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Advances in Respiratory Medicine 2019Immunodeficient children are at a high risk of disseminated Bacillus Calmette-Guérin [BCG] infection. We assessed the literature on clinical manifestations of BCGosis...
INTRODUCTION
Immunodeficient children are at a high risk of disseminated Bacillus Calmette-Guérin [BCG] infection. We assessed the literature on clinical manifestations of BCGosis in children with specific primary immunodeficiencies.
MATERIAL AND METHODS
We conducted a systematic review of clinical practice articles by searching Medline, PubMed, Embase, Scopus, Web of Science and Google Scholar from their inception to date.
RESULTS
Thirty-seven articles were included regarding BCG vaccination and its dissemination in children with primary immunodeficiencies. Articles on dissemination after intravesicular BCG were excluded from the study.
CONCLUSIONS
Since disseminated BCG vaccination may be the first manifestation of a primary immunodeficiency disease, a comprehensive search for immunological defects in children developing these problems after BCG vaccination seems rational.
Topics: Adjuvants, Immunologic; BCG Vaccine; Humans; Immunologic Deficiency Syndromes; Mycobacterium bovis; Tuberculosis; Vaccination
PubMed: 31476012
DOI: 10.5603/ARM.2019.0040