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ACS Applied Materials & Interfaces Jun 2024Inspired by the crucial role of matrix vesicles (MVs), a series of biomimetic vesicles (BVs) fabricated by calcium glycerophosphate (CaGP) modified polyurethane were...
Inspired by the crucial role of matrix vesicles (MVs), a series of biomimetic vesicles (BVs) fabricated by calcium glycerophosphate (CaGP) modified polyurethane were designed to mediate the mineralization through enzyme activation for bone therapy. In this study, alkaline phosphatase (ALP) was harbored in the porous BVs by adsorption (Ad-BVs) or entrapment (En-BVs). High encapsulation of ALP on En-BVs was effectively self-activating by calcium ions of CaGP-modified PU that specifically hydrolyzed the organophosphorus (CaGP) to inorganic phosphate, thus promoting the formation of the highly oriented bone-like apatite . Enzyme-catalyzed kinetics confirms the regulation of apatite crystallization by the synergistic action of self-activated ALP and the confined microcompartments of BVs. This leads to a supersaturated microenvironment, with the En-BVs group exhibiting inorganic phosphate (Pi) levels 4.19 times higher and Ca levels 3.67 times higher than those of simulated body fluid (SBF). Of note, the En-BVs group exhibited excellent osteo-inducing differentiation of BMSCs and the highest maturity with reduced bone loss in rat femoral defect . This innovative strategy of biomimetic vesicles is expected to provide valuable insights into the enzyme-activated field of bone therapy.
PubMed: 38900067
DOI: 10.1021/acsami.4c03978 -
Science Translational Medicine Jun 2024Current clinically used electronic implants, including cardiac pacing leads for epicardial monitoring and stimulation of the heart, rely on surgical suturing or direct...
Current clinically used electronic implants, including cardiac pacing leads for epicardial monitoring and stimulation of the heart, rely on surgical suturing or direct insertion of electrodes to the heart tissue. These approaches can cause tissue trauma during the implantation and retrieval of the pacing leads, with the potential for bleeding, tissue damage, and device failure. Here, we report a bioadhesive pacing lead that can directly interface with cardiac tissue through physical and covalent interactions to support minimally invasive adhesive implantation and gentle on-demand removal of the device with a detachment solution. We developed 3D-printable bioadhesive materials for customized fabrication of the device by graft-polymerizing polyacrylic acid on hydrophilic polyurethane and mixing with poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) to obtain electrical conductivity. The bioadhesive construct exhibited mechanical properties similar to cardiac tissue and strong tissue adhesion, supporting stable electrical interfacing. Infusion of a detachment solution to cleave physical and covalent cross-links between the adhesive interface and the tissue allowed retrieval of the bioadhesive pacing leads in rat and porcine models without apparent tissue damage. Continuous and reliable cardiac monitoring and pacing of rodent and porcine hearts were demonstrated for 2 weeks with consistent capture threshold and sensing amplitude, in contrast to a commercially available alternative. Pacing and continuous telemetric monitoring were achieved in a porcine model. These findings may offer a promising platform for adhesive bioelectronic devices for cardiac monitoring and treatment.
Topics: Animals; Swine; Rats; Monitoring, Physiologic; Pacemaker, Artificial; Rats, Sprague-Dawley; Electrodes, Implanted; Adhesives; Printing, Three-Dimensional; Models, Animal
PubMed: 38896601
DOI: 10.1126/scitranslmed.ado9003 -
RSC Advances Jun 2024Polymer foams can have heterogeneous and complex internal structures, especially when material blends or particles have been integrated to create composites. It becomes...
Polymer foams can have heterogeneous and complex internal structures, especially when material blends or particles have been integrated to create composites. It becomes even more challenging to probe and understand foam structure/properties when using non-uniform particles, such as biobased fillers. Optical or SEM imaging can only provide limited information as these are two-dimensional (2D) surface techniques. In this study, 3D X-ray tomography was applied to comprehensively analyze the structural features of biobased polyurethane foams containing porous rice hull fillers. The in-depth characterization at a wide range of length scale enabled us to quantify and obtain statistics of the unique trends in foam pore size and pore orientation corresponding to rice hull particle fraction and particle size. Rice hull particles were found to induce smaller cell formation. In addition, these biobased particles influenced cell expansion and caused cells to have less consistent orientation. Furthermore, after foam samples were subjected to cyclic compressive loading, X-ray tomography showed fractures in large (>100 μm) particles. This helps reveal the premature failing mechanism of composite foams with highly porous and coarse particles. The study elucidates novel microstructural evolution and deformation mechanisms using 3D X-ray tomography. The results offer new insights on internal structures for biobased composites and foams that are not previously possible through the conventional characterization tools.
PubMed: 38895520
DOI: 10.1039/d4ra02461c -
Materials (Basel, Switzerland) Jun 2024Polyurethane polishing pads are important in chemical mechanical polishing (CMP). Thus, understanding how to decrease the density but increase the porosity is a crucial...
Polyurethane polishing pads are important in chemical mechanical polishing (CMP). Thus, understanding how to decrease the density but increase the porosity is a crucial aspect of improving the efficiency of a polyurethane polishing pad. According to the principle of gas generation by thermal decomposition of sodium bicarbonate and ammonium bicarbonate, polyurethane polishing pad was prepared by a secondary foaming method. The influence of adding such an inorganic foaming agent as an auxiliary foaming agent on the structure, physical properties, and mechanical properties of polyurethane polishing pads was discussed. The results showed that compared with the polyurethane polishing pad without an inorganic foaming agent, the open-pore structure increased, the density decreased, and the porosity and water absorption increased significantly. The highest porosity and material removal rate (MRR) with sodium bicarbonate added was 3.3% higher than those without sodium bicarbonate and 33.8% higher than those without sodium bicarbonate. In addition, the highest porosity and MRR with ammonium bicarbonate were 7.2% higher and 47.8% higher than those without ammonium bicarbonate. Therefore, it was finally concluded that the optimum amount of sodium bicarbonate to be added was 3 wt%, and the optimum amount of ammonium bicarbonate to be added was 1 wt%.
PubMed: 38894023
DOI: 10.3390/ma17112759 -
Materials (Basel, Switzerland) Jun 2024Additive manufacturing (AM) is often used to create designs inspired by topology optimization and biological structures, yielding unique cross-sectional geometries...
Additive manufacturing (AM) is often used to create designs inspired by topology optimization and biological structures, yielding unique cross-sectional geometries spanning across scales. However, manufacturing defects intrinsic to AM can affect material properties, limiting the applicability of a uniform material model across diverse cross-sections. To examine this phenomenon, this paper explores the influence of specimen size and layer height on the compressive modulus of polycarbonate (PC) and thermoplastic polyurethane (TPU) specimens fabricated using fused filament fabrication (FFF). Micro-computed tomography imaging and compression testing were conducted on the printed samples. The results indicate that while variations in the modulus were statistically significant due to both layer height and size of the specimen in TPU, variations in PC were only statistically significant due to layer height. The highest elastic modulus was observed at a 0.2 mm layer height for both materials across different sizes. These findings offer valuable insights into design components for FFF, emphasizing the importance of considering mechanical property variations due to feature size, especially in TPU. Furthermore, locations with a higher probability of failure are recommended to be printed closer to the print bed, especially for TPU, because of the lower void volume fraction observed near the heated print bed.
PubMed: 38893943
DOI: 10.3390/ma17112677 -
Materials (Basel, Switzerland) Jun 2024Protection against fire and the corrosion of metals is necessary to ensure human safety. Most of the fire and corrosion inhibitors do not meet the ecological...
Hexakis[p-(hydroxymethyl)phenoxy]cyclotriphosphazene as an Environmentally Friendly Modifier for Polyurethane Powder Coatings with Increased Thermal Stability and Corrosion Resistance.
Protection against fire and the corrosion of metals is necessary to ensure human safety. Most of the fire and corrosion inhibitors do not meet the ecological requirements. Therefore, effective and ecological methods of protecting metals are currently a challenge for researchers. In this work, the influence of hexakis(4-(hydroxymethyl)phenoxy)cyclotriphosphazene (HHPCP) on the characteristics of powder coatings was examined. The coatings' properties were investigated by measuring the roughness, hardness, adhesion to the steel surface, cupping, gloss, scratch resistance, and water contact angle. The thermal stability was studied by furnace test and TGA analysis. The corrosion resistance test was carried out in a 3.5% NaCl solution. The distribution of phosphazene-derived segments in the coating was examined by GD-EOS analysis. Modified coatings show better corrosion and thermal resistance and can be used for the protection of the steel surface. Their better corrosion resistance is due to the electroactive properties of the phosphazene ring and its higher concentration at the coating surface, confirmed by GD-EOS analysis. The increase in thermal resistance is due to the effect of the formation of phosphoric metaphosphoric and polyphosphoric acids during the decomposition of HHCPC, which remain in the condensed char phase and play a crucial role in surface protection.
PubMed: 38893936
DOI: 10.3390/ma17112672 -
Materials (Basel, Switzerland) Jun 2024Hazelnut shells (HS), scientifically known as L. shells, are waste produced by companies that process nuts. The main objective of this study was to find an efficient...
Hazelnut shells (HS), scientifically known as L. shells, are waste produced by companies that process nuts. The main objective of this study was to find an efficient way to maximize the chemical potential of HS by solubilizing the hemicelluloses, which could then be used to recover sugars and, at the same time, increase the lignin content of this material to produce adhesives or high-strength foams. In order to optimize the pre-hydrolysis process, two different temperatures (160 and 170 °C) and times varying from 15 to 180 min were tested. All the remaining solid materials were then liquefied using polyalcohols with acid catalysis. The chemical composition of hazelnut shells was determined before and after the pre-hydrolysis. All of the process was monitored using Fourier Transform Infrared Spectroscopy with Attenuated Total Reflectance (FTIR-ATR) by determining the spectra of solids and liquids after the pre-hydrolysis and liquefaction steps. The highest solubilization of hazelnut shells was found for 170 °C and 180 min, resulting in a 25.8% solubilization. Chemical analysis after the hydrolysis process showed a gradual increase in the solubilization of hemicelluloses as both the temperature and time of the reactor were increased. Simultaneously, the percentages of α-cellulose and lignin in the material also increased with rises in temperature and duration. FTIR-ATR allowed for the detection of significant spectral changes in the hazelnut shells from their initial state to the solid residue and further into the liquefied phase. This confirmed that pre-hydrolysis was effective in enhancing the chemical composition of the material, making it more suitable for the production of adhesives, polyurethane foams, or in the production of bioplastics and composite materials, combined with other biopolymers or synthetic polymers to enhance the mechanical properties and biodegradability of the resulting materials.
PubMed: 38893931
DOI: 10.3390/ma17112667 -
Materials (Basel, Switzerland) May 2024In the pursuit of global energy conservation and emissions reductions, utilizing beverage cans as energy-absorbing components offers potential for a sustainable economy....
In the pursuit of global energy conservation and emissions reductions, utilizing beverage cans as energy-absorbing components offers potential for a sustainable economy. This study examines the impact of foam filling on the crushing behaviors and energy absorption of various types of beverage cans. Quasi-static compression tests were conducted on five geometrically sized cans filled with three densities of polyurethane foam to study their deformation modes and calculate crashworthiness parameters within the effective stroke. Results show that empty beverage cans have lower energy absorption capacities, and deformation modes become less consistent as can size increases. Higher foam density leads to increased total energy absorption, a slight reduction in the effective compression stroke, and a tendency for specific energy absorption to initially increase and then decrease. Regarding crush behavior, smaller cans transition from a diamond mode to a concertina mode, while larger cans exhibit a columnar bending mode. Next, the coupling effect of energy absorption between foam and cans was analyzed so as to reveal the design method of energy-absorbing components. The specific energy absorption of smaller cans filled with polyurethane foam is superior to that of similar empty cans. These findings provide valuable insights for selecting next-generation sustainable energy absorption structures.
PubMed: 38893919
DOI: 10.3390/ma17112655 -
Molecules (Basel, Switzerland) Jun 2024This work presents methods of obtaining polymeric hollow-fiber membranes produced via the dry-wet phase inversion method that were published in renowned specialized... (Review)
Review
This work presents methods of obtaining polymeric hollow-fiber membranes produced via the dry-wet phase inversion method that were published in renowned specialized membrane publications in the years 2010-2020. Obtaining hollow-fiber membranes, unlike flat membranes, requires the use of a special installation for their production, the most important component of which is the hollow fiber forming spinneret. This method is most often used in obtaining membranes made of polysulfone, polyethersulfone, polyurethane, cellulose acetate, and its derivatives. Many factors affect the properties of the membranes obtained. By changing the parameters of the spinning process, we change the thickness of the membranes' walls and the diameter of the hollow fibers, which causes changes in the membranes' structure and, as a consequence, changes in their transport/separation parameters. The type of bore fluid affects the porosity of the inner epidermal layer or causes its atrophy. Porogenic compounds such as polyvinylpyrrolidones and polyethylene glycols and other substances that additionally increase the membrane porosity are often added to the polymer solution. Another example is a blend of two- or multi-component membranes and dual-layer membranes that are obtained using a three-nozzle spinneret. In dual-layer membranes, one layer is the membrane scaffolding, and the other is the separation layer. Also, the temperature during the process, the humidity, and the composition of the solution in the coagulating bath have impact on the parameters of the membranes obtained.
PubMed: 38893513
DOI: 10.3390/molecules29112637 -
Polymers Jun 2024Current petrochemical-based adhesives adversely affect the environment through substantial volatile organic compound (VOC) emissions during production, contributing to... (Review)
Review
Current petrochemical-based adhesives adversely affect the environment through substantial volatile organic compound (VOC) emissions during production, contributing to air pollution and climate change. In contrast, vegetable oils extracted from bio-resources provide a compelling alternative owing to their renewability, abundance, and compatibility with adhesive formulation chemistry. This review aimed to critically examine and synthesize the existing scholarly literature on environmentally friendly, sustainable, and high-performance polyurethane adhesives (PUAs) developed from vegetable oils. The use of PUAs derived from vegetable oils promises to provide a long-term replacement while simultaneously maintaining or improving adhesive properties. This quality renders these adhesives appropriate for widespread use in various sectors, including construction, automotive manufacturing, packaging, textile, and footwear industries. This review intended to perform a comprehensive assessment and integration of the existing research, thereby identifying the raw materials, strengths, weaknesses, and gaps in knowledge concerning vegetable oil-based PUAs. In doing so, it responded to these gaps and proposes potential avenues for future research. Therefore, this review accomplishes more than merely evaluating the existing research; it fosters the advancement of greener PUA technologies by identifying areas for improvement and innovation towards more sustainable industrial practices by showcasing vegetable oil-based PUAs as viable, high-performance alternatives to their petroleum-based counterparts.
PubMed: 38891559
DOI: 10.3390/polym16111613