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The Pan African Medical Journal 2013
Topics: Aged; Angiomyoma; Calcinosis; Foot Diseases; Humans; Male
PubMed: 23646213
DOI: 10.11604/pamj.2013.14.77.2477 -
BMJ Case Reports May 2017This report describes a case of labial angioleiomyoma in a 52-year-old woman. The patient had noticed a slow-growing painless isolated mass in her upper lip for 6...
This report describes a case of labial angioleiomyoma in a 52-year-old woman. The patient had noticed a slow-growing painless isolated mass in her upper lip for 6 months. The mass was surgically excised, and pathological examination was consistent with angioleiomyoma. Surgical excision was curative, and there was no recurrence at 12-month follow-up.
Topics: Angiomyoma; Diagnosis, Differential; Female; Humans; Lip Neoplasms; Middle Aged
PubMed: 28500121
DOI: 10.1136/bcr-2016-219172 -
Modern Pathology : An Official Journal... Mar 2023Pericytic tumors are subclassified as myopericytomas, myofibromas, angioleiomyomas, and glomus tumors according to the current World Health Organization classification....
Pericytic tumors are subclassified as myopericytomas, myofibromas, angioleiomyomas, and glomus tumors according to the current World Health Organization classification. These pericytic tumors form a continuous morphologic spectrum, including those with combined morphology. However, to our knowledge, no widely accepted criteria for classifying tumors with combined morphology are available. Recent studies have identified platelet-derived growth factor receptor-beta (PDGFRB) gene mutations in a subset of myofibromas, myopericytomas, and myopericytomatoses but not in angioleiomyomas. NOTCH receptor 3 (NOTCH3) mutations have been reported in a subset of infantile myofibromatosis. To assess their potential role in classifying pericytic tumors, we investigated PDGFRB and NOTCH3 mutations in 41 pericytic tumors of variable morphology, including some combined forms. Our results show these mutations to be present in a variety of pericytic tumors, such as myopericytomas (PDGFRB, 3/11; NOTCH3, 4/11), myopericytomatoses (1/2; 1/2), myofibromas (3/6; 0/6), angioleiomyomas (2/13; 3/13), and glomus tumors (5/9; 1/9). Point mutations were identified in 3 tumors in PDGFRB exon 12 (Y562C, S574F, and G576S), 12 tumors in PDGFRB exon 14 (M655I, H657L, and N666K), and 9 tumors in NOTCH3 exon 25 (A1480S/T, D1481N, G1482S, T1490A, E1491K, G1494S, and V1512A). All PDGFRB mutations and NOTCH3 G1482S, T1490A, and G1494S mutations were classified as "deleterious/damaging" by ≥4 of 6 pathogenicity prediction tools in silico. Five-mutation-positive tumors, including 1 myopericytoma-angioleiomyoma, 2 myopericytomatoses-myofibroma, 1 myofibroma-myopericytoma and 1 angioleiomyoma-myopericytoma, were of combined morphology. Therefore, we found PDGFRB and NOTCH3 mutations to be detectable in a much wider variety of pericytic tumors than previously reported and confirmed myopericytomas, myofibromas, angioleiomyomas, and glomus tumors as members harboring PDGFRB or NOTCH3 mutations. Our results thus suggest that PDGFRB or NOTCH3 mutations are not useful for subclassifying members of the pericytic tumor family.
Topics: Humans; Myopericytoma; Angiomyoma; Glomus Tumor; Myofibroma; Receptor, Platelet-Derived Growth Factor beta; Mutation; Receptor, Notch3
PubMed: 36788105
DOI: 10.1016/j.modpat.2022.100070 -
Taiwanese Journal of Obstetrics &... Jun 2008
Topics: Angiofibroma; Angiomyoma; Female; Humans; Immunohistochemistry; Middle Aged; Vulvar Neoplasms
PubMed: 18603512
DOI: 10.1016/S1028-4559(08)60086-8 -
Archives of Pathology & Laboratory... Oct 2004Angioleiomyomas are common benign smooth muscle tumors that occur in the subcutis of the extremities and to a lesser extent, of the head and trunk. Rarely, these tumors...
Angioleiomyomas are common benign smooth muscle tumors that occur in the subcutis of the extremities and to a lesser extent, of the head and trunk. Rarely, these tumors have been reported in other deeper tissues, but never within the testis. We present what we believe to be the first report of intratesticular angioleiomyoma, occurring in a 58-year-old man with a painless testicular swelling. Orchidectomy was the treatment of choice in this patient, as there was no reliable imaging technique to clinically distinguish this benign lesion from the more common malignant intratesticular tumors.
Topics: Angiomyoma; Humans; Male; Middle Aged; Testicular Neoplasms
PubMed: 15387703
DOI: 10.5858/2004-128-1165-IA -
The Journal of Foot and Ankle Surgery :... 2013Tumors of the foot and ankle are rare, and the particular clinicopathologic features, therapeutic approach, and outcomes in this setting are not well established. From...
Tumors of the foot and ankle are rare, and the particular clinicopathologic features, therapeutic approach, and outcomes in this setting are not well established. From January 2000 to December 2010, 72 patients with primary musculoskeletal tumors of the foot and ankle, both benign and malignant, were treated at a single institution. Of the 72 patients, 56% were female. The median age was 52 years. Of the 72 tumors, 62 (86.11%) were located in the foot and 10 were located in the ankle; 63 (87.5%) were soft tissue tumors and 9 (12.5%) were bone tumors. Overall, 56 (78%) were benign tumors and 16 (22%) were malignant tumors. The most frequent soft tissue and bone diagnosis was giant cell tumor. The median follow-up period was 49 months. The vast majority of the tumors were located in the foot. Benign tumors were dominant, outnumbering malignant tumors by more than 3 to 1. The diversity of the histologic benign types was evident, with giant cell tumor, angiomyoma, and lipoma the most frequent. Regarding the malignant tumors, a clear male predominance was present, the median age was 45 years, and the most frequent tumor was synoviosarcoma. The 9-year overall and disease-free survival rate was 65% and 40%, respectively.
Topics: Adolescent; Adult; Aged; Amputation, Surgical; Ankle; Antineoplastic Agents; Bone Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Foot; Humans; Male; Middle Aged; Soft Tissue Neoplasms; Young Adult
PubMed: 23333280
DOI: 10.1053/j.jfas.2012.12.004 -
Ear, Nose, & Throat Journal Dec 2020Angioleiomyoma is a benign smooth muscle and vessel tumor; laryngeal localization is extremely rare with only 24 cases described in the literature; moreover, it should... (Review)
Review
Angioleiomyoma is a benign smooth muscle and vessel tumor; laryngeal localization is extremely rare with only 24 cases described in the literature; moreover, it should be considered in the differential diagnosis of laryngeal mass. Endoscopic complete surgical excision with dissection along capsule is now considered the gold-standard treatment for small and well-circumscribed laryngeal angioleiomyoma. We present a case of laryngeal angioleiomyoma successfully treated with carbon dioxide laser technology which resulted in a bleeding reduction and adequate hemostasis with less tissue damage and good functional outcome.
Topics: Aged; Angiomyoma; Humans; Laryngeal Neoplasms; Larynx; Lasers, Gas; Male; Medical Illustration; Rare Diseases
PubMed: 32603184
DOI: 10.1177/0145561320934930 -
Revista de Neurologia Jan 2016Intracranial angioleiomyomas are extremely rare lesions. Only 22 intracranial angioleiomyomas have been described in the literature and only three were infratentorial. (Review)
Review
INTRODUCTION
Intracranial angioleiomyomas are extremely rare lesions. Only 22 intracranial angioleiomyomas have been described in the literature and only three were infratentorial.
CASE REPORT
We report a case of an infratentorial angioleiomyoma in a 43 year-old-man, who underwent a brain computer tomography because of hearing loss. The MRI showed a 1.4 cm tumor, initially described as a meningioma, with progressive enhancement after gadolinium injection, an augmented apparent diffusion coefficient and a generalized metabolite decreased in the spectroscopy. The lesion was surgically removed through a suboccipital approach with a good evolution and without postoperative complications. In the immunohistological study, the lesion was mainly composed of multiple vessels and the immunohistochemistry was positive for actin and caldesmon. Two years after surgery, no recurrence has been found in the MRI.
CONCLUSION
Angioleiomyomas diagnostic may be complex, but some radiological features could help in the differential diagnostic. Angioleiomyomas are benign tumors associated with favorable outcomes after total resection, that in our case, did not show a significant bleeding risk.
Topics: Adult; Angiomyoma; Humans; Infratentorial Neoplasms; Male
PubMed: 26758353
DOI: No ID Found -
Medicine Nov 2016Angiomyofibroblastoma (AMFB) is an extremely rare disease. It commonly occurs in middle-aged females and mainly involves the vulvovaginal region. Pathological... (Review)
Review
INTRODUCTION
Angiomyofibroblastoma (AMFB) is an extremely rare disease. It commonly occurs in middle-aged females and mainly involves the vulvovaginal region. Pathological examination plays an important role in differentiating from other tumors. But far less published literature focus on the imaging characteristics of AMFB.
CLINICAL FINDINGS/DIAGNOSES
We reported a case of AMFB in a 73-year-old male, involving the mediastinum with computed tomography (CT) imaging and pathologic findings. Preoperative unenhanced CT scan of chest revealed a 6.9 × 7.4 × 9.3 cm mass with equal density, located in the posterior mediastinum. On contrast-enhanced CT images, the tumor presented moderate, heterogeneous enhancement. Due to the unclear interface between the tumor and adjacent tissues, this patient underwent operative partial resection of the tumor. The pathologic diagnosis was AMFB.
CONCLUSIONS
This tumor represents a further example of unusual location different from conventional AMFB. This case adds to the experience with AMFB by summarizing its characteristics, and also reviewing the literature.
Topics: Aged; Angiomyoma; Contrast Media; Diagnosis, Differential; Humans; Male; Mediastinal Neoplasms; Tomography, X-Ray Computed
PubMed: 27902605
DOI: 10.1097/MD.0000000000005484 -
Acta Neuropathologica Communications May 2022The International Society for the Study of Vascular Anomalies (ISSVA) has defined four vascular lesions in the central nervous system (CNS): arteriovenous malformations,...
The International Society for the Study of Vascular Anomalies (ISSVA) has defined four vascular lesions in the central nervous system (CNS): arteriovenous malformations, cavernous angiomas (also known as cerebral cavernous malformations), venous malformations, and telangiectasias. From a retrospective central radiological and histopathological review of 202 CNS vascular lesions, we identified three cases of unclassified vascular lesions. Interestingly, they shared the same radiological and histopathological features evoking the cavernous subtype of angioleiomyomas described in the soft tissue. We grouped them together with four additional similar cases from our clinicopathological network and performed combined molecular analyses. In addition, cases were compared with a cohort of 5 soft tissue angioleiomyomas. Three out 6 CNS lesions presented the same p.Gly41Cys GJA4 mutation recently reported in hepatic hemangiomas and cutaneous venous malformations and found in 4/5 soft tissue angioleiomyomas of our cohort with available data. Most DNA methylation profiles were not classifiable using the CNS brain tumor (version 12.5), and sarcoma (version 12.2) classifiers. However, using unsupervised t-SNE analysis and hierarchical clustering analysis, 5 of the 6 lesions grouped together and formed a distinct epigenetic group, separated from the clusters of soft tissue angioleiomyomas, other vascular tumors, inflammatory myofibroblastic tumors and meningiomas. Our extensive literature review identified several cases similar to these lesions, with a wide variety of denominations. Based on radiological and histomolecular findings, we suggest the new terminology of "dural angioleiomyomas" (DALM) to designate these lesions characterized by a distinct DNA methylation pattern and frequent GJA4 mutations.
Topics: Angiomyoma; Connexins; DNA Methylation; Hemangioma; Humans; Mutation; Retrospective Studies; Gap Junction alpha-4 Protein
PubMed: 35642047
DOI: 10.1186/s40478-022-01384-x