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JNMA; Journal of the Nepal Medical... Apr 2022Takayasu arteritis is a rare progressive chronic granular inflammation of the vessels that mainly affects the aorta and its branches. It is widely distributed in the...
UNLABELLED
Takayasu arteritis is a rare progressive chronic granular inflammation of the vessels that mainly affects the aorta and its branches. It is widely distributed in the world population and mainly involves young Asian women, manifesting as a systemic illness with myriads of cardiovascular signs and symptoms. The current case focuses on a young girl who had shoulder pain and weakness as the only manifestation of underlying Takayasu arteritis. Early clinical identification of the disease and control with disease-modifying anti-rheumatic drugs could improve the outcome and prevent devastating sequelae.
KEYWORDS
arteritis; inflammation; shoulder pain; takayasu arteritis.
Topics: Antirheumatic Agents; Aorta; Female; Humans; Inflammation; Shoulder Pain; Takayasu Arteritis
PubMed: 35633206
DOI: 10.31729/jnma.7443 -
Rheumatology International May 2023Takayasu's arteritis (TA) is a chronic granulomatous vasculitis that predominantly affects the aorta and its major branches. Despite advancements in the understanding of... (Review)
Review
Takayasu's arteritis (TA) is a chronic granulomatous vasculitis that predominantly affects the aorta and its major branches. Despite advancements in the understanding of the pathogenic pathways of vascular inflammation, the etiology and predisposing factors of TA remain to be fully understood. In susceptible individuals, exposure to adjuvants may trigger, unlock or unmask an autoimmune disorder, presenting as non-specific constitutional symptoms or a fully developed autoimmune syndrome such as vasculitis. Here, we hypothesize that TA could be triggered by siliconosis, a subtype of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). ASIA, also known as Shoenfeld syndrome, encompasses a wide range of autoimmune and immune-mediated diseases resulting from dysregulation of the immune response after exposure to agents with adjuvant activity. This case report describes the development of large artery vasculitis, TA, in an individual one year following the placement of silicone breast implants. The patient initially presented with non-specific symptoms, and multiple imaging methods were employed, including ultrasound diagnostics, CT angiography, and 18-fluorodeoxyglucose positron emission tomography/CT. These techniques revealed vasculitic alterations in the carotid arteries and thoracic aorta. Initial treatment with glucocorticosteroids proved ineffective, prompting the addition of steroid-sparing immunosuppressive agents. Due to the distinct clinical symptoms, disease progression, implant-associated fibrosis, and resistance to therapy, the potential involvement of implants in the development of large-vessel vasculitis was considered, and a potential association with ASIA was postulated. Although there is limited evidence to support a direct link between adjuvants and the pathogenesis of TA, similarities in cellular immunity between the two conditions exist. The diagnosis of this complex and potentially debilitating condition requires a comprehensive clinical examination, laboratory evaluation, and instrumental assessment. This will aid in identifying potential contributing factors and ensuring successful treatment.
Topics: Humans; Takayasu Arteritis; Positron-Emission Tomography; Aorta; Carotid Arteries; Immunosuppressive Agents; Adjuvants, Immunologic
PubMed: 36920514
DOI: 10.1007/s00296-023-05309-2 -
Cellular Physiology and Biochemistry :... 2016Arteritis is an inflammatory disease of the vascular wall leading to ischemia and vascular occlusion. Complications of arteritis include anemia, which could, at least in...
BACKGROUND/AIMS
Arteritis is an inflammatory disease of the vascular wall leading to ischemia and vascular occlusion. Complications of arteritis include anemia, which could, at least in theory, result from suicidal erythrocyte death or eryptosis, which is characterized by erythrocyte shrinkage and phosphatidylserine (PS) exposure at the erythrocyte surface. Cellular mechanisms involved in the stimulation of eryptosis include increased cytosolic Ca2+-concentration ([Ca2+]i), oxidative stress and ceramide formation. The present study explored whether and how arteritis influences eryptosis.
METHODS
Blood was drawn from patients suffering from arteritis (n=17) and from healthy volunteers (n=21). PS exposure was estimated from annexin V-binding, erythrocyte volume from forward scatter, [Ca2+]i from Fluo3-fluorescence, reactive oxygen species (ROS) from DCFDA fluorescence and ceramide abundance from FITC-conjugated antibody binding in flow cytometry. The patients suffered from anemia despite 2.8±0.4% reticulocytes.
RESULTS
The percentage of PS-exposing erythrocytes was significantly higher in patients (1.1±0.1%) than in healthy volunteers (0.3±0.1%). The increase in PS exposure was paralleled by increase in oxidative stress and [Ca2+]i but not by significant changes of ceramide abundance. Erythrocyte PS exposure and ROS production were significantly enhanced in erythrocytes exposed to patient plasma as compared to exposure to plasma from healthy volunteers.
CONCLUSION
Arteritis is associated with enhanced eryptosis due to increased [Ca2+]i and oxidative stress. The eryptosis contributes to or even accounts for the anemia in those patients. As eryptotic erythrocytes adhere to endothelial cells of the vascular wall, they could impede microcirculation and thus contribute to vascular occlusion.
Topics: Aged; Anemia; Aniline Compounds; Annexin A5; Arteritis; Calcium; Case-Control Studies; Ceramides; Eryptosis; Erythrocytes; Female; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Humans; Male; Middle Aged; Oxidative Stress; Phosphatidylserines; Primary Cell Culture; Reactive Oxygen Species; Xanthenes
PubMed: 27544243
DOI: 10.1159/000447814 -
Reumatismo Dec 2022Takayasu arteritis (TA) is an extremely uncommon vasculitis that primarily affects the aorta and its branches. Due to the genetic and ethnicity effect, a diverse array...
Takayasu arteritis (TA) is an extremely uncommon vasculitis that primarily affects the aorta and its branches. Due to the genetic and ethnicity effect, a diverse array of TA clinical manifestations has been reported worldwide. The purpose of the present study was to compare the clinicodemographic characteristics and pattern of vascular involvement of Iranian and Turkish TA patients. This study was a retrospective, cross-sectional investigation of 126 TA patients in Iran and Turkey. All of the variables analyzed were extracted from historical medical records. In 126 TA patients, the ratio of females to males was 8.6:1, and the average age at onset of disease was 30.5±11.1 years. Fatigue (49.2%) and a weak or absent pulse (79.4%) were the most prevalent symptoms and signs, respectively. The most prevalent angiographic classifications were types V and I in Iranian patients (41.09%) and type I in the Turkish population (47.7%) The left subclavian artery was the vessel most frequently affected by TA (66.6%). Our findings indicated that there were no significant differences between the two countries in terms of clinicodemographic characteristics or vascular involvement. Some clinical manifestations, such as claudication, were more prevalent in the Turkish population due to a higher incidence of occlusive lesions in the right subclavian artery.
Topics: Male; Female; Humans; Young Adult; Adult; Takayasu Arteritis; Retrospective Studies; Iran; Turkey; Cross-Sectional Studies
PubMed: 36580066
DOI: 10.4081/reumatismo.2022.1487 -
Rheumatology (Oxford, England) Nov 2021GCA is the most common large vessel vasculitis in the elderly population. In recent years, advanced imaging has changed the way GCA can be diagnosed in many locations.... (Review)
Review
GCA is the most common large vessel vasculitis in the elderly population. In recent years, advanced imaging has changed the way GCA can be diagnosed in many locations. The GCA fast-track clinic approach combined with US examination allows prompt treatment and diagnosis with high certainty. Fast-track clinics have been shown to improve prognosis while being cost effective. However, all diagnostic modalities are highly operator dependent, and in many locations expertise in advanced imaging may not be available. In this paper, we review the current evidence on GCA diagnostics and propose a simple algorithm for diagnosing GCA for use by rheumatologists not working in specialist centres.
Topics: Aged; Early Detection of Cancer; Early Medical Intervention; Giant Cell Arteritis; Humans; Ultrasonography
PubMed: 34255830
DOI: 10.1093/rheumatology/keab547 -
Annals of the Rheumatic Diseases May 2002
Topics: Anemia, Sickle Cell; Arteritis; Humans; Salmonella Infections
PubMed: 11959783
DOI: 10.1136/ard.61.5.477 -
Proceedings of the Royal Society of... Aug 1970
Topics: Arteritis; Erythema Nodosum; Humans; Hypersensitivity; Polyarteritis Nodosa; Purpura; Skin Diseases; Vascular Diseases
PubMed: 4393789
DOI: No ID Found -
British Medical Journal May 1958
Topics: Aorta; Aortic Diseases; Arteritis; Disease; Takayasu Arteritis
PubMed: 13536470
DOI: No ID Found -
Proceedings of the Royal Society of... Dec 1946
Topics: Arteries; Arteritis; Giant Cell Arteritis; Humans; Inflammation; Occipital Bone; Temporal Arteries
PubMed: 19993455
DOI: No ID Found -
The British Journal of Ophthalmology May 1952
Topics: Arteritis; Retina
PubMed: 14925299
DOI: 10.1136/bjo.36.5.268