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Facial Plastic Surgery Clinics of North... Aug 2017Skin is composed of the epidermis, dermis, and adnexal structures. The epidermis is composed of 4 layers-the stratums basale, spinosum, granulosum, and corneum. The... (Review)
Review
Skin is composed of the epidermis, dermis, and adnexal structures. The epidermis is composed of 4 layers-the stratums basale, spinosum, granulosum, and corneum. The dermis is divided into a superficial papillary dermis and deeper reticular dermis. Collagen and elastin within the reticular dermis are responsible for skin tensile strength and elasticity, respectively. The 2 most common kinds of nonmelanoma skin cancers are basal cell and squamous cell carcinoma. Both are caused by a host of environmental and genetic factors, although UV light exposure is the single greatest predisposing factor.
Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermis; Epidermal Cells; Epidermis; Gene-Environment Interaction; Humans; Skin; Skin Neoplasms
PubMed: 28676156
DOI: 10.1016/j.fsc.2017.03.001 -
Deutsche Krankenpflegezeitschrift Mar 1993
Topics: Communication; Disabled Persons; Exercise; Humans; Perception
PubMed: 8482205
DOI: No ID Found -
Krankenpflege. Soins Infirmiers 2016
Topics: Caregivers; Communication; Communication Disorders; Disabled Persons; Humans; Meditation; Nonverbal Communication; Nurse-Patient Relations; Professional-Family Relations; Social Support; Switzerland; Trust
PubMed: 27220140
DOI: No ID Found -
The Journal of Physiology Dec 2007
Review
Topics: Action Potentials; Animals; Dendrites; Humans; Pyramidal Cells; Synapses
PubMed: 18056111
DOI: 10.1113/jphysiol.2007.146977 -
Development (Cambridge, England) Nov 2018The folding of epithelial tissues is crucial for development of three-dimensional structure and function. Understanding this process can assist in determining the...
The folding of epithelial tissues is crucial for development of three-dimensional structure and function. Understanding this process can assist in determining the etiology of developmental disease and engineering of tissues for the future of regenerative medicine. Folding of epithelial tissues towards the apical surface has long been studied, but the molecular mechanisms that mediate epithelial folding towards the basal surface are just emerging. Here, we utilize zebrafish neuroepithelium to identify mechanisms that mediate basal tissue folding to form the highly conserved embryonic midbrain-hindbrain boundary. Live imaging revealed Wnt5b as a mediator of anisotropic epithelial cell shape, both apically and basally. In addition, we uncovered a Wnt5b-mediated mechanism for specific regulation of basal anisotropic cell shape that is microtubule dependent and likely to involve JNK signaling. We propose a model in which a single morphogen can differentially regulate apical versus basal cell shape during tissue morphogenesis.
Topics: Animals; Anisotropy; Cell Shape; Embryo, Nonmammalian; Epithelium; JNK Mitogen-Activated Protein Kinases; Mesencephalon; Microtubules; Morphogenesis; Neuroepithelial Cells; Polymerization; Rhombencephalon; Tubulin; Zebrafish
PubMed: 30333212
DOI: 10.1242/dev.167031 -
Biology Open Nov 2018Basal constriction occurs at the zebrafish midbrain-hindbrain boundary constriction (MHBC) and is likely a widespread morphogenetic mechanism. 3D reconstruction...
Basal constriction occurs at the zebrafish midbrain-hindbrain boundary constriction (MHBC) and is likely a widespread morphogenetic mechanism. 3D reconstruction demonstrates that MHBC cells are wedge-shaped, and initially constrict basally, with subsequent apical expansion. is expressed in the MHB and is required for basal constriction. Consistent with a requirement for this pathway, expression of dominant negative Gsk3β overcomes knockdown. Immunostaining identifies focal adhesion kinase (Fak) as active in the MHB region, and knockdown demonstrates Fak is a regulator of basal constriction. Tissue specific knockdown further indicates that Fak functions cell autonomously within the MHBC. Fak acts downstream of , suggesting that Wnt5b signals locally as an early step in basal constriction and acts together with more widespread Fak activation. This study delineates signaling pathways that regulate basal constriction during brain morphogenesis.
PubMed: 30305282
DOI: 10.1242/bio.034520 -
Il Policlinico. Sezione Pratica Mar 1958
Topics: Basal Metabolism
PubMed: 13553834
DOI: No ID Found -
Tijdschrift Voor Psychiatrie 2019Idiopathic basal ganglia calcification is a rare neuropathological syndrome characterised by symmetrical and bilateral calcifications found primarily in the basal...
Idiopathic basal ganglia calcification is a rare neuropathological syndrome characterised by symmetrical and bilateral calcifications found primarily in the basal ganglia. Psychosis is describedas an acute presentation of idiopathic ganglia calcification. We describe the development of psychosis in a 48-year-old man, initially hospitalised on the neurology ward due to syncope. A ct scan of the brain showed bilateral, symmetrical calcification of the basal ganglia and nucleus dentatus. Laboratory research excluded other pathological disorders. The patient was referred to a psychiatric ward, where the administration of risperidone led to alleviation of his mental state. This case report underlines the importance of an accurate, comprehensive differential diagnosis and the associated significance of neuroimaging.
Topics: Basal Ganglia; Brain; Brain Diseases; Calcinosis; Diagnosis, Differential; Humans; Male; Middle Aged; Neuroimaging; Psychotic Disorders
PubMed: 30640406
DOI: No ID Found -
Frontiers in Cell and Developmental... 2021Apart from mutations in the gene, p53 functions can be alternatively compromised by a decrease in nuclear p53 protein levels or activities. In accordance, enhanced p53... (Review)
Review
Apart from mutations in the gene, p53 functions can be alternatively compromised by a decrease in nuclear p53 protein levels or activities. In accordance, enhanced p53 protein turnover due to elevated expression of the critical p53 E3 ligase MDM2 or MDM2/MDMX is found in many human cancers. Likewise, the HPV viral E6 protein-mediated p53 degradation critically contributes to the tumorigenesis of cervical cancer. In addition, growth-promoting signaling-induced cell proliferation is accompanied by p53 downregulation. Animal studies have also shown that loss of p53 is essential for oncogenes to drive malignant transformation. The close association between p53 downregulation and carcinogenesis implicates a critical role of basally expressed p53. In accordance, available evidence indicates that a reduced level of basal p53 is usually associated with disruption of homeostasis, suggesting a homeostatic function mediated by basal p53. However, basally expressed p53 under non-stress conditions is maintained at a relatively low abundance with little transcriptional activity, raising the question of how basal p53 could protect homeostasis. In this review, we summarize the findings pertinent to basal p53-mediated activities in the hope of developing a model in which basally expressed p53 functions as a barrier to anabolic metabolism to preserve homeostasis. Future investigation is necessary to characterize basal p53 functionally and to obtain an improved understanding of p53 homeostatic function, which would offer novel insight into the role of p53 in tumor suppression.
PubMed: 34888311
DOI: 10.3389/fcell.2021.775312