidence rate on ophthalmic complications having different dialysis time before kidney transplantation was given Chi-square test and Chi-square linear trend test.
RESULTS
Among 183 patients with kidney transplantation, 95 patients (51.9%) had at least one ophthalmic complication and the rest 88 patients (48.1%) had no significant abnormality at the eye region. The most common ophthalmic complications were pinguecula/conjunctival degeneration (31 cases), the following was caligo lentis (24 cases). The main manifestations were grayish white granule and plaque turbidity occurred in posterior capsule at the posterior pole of crystaline lens. The angulus iridocornealis of 5 patients (5.3%) with cataract and glaucoma were all open-angle through the detection by gonioscope. Through visual field examination, there were 2 patients with paracentral scotoma, 2 patients with arcuate scotoma and one case with nasal step.
CONCLUSION
The experiments verify that the incidence of glaucomawas relates to the dialysis time before kidney transplantation, and the incidence rate might be higher if the dialysis time is longer.
PubMed: 22773990
DOI: 10.3980/j.issn.2222-3959.2012.03.23 -
Annales de Pathologie Jun 2012Our study aim is to assess the distribution of conjunctival eye lesions received in our institution between 01/01/1999 and 16/10/2010, in order to put forward the... (Review)
Review
Our study aim is to assess the distribution of conjunctival eye lesions received in our institution between 01/01/1999 and 16/10/2010, in order to put forward the diagnostic difficulties associated with this location and the specific terms employed for ophthalmologic pathology. Twenty-one samples were analyzed. The non-tumoral lesions accounted for more than one half (pterygium, pinguecula, epithelial cyst, foreign body). The tumoral lesions were mainly represented by naevi. The naevi were characterized in this location by the presence of intralesional epithelial cysts, which distinguished them from primary acquired melanosis and melanoma. Only one case of papilloma was observed. In one fourth of the cases, the final pathological diagnosis was different from the clinical diagnosis. It seems legitimate to recommend a pathological analysis of conjunctiva lesions systematically.
Topics: Adolescent; Adult; Aged; Conjunctival Diseases; Female; France; Hospitals, University; Humans; Male; Middle Aged; Retrospective Studies; Time Factors; Young Adult
PubMed: 22748330
DOI: 10.1016/j.annpat.2012.03.001 -
Clinics (Sao Paulo, Brazil) 2012The aim of this study was to report the type and frequency of ocular manifestations in Brazilian psoriatic arthritis patients.
OBJECTIVES
The aim of this study was to report the type and frequency of ocular manifestations in Brazilian psoriatic arthritis patients.
METHODS
We conducted a cross-sectional study in a Brazilian tertiary hospital. The test group included 40 patients who had psoriatic arthritis according to the Classification Criteria for Psoriatic Arthritis. A control group of 40 individuals was matched for age and gender. All of the patients underwent ophthalmic evaluation, which included best-corrected visual acuity, slit lamp and fundus examinations, and dry eye diagnostic tests (Schirmer I, tear breakup time and rose bengal). Demographic parameters were also evaluated.
RESULTS
The mean age of the patients was 53.9±13.1 years; the mean disease duration was 8±10.5 years. Most of the patients were women (60%), and the majority had polyarticular disease (57.5%). Several ocular abnormalities were found, including punctate keratitis, pinguecula, blepharitis, pterygium, cataract, glaucoma, uveitis, and retinal microvascular abnormalities. There were no significant differences in the rates of these abnormalities compared with the control group, however. The Keratoconjunctivitis sicca and dry eye diagnostic tests were more often positive in the patients with psoriatic arthritis than in the control group.
CONCLUSIONS
In this study, keratoconjunctivitis sicca was the most common ocular finding related to psoriatic arthritis. Therefore, we recommend early ophthalmologic evaluations for all psoriatic arthritis patients who complain of eye symptoms.
Topics: Arthritis, Psoriatic; Brazil; Epidemiologic Methods; Female; Humans; Keratoconjunctivitis Sicca; Male; Middle Aged
PubMed: 22473406
DOI: 10.6061/clinics/2012(03)08 -
Archivos de La Sociedad Espanola de... Mar 2012We present a case report of a 28-year-old patient with a lesion that is compatible both clinically and histopathologically with conjunctival keratoacanthoma. The...
CASE REPORT
We present a case report of a 28-year-old patient with a lesion that is compatible both clinically and histopathologically with conjunctival keratoacanthoma. The treatment given was complete excision and 0.04% mitomycin C eye drops in the postoperative period. The outcome was a complete clinical remission during the follow-up period (6 months).
DISCUSSION
It is important to make a correct differential diagnosis between keratoacanthoma and squamous cell carcinoma, as well as carrying out close monitoring after surgery due to the possibility of relapse and conversion to squamous cell carcinoma. For this reason, we propose the use of conjunctival impression cytology as a non-invasive method for monitoring such patients.
Topics: Adult; Carcinoma, Squamous Cell; Combined Modality Therapy; Conjunctival Diseases; Conjunctival Neoplasms; Diagnosis, Differential; Epithelial Cells; Fluorometholone; Histocytological Preparation Techniques; Humans; Hyperemia; Keratoacanthoma; Male; Mitomycin; Pinguecula
PubMed: 22423657
DOI: 10.1016/j.oftal.2011.08.002 -
Cornea Mar 2012To assess the relationship between age and the incidence and severity of pinguecula in patients with diabetes mellitus, and to compare the grade of pinguecula between...
PURPOSE
To assess the relationship between age and the incidence and severity of pinguecula in patients with diabetes mellitus, and to compare the grade of pinguecula between control subjects and patients with diabetes.
METHODS
A total of 160 patients with type 2 diabetes aged 31 to 70 years (DM group) and 160 control subjects aged 31 to 70 years (control group) were enrolled. The grade of pinguecula at 2 locations (nasal and temporal) was assessed in all subjects by a grading system.
RESULTS
There was an age-related increase in the grade of pinguecula in both the DMgroup (r = 0.52; P < 0.0001) and the control group (r = 0.51; P < 0.0001). The grade and prevalence of pinguecula were higher in the DM group than in the control group for pinguecula of the nasal conjunctiva (grade: P < 0.0001; and prevalence: 55.0% vs. 40.0%, P = 0.0072) and the temporal conjunctiva (grade: P < 0.0001; and prevalence: 54.4% vs. 40.0%, P = 0.0100). Multivariate logistic regression analysis revealed that age and diabetes were associated with an increased prevalence of nasal or temporal pinguecula (all P < 0.05). Diabetes mellitus was independently associated with the severity of pinguecula (nasal: odds ratio = 1.19; temporal: odds ratio = 1.22) after adjustment for age.
CONCLUSIONS
This is the first assessment of the relationship between pinguecula and diabetes mellitus. Our results suggest that diabetes mellitus may be a factor associated with the development of pinguecula.
Topics: Adult; Age Distribution; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Humans; Incidence; Japan; Male; Middle Aged; Multivariate Analysis; Pinguecula; Prevalence; Prospective Studies; Severity of Illness Index
PubMed: 22420025
DOI: 10.1097/ico.0b013e3182254170 -
Cornea Nov 2012To determine the prevalence of external punctal stenosis (EPS) and to investigate its associations in a general adult population in northwestern Spain.
PURPOSE
To determine the prevalence of external punctal stenosis (EPS) and to investigate its associations in a general adult population in northwestern Spain.
METHODS
A total of 1155 subjects ≥ 40 years were selected by an age-stratified random sample procedure in O Salnés (Spain). An interview was carried out to collect history of systemic diseases and lifestyle details, and a comprehensive ophthalmic evaluation in which EPS was recorded. The prevalence of EPS and its relationship with demographic, lifestyle, and systemic and ocular factors was investigated. All calculations were weighted to give unbiased estimates.
RESULTS
From 937 eligible subjects, 621 (66.3%) participated [mean age (SD), 63.4 (14.5) years; range, 40-96 years; 37.0% men). The prevalence of EPS was 17.3% [95% confidence interval (CI), 14.8-19.8). This prevalence increased significantly with aging (P = 0.000) and was 13.8% (95% CI, 10.3-18.3) in men and 19.4% (95% CI, 16.1-23.2) in women. After controlling for age and sex, EPS was associated with outdoor occupational activity (age and sex adjusted odd ratio [ORa], 2.22; 95% CI, 1.31-3.37) and with degenerative disorders such as pinguecula (ORa, 1.48; 95% CI, 1.15-1.89) but not with inflammatory disorders such as blepharitis or dry eye. A multivariable analysis in which sex differences also became significant (P = 0.024) confirmed these associations.
CONCLUSIONS
External punctual stenosis is a common disorder associated with outdoor occupational activity. Processes associated with tissue degeneration but not with inflammation are highly prevalent among subjects with EPS. Modifiable factors, such as sun exposure, must be addressed to reduce the impact of this disorder.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cross-Sectional Studies; Eyelid Diseases; Female; Humans; Lacrimal Duct Obstruction; Male; Middle Aged; Occupational Exposure; Pinguecula; Prevalence; Risk Factors; Spain; Surveys and Questionnaires; Tears
PubMed: 22367046
DOI: 10.1097/ICO.0b013e31823f8eca -
Graefe's Archive For Clinical and... Jul 2012One of the most frequent ocular features of systemic sclerosis (SSc) is dry eye disease (DED), which has been identified to occur in 37-79% of patients. Although several...
BACKGROUND
One of the most frequent ocular features of systemic sclerosis (SSc) is dry eye disease (DED), which has been identified to occur in 37-79% of patients. Although several studies have found weak or no correlations between symptoms and signs of dry eye, symptoms are often the motivation for seeking eye care, and are therefore a critical outcome measure when assessing treatment effect. The aim of this study is to evaluate the impact of symptoms of dry eye on vision-related quality of life in patients with systemic sclerosis, and to investigate the relation between clinical tests and symptoms of dry eye in these patients.
METHODS
In this cross-sectional study, 45 consecutive patients with SSc were enrolled. For evaluation of the symptoms the "Ocular Surface Disease Index (OSDI)" questionnaire was applied to all patients. After that, all individuals were submitted to a full ophthalmic examination, including the following tests: tear break-up time, Schirmer I, rose bengal staining. Patients were then grouped into dry eye and non-dry eye groups with regard to the diagnosis of dry eye. Mann-Whitney test was used to compare continuous variables, whereas the Fisher exact test was used to compare categorical data between groups. Spearman's correlation test was used to analyze the correlations between clinical tests and OSDI scores. P values <0.05 were considered significant.
RESULTS
Dry eye disease was diagnosed in 22 patients (48.9%). Other ocular surface abnormalities found were: blepharitis (40% of the patients), pterygium (15.6%), pinguecula (82.2%), and superficial punctate keratitis (26.7%). Among the 45 patients, 29 patients (64.4%) had symptoms of ocular surface disease. The mean OSDI score was 26.8 ± 25.8 (SD). There were no statistically significant differences in OSDI scores between DED and non-DED patients. No substantive correlations were found between OSDI scores and TBUT, Schirmer I, or rose bengal staining score, and none of the observed correlations reached statistical significance.
CONCLUSION
Symptoms of dry eye have a moderate impact on vision-related quality of life in patients with systemic sclerosis and do not correlate well with clinical findings.
Topics: Adult; Aged; Cross-Sectional Studies; Female; Humans; Keratoconjunctivitis Sicca; Male; Middle Aged; Quality of Life; Scleroderma, Systemic; Sickness Impact Profile; Surveys and Questionnaires; Tears; Vision Disorders; Young Adult
PubMed: 22349977
DOI: 10.1007/s00417-012-1938-3 -
Cornea Nov 2012To describe the prevalence and associations of meibomian gland dysfunction (MGD) in an urban Malay population in Singapore.
PURPOSE
To describe the prevalence and associations of meibomian gland dysfunction (MGD) in an urban Malay population in Singapore.
METHODS
Population-based cross-sectional study of 3280 (78.7% response rate) Malay persons aged 40 to 80 years, living in Singapore. MGD was defined by a slit-lamp clinical examination as either lid margin telangiectasia or meibomian gland orifice plugging in at least one eye. Participants underwent a standardized questionnaire and clinical examination, including laboratory investigations. Data were analyzed for 3271 persons.
RESULTS
The age-standardized prevalence of MGD was 56.3% [95% confidence interval (CI), 53.3-59.4]. A higher MGD prevalence was found in male participants across all age groups [odds ratio (OR), 1.30; 95% CI, 1.35-1.79], postmenopausal women (OR, 1.64; 95% CI, 1.19-2.33), and all participants with pinguecula (OR, 2.43; 95% CI, 2.08-2.85), high diastolic blood pressure (OR, 1.32; 95% CI, 1.08-1.62), and use of angiotensin II receptor blockers (OR, 4.02; 95% CI, 1.74-9.27).
CONCLUSIONS
MGD was highly prevalent in this Asian population and associated with various systemic and ocular conditions.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Asian People; Cross-Sectional Studies; Eyelid Diseases; Female; Humans; Male; Meibomian Glands; Middle Aged; Prevalence; Risk Factors; Sex Distribution; Singapore; Surveys and Questionnaires; Urban Population
PubMed: 22236788
DOI: 10.1097/ICO.0b013e31823f0977 -
Ophthalmology and Eye Diseases 2012The focus of this study was to evaluate the visual status of mine workers who were directly involved in mining and/or are exposed to the mining environment.
OBJECTIVE
The focus of this study was to evaluate the visual status of mine workers who were directly involved in mining and/or are exposed to the mining environment.
METHODS
A hospital based cross-sectional study was conducted. Four hundred and six (406) workers were conveniently sampled for the study. Information on their socio-demographic data was also collected. In addition, all participants underwent ophthalmic examination.
RESULTS
The mean age of the workers was 41.1 years. Visual impairment was found in 114 (28.1%) of the study population of which refractive error (56.8%) was the major cause. Presbyopia was also observed in 45.5% of the workers with only 30.3% of them wearing near correction. The prevalence of eye diseases were pterygium/pingueculae (25.8%), conjunctivitis (26.8%), suspected glaucoma (15.3%), and cataract (7.4%).
CONCLUSIONS
Visual impairment and eye diseases were found among the miners.
PubMed: 23650456
DOI: 10.4137/OED.S9204