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Revista Brasileira de Epidemiologia =... 2020To update findings of observational analytical studies on the association between occupational exposure to organophosphates and hematologic malignancies.
OBJECTIVE
To update findings of observational analytical studies on the association between occupational exposure to organophosphates and hematologic malignancies.
METHODOLOGY
Systematic literature review, including cohort and case-control studies, without limitation of publication time, in Portuguese and English. The articles were traced from June 2017 to July 2019 in PubMed, MEDLINE, LILACS, Web of Science, and Scopus databases. The qualitative bias risk assessment was performed using the Newcastle-Ottawa Scale and the Downs and Black Checklist. Results were presented according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA).
RESULTS
Seventeen studies evaluated as good/high methodological quality were eligible. Exposure to diazinon (1 cohort), phonophos (1 cohort), dichlorvos, crotoxiphos and famphur (1 case control) was associated with leukemia, while exposure to organophosphate was associated to lymphomas (6 case control); the risk of non-Hodgkin's lymphoma was higher in those exposed to diazinon (1 control case) and malathion (3 control case) than non-exposed ones. Multiple myeloma occurred more commonly in organophosphate exposed than in non-exposed individuals (1 case-control).
CONCLUSION
Occupational exposure to organophosphates increases the risk of hematologic malignancies, especially among individuals with longer exposure periods. Worker monitoring and exposure control measures are recommended.
Topics: Hematologic Neoplasms; Humans; Occupational Exposure; Organophosphate Poisoning; Pesticides; Risk Assessment; Risk Factors; Time Factors
PubMed: 32401913
DOI: 10.1590/1980-549720200022