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British Journal of Industrial Medicine Apr 1970160-166. During the years 1957 to 1963, 59 cases of hyperplastic squamous lesions were referred to us from a local patent fuel works where ovoids were made by fusing...
160-166. During the years 1957 to 1963, 59 cases of hyperplastic squamous lesions were referred to us from a local patent fuel works where ovoids were made by fusing coal dust and pitch together by steam heat. We carried out a survey of all the personnel exposed to the pitch hazard and at the same time examined a control group of men of the same age group. The pitch workers examined totalled 144 and they were re-examined after a period of two years. The control group consisted of 263 persons selected from dermatological out-patients. The clinical findings were classified into six main groups: (1) benign proliferative lesions; (2) pre-malignant and malignant epidermoid lesions; (3) pitch acanthoma (pitch warts); (4) photo-sensitivity; (5) acneiform lesions; and (6) scrotal changes. 1. Benign proliferative lesions: There was little difference between the incidence of these lesions in the pitch workers and in the control group. 2. Pre-malignant and malignant epidermoid lesions: (a) Squamous keratoses were slightly more common in the pitch workers (12%) than in the controls (10%). (b) Chronic tar dermatosis was found in 5% of pitch workers who had an exposure to pitch ranging from 30 to 50 years. No controls showed these changes. (c) Squamous-cell carcinoma incidence was 2·8% in pitch workers compared with 0·4% in the controls. 3. Pitch acanthoma: At the initial examination the incidence of pitch acanthoma in the pitch workers was 3·5% compared with 2·7% in the controls. However, on the two-year follow-up there was an increase in incidence in the pitch workers of 15·7%. Only 10·4% of all pitch workers developed pitch acanthoma. The incidence was related not only to the duration of exposure but also to the degree of pitch contamination of the skin. The highest incidence was recorded in those with the greatest skin contamination, 24% compared with 3·2% in those with low exposure. Spontaneous regression was noticed in 26% of cases. 4. Photo-sensitivity: 57 (4%) pitch workers recorded photo-sensitivity (`smarts'). There was no relationship between the incidence of `smart' and pitch warts or acne. 5. Acneiform lesions: All acneiform lesions were much more common in the pitch workers (93%) than in the controls (31%). 6. Scrotal changes: 13·5% of all the pitch workers showed one or more of our recorded lesions. There was a 3·5% incidence of kerato-acanthoma and there was one squamous carcinoma. In this series there is an increased susceptibility to some proliferative lesions, either premalignant or malignant, in pitch workers when compared with the controls. Only 10·7% of the working population were affected with pitch acanthoma and of these 50% had multiple warts. Even though there is an increasing incidence with increased exposure, this is not absolute and our findings suggest that there is also a personal susceptibility to pitch.
Topics: Acne Vulgaris; Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Coal Tar; Dermatitis, Contact; Humans; Keratosis; Male; Middle Aged; Occupational Diseases; Photosensitivity Disorders; Pigmentation; Racial Groups; Scrotum; Skin Neoplasms; Warts
PubMed: 4246788
DOI: 10.1136/oem.27.2.160 -
Indian Journal of Dermatology,... 2023
Topics: Humans; Acanthoma; Skin Neoplasms; Acantholysis
PubMed: 37317765
DOI: 10.25259/IJDVL_970_2022 -
Head & Neck Oncology Jan 2009This review outlines the histological features of intra-oral skin flaps and their pathology as encountered in a routine head and neck diagnostic histopathology service.... (Review)
Review
This review outlines the histological features of intra-oral skin flaps and their pathology as encountered in a routine head and neck diagnostic histopathology service. Problems in recognising and interpreting unfamiliar and complex appearances, and areas of diagnostic and prognostic uncertainty, are highlighted.
Topics: Acanthoma; Candidiasis, Chronic Mucocutaneous; Carcinoma, Squamous Cell; Humans; Hyperplasia; Mouth Neoplasms; Surgical Flaps
PubMed: 19284680
DOI: 10.1186/1758-3284-1-2 -
World Journal of Clinical Cases Sep 2020Epidermolytic acanthoma (EA) is a rare benign skin lesion, usually found in the genital area of men and women, with epidermolytic hyperkeratosis as its distinguishing...
BACKGROUND
Epidermolytic acanthoma (EA) is a rare benign skin lesion, usually found in the genital area of men and women, with epidermolytic hyperkeratosis as its distinguishing histologic characteristic. It is commonly misdiagnosed as condyloma accuminatum, verruca, and seborrheic keratosis. Since this lesion is benign, treatment is not necessary. However, it is often misdiagnosed, and patients are likely to undergo incorrect counseling and unnecessary treatment, causing undue burden to the patient. This study seeks to increase awareness of this rare condition to prevent future misdiagnoses.
CASE SUMMARY
A 55-year-old man living with human immunodeficiency virus presented for anal cancer screening. His physical examination revealed a flesh colored papule at the anal margin. The initial differential diagnosis included molluscum contagiosum, anal condyloma, and basal cell carcinoma. The lesion was excised to obtain a definitive diagnosis and was discovered to be EA.
CONCLUSION
EA is often misdiagnosed due to its similarity to other dermatologic conditions. Careful examination and pathologic evaluation should be obtained to ensure proper diagnosis.
PubMed: 33024766
DOI: 10.12998/wjcc.v8.i18.4094 -
JAAD Case Reports May 2021
PubMed: 33912638
DOI: 10.1016/j.jdcr.2021.03.018 -
Actas Dermo-sifiliograficas Dec 2022
Topics: Humans; Acanthoma; Skin Neoplasms; Sebaceous Glands
PubMed: 36543467
DOI: 10.1016/j.ad.2021.08.010 -
Journal of Cutaneous Pathology Jun 2020Epidermolytic acanthoma (EA) is a rare acquired lesion demonstrating a characteristic histopathological pattern of epidermal degeneration referred to as epidermolytic...
BACKGROUND
Epidermolytic acanthoma (EA) is a rare acquired lesion demonstrating a characteristic histopathological pattern of epidermal degeneration referred to as epidermolytic hyperkeratosis (EHK). On histopathological analysis, EA appears nearly identical to inherited EHK-associated dermatoses such as epidermolytic ichthyosis and ichthyosis bullosa of Siemens. While it has been speculated that EA is caused by mutations in KRT10, KRT1, or KRT2 found in these inherited dermatoses, none have yet been identified. Herein, we aim to identify the contributions of keratin mutations to EA.
METHODS
Using genomic DNA extracted from paraffin-embedded samples from departmental archives, we evaluated a discovery cohort using whole-exome sequencing (WES) and assessed remaining samples using Sanger sequencing screening and restriction fragment length polymorphism (RFLP) analysis.
RESULTS
DNA from 16/20 cases in our sample was of sufficient quality for polymerase chain reaction amplification. WES of genomic DNA from lesional tissue revealed KRT10 c.466C > T, p.Arg156Cys mutations in 2/3 samples submitted for examination. RFLP analysis of these samples as well as eight additional samples confirmed the mutations identified via WES and identified four additional cases with Arg156 mutations. In sum, 6/11 screened cases showed hotspot mutation in KRT10.
CONCLUSIONS
Hotspot mutations in the Arg156 position of KRT10, known to cause epidermolytic ichthyosis, also underlie EA.
Topics: Acanthoma; Adult; Aged; Aged, 80 and over; Female; Genomics; Humans; Hyperkeratosis, Epidermolytic; Ichthyosis Bullosa of Siemens; Keratin-10; Keratins; Male; Middle Aged; Mutation; Skin Neoplasms; Exome Sequencing
PubMed: 32045015
DOI: 10.1111/cup.13664 -
Indian Journal of Dermatology,... 2011Dermatoscopy is a cheap and non-invasive diagnostic technique that improves the diagnostic accuracy of non-pigmented benign and malignant skin tumors. Dermatologist... (Review)
Review
Dermatoscopy is a cheap and non-invasive diagnostic technique that improves the diagnostic accuracy of non-pigmented benign and malignant skin tumors. Dermatologist should be aware of dermatoscopic features of non-melanocytic skin tumors to reach the correct diagnosis.
Topics: Acanthoma; Biopsy, Needle; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatology; Dermoscopy; Diagnosis, Differential; Female; Histiocytoma, Benign Fibrous; Humans; Immunohistochemistry; Keratosis, Actinic; Male; Melanocytes; Nevus, Pigmented; Sensitivity and Specificity; Skin Neoplasms
PubMed: 21220874
DOI: 10.4103/0378-6323.74966 -
JAAD Case Reports Jan 2020
PubMed: 31890829
DOI: 10.1016/j.jdcr.2019.10.028 -
Journal of Clinical Medicine Apr 2024Clear cell acanthoma (CCA) and squamous cell carcinoma (SCC) represent distinct entities within dermatological oncology, each posing unique diagnostic and therapeutic... (Review)
Review
Clear cell acanthoma (CCA) and squamous cell carcinoma (SCC) represent distinct entities within dermatological oncology, each posing unique diagnostic and therapeutic challenges. CCA is a rare, benign epidermal growth, often not associated with human papillomavirus (HPV) infection, whereas SCC, a more aggressive form of skin cancer, has been linked to both ultraviolet (UV) exposure and HPV. Understanding the co-occurrence of these conditions in a single patient can enhance diagnostic accuracy and therapeutic outcomes. We report a 64-year-old male who underwent an operation for a verruciform lesion in the right groin, which was diagnosed as HPV-positive CCA alongside keratinised SCC. A literature search across January 2024 revealed limited evidence directly linking HPV to CCA, suggesting a need for further investigation. The speculative association between HPV and CCA warrants deeper exploration, especially considering the potential for HPV to contribute to lesion development through indirect mechanisms. The coexistence of CCA and SCC in an elderly patient presents a unique clinical scenario. This emphasises the need for vigilant diagnosis and tailored treatment strategies, highlighting the gap in understanding the pathogenesis of CCA, particularly its potential association with HPV. Further research is crucial for elucidating the complex interactions governing these conditions and for developing targeted interventions.
PubMed: 38731009
DOI: 10.3390/jcm13092482