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Plant, Cell & Environment Oct 2016Elevated concentrations of soluble aluminium (Al) reduce root growth in acid soils, but much remains unknown regarding the toxicity of this Al as well as the mechanisms... (Review)
Review
Elevated concentrations of soluble aluminium (Al) reduce root growth in acid soils, but much remains unknown regarding the toxicity of this Al as well as the mechanisms by which plants respond. This review examines changes in phytohormones in Al-stressed plants. Al often results in a rapid 'burst' of ethylene in root apical tissues within 15-30 min, with this regulating an increase in auxin. This production of ethylene and auxin seems to be a component of a plant-response to toxic Al, resulting in cell wall modification or regulation of organic acid release. There is also evidence of a role of auxin in the expression of Al toxicity itself, with Al decreasing basipetal transport of auxin, thereby potentially decreasing wall loosening as required for elongation. Increasingly, changes in abscisic acid in root apices also seem to be involved in plant-responses to toxic Al. Changes in cytokinins, gibberellins and jasmonates following exposure to Al are also examined, although little information is available. Finally, although not a phytohormone, concentrations of nitric oxide change rapidly in Al-exposed tissues. The information presented in this review will assist in focusing future research efforts in examining the importance of phytohormones in plant tissues exposed to toxic levels of Al.
Topics: Aluminum; Ethylenes; Indoleacetic Acids; Models, Biological; Plant Growth Regulators; Plant Physiological Phenomena; Plant Roots; Plants; Rhizosphere; Stress, Physiological
PubMed: 27352002
DOI: 10.1111/pce.12786 -
Journal of Trace Elements in Medicine... Jul 2021Aluminium salts are the most common adjuvants in infant vaccines. The aluminium content of a vaccine is provided by the manufacturer and is indicated on the patient...
BACKGROUND
Aluminium salts are the most common adjuvants in infant vaccines. The aluminium content of a vaccine is provided by the manufacturer and is indicated on the patient information leaflet. There is no independent verification, for example by the European Medicines Agency, of the aluminium content of infant vaccines.
METHODS
We have measured the aluminium content of thirteen infant vaccines using microwave-assisted acid and peroxide digestion followed by transversely heated graphite furnace atomic absorption spectrometry. Our data are compared with manufacturer's data using full statistical analyses including Bayesian methods.
RESULTS
We found that only three vaccines contained the amount of aluminium indicated by the manufacturer. Six vaccines contained a statistically significant (P < 0.05) greater quantity while four vaccines contained a statistically significant (P < 0.05) lower quantity. The range of content for any single vaccine varied considerably, for example, from 0.172 to 0.602 mg/vaccine for Havrix.
CONCLUSIONS
The data have raised specific questions about the significance of the aluminium content of vaccines and identified areas of extremely limited information. Since aluminium is a known toxin in humans and specifically a neurotoxin, its content in vaccines should be accurate and independently monitored to ensure both efficacy and safety.
Topics: Aluminum; Bayes Theorem; Humans; Infant; Vaccines
PubMed: 33887692
DOI: 10.1016/j.jtemb.2021.126762 -
New Solutions : a Journal of... May 2022Northern Ontario gold and uranium miners represent the largest cohort of industrial laborers who were historically exposed to daily nonconsensual industrial medical...
Northern Ontario gold and uranium miners represent the largest cohort of industrial laborers who were historically exposed to daily nonconsensual industrial medical treatments involving the inhalation of finely ground aluminum dust known as McIntyre Powder. The daughter of one of those miners founded the McIntyre Powder Project in 2015 to document health issues in exposed miners, in an effort to determine whether her father's Parkinson's was related to aluminum inhalation. In response, 553 miners registered with the McIntyre Powder Project between 2015 and 2021 either directly or by their next-of-kin. This paper compiles their lived experiences of being subjected to McIntyre Powder, which contrasts starkly with the official narrative of the northern Ontario mining industry, which licensed its use globally. Additionally, this paper illuminates concerning industrial practices that emerged from the miners' disclosures, involving incentivized claims suppression, and raising serious questions about the effectiveness of medical screening and regulatory enforcement.
Topics: Aluminum; Female; Humans; Male; Miners; Occupational Exposure; Ontario; Powders
PubMed: 35138189
DOI: 10.1177/10482911221079056 -
Food Research International (Ottawa,... Oct 2023In the present study we investigated the capacities of a panel of 25 solid sorbents represented by layered structures, inorganic oxides and hydroxides, and...
In the present study we investigated the capacities of a panel of 25 solid sorbents represented by layered structures, inorganic oxides and hydroxides, and phyllosilicates, to effectively remove in high yield Tartrazine (E102) and Brilliant Blue FCF (E133) from aqueous solutions, and more notable, green colored food matrices. Quantification of the title compounds have been achieved by HPLC-DAD analyses. Contents of E102 and E133 in real samples were in the range 1.3-36.5 μg/mL and 1.0-20.1 μg/mL, respectively. After a treatment of 1 min., in most cases a complete bleaching of solutions and deep coloring of the solid phase was recorded. The most effective solids to this aim were seen to be aluminium based ayered double hydroxides. In the case of magnesium oxide for E102, and magnesium aluminium D. benzensulfonate SDS 01 H8L and Florisil for E133, a selective adsorption (>99.9 %) of only one dye was observed. The adsorption recorded was strictly dependent on the loading of the sorbent. Related values were 300 mg for the separation of E102 by magnesium oxide from all the five food matrices under investigation, and in the range 200 mg-300 mg for magnesium aluminium D. benzensulfonate SDS 01 H8L and Florisil in the case of E133. The application of Langmuir and Freundlich models suggested that the adsorption may take place in the inner layers of the solids with a favourable thermodynamique outcome. Findings described herein offer the concrete possibility of quantifications of individual dyes in matrices containing more than one food colorant.
Topics: Tartrazine; Aluminum; Magnesium; Magnesium Oxide; Beverages; Coloring Agents
PubMed: 37689866
DOI: 10.1016/j.foodres.2023.113094 -
Applied and Environmental Microbiology Aug 2019Several studies undertaken on the biodeterioration of concrete sewer infrastructures have highlighted the better durability of aluminate-based materials. The...
Several studies undertaken on the biodeterioration of concrete sewer infrastructures have highlighted the better durability of aluminate-based materials. The bacteriostatic effect of aluminum has been suggested to explain the increase in durability of these materials. However, no clear demonstration of the negative effect of aluminum on cell growth has been yet provided in the literature. In the present study, we sought to investigate the inhibitory potential of dissolved aluminum on nonsterile microbial cultures containing sulfur-oxidizing microorganisms. Both kinetic (maximum specific growth rate) and stoichiometric (oxygen consumption yield) parameters describing cells activity were accurately determined by using respirometry measurements coupled with modeled data obtained from fed-batch cultures run for several days at pH below 4 and with increasing total aluminum (Al) concentrations from 0 to 100 mM. Short-term inhibition was observed for cells poorly acclimated to high salinity. However, inhibition was significantly attenuated for cells grown on mortar substrate. Moreover, after a rapid adaptation, and for an Al concentration up to 100 mM, both kinetic and stoichiometric growth parameters remained similar to those obtained in control culture conditions where no aluminum was added. This argued in favor of the impact of ionic strength change on the growth of sulfur-oxidizing microorganism rather than an inhibitory effect of dissolved aluminum. Other assumptions must therefore be put forward in order to explain the better durability of cement containing aluminate-based materials in sewer networks. Among these assumptions, the influence of physical or chemical properties of the material (phase reactivity, porosity, etc.) might be proposed. Biodeterioration of cement infrastructures represents 5 to 20% of observed deteriorations within the sewer network. Such biodeterioration events are mainly due to microbial sulfur-oxidizing activity which produces sulfuric acid able to dissolve cementitious material. Calcium aluminate cement materials are more resistant to biodeterioration compared to the commonly used Portland cement. Several theories have been suggested to describe this resistance, and the bacteriostatic effect of aluminum seems to be the most plausible explanation. However, results reported by the several studies on this exact topic are highly controversial. This present study provides a comprehensive analysis of the influence of dissolved aluminum on growth parameters of long-term cultures of sulfur-oxidizing bacterial consortia sampled from different origins. Kinetic and stoichiometric parameters estimated by respirometry measurements and modeling showed that total dissolved-aluminum concentrations up to 100 mM were not inhibitory, but it is more likely that a sudden increase in the ionic strength affects cell growth. Therefore, it appears that the bacteriostatic effect of aluminum on microbial growth cannot explain the better durability of aluminate based cementitious materials.
Topics: Aluminum; Bacteria; Construction Materials; Corrosion; Oxidation-Reduction; Sulfur
PubMed: 31126946
DOI: 10.1128/AEM.00302-19 -
Plant Physiology and Biochemistry : PPB May 2024Stomatal operation is crucial for optimising plant water and gas exchange and represents a major trait conferring abiotic stress tolerance in plants. About 56% of... (Review)
Review
Stomatal operation is crucial for optimising plant water and gas exchange and represents a major trait conferring abiotic stress tolerance in plants. About 56% of agricultural land around the globe is classified as acidic, and Al toxicity is a major limiting factor affecting plant performance in such soils. While most of the research work in the field discusses the impact of major abiotic stresses such as drought or salinity on stomatal operation, the impact of toxic metals and, specifically aluminium (Al) on stomatal operation receives much less attention. We aim to fill this knowledge gap by summarizing the current knowledge of the adverse effects of acid soils on plant stomatal development and operation. We summarised the knowledge of stomatal responses to both long-term and transient Al exposure, explored molecular mechanisms underlying plant adaptations to Al toxicity, and elucidated regulatory networks that alleviate Al toxicity. It is shown that Al-induced stomatal closure involves regulations of core stomatal signalling components, such as ROS, NO, and CO and key elements of ABA signalling. We also discuss possible targets and pathway to modify stomatal operation in plants grown in acid soils thus reducing the impact of Al toxicity on plant growth and yield.
Topics: Aluminum; Plant Stomata; Soil; Crops, Agricultural; Adaptation, Physiological
PubMed: 38615443
DOI: 10.1016/j.plaphy.2024.108626 -
BMC Public Health Sep 2020Lead exposure remains a significant public health problem, particularly in the informal sector. Recycling of scrap metal into artisanal pots is a growing concern in... (Review)
Review
Lead exposure remains a significant public health problem, particularly in the informal sector. Recycling of scrap metal into artisanal pots is a growing concern in poorly resourced countries. Owing to the relatively light weight and low cost of the artisanal pots, as well as good conductivity which equates to lower usage of wood fuel, the pots are widely used. The aim of this article is to describe current insights and emerging evidence of health risks associated with artisanal pot making and usage. This thriving industry, particularly in poorly resourced communities, has multifaceted occupational, environmental and human health impacts. Given the complexity, innovative solutions need to be prioritized, evaluated and scaled up in relevant settings.
Topics: Aluminum; Cooking; Cooking and Eating Utensils; Humans; Metals; Public Health
PubMed: 32938416
DOI: 10.1186/s12889-020-09485-9 -
International Journal of Molecular... Apr 2022Aluminium (Al) compounds are used as adjuvants in human and veterinary prophylactic vaccines due to their improved tolerability compared to other adjuvants. These... (Review)
Review
Aluminium (Al) compounds are used as adjuvants in human and veterinary prophylactic vaccines due to their improved tolerability compared to other adjuvants. These Al-based adjuvants form microparticles (MPs) of heterogeneous sizes ranging from ~0.5 to 10 µm and generally induce type 2 (Th2)-biased immune responses. However, recent literature indicates that moving from micron dimension particles toward the nanoscale can modify the adjuvanticity of Al towards type 1 (Th1) responses, which can potentially be exploited for the development of vaccines for which Th1 immunity is crucial. Specifically, in the context of cancer treatments, Al nanoparticles (Al-NPs) can induce a more balanced (Th1/Th2), robust, and durable immune response associated with an increased number of cytotoxic T cells compared to Al-MPs, which are more favourable for stimulating an oncolytic response. In this review, we compare the adjuvant properties of Al-NPs to those of Al-MPs in the context of infectious disease vaccines and cancer immunotherapy and provide perspectives for future research.
Topics: Adjuvants, Immunologic; Adjuvants, Pharmaceutic; Aluminum; Humans; Nanoparticles; Vaccines
PubMed: 35563097
DOI: 10.3390/ijms23094707 -
Journal of Pharmaceutical Sciences Feb 2011Aluminum-containing adjuvants have been used to enhance the immune response against killed, inactivated, and subunit antigens for more than seven decades. Nevertheless,... (Review)
Review
Aluminum-containing adjuvants have been used to enhance the immune response against killed, inactivated, and subunit antigens for more than seven decades. Nevertheless, we are only beginning to gain important insight as to what may be some very fundamental parameters for optimizing their use. For example, there is evidence that the conventional approach of maximizing antigen binding (amount and/or strength) may not result in an optimal immune response. Adsorption of antigen onto the adjuvant has recently been suggested to decrease the thermal stability of some antigens; however, whether adsorption-induced alterations to the structure and/or stability of the antigen have consequences for the elicited immune response is unclear. Finally, the thermal stability of vaccines with aluminum-containing adjuvants is not robust. Optimizing the stability of these vaccines requires an understanding of the freeze sensitivity of the adjuvant, freeze and heat sensitivity of the antigen in the presence of the adjuvant, and perhaps most important, how (or whether) various approaches to formulation can be used to address these instabilities. This review attempts to summarize recent findings regarding issues that may dictate the success of vaccines with aluminum-containing adjuvants.
Topics: Adjuvants, Immunologic; Aluminum; Animals; Antigens; Humans; Temperature; Vaccines
PubMed: 20740674
DOI: 10.1002/jps.22284 -
BioMed Research International 2014The aetiology of neurodegenerative diseases (ND) seems to involve susceptibility genes and environmental factors. Toxic metals are considered major environmental...
The aetiology of neurodegenerative diseases (ND) seems to involve susceptibility genes and environmental factors. Toxic metals are considered major environmental pollutants. Following our study of a case of multiple sclerosis (MS) improvement due to removal of aluminium (Al) and other toxic metals, we have examined the possible relationship between Al intoxication and ND. We used the slow intravenous treatment with the chelating agent EDTA (calcium disodium ethylene diamine tetraacetic acid) (chelation test) to remove Al and detected it in the urine collected from the patients for 12 hours. Patients affected by MS represented 85.6% of total ND. Al was present in 44.8% of cases comprehensive of ND and healthy patients. Al levels were significantly higher in ND patients than in healthy subjects. We here show that treatment of patients affected by Al burden with ten EDTA chelation therapies (EDTA intravenous administration once a week) was able to significantly reduce Al intoxication.
Topics: Adolescent; Adult; Aged; Aluminum; Chelating Agents; Chelation Therapy; Cohort Studies; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Neurodegenerative Diseases; Neurotoxins; Treatment Outcome; Young Adult
PubMed: 25243176
DOI: 10.1155/2014/758323