-
Journal of Clinical Medicine Jan 2022This systematic review and meta-analysis aimed at assessing the diagnostic accuracy of emerging technologies, such as laser fluorescence (LF), transillumination,... (Review)
Review
This systematic review and meta-analysis aimed at assessing the diagnostic accuracy of emerging technologies, such as laser fluorescence (LF), transillumination, light-emitting diode devices, optical coherence tomography (OCT), alternating current impedance spectroscopy, fluorescence cameras (FC), photo-thermal radiometry, and modulated luminescence technology. In vivo and in vitro results of such non-ionizing, non-invasive, and non-destructive methods' effectiveness in non-cavitated dentin caries detection are sometimes ambiguous. Following the PRISMA guidelines, 34 relevant research articles published between 2011-2021 were selected. The risk of bias was assessed with a tool tailored for caries diagnostic studies, and subsequent quantitative uni- and bi-variate meta-analysis was carried out in separate sub-groups according to the investigated surface (occlusal/proximal) and study setting (in vivo/in vitro). In spite of the high heterogeneity across the review groups, in vitro studies on LF and FC proved a good diagnostic ability for the occlusal surface, with area under the curve (AUC) of 0.803 (11 studies) and 0.845 (five studies), respectively. OCT studies reported an outstanding performance with an overall AUC = 0.945 (four studies). Promising technologies, such as OCT or FC VistaProof, still need well-designed and well-powered studies to accrue experimental and clinical data for conclusive medical evidence, especially for the proximal surface. Registration: INPLASY202210097.
PubMed: 35160127
DOI: 10.3390/jcm11030674 -
International Journal of Dentistry 2021Resin-dentin bond strength decreases over time. This reduction is related to the loss of hybrid layer integrity. Collagenolytic enzymes, especially matrix... (Review)
Review
OBJECTIVES
Resin-dentin bond strength decreases over time. This reduction is related to the loss of hybrid layer integrity. Collagenolytic enzymes, especially matrix metalloproteinases (MMPs), are responsible for the degradation of the collagen matrix of the hybrid layer. Various MMP inhibitors with the ability to prevent enzymatic degradation have been identified. This study aimed to systematically review the literature for studies which evaluated the effect of MMP inhibitors on the immediate and aged dentin bond strengths. Screening and analysis were carried out by two reviewers. Two databases were searched, and from a total of 740 articles, 43 were accepted for full review. 21 articles with 0.2%-2% chlorhexidine (CHX) treatments were included for meta-analysis. A risk of bias assessment was performed on all studies chosen for meta-analysis. A variety of MMP inhibitors have been studied, CHX being the most widely used.
CONCLUSIONS
A clear trend for a lower loss of dentin bond strength was observed with different MMP inhibitors. In meta-analysis, no significant difference was seen between the CHX and control in the immediate bond strengths. Bond strengths in the CHX group were significantly higher than the control group after aging ( < 0.001). The percentage of fractures occurring at the adhesive interface increased after aging. Five out of 21 studies included in the meta-analysis had high and the rest medium risk of bias. More long-term studies with lower risks of bias should be carried out to increase the reliability of results. The use of MMP inhibition with chlorhexidine can be recommended to increase the longevity of resin-dentin bond strength.
PubMed: 34135969
DOI: 10.1155/2021/9949699 -
Pediatric Dentistry Mar 2019The purpose of this study was to perform a systematic review to assess current evidence for association between various risk factors and the prevalence or incidence of... (Meta-Analysis)
Meta-Analysis
The purpose of this study was to perform a systematic review to assess current evidence for association between various risk factors and the prevalence or incidence of early childhood caries (ECC). Two reviewers searched various databases until January 2019. The Newcastle-Ottawa scale was used to perform risk of bias assessment. The included studies were categorized according to the World Bank classification. Data were summarized in a meta-analysis using fixed and random effects inverse-generic meta-analyses. A total of 7,034 records involving 89 studies that evaluated 1,352,097 individuals were included; 23 were high, 46 were moderate, and 20 were of low quality. A total of 123 risk factors were found. Meta-analysis revealed that the strongest risk factors found in the high-income countries were presence of dentinal caries (dmft greater than zero; odds ratio [OR] equals 4.21 [2.18 to 8.16]) and high levels of mutans streptococci (OR equals 3.83 [1.81 to 8.09]). In upper-middle-income countries, presence of enamel defects (OR equals 14.62 [6.10 to 35.03]) was found to be the strongest risk factor. The strongest risk factors associated with early childhood caries was the presence of enamel defects, presence of dentinal caries and high levels of mutans streptococci.
Topics: DMF Index; Dental Caries; Dental Enamel; Humans; Risk Factors; Streptococcus mutans
PubMed: 30992106
DOI: No ID Found -
International Journal of Clinical... 2021The purpose of this research was to analyze the role of chitosan in the remineralization of enamel and dentin. (Review)
Review
AIM AND OBJECTIVE
The purpose of this research was to analyze the role of chitosan in the remineralization of enamel and dentin.
MATERIALS AND METHODS
An electronic search was done for articles published from January 2009 to January 2020. A manual search was done from bibliographies of selected articles for relevant articles that were unexplored. Only studies conducted on the application of chitosan for remineralization of enamel and dentin were included in the study.
RESULTS
Of the 162 articles that were searched, only 15 studies were selected for the study. These studies met the inclusion criteria and were published from January 2009 to January 2020.
CONCLUSION
The review provides insight into the mechanism of remineralization of enamel and dentin. The properties of chitosan make it an ideal biomaterial that can be employed in the formulation of a novel remineralizing gel. However, more studies, clinical trials, and research are essential to transform chitosan-based remineralizing gels from research to clinical use.
CLINICAL SIGNIFICANCE
This review article opens a new window of opportunities for remineralizing enamel and dentin which have been long considered a challenging job.
HOW TO CITE THIS ARTICLE
Nimbeni SB, Nimbeni BS, Divakar DD. Role of Chitosan in Remineralization of Enamel and Dentin: A Systematic Review. Int J Clin Pediatr Dent 2021;14(4):562-568.
PubMed: 34824515
DOI: 10.5005/jp-journals-10005-1971 -
Journal of Dental Research Aug 2014The aim of this study was to systematically review the literature for in vitro and ex vivo studies that evaluated the effect of matrix metalloproteinase (MMP) inhibitors... (Meta-Analysis)
Meta-Analysis Review
The aim of this study was to systematically review the literature for in vitro and ex vivo studies that evaluated the effect of matrix metalloproteinase (MMP) inhibitors during the adhesive procedure on the immediate and long-term resin-dentin bond strength. The search was conducted in 6 databases with no publication year or language limits, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. From 1,336 potentially eligible studies, 48 were selected for full-text analysis, and 30 were included for review, with 17 considered in the meta-analysis. Two reviewers independently selected the studies, extracted the data, and assessed the risk of bias. Pooled effect estimates were expressed as the weighted mean difference between groups. The most used MMP inhibitor was chlorhexidine (CHX). Immediate bond strength results showed no difference between 2% CHX and control; however, a difference was found between 0.2% CHX and control at baseline. After aging, CHX presented higher bond strength values compared to control groups (p < .05). However, this was not observed for longer periods of aging. High heterogeneity was found in some comparisons, especially for the water storage aging subgroup. Subgroup analyses showed that self-etching and etch-and-rinse adhesives are benefited by the CHX use. From the studies included, only 1 presented low risk of bias, while the others showed medium or high risk of bias. The use of MMP inhibitors did not affect the immediate bond strength overall, while it influenced the aged bond strength. Aging procedures influenced bond strength values of the dentin adhesion stability.
Topics: Acid Etching, Dental; Chlorhexidine; Dental Bonding; Dentin; Humans; Matrix Metalloproteinase Inhibitors; Stress, Mechanical; Time Factors
PubMed: 24935066
DOI: 10.1177/0022034514538046 -
Caries Research 2019To investigate whether silver diamine fluoride (SDF) is effective in preventing new caries lesions in primary teeth when compared to placebo or active treatments. (Meta-Analysis)
Meta-Analysis
OBJECTIVES
To investigate whether silver diamine fluoride (SDF) is effective in preventing new caries lesions in primary teeth when compared to placebo or active treatments.
METHODS
Systematic review (CRD42016036963) of controlled clinical trials. Searches were performed in 9 electronic databases, 5 registers of ongoing trials, and reference lists of identified review articles. Two researchers carried out data extraction and quality appraisal independently. The primary outcome was the difference in caries increment (decayed, missing, and filled surfaces or teeth - dmfs or dmft) between SDF and control groups. These differences were pooled as weighted mean differences (WMD) and prevented fractions (PF).
RESULTS
Searches yielded 2,366 unique records; 6 reports of 4 trials that randomized 1,118 and analyzed 915 participants were included. Two trials compared SDF to no treatment, 1 compared SDF to placebo and sodium fluoride varnish (FV), and 1 compared SDF to high-viscosity glass ionomer cement (GIC). All studies had at least 1 domain with unclear or high risk of bias. After 24 months of follow-up, in comparison to placebo, no treatment, and FV, SDF applications significantly reduced the development of new dentin caries lesions (placebo or no treatment: WMD = -1.15, PF = 77.5%; FV: WMD = -0.43, PF = 54.0%). GIC was more effective than SDF after 12 months of follow-up but the difference between them was not statistically significant (WMD, dmft: 0.34, PF: -6.09%).
CONCLUSION
When applied to caries lesions in primary teeth, SDF compared to no treatment, placebo or FV appears to effectively prevent dental caries in the entire dentition. However, trials specifically designed to assess this outcome are needed.
Topics: Cariostatic Agents; Child; Child, Preschool; Controlled Clinical Trials as Topic; Dental Caries; Fluorides, Topical; Follow-Up Studies; Glass Ionomer Cements; Humans; Inflammation; Quaternary Ammonium Compounds; Silver Compounds; Sodium Fluoride; Taste Disorders; Tooth Discoloration; Tooth, Deciduous
PubMed: 29874642
DOI: 10.1159/000488686 -
Journal of Dental Research Mar 2011Treatment of dentin hypersensitivity with oxalates is common, but oxalate efficacy remains unclear. Our objective was to systematically review clinical trials reporting... (Meta-Analysis)
Meta-Analysis Review
Treatment of dentin hypersensitivity with oxalates is common, but oxalate efficacy remains unclear. Our objective was to systematically review clinical trials reporting an oxalate treatment compared with no treatment or placebo with a dentin hypersensitivity outcome. Risk-of-bias assessment and data extraction were performed independently by two reviewers. Standardized mean differences (SMD) were estimated by random-effects meta-analysis. Of 677 unique citations, 12 studies with high risk-of-bias were included. The summary SMD for 3% monohydrogen-monopotassium oxalate (n = 8 studies) was -0.71 [95% Confidence Interval: -1.48, 0.06]. Other treatments, including 30% dipotassium oxalate (n = 1), 30% dipotassium oxalate plus 3% monohydrogen monopotassium oxalate (n = 3), 6% monohydrogen monopotassium oxalate (n = 1), 6.8% ferric oxalate (n = 1), and oxalate-containing resin (n = 1), also were not statistically significantly different from placebo treatments. With the possible exception of 3% monohydrogen monopotassium oxalate, available evidence currently does not support the recommendation of dentin hypersensitivity treatment with oxalates.
Topics: Bias; Controlled Clinical Trials as Topic; Dentin Desensitizing Agents; Dentin Sensitivity; Humans; Oxalates; Pain Measurement
PubMed: 21191127
DOI: 10.1177/0022034510389179 -
Frontiers in Bioengineering and... 2022To systematically review studies that evaluated the effects of plant extracts on dentin bonding strength. Six electronic databases (PubMed, Embase, VIP, CNKI, Wanfang... (Review)
Review
To systematically review studies that evaluated the effects of plant extracts on dentin bonding strength. Six electronic databases (PubMed, Embase, VIP, CNKI, Wanfang and The Cochrane Library) were searched from inception to September 2021 in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA). studies that compared the performance of dental adhesives with and without the plant extracts participation were included. The reference lists of the included studies were manually searched. Two researchers carried out study screening, data extraction and risk of bias assessment, independently and in duplicate. Meta-analysis was conducted using Review Manager 5.3. A total of 62 studies were selected for full-text analysis. 25 articles used the plant extracts as primers, while five added the plant extracts into adhesives. The meta-analysis included 14 articles of studies investigating the effects of different plant extract primers on dentin bonding strength of etch-and-rinse and self-etch adhesives, respectively. The global analysis showed statistically significant difference between dental adhesives with and without plant extract primers. It showed that the immediate bond strength of dental adhesives was improved with the application of plant extract primers. The application of proanthocyanidin (PA) primers have positive effect on the immediate bonding strength of dental adhesives irrespective of etch-and-rinse or self-etch modes.
PubMed: 35284411
DOI: 10.3389/fbioe.2022.836042 -
Journal of Conservative Dentistry : JCD 2018The purpose of this study was to systematically evaluate the dentin bond strength of etch-and-rinse and self-etch adhesives to primary teeth. In this study, PubMed, ISI... (Review)
Review
The purpose of this study was to systematically evaluate the dentin bond strength of etch-and-rinse and self-etch adhesives to primary teeth. In this study, PubMed, ISI (all databases), Scopus, and Cochrane Database were searched according to the selected keywords up to May 11, 2016. The full texts of published articles that appeared to meet the primary criteria for inclusion in this study were obtained. Due to the variation in the methods used, the studies were divided into 2 groups: Group 1 - studies that evaluated the micro-tensile bond strengths (MTBSs) of two-step etch-and-rinse adhesives and two-step self-etch adhesives and Group 2 - studies that evaluated the MTBSs of two-step etch-and-rinse adhesives and one-step self-etch adhesives. The initial search yielded 1447 publications. After a methodological assessment, 8 publications were selected. The results of this study showed that the MTBS of the etch-and-rinse adhesives and the two-step self-etch adhesives were similar (P = 0.34), and both were significantly higher than that of the one-step self-etch adhesive (P = 0.001). This meta-analysis showed that the application of two-step self-etch adhesives performs well when used for primary dentin and can be used to save time in pediatric dentistry.
PubMed: 29899624
DOI: 10.4103/JCD.JCD_287_17 -
Clinical Oral Investigations Dec 2021To investigate the treatment efficacy of low-level light therapy on dentin hypersensitivity. (Meta-Analysis)
Meta-Analysis Review
OBJECTIVE
To investigate the treatment efficacy of low-level light therapy on dentin hypersensitivity.
MATERIALS AND METHODS
Following the PRISMA guideline, six electronic databases supplemented with bibliographies were searched till December 2020. Two reviewers performed the screenings independently with a reliability assessment. Studies fulfilling the pre-registered eligibility criteria were included for risk-of-bias assessment and data synthesis.
RESULTS
Thirty-five articles ultimately informed this systematic review based on the eligibility criteria and underwent risk-of-bias assessment (ĸ = 0.86). Quantitative results were deduced by meta-analysis of 20 randomised controlled trials: LLLT showed favourable outcomes compared to placebos for immediate (SMD: 1.09, 95% CI: 0.47 to 1.70), interim (SMD: 1.32, 95% CI: 0.41 to 2.23), and persistent efficacies (SMD: 2.86, 95% CI: 1.98 to 3.74). However, substantial heterogeneity existed among included studies (I: 64-95%). Regarding comparisons with other desensitising strategies, LLLT showed no significant benefits in DH alleviation over others except fluorides for interim efficacy (SMD: 0.31, 95% CI: 0.10 to 0.52) and persistent efficacy (SMD: 0.45, 95% CI: 0.03 to 0.86).
CONCLUSIONS
This systematic review shows that LLLT has positive immediate, interim, and persistent DH-treatment efficacies compared with placebo. No superior treatment effects of LLLT were observed except fluoride agent use. Further studies are warranted-RCTs with low risk of bias, consistent technical settings, comprehensive assessments, and long follow-up periods.
CLINICAL RELEVANCE
This systematic review bridges a critical research gap by analysing clinical evidence in the DH-alleviating efficacy of LLLT in comparison with placebo and other in-office desensitising strategies.
Topics: Dentin Sensitivity; Fluorides; Humans; Low-Level Light Therapy; Reproducibility of Results; Treatment Outcome
PubMed: 34642786
DOI: 10.1007/s00784-021-04183-1