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The American Journal of Cardiology Oct 1993An assessment of complications is essential to the evaluation of directional coronary atherectomy. Major complications--such as death, Q wave myocardial infarction, or... (Review)
Review
An assessment of complications is essential to the evaluation of directional coronary atherectomy. Major complications--such as death, Q wave myocardial infarction, or the need for emergency bypass surgery to correct acute vessel closure--result from a variety of familiar mechanisms, including dissection, thrombosis, or guiding catheter injury. In addition, unique complications of this device, such as catheter nose cone injury or vascular perforation, may also result in severe ischemia. With prompt recognition of the cause, most ischemic complications can be successfully treated in the catheterization laboratory. Less severe complications, such as femoral vascular injury, also require recognition and appropriate treatment in order to minimize sequelae. Although several large series have now documented that the overall incidence of atherectomy complications appears similar to that reported for conventional balloon angioplasty, no direct comparisons can be made until randomized trials (such as Coronary Angioplasty Versus Excisional Atherectomy Trial [CAVEAT]) are analyzed, to control for potential demographic or lesion-specific influences on complication rates.
Topics: Atherectomy, Coronary; Cardiac Catheterization; Coronary Artery Bypass; Coronary Artery Disease; Coronary Thrombosis; Coronary Vasospasm; Coronary Vessels; Emergencies; Humans; Myocardial Infarction; Postoperative Complications
PubMed: 8213570
DOI: 10.1016/0002-9149(93)91038-j -
Journal of Interventional Cardiology Aug 2018To evaluate the outcomes of rotational atherectomy for heavily-calcified side branches of coronary bifurcation lesions.
Feasibility and clinical outcomes of rotational atherectomy for heavily-calcified side branches of complex coronary bifurcation lesions in the real-world practice of the drug-eluting stent era.
OBJECTIVES
To evaluate the outcomes of rotational atherectomy for heavily-calcified side branches of coronary bifurcation lesions.
BACKGROUND
Side-branch (SB) preservation is clinically important but technically challenging in heavily-calcified non-left main true bifurcation lesions. SB rotational atherectomy (SB RA) is sometimes mandatory but the clinical outcomes are not well studied.
METHODS
We retrospectively studied the outcomes of patients who underwent RA at our institute for heavily calcified, balloon-uncrossable or-undilatable SB lesions over an approximately 5-year period (January 2011 to September 2016).
RESULTS
Two hundred and forty-four patients underwent main vessel only RA (SB-MV + RA group) and another 48 patients underwent SB RA (SB + MV ± RA group) for 49 side branches. The demographic variables were comparable between the two groups. However, patients underwent SB RA experienced more SB perforations and greater acute contrast-induced nephropathy (CIN). Among the SB RA patients, 30 (62.5%) underwent RA for both SB and MV (SB + MV + RA subgroup), whereas the other 18 underwent SB only RA (SB + MV-RA subgroup). Patients in these two subgroups could be completed with similar procedural, fluoroscopic durations, and contrast doses. The long-term MACE rate of SB RA was 27.1% over a mean follow-up period of 25.1 months with no differences between the two subgroups.
CONCLUSIONS
RA for SB preservation in complex and heavily-calcified bifurcation lesions was feasible with high success rate and quite favorable long-term outcomes in the drug-eluting stent (DES) era. Given the higher rates in SB perforation and acute CIN, we recommend that SB RA should be conducted by experienced operators.
Topics: Aged; Atherectomy, Coronary; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Female; Humans; Long Term Adverse Effects; Male; Middle Aged; Retrospective Studies; Taiwan; Treatment Outcome; Vascular Calcification
PubMed: 29667231
DOI: 10.1111/joic.12515 -
Cirugia Y Cirujanos 2021La aterosclerosis es una patología sistémica que afecta a todo el sistema vascular. El tabaquismo, la hiperlipidemia, la diabetes mellitus, la edad avanzada y la...
La aterosclerosis es una patología sistémica que afecta a todo el sistema vascular. El tabaquismo, la hiperlipidemia, la diabetes mellitus, la edad avanzada y la hipertensión son factores de riesgo conocidos para el desarrollo de aterosclerosis. El tratamiento quirúrgico en la enfermedad arterial periférica ha sido reemplazado por opciones de tratamiento endovascular en los últimos años debido a la mortalidad y la morbilidad. En nuestro estudio, nuestro objetivo fue presentar la efectividad de la aterectomía, el balón liberador de fármacos y la terapia combinada con valores determinados por espectroscopía de infrarrojo cercano en pacientes con enfermedad arterial periférica aterosclerótica. Material y métodos: Los pacientes con claudicación intermitente o isquemia crítica de la pierna (Rutherford clase 3 o más) han sido vistos en el estudio. Hubo 30 pacientes masculinos y 9 femeninos. Los pacientes fueron seguidos antes, en la primera hora después y en el tercer mes después del procedimiento, con un índice simultáneo de presión tobillo-brazo (ABI), mediciones de la distancia a pie y medición de la oxigenación de los tejidos mediante el método de espectroscopía de infrarrojo cercano (NIR). Resultado: cuando los pacientes con mediciones similares de ABI postoperatorio se evaluaron con NIR, se observó una mayor oxigenación venosa en los pacientes que usaron métodos de tratamiento combinados con aterectomía. Según estos resultados, pensamos que los métodos de tratamiento combinados con aterectomía han aumentado la mirocirculación y la circulación colateral más que otros métodos. Atherosclerosis is a systemic pathology involving the entire vascular system. Smoking, hyperlipidemia, diabetes mellitus, advanced age, and hypertension are known risk factors for the development of atherosclerosis. Surgical treatment in peripheral arterial disease (PAD) has been replaced by endovascular treatment options in recent years due to mortality and morbidity. In our study, we aimed to present the effectiveness of atherectomy, drug-eluting balloon, and combined therapy with values determined by near-infrared spectroscopy (NIRS) in patients they have atherosclerotic PAD. Materials and methods: Patients with intermittent claudication or critical leg ischemia (Rutherford class 3 or more) have been viewed in the study. There were 30 male and 9 female patients. Patients were followed up before, at the 1 h after and at the 3 month after the procedure, with simultaneous ankle-brachial pressure index (ABPI), walking distance measurements, and measurement of tissue oxygenation by NIRS method. Results: When patients with similar post-operative ABPI measurements were evaluated with NIRS, venous oxygenation was observed higher in patients used treatment methods combined with atherectomy. According to these results, we thought that treatment methods combined with atherectomy have increased microcirculation and collateral circulation more than other methods.
Topics: Atherectomy; Combined Modality Therapy; Drug-Eluting Stents; Female; Humans; Male; Pharmaceutical Preparations; Retrospective Studies; Spectroscopy, Near-Infrared
PubMed: 34037605
DOI: 10.24875/CIRU.20000353 -
Nagoya Journal of Medical Science May 2019Neointimal calcification after stent implantation has been reported as one of the forms of neoatherosclerosis. There are a few patients with in-stent restenosis (ISR)...
Neointimal calcification after stent implantation has been reported as one of the forms of neoatherosclerosis. There are a few patients with in-stent restenosis (ISR) and an undilatable calcified neointima who require rotational atherectomy to achieve sufficient acute gain in lumen diameter. However, the clinical outcomes of rotational atherectomy for undilatable calcified ISR have not been fully elucidated. Therefore, we investigated the safety and efficacy of rotational atherectomy for treating calcified ISR. This retrospective study included 17 patients (20 lesions) who had undergone percutaneous coronary intervention including rotational atherectomy to treat ISR with severely calcified neointima. Kaplan-Meier analysis was used to analyze the data. The mean age of the enrolled patients was 67±18 years, and 71% were men. The patients had highly atherogenic characteristics: 65% had diabetes mellitus and 53% were receiving hemodialysis. Procedural success was obtained in 19 (95%) patients, and the acute gain in lumen diameter was acceptable (1.7±0.6 mm). However, during a median follow-up of 571 days, the incidences of major adverse cardiac and cerebrovascular events per patient and clinical-driven target lesion revascularizations per lesion were relatively high. There were no differences in clinical outcomes according to the baseline characteristics, type of restenotic stents, and therapeutic strategy. In conclusion, clinical outcomes of rotational atherectomy for severely calcified ISR were unfavorable despite a high success rate and acceptable acute gain in lumen diameter.
Topics: Aged; Aged, 80 and over; Atherectomy; Coronary Restenosis; Drug-Eluting Stents; Humans; Kaplan-Meier Estimate; Middle Aged; Neointima; Retrospective Studies
PubMed: 31239599
DOI: 10.18999/nagjms.81.2.313 -
Current Cardiology Reviews May 2014Successful revascularisation of chronic total occlusions (CTOs) remains one of the greatest challenges in the era of contemporary percutaneous coronary intervention... (Review)
Review
Successful revascularisation of chronic total occlusions (CTOs) remains one of the greatest challenges in the era of contemporary percutaneous coronary intervention (PCI). Such lesions are encountered with increasing frequency in current clinical practice. A predictable increase in the future burden of CTO management can be anticipated given the ageing population, increased rates of renal failure, graft failure and diabetes mellitus. Given recent advances and developments in CTO PCI management, successful recanalisation can be anticipated in the majority of procedures undertaken at high-volume centres when performed by expert operators. Despite advances in device technology, the management of resistant, calcific lesions remains one of the greatest challenges in successful CTO intervention. Established techniques to modify calcific lesions include the use of high-pressure non-compliant balloon dilation, cutting-balloons, anchor balloons and high speed rotational atherectomy (HSRA). Novel approaches have proven to be safe and technically feasible where standard approaches have failed. A step-wise progression of strategies is demonstrated, from well-recognised techniques to techniques that should only be considered when standard manoeuvres have proven unsuccessful. These methods will be described in the setting of clinical examples and include use of very high-pressure non-compliant balloon dilation, intentional balloon rupture with vessel dissection or balloon assisted micro-dissection (BAM), excimer coronary laser atherectomy (ECLA) and use of HSRA in various 'offlabel' settings.
Topics: Atherectomy, Coronary; Chronic Disease; Coronary Angiography; Coronary Occlusion; Humans; Treatment Outcome
PubMed: 24694106
DOI: 10.2174/1573403x10666140331124954 -
Circulation Journal : Official Journal... May 2021
Topics: Atherectomy, Coronary; Coronary Artery Disease; Humans; Lithotripsy
PubMed: 33583927
DOI: 10.1253/circj.CJ-20-1272 -
The American Journal of Cardiology Oct 1993Until recently, it has not been clear how much of the effect of directional coronary atherectomy is due to tissue removal per se, and whether the long-term results of... (Review)
Review
Until recently, it has not been clear how much of the effect of directional coronary atherectomy is due to tissue removal per se, and whether the long-term results of the procedure are helped or harmed when the operator attempts to obtain the "near zero percent" residual stenosis of which this technique is capable. This article summarizes the findings of a series of studies that have addressed these important questions and proposes a prescription for the optimal performance of directional atherectomy. Analysis of retrieved tissue weights compared with measured increases in luminal volume shows that about half of the improvement seen after directional atherectomy results from mechanical dilation. Because this "facilitated" dilation appears to take place within the bases of the trenches created by atherectomy cuts (rather than being randomly distributed in fractures throughout the plaque substance), a larger and smoother lumen is possible compared with that seen after conventional balloon dilation. Although the recovery of deep vessel wall components (media and even adventitia) is common, it generally does not cause either acute complications (i.e., perforation) or increase the probability of subsequent restenosis. Rather, reduction in the probability of late restenosis appears to be most directly related to the ability of directional atherectomy to provide the largest acute luminal diameter safely possible, thus providing better tolerance of subsequent intimal hyperplasia before hemodynamically significant renarrowing results at the treatment site.
Topics: Angioplasty, Balloon, Coronary; Atherectomy, Coronary; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Humans; Hyperplasia; Recurrence; Treatment Outcome; Tunica Intima
PubMed: 8213573
DOI: 10.1016/0002-9149(93)91040-o -
Journal of Vascular Surgery Aug 2022Despite limited evidence supporting atherectomy alone over stenting/angioplasty as the index peripheral vascular intervention (PVI), the use of atherectomy has rapidly...
OBJECTIVE
Despite limited evidence supporting atherectomy alone over stenting/angioplasty as the index peripheral vascular intervention (PVI), the use of atherectomy has rapidly increased in recent years. We previously identified a wide distribution of atherectomy practice patterns among US physicians. The aim of this study was to investigate the association of index atherectomy with reintervention.
METHODS
We used 100% Medicare fee-for-service claims to identify all beneficiaries who underwent elective first-time femoropopliteal PVI for claudication between January 1, 2019, and December 31, 2019. Subsequent PVI reinterventions were examined through June 30, 2021. Kaplan-Meier curves were used to compare rates of PVI reinterventions for patients who received index atherectomy versus nonatherectomy procedures. Reintervention rates were also described for physicians by their overall atherectomy use (by quartile). A hierarchical Cox proportional hazard model was used to evaluate patient and physician-level characteristics associated with reinterventions.
RESULTS
A total of 15,246 patients underwent an index PVI for claudication in 2019, of which 59.7% were atherectomy. After a median of 603 days (interquartile range, 77-784 days) of follow-up, 41.2% of patients underwent a PVI reintervention, including 48.9% of patients who underwent index atherectomy versus 29.8% of patients who underwent index nonatherectomy (P < .001). Patients treated by high physician users of atherectomy (quartile 4) received more reinterventions than patients treated by standard physician users (quartiles 1-3) (56.8% vs 39.6%; P < .001). After adjustment, patient factors association with PVI reintervention included receipt of index atherectomy (adjusted hazard ratio [aHR], 1.33; 95% confidence interval [CI], 1.21-1.46), Black race (vs White; aHR; 1.18; 95% CI, 1.03-1.34), diabetes (aHR, 1.13; 95% CI, 1.07-1.21), and urban residence (aHR, 1.11; 95% CI, 1.01-1.22). Physician factors associated with reintervention included male sex (aHR, 1.52; 95% CI, 1.12-2.04), high-volume PVI practices (aHR, 1.23; 95% CI, 1.10-1.37), and physicians with a high use of index atherectomy (aHR, 1.49; 95% CI, 1.27-1.74). Vascular surgeons had a lower risk of PVI reintervention than cardiologists (vs vascular; aHR, 1.22; 95% CI, 1.09-1.38), radiologists (aHR, 1.55; 95% CI, 1.31-1.83), and other specialties (aHR, 1.59; 95% CI, 1.20-2.11). The location of services delivered was not associated with reintervention (P > .05).
CONCLUSIONS
The use of atherectomy as an index PVI for claudication is associated with higher PVI reintervention rates compared with nonatherectomy procedures. Similarly, high physician users of atherectomy perform more PVI reinterventions than their peers. The appropriateness of using atherectomy for initial treatment of claudication needs critical reevaluation.
Topics: Aged; Atherectomy; Humans; Intermittent Claudication; Male; Medicare; Peripheral Arterial Disease; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome; United States
PubMed: 35276258
DOI: 10.1016/j.jvs.2022.02.034 -
Journal of Vascular Surgery Dec 2018Peripheral atherectomy has been shown to have technical success in single-arm studies, but clinical advantages over angioplasty and stenting have not been demonstrated,...
OBJECTIVE
Peripheral atherectomy has been shown to have technical success in single-arm studies, but clinical advantages over angioplasty and stenting have not been demonstrated, leaving its role unclear. We sought to describe patterns of atherectomy use in a real-world U.S. cohort to understand how it is currently being applied.
METHODS
The Vascular Quality Initiative was queried to identify all patients who underwent peripheral vascular intervention from January 2010 to September 2016. Descriptive statistics were performed to analyze demographics of the patients, comorbidities, indication, treatment modalities, and lesion characteristics. The intermittent claudication (IC) and critical limb ischemia (CLI) cohorts were analyzed separately.
RESULTS
Of 85,605 limbs treated, treatment indication was IC in 51% (n = 43,506) and CLI in 49% (n = 42,099). Atherectomy was used in 15% (n = 13,092) of cases, equivalently for IC (15%; n = 6674) and CLI (15%; n = 6418). There was regional variation in use of atherectomy, ranging from a low of 0% in one region to a high of 32% in another region. During the study period, there was a significant increase in the proportion of cases that used atherectomy (11% in 2010 vs 18% in 2016; P < .0001). Compared with nonatherectomy cases, those with atherectomy use had higher incidence of prior peripheral vascular intervention (IC, 55% vs 43% [P < .0001]; CLI, 47% vs 41% [P < .0001]), greater mean number of arteries treated (IC, 1.8 vs 1.6 [P < .0001]; CLI, 2.1 vs 1.7 [P < .0001]), and lower proportion of prior leg bypass (IC, 10% vs 14% [P < .0001]; CLI, 11% vs 17% [P < .0001]). There was lower incidence of failure to cross the lesion (IC, 1% vs 4% [P < .0001]; CLI, 4% vs 7% [P < .0001]) but higher incidence of distal embolization (IC, 1.9% vs 0.8% [P < .0001]; CLI, 3.0% vs 1.4% [P < .0001]) and, in the CLI cohort, arterial perforation (1.4% vs 1.0%; P = .01).
CONCLUSIONS
Despite a lack of evidence for atherectomy over angioplasty and stenting, its use has increased across the United States from 2010 to 2016. It is applied equally to IC and CLI populations, with no identifiable pattern of comorbidities or lesion characteristics, suggesting that indications are not clearly delineated or agreed on. This study places impetus on further understanding of the optimal role for atherectomy and its long-term clinical benefit in the management of peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Atherectomy; Comorbidity; Critical Illness; Databases, Factual; Female; Health Care Surveys; Healthcare Disparities; Humans; Intermittent Claudication; Ischemia; Male; Middle Aged; Peripheral Arterial Disease; Practice Patterns, Physicians'; Registries; Retrospective Studies; Risk Factors; Surgeons; Time Factors; Treatment Outcome; United States
PubMed: 29937287
DOI: 10.1016/j.jvs.2018.03.417 -
The Journal of Invasive Cardiology Jun 2021Chronic total occlusions (CTOs) and long lesions have been associated with higher reocclusion rates in femoropopliteal arteries and increased need for revascularization.... (Observational Study)
Observational Study
BACKGROUND
Chronic total occlusions (CTOs) and long lesions have been associated with higher reocclusion rates in femoropopliteal arteries and increased need for revascularization. While several studies have analyzed atherectomy samples, no study to date has correlated the tissue characteristics of CTOs with clinical outcomes. This pilot study assessed lesions in order to predict clinical outcomes based on lesion characteristics.
METHODS
Patients presenting with femoropopliteal (FP) CTO lesions, including in-stent restenosis and de novo lesions, were enrolled in a prospective, observational study. With patient consent, CTOs were crossed using a crossing catheter guided by optical coherence tomography (OCT) imaging. Atherectomy was performed with a directional atherectomy device and tissue samples were collected and subjected to histopathological analysis for the presence of adventitial tissue and thrombus, and the amounts of hypercellular cells, fibrocellular material, fibrous tissue, and lipid-rich tissue in the excised tissue were measured. The compiled data were correlated with clinical outcomes, as recorded at each patient's clinical follow-up visit.
RESULTS
All CTO lesions (n = 19) were successfully crossed, with no dissections or perforations. Adventitial tissue was found in excised tissue from all 19 lesions (up to 57% of total lesion area), and thrombus was found in 15 lesions (up to 34% of total lesion area). The amount of hypercellular cells, fibrocellular material, fibrous tissue, and lipid-rich tissue present in the excised tissue did not correlate with the incidence of target-lesion revascularization (TLR). At 6-month follow-up exam, 79% of the treated lesions had TLR. Risk of TLR was assessed based on weighted risk of each variable; the results determined that occurrence of TLR was associated with elevated levels of adventitia and thrombus in the lesions and with lesions >15 cm in length. There was a significant correlation (P<.05) between TLR and the lesion characterization as set forth in the present study.
CONCLUSIONS
Pairing the histological analysis, including content of adventitia and thrombus, with lesion length and binary clinical outcomes enabled the predictive incidence of TLR in this pilot study. Further work needs to be conducted to validate these findings in larger studies.
Topics: Angioplasty, Balloon; Atherectomy; Femoral Artery; Humans; Peripheral Arterial Disease; Pilot Projects; Popliteal Artery; Prospective Studies; Stents; Time Factors; Treatment Outcome; Vascular Patency
PubMed: 34001676
DOI: No ID Found