-
Annals of the Royal College of Surgeons... Nov 1976The plasma fibrinogen concentration is directly related to blood viscosity, which in turn is inversely related to blood flow. The way in which the plasma fibrinogen...
The plasma fibrinogen concentration is directly related to blood viscosity, which in turn is inversely related to blood flow. The way in which the plasma fibrinogen level affects the clinical status of patients with peripheral vascular disease is discussed with reference to both retrospective and prospective studies of patients undergoing major arterial surgery. Animal experiments are described in which the effect of reducing the plasma fibrinogen level with oral clofibrate and parenteral Arvin (ancrod) on the patency of Dacron arterial grafts was studied.
Topics: Ancrod; Animals; Blood Flow Velocity; Blood Vessels; Blood Viscosity; Body Temperature; Clofibrate; Depression, Chemical; Fibrinogen; Hematocrit; Humans; Intermittent Claudication; Postoperative Complications; Rabbits; Vascular Surgical Procedures
PubMed: 984690
DOI: No ID Found -
British Medical Journal Jan 1977
Topics: Adult; Ancrod; Antibody Formation; Endopeptidases; Female; Humans; Hydrocortisone; Thromboembolism
PubMed: 837082
DOI: 10.1136/bmj.1.6056.290-c -
Texas Heart Institute Journal 1995Anticoagulation in the form of intravenous heparin is used after coronary angioplasty to prevent thrombosis. Ancrod, a rapid-acting defibrinogenating agent, has been...
Anticoagulation in the form of intravenous heparin is used after coronary angioplasty to prevent thrombosis. Ancrod, a rapid-acting defibrinogenating agent, has been used in various clinical settings that require anticoagulation. We present the use of ancrod after percutaneous transluminal coronary angioplasty in a patients with heparin-induced thrombopathia.
Topics: Aged; Ancrod; Angioplasty, Balloon, Coronary; Anticoagulants; Blood Coagulation Disorders; Female; Heparin; Humans
PubMed: 8605439
DOI: No ID Found -
Clinical and Experimental Immunology May 1975Quantitative studies of the effects of defibrination (with ancrod) have been undertaken in two forms of allergic glomerular damage, nephrotoxic serum nephritis and acute...
Quantitative studies of the effects of defibrination (with ancrod) have been undertaken in two forms of allergic glomerular damage, nephrotoxic serum nephritis and acute serum sickness in rabbits. No differences in intrarenal fixation of nephrotoxic antibody, complement activation or host antibody response were detected between defibrinated and untreated rabbits with nephrotoxic serum nephritis. Defibrination prevented intraglomerular fibrin deposition in this disease; but some glomerular damage as shown by a rise in blood urea and endothelial proliferation still occurred in defibrinated animals. No differences in immune elimination of BSA, circulating immune complex formation or intrarenal localization of immune complexes were noted in defibrinated animals with acute serum sickness. No intraglomerular fibrin deposition was detected in treated or untreated animals in this disease model. It is concluded that the protective effects of ancrod are directly related to defibrination, and not to any other modification of allergic events.
Topics: Ancrod; Animals; Antibodies; Antigen-Antibody Complex; Basement Membrane; Disease Models, Animal; Endopeptidases; Fibrin; Immunoglobulin G; Kidney Glomerulus; Male; Nephritis; Proteinuria; Rabbits; Serum Albumin, Bovine; Serum Sickness; Urea
PubMed: 1212811
DOI: No ID Found -
Blood Sep 1992
Topics: Ancrod; Clinical Trials as Topic; Humans; Plasminogen Inactivators; Thrombosis
PubMed: 1520890
DOI: No ID Found -
BMJ (Clinical Research Ed.) May 1993
Topics: Ancrod; Heparin; Humans; Thrombocytopenia
PubMed: 8518620
DOI: 10.1136/bmj.306.6889.1410-a -
British Journal of Experimental... Feb 1975Delayed hypersensitivity was induced in rats by means of sheep erythrocytes and bovine serum albumin-lipid conjugate. Administration of heparin to rats sensitized to...
Delayed hypersensitivity was induced in rats by means of sheep erythrocytes and bovine serum albumin-lipid conjugate. Administration of heparin to rats sensitized to either antigen resulted in diminution of the delayed hypersensitivity reaction. Administration of ancrod, however, failed to inhibit the delayed cellular reaction to either antigen. Granuloma formation remained unaffected when rats were injected with either heparin or ancrod. The lack of ancrod effect, in contrast to heparin effect, on delayed hypersensitivity is discussed.
Topics: Ancrod; Animals; Endopeptidases; Erythrocytes; Female; Fibrinogen; Heparin; Hypersensitivity, Delayed; Rats; Serum Albumin, Bovine; Skin; Skin Tests
PubMed: 1203167
DOI: No ID Found -
Anesthesiology Mar 1994
Normal activated clotting time despite adequate anticoagulation with ancrod in a patient with heparin-associated thrombocytopenia and thrombosis undergoing cardiopulmonary bypass.
Topics: Aged; Ancrod; Blood Coagulation; Cardiopulmonary Bypass; Fibrin; Heparin; Humans; Male; Thrombocytopenia; Thrombophlebitis; Time Factors; Whole Blood Coagulation Time
PubMed: 8141466
DOI: 10.1097/00000542-199403000-00029 -
Journal of Clinical Pathology Jul 1975
Topics: Aluminum Hydroxide; Ancrod; Aprotinin; Blood Coagulation Tests; Factor VIII; Factor XI; Factor XII; Fibrinogen; In Vitro Techniques; Kaolin; Phospholipids; Thrombin; Thromboplastin; Tromethamine
PubMed: 239026
DOI: 10.1136/jcp.28.7.596 -
Annals of Surgery Dec 1973
Comparative Study
Topics: Animals; Blood Coagulation; Blood Coagulation Tests; Dogs; Hemorrhage; Hemostasis; Hemostatics; Heparin; Microcirculation; Peptide Hydrolases; Platelet Adhesiveness; Postoperative Complications; Venoms
PubMed: 4759405
DOI: 10.1097/00000658-197312000-00008