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Roczniki Panstwowego Zakladu Higieny 2014A vegetarian diet may be adopted for various reasons that can include ecological, economic, religious, ethical and health considerations. In the latter case they arise... (Review)
Review
A vegetarian diet may be adopted for various reasons that can include ecological, economic, religious, ethical and health considerations. In the latter case they arise from the desire to lose weight, in tackling obesity, improving physical fitness and/or in reducing the risk of acquiring certain diseases. It has been shown that properly applied vegetarian diet is the most effective way of reducing body mass (expressed as BMI), improving the plasma lipid profile and in decreasing the incidence of high arterial blood pressure, cardiovascular disease, stroke, metabolic syndrome and arteriosclerosis. In addition, improved insulin sensitivity together with lower rates of diabetes and cancer has been observed. Some studies have however found that a vegetarian diet may result in changes adversely affecting the body. These could include; hyperhomocysteinaemia, protein deficiency, anaemia, decreased creatinine content in muscles and menstrual disruption in women who undertake increased physical activity. Some of these changes may decrease the ability for performing activities that require physical effort. Nevertheless, on balance it can be reasonably concluded that the beneficial effects of a vegetarian diet significantly, by far, outweigh the adverse ones. It should also be noted that the term 'vegetarian diet' is not always clearly defined in the literature and it may include many dietary variations.
Topics: Adult; Cardiovascular Diseases; Deficiency Diseases; Diabetes Mellitus, Type 2; Diet, Vegetarian; Female; Health Status; Humans; Male; Metabolic Syndrome; Motor Activity; Neoplasms; Nutritional Status; Obesity; Risk Assessment; Risk Factors
PubMed: 24964573
DOI: No ID Found -
Comprehensive Physiology Apr 2012Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause of most chronic diseases. The initial third of the article considers:... (Review)
Review
Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause of most chronic diseases. The initial third of the article considers: activity and prevention definitions; historical evidence showing physical inactivity is detrimental to health and normal organ functional capacities; cause versus treatment; physical activity and inactivity mechanisms differ; gene-environment interaction (including aerobic training adaptations, personalized medicine, and co-twin physical activity); and specificity of adaptations to type of training. Next, physical activity/exercise is examined as primary prevention against 35 chronic conditions [accelerated biological aging/premature death, low cardiorespiratory fitness (VO2max), sarcopenia, metabolic syndrome, obesity, insulin resistance, prediabetes, type 2 diabetes, nonalcoholic fatty liver disease, coronary heart disease, peripheral artery disease, hypertension, stroke, congestive heart failure, endothelial dysfunction, arterial dyslipidemia, hemostasis, deep vein thrombosis, cognitive dysfunction, depression and anxiety, osteoporosis, osteoarthritis, balance, bone fracture/falls, rheumatoid arthritis, colon cancer, breast cancer, endometrial cancer, gestational diabetes, pre-eclampsia, polycystic ovary syndrome, erectile dysfunction, pain, diverticulitis, constipation, and gallbladder diseases]. The article ends with consideration of deterioration of risk factors in longer-term sedentary groups; clinical consequences of inactive childhood/adolescence; and public policy. In summary, the body rapidly maladapts to insufficient physical activity, and if continued, results in substantial decreases in both total and quality years of life. Taken together, conclusive evidence exists that physical inactivity is one important cause of most chronic diseases. In addition, physical activity primarily prevents, or delays, chronic diseases, implying that chronic disease need not be an inevitable outcome during life.
Topics: Adaptation, Physiological; Chronic Disease; Exercise; Gene-Environment Interaction; Humans; Metabolic Syndrome; Motor Activity; Pharmacogenetics; Physical Fitness; Risk Factors; Sedentary Behavior; Twin Studies as Topic
PubMed: 23798298
DOI: 10.1002/cphy.c110025 -
Nutricion Hospitalaria Sep 2013The benefits of regular physical activity have been known since ancient Greek. But in the last Century the scientific knowledge around this topic has progressed... (Review)
Review
The benefits of regular physical activity have been known since ancient Greek. But in the last Century the scientific knowledge around this topic has progressed enormously, starting with the early studies of JN Morris and RS Paffenberger, who demonstrated that physical activity at work reduced incidence of cardiovascular disease and mortality. In the Harvard alumni study, the lowest risk was associated with a weekly output of 1000 to 2000 kcal performing vigorous activities. Further studies in all age groups have supported these findings and have added that even moderate levels of physical activity provide considerable benefits to health, including lower prevalence of overweight and obesity at all ages. Metabolic fat oxidation rate is highest at exercise intensities between 45 and 65% of VO2max. This means that people must be active regularly and force physiological mechanisms at certain intensities. All this body of evidence has contributed to current WHO physical activity recommendations of 150 min/week of moderate to vigorous physical activity (MVPA) in adults and elderly, and 60 min/day of MVPA in children and adolescents, with additional strength training, apart from adopting an active lifestyle. In the last 50 years, occupational physical activity has been reduced for about 120 kcal/day, and sedentarism has emerged as an additional risk factor to physical inactivity. Even if less than 60 min of TV time in adults have been related to lower average BMI, there is still a need for research to determine the appropriate dose of exercise in combination with sedentary behaviours and other activities in the context of our modern lifestyle in order to prevent obesity at all ages. As public health measures have failed to stop the obesity epidemic in the last 3 decades, there is clearly a need to change the paradigm. The inclusion of sport scientists, physical education teachers and other professionals in the multidisciplinary team which should be responsible for drawing the road map to prevent the increase of the obesity epidemic effectively is a "must" from our point of view.
Topics: Adult; Cardiovascular Diseases; Child; Health Status; Humans; Life Style; Motor Activity; Obesity; Sedentary Behavior; Sports
PubMed: 24010748
DOI: 10.3305/nh.2013.28.sup5.6923 -
Roczniki Panstwowego Zakladu Higieny 2018An important factor in maintaining elderly people in good health is an appropriate level of physical activity. The research into physical activity level of the elderly...
BACKGROUND
An important factor in maintaining elderly people in good health is an appropriate level of physical activity. The research into physical activity level of the elderly is quite crucial as the low level of such activity may lead to disability and that, in turn, generates the need of additional care which constitutes a serious social problem. As the existing data seem to lack a lot, new research would enrich our knowledge in new conclusions.
OBJECTIVE
The aim of the study is to analyze and estimate the physical activity of the elderly persons with overweight or obesity elderly.
MATERIAL AND METHODS
The research group consisted of 360 overweight and obese elderly people. The criteria of inclusion into a research group were living in family homes, overweight (BMI=25.0-29.9 kg/m2) or obesity (BMI ≥ 30 kg/m2), no contraindications to physical activity, age between 60 and 74 and written consent for the participation of the experiment. The control group consisted of 360 people without overweight and obesity. The inclusion criteria included age 60-74 BMI<25.0 kg/m2 and living at family home. The data was gathered with the use of the International Physical Activity Questionnaire (IPAQ).
RESULTS
The average age in the test group was 67,03±4,264 and in control group 66,59±4,050. The research has shown that the level of physical activity of overweight and obese senior citizens was lower than in people with correct body mass. Frequency of high intensity of physical activity undertaken by seniors in the test group was 0.7 day per week and lasted 16.1 minutes a day ( in the control group 2.5 days per day and 32.8 minutes per day, respectively). The IPAQ examination has shown that 95.8% of the test group participants had insufficient level of professional activity, 99.7% in transport-related physical activity, 86.1% in household chores and 99.4% in free time physical activity.
CONCLUSIONS
The level of physical activity of the elderly in the test group was very low, much lower than in people of the same age but with correct body mass. The lowest level of physical activity was noted in transport-related physical activity and leisure time physical activity.
Topics: Activities of Daily Living; Aged; Body Composition; Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Exercise; Female; Health Behavior; Humans; Male; Middle Aged; Motor Activity; Obesity; Overweight
PubMed: 30525327
DOI: 10.32394/rpzh.2018.0042 -
Biomedical Engineering Online Sep 2018Adults with sedentary lifestyles seem to face a higher risk of falling in their later years. Several causes, such as impairment of strength, coordination, and cognitive... (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
Adults with sedentary lifestyles seem to face a higher risk of falling in their later years. Several causes, such as impairment of strength, coordination, and cognitive function, influence worsening health conditions, including balancing ability. Many modalities can be applied to improve the balance function and prevent falling. Several studies have also recorded the effects of balance training in elderly adults for fall prevention. Accordingly, the aim of this study is to define the effect of virtual reality-based balance training on motor learning and postural control abilities in healthy adults.
METHODS
For this study, ten subjects were randomly allocated into either the conventional exercise (CON) or the virtual reality (VR) group. The CON group underwent physical balance training, while the VR group used the virtual reality system 4 weeks. In the VR group, the scores from three game modes were utilized to describe the effect of motor learning and define the learning curves that were derived with the power law function. Wilcoxon Signed Ranks Test was performed to analyze the postural control in five standing tasks, and data were collected with the help of a force plate.
RESULTS
The average score was used to describe the effect of motor learning by deriving the mathematical models for determining the learning curve. Additionally, the models were classified into two exponential functions that relied on the aim and requirement skills. A negative exponential function was observed in the game mode, which requires the cognitive-motor function. In contrast, a positive exponential function was found in the game with use of only the motor skill. Moreover, this curve and its model were also used to describe the effect of learning in the long term and the ratio of difficulty in each game. In the balance performance, there was a significant decrease in the center of pressure parameters in the VR group, while in the CON group, there was a significant increase in the parameters during some foot placements, especially in the medio-lateral direction.
CONCLUSION
The proposed VR-based training relies on the effect of motor learning in long-term training though different kinds of task training. In postural analysis, both exercise programs are emphasized to improve the balance ability in healthy adults. However, the virtual reality system can promote better outcomes to improve postural control post exercising. Trial registration Retrospectively registered on 25 April 2018. Trial number TCTR20180430005.
Topics: Accidental Falls; Adult; Female; Healthy Volunteers; Humans; Learning; Male; Middle Aged; Motor Activity; Postural Balance; Virtual Reality
PubMed: 30227884
DOI: 10.1186/s12938-018-0550-0 -
Cell Dec 2006Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to...
Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. Treatment of mice with RSV significantly increased their aerobic capacity, as evidenced by their increased running time and consumption of oxygen in muscle fibers. RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in PGC-1alpha acetylation and an increase in PGC-1alpha activity. This mechanism is consistent with RSV being a known activator of the protein deacetylase, SIRT1, and by the lack of effect of RSV in SIRT1(-/-) MEFs. Importantly, RSV treatment protected mice against diet-induced-obesity and insulin resistance. These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis.
Topics: Acetylation; Adult; Animals; Dietary Fats; Energy Metabolism; Gene Expression Regulation; Humans; Insulin Resistance; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mitochondria, Muscle; Motor Activity; Muscle Fibers, Skeletal; Obesity; Oxidative Phosphorylation; Oxygen Consumption; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Polymorphism, Single Nucleotide; Resveratrol; Sirtuin 1; Sirtuins; Specific Pathogen-Free Organisms; Stilbenes; Trans-Activators; Transcription Factors
PubMed: 17112576
DOI: 10.1016/j.cell.2006.11.013 -
BMC Health Services Research Jul 2018Anxiety disorders are common, yet treatment options in general practice are often limited to medication or CBT. There is a lack of evidence for the effectiveness of... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Anxiety disorders are common, yet treatment options in general practice are often limited to medication or CBT. There is a lack of evidence for the effectiveness of exercise in the treatment of anxiety in patients who present to general practice and also about the intensity of exercise required to lead to improvement. The aim of this systematic review was to assess the use of exercise versus waiting list control groups in the treatment of anxiety and also to assess the benefit of high intensity exercise vs low intensity exercise. Long term follow up scores were also analysed. We included patients who met diagnostic criteria for anxiety disorders or had clinically raised anxiety levels on a validated rating scale and performed a subgroup analysis of the outcomes between the two groups. The intervention was any aerobic exercise programme carried out for at least two weeks, or exercise carried out at high intensity for at least two weeks. The comparison groups were either a waiting list control group or low intensity exercise.
METHOD
Systematic review of randomised controlled trials. Three databases were searched; CENTRAL, Medline and Embase. Outcome assessment was based on validated anxiety rating scales. The quality of the studies was appraised according to the Cochrane Risk of Bias tool. Effect sizes were calculated using the standardised mean difference.
RESULTS
Fifteen studies were identified with a total of 675 patients. Nine trials had participants with diagnosed anxiety disorders and six trials had participants with raised anxiety on a validated rating scale. Aerobic exercise was effective in the treatment of raised anxiety compared to waiting list control groups (effect size - 0.41, 95% CI = - 0.70 to - 0.12). High intensity exercise programmes showed greater effects than low intensity programmes. There was no significant difference in outcomes between groups of patients with diagnosed anxiety disorders and patients who had raised anxiety on a rating scale. Conclusions were limited by the small number of studies and wide variation in the delivery of exercise interventions.
CONCLUSION
Exercise programmes are a viable treatment option for the treatment of anxiety. High intensity exercise regimens were found to be more effective than low intensity regimens. The results have implications for the use of exercise schemes in General Practice.
Topics: Anxiety Disorders; Control Groups; Exercise; Exercise Therapy; General Practice; Humans; Outcome Assessment, Health Care; Randomized Controlled Trials as Topic; Waiting Lists
PubMed: 30012142
DOI: 10.1186/s12913-018-3313-5 -
The International Journal of Behavioral... Jul 2017Well-designed research trials are critical for determining the efficacy and effectiveness of nutrition education interventions. To determine whether behavioral and/or... (Review)
Review
BACKGROUND
Well-designed research trials are critical for determining the efficacy and effectiveness of nutrition education interventions. To determine whether behavioral and/or cognition changes can be attributed to an intervention, the experimental design must include a control or comparison condition against which outcomes from the experimental group can be compared. Despite the impact different types of control groups can have on study outcomes, the treatment provided to participants in the control condition has received limited attention in the literature.
METHODS
A systematic review of control groups in nutrition education interventions was conducted to better understand how control conditions are described in peer-reviewed journal articles compared with experimental conditions. To be included in the systematic review, articles had to be indexed in CINAHL, PubMed, PsycINFO, WoS, and/or ERIC and report primary research findings of controlled nutrition education intervention trials conducted in the United States with free-living consumer populations and published in English between January 2005 and December 2015. Key elements extracted during data collection included treatment provided to the experimental and control groups (e.g., overall intervention content, tailoring methods, delivery mode, format, duration, setting, and session descriptions, and procedures for standardizing, fidelity of implementation, and blinding); rationale for control group type selected; sample size and attrition; and theoretical foundation.
RESULTS
The search yielded 43 publications; about one-third of these had an inactive control condition, which is considered a weak study design. Nearly two-thirds of reviewed studies had an active control condition considered a stronger research design; however, many failed to report one or more key elements of the intervention, especially for the control condition. None of the experimental and control group treatments were sufficiently detailed to permit replication of the nutrition education interventions studied.
CONCLUSIONS
Findings advocate for improved intervention study design and more complete reporting of nutrition education interventions.
Topics: Control Groups; Diet; Health Education; Humans; Research
PubMed: 28693581
DOI: 10.1186/s12966-017-0546-3 -
PloS One 2015Important considerations for exercise trials in cancer patients are contamination and differential drop-out among the control group members that might jeopardize the... (Review)
Review
PURPOSE
Important considerations for exercise trials in cancer patients are contamination and differential drop-out among the control group members that might jeopardize the internal validity. This systematic review provides an overview of different control groups design characteristics of exercise-oncology trials and explores the association with contamination and drop-out rates.
METHODS
Randomized controlled exercise-oncology trials from two Cochrane reviews were included. Additionally, a computer-aided search using Medline (Pubmed), Embase and CINAHL was conducted after completion date of the Cochrane reviews. Eligible studies were classified according to three control group design characteristics: the exercise instruction given to controls before start of the study (exercise allowed or not); and the intervention the control group was offered during (any (e.g., education sessions or telephone contacts) or none) or after (any (e.g., cross-over or exercise instruction) or none) the intervention period. Contamination (yes or no) and excess drop-out rates (i.e., drop-out rate of the control group minus the drop-out rate exercise group) were described according to the three design characteristics of the control group and according to the combinations of these three characteristics; so we additionally made subgroups based on combinations of type and timing of instructions received.
RESULTS
40 exercise-oncology trials were included based on pre-specified eligibility criteria. The lowest contamination (7.1% of studies) and low drop-out rates (excess drop-out rate -4.7±9.2) were found in control groups offered an intervention after the intervention period. When control groups were offered an intervention both during and after the intervention period, contamination (0%) and excess drop-out rates (-10.0±12.8%) were even lower.
CONCLUSIONS
Control groups receiving an intervention during and after the study intervention period have lower contamination and drop-out rates. The present findings can be considered when designing future exercise-oncology trials.
Topics: Control Groups; Exercise; Humans; Neoplasms; Quality of Life; Randomized Controlled Trials as Topic; Research Design; Survivors
PubMed: 25815479
DOI: 10.1371/journal.pone.0120996 -
Seminars in Arthritis and Rheumatism Aug 2021To assess how patient characteristics and study design influence the effectiveness of control interventions in hand OA trials. (Meta-Analysis)
Meta-Analysis Review
OBJECTIVES
To assess how patient characteristics and study design influence the effectiveness of control interventions in hand OA trials.
METHODS
The study protocol was registered in PROSPERO (CRD42020163473). Two authors independently searched four electronic databases from their inception to December 31, 2019. Randomized and non-randomized controlled hand OA trials were included if pain intensity was assessed using a validated scale. We allocated control groups into one of the following: placebo, add-on treatment, no treatment, or active treatment. The standardized mean differences (d) of pain, as well as subjective function and hand strength, were pooled with 95% confidence intervals (CI) and 90% prediction intervals using random-effects models. Meta-regression and post-hoc subgroup analyses were performed to investigate which factors potentially impacted placebo analgesia and between-study heterogeneity.
RESULTS
Thirty-one placebo, 11 add-on, 12 no-treatment, and 10 active-treatment controls were included in meta-analyses. Effective pain relief was observed in placebo (d = -0.50, 95% CI -0.63 to -0.37), add-on (d = -0.35, 95% CI -0.59 to -0.12), and active-treatment (d = -0.92, 95% CI -1.35 to -0.48) groups. In subjective function, these treatments had smaller but beneficial effects; hand strength, contrastingly, was not improved. Placebo effects were larger when flare designs were used (d = -0.96) and more homogeneous when minimum pain thresholds were set (d = -0.46, 90% prediction intervals -0.79 to -0.14).
CONCLUSION
Placebo, add-on, and active control treatments were more effective than the no treatment control in relieving hand pain and improving subjective function. By choosing minimum pain thresholds and flare requirements at patient enrollment, moderate pain relief may be replicated among control participants in future randomized placebo-controlled trials.
Topics: Control Groups; Hand; Humans; Osteoarthritis; Pain; Randomized Controlled Trials as Topic
PubMed: 34146952
DOI: 10.1016/j.semarthrit.2021.04.006