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British Journal of Cancer Nov 1992Malignant carcinoid tumours, islet cell tumours and medullary carcinomas of the thyroid are tumours with similar clinical features. In patients with unresectable or... (Clinical Trial)
Clinical Trial
Malignant carcinoid tumours, islet cell tumours and medullary carcinomas of the thyroid are tumours with similar clinical features. In patients with unresectable or metastatic tumours leukocyte interferon (IFN) and recombinant human (rh) IFN have demonstrated efficacy. Twenty-four evaluable patients with progressive tumours were treated with 2.5 megaunits rh IFN alpha-2b, administered once daily subcutaneously, for a median duration of 7 months (range 0.5-37+). Two carcinoid patients demonstrated a response in tumour size, 80% showed stable disease (SD). Sixty percent of the carcinoid patients with elevated urinary 5-hydroxyindoleacetic (5-HIAA) levels reached a biochemical partial response of the urinary 5-HIAA levels (median duration 13.5 months). In the patients with an islet cell or medullary tumour and an elevated tumour marker, the marker did not further increase. Of the 12 carcinoid patients evaluable for a symptomatic response, ten (83%) experienced a relieve of symptoms. IFN alpha-2b dose reduction or discontinuation due to toxicity was necessary in three and ten patients, respectively. No neutralising IFN alpha-2b antibodies developed despite prolonged treatment. In conclusion, IFN alpha-2b had a beneficial effect in patients with progressive tumours, while long-term IFN alpha-2b treatment did not augment neutralising antibodies. In view of the IFN alpha-2b-related toxicity, administration of IFN alpha-2b on alternating days may be preferable.
Topics: Adenoma, Islet Cell; Adult; Aged; Apudoma; Biomarkers, Tumor; Blood Platelets; Carcinoid Tumor; Catecholamines; Drug Administration Schedule; Female; Histamine; Humans; Hydroxyindoleacetic Acid; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Neoplasm Metastasis; Pancreatic Neoplasms; Phosphopyruvate Hydratase; Recombinant Proteins; Serotonin; Thyroid Neoplasms
PubMed: 1384643
DOI: 10.1038/bjc.1992.372 -
Journal of Clinical Pathology Apr 1984The monoclonal antibody NK1 C3, synthesised by the Netherlands Cancer Institute, has been used to assess its value in the diagnosis of melanocytic lesions. The antigen...
The monoclonal antibody NK1 C3, synthesised by the Netherlands Cancer Institute, has been used to assess its value in the diagnosis of melanocytic lesions. The antigen recognised by this antibody is not denatured by formalin fixation, with the result that the antibody can be used for retrospective studies on conventionally processed material. Positive results were obtained in primary melanoma (18/18), secondary melanoma (21/21), junctional and compound naevi (32/32), intradermal naevi (9/12), congenital naevi (3/3), so called dysplastic naevi (13/13), blue naevi (5/5), and Spitz tumours (3/14). Non-melanocytic tumours were tested for comparison. The results showed relative but not complete specificity of the antibody for melanocytic tumours, with positive results only in breast and prostate tumours (2/6 and 2/5 respectively). Negative results were obtained with basal and squamous cell carcinoma, appendage tumours, neural tumours, and apudomas. The staining pattern of NK1 C3 was compared with that of antibodies to S100 protein and to neurone specific enolase. Compared with S100 protein NK1 C3 gave stronger staining of a higher percentage of cells in the 12 specimens in which a direct comparison was made. Antibody raised against neurone specific enolase in sheep gave very poor results with heavy background staining. We suggest that NK1 C3 is a useful addition to the battery of monoclonal antibodies of value to the diagnostic histopathologist.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Cell Membrane; Diagnosis, Differential; Humans; Immunoenzyme Techniques; Melanoma; Nevus; Nevus, Pigmented; Retrospective Studies; S100 Proteins; Skin Neoplasms; Staining and Labeling
PubMed: 6200506
DOI: 10.1136/jcp.37.4.367 -
FEBS Letters Oct 1980
Comparative Study
Topics: Alloxan; Animals; Apudoma; Diabetes Mellitus, Experimental; Guanylate Cyclase; Humans; Kidney; Organ Specificity; Streptozocin; Structure-Activity Relationship
PubMed: 6108240
DOI: 10.1016/0014-5793(80)81031-3 -
Journal of the National Medical... Jan 1987A young man presented with combative psychosis and elevated levels of plasma adrenocorticotropic hormone (ACTH). A solitary vascular pancreatic mass and diffuse vascular...
A young man presented with combative psychosis and elevated levels of plasma adrenocorticotropic hormone (ACTH). A solitary vascular pancreatic mass and diffuse vascular hepatic nodules were demonstrated on selective splenic and hepatic arteriograms. These classic angiographic findings are used to emphasize the role of angiography in initial radiographic evaluation and to summarize the angiographic appearance of functioning pancreatic adenomas. Even though this is an aggressive tumor, early diagnosis and intensive treatment may allow prolonged remission, if not cure.
Topics: ACTH Syndrome, Ectopic; Adenoma, Islet Cell; Adult; Angiography; Apudoma; Humans; Liver Neoplasms; Male; Paraneoplastic Endocrine Syndromes
PubMed: 3029392
DOI: No ID Found -
Gut May 1983Two patients have been studied with a two and a half and nine year history of metastatic pancreatic apudoma. In both patients the main feature was chronic watery...
Two patients have been studied with a two and a half and nine year history of metastatic pancreatic apudoma. In both patients the main feature was chronic watery diarrhoea with remissions after partial tumour resection and streptozotocin therapy. Plasma levels of circulating VIP and neurotensin were persistently raised in both patients. Chromatographic analysis of the plasma showed that a significant proportion of the raised immunoreactivity of both peptides eluted in an identical position to pure VIP and neurotensin. The extremely high concentrations of neurotensin did not appear to result in any feature which would allow distinction from the classical VIPoma syndrome.
Topics: Adult; Apudoma; Female; Gastrointestinal Hormones; Humans; Male; Middle Aged; Neurotensin; Pancreatic Neoplasms; Vasoactive Intestinal Peptide
PubMed: 6840620
DOI: 10.1136/gut.24.5.448 -
Archives of Disease in Childhood Mar 1985A 9 year old girl underwent laparotomy because of intermittent diarrhoea, present since infancy. Histology of a mass at the head of pancreas and multiple hepatic nodules...
A 9 year old girl underwent laparotomy because of intermittent diarrhoea, present since infancy. Histology of a mass at the head of pancreas and multiple hepatic nodules suggested an apudoma. Plasma serotonin and urinary excretion of 5 hydroxy indole acetic acid were raised. The child is asymptomatic four years after diagnosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Diarrhea; Female; Humans; Hydroxyindoleacetic Acid; Malignant Carcinoid Syndrome
PubMed: 2580492
DOI: 10.1136/adc.60.3.269 -
Journal of Nuclear Medicine : Official... Jul 1986
Topics: 3-Iodobenzylguanidine; Aged; Apudoma; Carcinoid Tumor; Female; Humans; Iodine Radioisotopes; Iodobenzenes; Male; Middle Aged; Radionuclide Imaging
PubMed: 3723196
DOI: No ID Found -
British Medical Journal Apr 1980
Topics: Apudoma; Endorphins; Enkephalins; Humans
PubMed: 7388437
DOI: 10.1136/bmj.280.6222.1121 -
Annals of the Royal College of Surgeons... Sep 1994
Topics: Apudoma; Humans; Liver Neoplasms; Male; Octreotide; Pancreatic Neoplasms
PubMed: 7979086
DOI: No ID Found -
British Medical Journal Jan 1979
Topics: Adult; Apudoma; Drug Interactions; Humans; Insulin; Male; Neoplasm Metastasis; Pancreatic Neoplasms; Phenytoin; Streptozocin
PubMed: 153776
DOI: 10.1136/bmj.1.6156.127-c