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British Medical Journal (Clinical... Mar 1985
Topics: Almitrine; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Peripheral Nervous System Diseases; Piperazines
PubMed: 2983821
DOI: 10.1136/bmj.290.6472.896 -
Journal of the Royal Society of Medicine Jan 1985
Review
Topics: Albuterol; Almitrine; Ampicillin; Bronchitis; Carbon Dioxide; Humans; Hypoxia; Oxygen Inhalation Therapy; Partial Pressure; Piperazines; Pulmonary Emphysema; Pulmonary Gas Exchange; Respiration, Artificial; Respiratory Insufficiency; Terbutaline
PubMed: 3918168
DOI: 10.1177/014107688507800112 -
British Medical Journal (Clinical... Nov 1984
Topics: Adrenergic beta-Agonists; Almitrine; Bronchitis; Humans; Hypertension, Pulmonary; Nifedipine; Piperazines; Pulmonary Emphysema; Pulmonary Heart Disease; Smoking; Vasodilator Agents
PubMed: 6149785
DOI: 10.1136/bmj.289.6456.1398 -
Anesthesiology Nov 1984
Topics: Almitrine; Chemoreceptor Cells; Halothane; Humans; Oxygen; Piperazines; Respiration
PubMed: 6497013
DOI: 10.1097/00000542-198411000-00038 -
Anesthesiology Feb 1984The changes in ventilation and breathing pattern induced by the substitution of pure oxygen for room air were tested in patients during stable halothane anesthesia...
The changes in ventilation and breathing pattern induced by the substitution of pure oxygen for room air were tested in patients during stable halothane anesthesia before and after the administration of almitrine bismesilate, a specific stimulant of the peripheral chemoreceptors. Ventilation was monitored in 25 patients for 15 min while breathing an air-halothane (1.5%) mixture and while breathing then for 10 min an O2-halothane (1.5%) mixture. The maneuver was repeated in 11 of these patients after the infusion of 0.5 mg/kg of almitrine bismesilate. Before almitrine administration, O2 inhalation caused a progressive decrease of minute-ventilation (VE) reaching 94.5 +/- 1.4% (mean +/- SEM) of the initial value at the tenth minute (P less than 0.01). This decrease was secondary to a progressive increase of inspiratory and expiratory times. Almitrine bismesilate caused a significant increase in VE (+11.6%), tidal volume (+14.0%), and mean inspiratory flow (+10.0%) when breathing the air-halothane mixture. Ten minutes after O2 administration, these variables were not different from those observed before almitrine infusion. This study shows that during halothane anesthesia, hypoxic ventilatory drive is not abolished but is depressed severely. Almitrine bismesilate can restore the hypoxic ventilatory drive.
Topics: Adult; Almitrine; Chemoreceptor Cells; Halothane; Humans; Male; Oxygen; Piperazines; Pulmonary Ventilation; Respiration; Tidal Volume
PubMed: 6696234
DOI: 10.1097/00000542-198402000-00008 -
Thorax Mar 1983The respiratory effects of intravenously infused almitrine were evaluated in healthy volunteers. In the dose range 0.25-1.0 mg/kg/hour it caused large and dose-dependent...
The respiratory effects of intravenously infused almitrine were evaluated in healthy volunteers. In the dose range 0.25-1.0 mg/kg/hour it caused large and dose-dependent increases in hypoxic chemosensitivity, which were longlasting and more persistent than the drug's retention in the plasma. Increases in sensitivity to hypercapnia were much less and were detected only when the plasma almitrine exceeded 200 ng/ml. Small increases in resting ventilation and metabolic rate with a decrease in mixed venous carbon dioxide tension occurred only at the highest infusion rate. The findings accord with an action of almitrine in the peripheral chemoreceptors, which may be of therapeutic value in managing some cases of respiratory failure.
Topics: Adult; Almitrine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Infusions, Parenteral; Male; Piperazines; Respiration; Respiratory Function Tests
PubMed: 6134350
DOI: 10.1136/thx.38.3.200 -
British Journal of Anaesthesia Jun 1982Five female patients received fentanyl 0.0066 mg kg-1 i.v. (group A); five other female patients received the same dose of fentanyl, followed immediately by almitrine... (Clinical Trial)
Clinical Trial
Five female patients received fentanyl 0.0066 mg kg-1 i.v. (group A); five other female patients received the same dose of fentanyl, followed immediately by almitrine 0.5 mg kg-1 i.v. (group B) and 20 minor gynaecological operations were performed under a combination of almitrine 0.5 mg kg-1 and fentanyl 0.0066 mg kg-1 (group C). In group A, fentanyl produced a marked and significant respiratory depression (P less than 0.001). In group B and C, almitrine antagonized the fentanyl-induced respiratory depression. Analgesia did not seem to be affected.
Topics: Adult; Almitrine; Analgesia; Central Nervous System Stimulants; Depression, Chemical; Female; Fentanyl; Humans; Piperazines; Respiration
PubMed: 6123336
DOI: 10.1093/bja/54.6.617