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Frontiers in Endocrinology 2020Several studies including some genome-wide association studies (GWAS) had shown that BAK1 gene rs210138 polymorphisms might be associated with testicular germ cell... (Meta-Analysis)
Meta-Analysis
Several studies including some genome-wide association studies (GWAS) had shown that BAK1 gene rs210138 polymorphisms might be associated with testicular germ cell tumors (TGCT). Here we tried to sum up the association through a systematic review and meta-analysis. Studies associated with BAK1 rs210138 and TGCT was systematically searched in databases. The effect size was pooled according to ORs and 95% CIs. Our systematic review and meta-analysis comprised 14 articles. Significantly increased risk of TGCT was found in eligible GWAS and follow-up studies, in overall group and its Caucasian subgroup. Compared with adenine (A), BAK1 rs210138 guanine (G) is associated with increased risk of TGCT. Well-planned studies with larger sample size and more subgroups are needed to verify the risk identified in our systematic review and meta-analysis.
Topics: Case-Control Studies; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Neoplasms, Germ Cell and Embryonal; Polymorphism, Single Nucleotide; Testicular Neoplasms; bcl-2 Homologous Antagonist-Killer Protein
PubMed: 32038496
DOI: 10.3389/fendo.2020.00002