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British Medical Journal Apr 1951
Topics: Carcinoma; Humans; Neoplasms, Glandular and Epithelial
PubMed: 14830810
DOI: 10.1136/bmj.1.4712.920 -
The Journal of Dermatology Jan 1994An 83-year-old woman had developed an asymptomatic, yellowish, dome-shaped skin tumor on her scalp which had enlarged for a period of 60 years to 10 x 10 x 10 mm in...
An 83-year-old woman had developed an asymptomatic, yellowish, dome-shaped skin tumor on her scalp which had enlarged for a period of 60 years to 10 x 10 x 10 mm in size. Histopathologically, the tumor consisted of undifferentiated basaloid cells, differentiated sebaceous cells and transitional cells. Although the basaloid cells resembled those of basal cell epithelioma (BCE), the tumor was distinct from BCE in the following points; existence of cystic spaces, no peripheral palisading, no proliferation of connective tissue stroma, and no tendency toward local invasion. Immunohistochemical studies using antikeratin monoclonal antibodies revealed that the tumor contained both the keratin types of BCE and of sebaceous glands. Electron microscopically, the tumor cells contained lipid droplets and keratohyaline granules in their cytoplasm. It is suggested that "sebaceous epithelioma" is a benign skin tumor which may be distinguished cytologically from BCE.
Topics: Aged; Aged, 80 and over; Carcinoma; Female; Humans; Scalp; Sebaceous Gland Neoplasms
PubMed: 8157819
DOI: 10.1111/j.1346-8138.1994.tb01407.x -
Archives of Dermatology and Syphilology Sep 1946
Topics: Carcinoma; Humans; Neoplasms; Neoplasms, Glandular and Epithelial; Skin; Skin Neoplasms
PubMed: 20996839
DOI: No ID Found -
Pathology, Research and Practice 2001Purely benign mesenchymal spindle cell neoplasms of the breast are currently labeled under various terms in the literature (benign spindle cell tumor, fibroma, spindle... (Review)
Review
Purely benign mesenchymal spindle cell neoplasms of the breast are currently labeled under various terms in the literature (benign spindle cell tumor, fibroma, spindle cell lipoma, myofibroblastoma, solitary fibrous tumor, myogenic stromal tumor). The lack of strict diagnostic criteria to clearly indicate such mesenchymal neoplasms is the main reason which generated the risk of terming the same lesion under different names or, conversely, of collecting different types under the same term. Although such neoplasms exhibit morphological and immunophenotypical heterogeneity, they actually represent variations of the same tumor entity, likely arising from the uncommitted vimentin+/CD34+ fibroblasts of the mammary stroma, capable of multidirectional mesenchymal differentiation. To cover the entire spectrum of such lesions, the term "benign spindle cell tumors (BSCTs) of the mammary stroma" is advocated. BSCTs can be subtyped into four main groups by light microscopy (LM) and immunocytochemistry (ICC): fibroblastic, myofibroblastic, fibrohistiocytic, and mixed forms. A simple and practical approach to a nosologically correct diagnosis and a list of differential diagnoses are presented. The awareness of the diversity of morphological and immunophenotypical features of BSCTs of the mammary stroma, including uncommon variants, is helpful to avoid confusion with other monomorphic bland-looking benign and malignant spindle cell tumors and tumor-like lesions of the breast.
Topics: Breast Neoplasms; Carcinoma; Female; Humans; Immunophenotyping
PubMed: 11482575
DOI: 10.1078/0344-0338-00112 -
Archives of Dermatology and Syphilology Apr 1948
Topics: Carcinoma, Basal Cell; Humans; Neoplasms; Neoplasms, Basal Cell; Skin; Skin Neoplasms
PubMed: 18886278
DOI: 10.1001/archderm.1948.01520170077010 -
Journal of Cutaneous Pathology Oct 1984Neoplasms with sebaceous differentiation cover a broad spectrum. They range from benign sebaceous hyperplasia and adenomas to locally infiltrative sebaceous epitheliomas... (Review)
Review
Neoplasms with sebaceous differentiation cover a broad spectrum. They range from benign sebaceous hyperplasia and adenomas to locally infiltrative sebaceous epitheliomas which have biologic behaviors similar to basal cell carcinomas, to sebaceous carcinomas which can have very malignant biologic behaviors. In this paper, we have purposely excluded the nevus sebaceus of Jadassohn, a nevoid tumor composed of several cutaneous elements. As sebaceous glands are only one part of this tumor, it is better classified as an organoid nevus.
Topics: Adenocarcinoma; Adenoma; Adult; Carcinoma; Diagnosis, Differential; Eyelid Neoplasms; Humans; Male; Sebaceous Gland Neoplasms
PubMed: 6392373
DOI: 10.1111/j.1600-0560.1984.tb00397.x -
Prensa Medica Argentina Feb 1957
Topics: Carcinoma; Cysts; Neoplasms, Glandular and Epithelial
PubMed: 13453225
DOI: No ID Found -
Medical Molecular Morphology Jun 2014The recent classification of renal tumors is based on genetic evidence as well as on histologic features. Malignant tumor includes clear cell renal carcinoma (RCC),... (Review)
Review
The recent classification of renal tumors is based on genetic evidence as well as on histologic features. Malignant tumor includes clear cell renal carcinoma (RCC), multilocular cystic RCC, papillary RCC, chromophobe RCC, carcinoma of the collecting duct of Bellini, renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions and mucinous tubular and spindle cell carcinoma. Benign tumor is subdivided into papillary adenoma, renal oncocytoma and metanephric adenoma. Recently, new disease entities such as acquired cystic disease-associated RCC, clear cell papillary RCC and renal carcinoma with t(6;11)(p21:q12) have been discovered. In this article, we briefly review and introduce the clinical, morphological and genetic features of these tumor entities.
Topics: Histological Techniques; Humans; Kidney Neoplasms; Neoplasms, Glandular and Epithelial; World Health Organization
PubMed: 23529139
DOI: 10.1007/s00795-013-0033-0 -
Asia-Pacific Journal of Ophthalmology... 2017Lacrimal gland tumors are rare and constitute a wide spectrum of different entities ranging from benign epithelial and lymphoid lesions to high-grade carcinomas,... (Review)
Review
Lacrimal gland tumors are rare and constitute a wide spectrum of different entities ranging from benign epithelial and lymphoid lesions to high-grade carcinomas, lymphomas, and sarcomas with large differences in prognosis and clinical management. The symptoms and findings of a lacrimal gland lesion are a growing mass at the site of the lacrimal gland, including displacement of the eyeball, decreased motility, diplopia, and ptosis. Pain is the cardinal symptom of an adenoid cystic carcinoma. Radiological findings characteristically include an oval, well-demarcated mass for benign lesions whereas malignant lesions typically display calcifications, destruction of bone, and invasion of adjacent structures. The diagnosis ultimately relies on histology, as does the choice of treatment and the prognosis. In recent years, the understanding of the biology of numerous types of lacrimal gland neoplasia has improved and the choice of treatment has changed accordingly and holds further promise for future targeted therapies. Treatment of benign epithelial lesions is surgical excision whereas carcinomas often require adjuvant radiotherapy and/or chemotherapy. In contrast, the cornerstone in management of lymphoid lesions is chemotherapy, often including a monoclonal antibody. This article presents an update on the clinical, radiological, histological, and molecular features, along with treatment strategies for tumors of the lacrimal gland.
Topics: Combined Modality Therapy; Eye Neoplasms; Humans; Lacrimal Apparatus; Lacrimal Apparatus Diseases; Neoplasm Staging; Neoplasms, Glandular and Epithelial; Prognosis
PubMed: 28399336
DOI: 10.22608/APO.201707 -
A.M.A. Archives of Dermatology and... Jan 1952
Topics: Humans; Neoplasms, Glandular and Epithelial; Skin Neoplasms
PubMed: 14877304
DOI: No ID Found