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Retina (Philadelphia, Pa.) Sep 2022
Topics: Anterior Chamber; Humans; Lenses, Intraocular
PubMed: 31083001
DOI: 10.1097/IAE.0000000000002548 -
Indian Journal of Ophthalmology Dec 2022
Topics: Child; Humans; Anterior Chamber; Lenses, Intraocular
PubMed: 36453376
DOI: 10.4103/ijo.IJO_1644_22 -
Journal Francais D'ophtalmologie Dec 2023
Topics: Humans; Anterior Chamber
PubMed: 37620190
DOI: 10.1016/j.jfo.2023.05.018 -
PloS One 2023Anterior chamber depth (ACD) is a quantitative trait associated with primary angle closure glaucoma (PACG). Although ACD is highly heritable, known genetic variations...
Anterior chamber depth (ACD) is a quantitative trait associated with primary angle closure glaucoma (PACG). Although ACD is highly heritable, known genetic variations explain a small fraction of the phenotypic variability. The purpose of this study was to identify additional ACD-influencing loci using strains of mice. Cohorts of 86 N2 and 111 F2 mice were generated from crosses between recombinant inbred BXD24/TyJ and wild-derived CAST/EiJ mice. Using anterior chamber optical coherence tomography, mice were phenotyped at 10-12 weeks of age, genotyped based on 93 genome-wide SNPs, and subjected to quantitative trait locus (QTL) analysis. In an analysis of ACD among all mice, six loci passed the significance threshold of p = 0.05 and persisted after multiple regression analysis. These were on chromosomes 6, 7, 11, 12, 15 and 17 (named Acdq6, Acdq7, Acdq11, Acdq12, Acdq15, and Acdq17, respectively). Our findings demonstrate a quantitative multi-genic pattern of ACD inheritance in mice and identify six previously unrecognized ACD-influencing loci. We have taken a unique approach to studying the anterior chamber depth phenotype by using mice as genetic tool to examine this continuously distributed trait.
Topics: Animals; Mice; Anterior Chamber; Chromosomes, Human, Pair 6; Genotype; Inheritance Patterns; Quantitative Trait Loci
PubMed: 37624784
DOI: 10.1371/journal.pone.0286897 -
JAMA Ophthalmology Jan 2024
Topics: Humans; Anterior Chamber; Corneal Transplantation; Iris; Female; Middle Aged; Postoperative Complications
PubMed: 38095889
DOI: 10.1001/jamaophthalmol.2023.5583 -
Journal of AAPOS : the Official... Jun 2014A 14-year-old boy presented with a 6-month history of small white masses in his right eye. Examination revealed a white floating fluffy lesion and 2 vegetative hornlike...
A 14-year-old boy presented with a 6-month history of small white masses in his right eye. Examination revealed a white floating fluffy lesion and 2 vegetative hornlike white lesions originating at the periphery of the iris. On ultrasound biomicroscopy, a normal echogenic mass was detected on the inferior iris root and angle, with no posterior chamber or cilliary body involvement. Histopathology following an excisional biopsy revealed keratinous material. There was no recurrence during 10 months of follow-up.
Topics: Adolescent; Anterior Chamber; Cysts; Gonioscopy; Humans; Iris Diseases; Keratins; Male; Microscopy, Acoustic
PubMed: 24797250
DOI: 10.1016/j.jaapos.2013.12.012 -
International Ophthalmology Clinics 1994
Review
Topics: Anterior Chamber; Eye Diseases; Gonioscopy; Humans; Microscopy; Ultrasonography
PubMed: 7960522
DOI: 10.1097/00004397-199403430-00025 -
Archivos de La Sociedad Espanola de... May 2017
Topics: Anterior Chamber; Fluorocarbons; Humans
PubMed: 27956324
DOI: 10.1016/j.oftal.2016.10.024 -
Canadian Journal of Ophthalmology.... Apr 2021
Topics: Anterior Chamber; Glaucoma Drainage Implants; Humans; Intraocular Pressure
PubMed: 32780987
DOI: 10.1016/j.jcjo.2020.07.008 -
Translational Vision Science &... Jan 2023The anterior chamber angle (ACA) is a critical factor in posterior chamber phakic intraocular lens (EVO Implantable Collamer Lens [ICL]) implantation. Herein, we...
PURPOSE
The anterior chamber angle (ACA) is a critical factor in posterior chamber phakic intraocular lens (EVO Implantable Collamer Lens [ICL]) implantation. Herein, we predicted postoperative ACAs to select the optimal ICL size to reduce narrow ACA-related complications.
METHODS
Regression models were constructed using pre-operative anterior segment optical coherence tomography metrics to predict postoperative ACAs, including trabecular-iris angles (TIAs) and scleral-spur angles (SSAs) at 500 µm and 750 µm from the scleral spur (TIA500, TIA750, SSA500, and SSA750). Data from three expert surgeons were assigned to the development (N = 430 eyes) and internal validation (N = 108 eyes) datasets. Additionally, data from a novice surgeon (N = 42 eyes) were used for external validation.
RESULTS
Postoperative ACAs were highly predictable using the machine-learning (ML) technique (extreme gradient boosting regression [XGBoost]), with mean absolute errors (MAEs) of 4.42 degrees, 3.77 degrees, 5.25 degrees, and 4.30 degrees for TIA500, TIA750, SSA500, and SSA750, respectively, in internal validation. External validation also showed MAEs of 3.93 degrees, 3.86 degrees, 5.02 degrees, and 4.74 degrees for TIA500, TIA750, SSA500, and SSA750, respectively. Linear regression using the pre-operative anterior chamber depth, anterior chamber width, crystalline lens rise, TIA, and ICL size also exhibited good performance, with no significant difference compared with XGBoost in the validation sets.
CONCLUSIONS
We developed linear regression and ML models to predict postoperative ACAs for ICL surgery anterior segment metrics. These will prevent surgeons from overlooking the risks associated with the narrowing of the ACA.
TRANSLATIONAL RELEVANCE
Using the proposed algorithms, surgeons can consider the postoperative ACAs to increase surgical accuracy and safety.
Topics: Humans; Phakic Intraocular Lenses; Lens Implantation, Intraocular; Myopia; Lens, Crystalline; Anterior Chamber
PubMed: 36607625
DOI: 10.1167/tvst.12.1.10