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Journal of Cytology Jan 2013Myoepithelioma of the breast is very rare. Breast myoepithelioma can develop in women from their early 20s right up to their 80s, but it is most common in women over 50....
Myoepithelioma of the breast is very rare. Breast myoepithelioma can develop in women from their early 20s right up to their 80s, but it is most common in women over 50. We report a case of 20-year-old female, who presented with a well-defined breast lump of 3 × 3 cm in size. Fine needle aspiration was performed. The cytological findings revealed good cellularity comprising monomorphic loosely cohesive sheets of plasmacytoid, round to polygonal cells with round to ovoid eccentrically placed nuclei, finely dispersed chromatin, and moderate amount of cytoplasm. On the basis of cytological findings, a diagnosis of benign myoepithelioma (plasmacytoid type) was made which was confirmed on histopathologic examination. The breast is a very rare localization for this type of tumor. The benign character of the disease in conjunction with its slow progression could delay its detection and diagnosis. A detailed pathology examination is a prerequisite for avoidance of misleading diagnosis.
PubMed: 23661946
DOI: 10.4103/0970-9371.107518 -
Journal of Pharmacy & Bioallied Sciences Aug 2015Myoepithelioma is a benign salivary gland tumor in the head and neck region, accounting for 1-1.5% of all glandular tumors. The diagnosis is rendered...
Myoepithelioma is a benign salivary gland tumor in the head and neck region, accounting for 1-1.5% of all glandular tumors. The diagnosis is rendered histopathologically, and it includes the proliferation of myoepithelial cells, without chondroid or myxochondroid stroma and ductal components (up to 5% of ductal component is acceptable). In our case report, this lesion has occurred in a 46-year-old female patient, and presented as well defined, nodular growth on the right posterior palatal region. Bony erosion and invasion were observed radiographically, and the lesion was excised surgically, with 1-2 cm of clear margin. The microscopic features included proliferating tumor sheets, composed of bland looking spindle and plasmacytoid shaped myoepithelial cells, and few cells showed clear cytoplasm, which were confirmed immunohistochemically as myoepithelial cells. Thus, the final diagnosis of benign myoepithelioma was rendered and no recurrence had been reported so far in the regular follow-up.
PubMed: 26538968
DOI: 10.4103/0975-7406.163560 -
Archives of Pathology & Laboratory... Nov 2001This report describes a benign myoepithelioma of the lung that occurred in a 60-year-old woman. The patient had experienced hoarseness for 6 weeks, and a computed... (Review)
Review
This report describes a benign myoepithelioma of the lung that occurred in a 60-year-old woman. The patient had experienced hoarseness for 6 weeks, and a computed tomographic scan showed a nodule of approximately 2 cm in diameter at the peripheral portion of her right upper lung. Positron emission tomography showed no uptake of F-18 fluorodeoxyglucose in the nodule. Wedge biopsy of the lesion showed benign spindle cells arranged in a whorled pattern. The cells were positive for both cytokeratin and smooth muscle actin, which corresponded to the presence of tonofilaments and myofilaments that were identified ultrastructurally. The features of the present case of benign myoepithelioma that differ from features of previously reported benign and malignant cases of myoepithelioma in the lung are discussed in the report.
Topics: Actin Cytoskeleton; Actins; Biopsy; Cell Nucleus; Cytoplasm; Deoxyglucose; Female; Fluorine Radioisotopes; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Keratins; Lung Neoplasms; Middle Aged; Muscle, Smooth; Myoepithelioma; Tomography, Emission-Computed; Tomography, X-Ray Computed; Vimentin
PubMed: 11698012
DOI: 10.5858/2001-125-1494-BMOTL -
BMJ Case Reports Jun 2021Myoepitheliomas are rare benign tumours that affect the exocrine glands and are sporadically located in the salivary glands. The most common location of myoepithelioma...
Myoepitheliomas are rare benign tumours that affect the exocrine glands and are sporadically located in the salivary glands. The most common location of myoepithelioma in the oral cavity is the parotid gland and it is seldom encountered in the palate. The diagnosis of this entity is challenging since its clinical presentation may resemble those of more common neoplasms, rendering a complex histopathological diagnosis. The aim of the present case report is to describe an unusual case of myoepithelioma of the soft palate in a male patient, which developed as an asymptomatic, slowly growing mass. The tumour was assessed with histopathological examination and the diagnosis was verified via immunohistochemistry. Finally, the treatment included surgical resection of the tumour and no signs of recurrence were noted 2.5 years after the surgical procedure. Early diagnosis and treatment plays an important role in the prognosis of this pathological entity.
Topics: Humans; Immunohistochemistry; Male; Myoepithelioma; Neoplasm Recurrence, Local; Palate, Soft; Salivary Gland Neoplasms
PubMed: 34187791
DOI: 10.1136/bcr-2020-240384 -
Journal of Oral and Maxillofacial... Dec 2011
Review
Topics: Diagnosis, Differential; Humans; Male; Mandibular Neoplasms; Mouth Floor; Myoepithelioma; Salivary Gland Neoplasms; Salivary Glands, Minor; Tomography, X-Ray Computed; Young Adult
PubMed: 21507539
DOI: 10.1016/j.joms.2010.12.034 -
European Archives of... Mar 2005Myoepithelioma of the lacrimal gland is an extremely rare monomorphic adenoma, with only six previously reported cases in the literature. We herein report the... (Review)
Review
Myoepithelioma of the lacrimal gland is an extremely rare monomorphic adenoma, with only six previously reported cases in the literature. We herein report the radiological, clinical and histopathological evaluation of a 46-year-old patient with a history of right eye proptosis and progressive diplopia. A mass in the right lacrimal fossa was detected at MRI and turned out to be benign myoepithelioma of the lacrimal gland at the histopathological examination. The patient underwent excision of the mass by means of a coronal bitemporal approach and lateral orbitotomy. The lesion was entirely removed "en-bloc" with the lacrimal gland. MRI did not show any evidence of recurrent disease 12 months after surgery. The patient was clinically free of disease after 22 months. Surgery is the treatment of choice for this kind of lesion. The coronal bi-temporal approach herein reported offered good exposure of the entire lesion and a satisfactory aesthetic result. Periodic postoperative radiological evaluations with MRI are mandatory.
Topics: Eye Neoplasms; Humans; Lacrimal Apparatus; Magnetic Resonance Imaging; Male; Middle Aged; Myoepithelioma; Neoplasm Staging; Surgical Procedures, Operative
PubMed: 15138773
DOI: 10.1007/s00405-004-0787-z -
Journal of Dental Sciences Mar 2017Myoepithelioma is a rare form of salivary gland tumor composed entirely of myoepithelial cells. This tumor was formerly considered to be a subtype of pleomorphic...
Myoepithelioma is a rare form of salivary gland tumor composed entirely of myoepithelial cells. This tumor was formerly considered to be a subtype of pleomorphic adenoma; however, in the 1991 World Health Organization classification, it is listed as an independent entity. The most favorable site of occurrence of myoepithelioma is the parotid gland. Here, we report an extremely rare case of myoepithelioma of the upper lip. A 56-year-old woman presented with a painless mass on her upper lip. Magnetic resonance imaging revealed a 23 mm × 18 mm well-defined ovoid tumor. A benign minor salivary gland tumor was clinically suspected, and the patient underwent complete resection of the tumor under general anesthesia. The tumor was histopathologically diagnosed as a benign myoepithelioma of the minor salivary gland. Immunohistochemically, the tumor cells were positive for S-100 protein, AE1/AE3, CAM5.2, CK7, vimentin, and calponin, confirming the morphologic diagnosis of myoepithelioma. The patient's postoperative clinical course was uneventful, and satisfactory results were obtained both functionally and esthetically. To the best of our knowledge, this is the sixth case of myoepithelioma of the upper lip reported in English-language research.
PubMed: 30895031
DOI: 10.1016/j.jds.2013.02.020 -
Revue de Pneumologie Clinique Nov 2004Benign myoepithelioma of the lung is a benign tumor caused by proliferating myoepithelial cells with no ductal component. These tumors are exceptional: only three cases... (Review)
Review
Benign myoepithelioma of the lung is a benign tumor caused by proliferating myoepithelial cells with no ductal component. These tumors are exceptional: only three cases have been reported in the literature. We report a fourth case in a 37-year-old woman at 8 months gestation. Pathological proof of diagnosis was obtained.
Topics: Adult; Female; Humans; Lung Neoplasms; Myoepithelioma
PubMed: 15687912
DOI: 10.1016/s0761-8417(04)72114-8 -
The Annals of Otology, Rhinology, and... 1985Myoepithelial cells are integral components of normal salivary glands. Their active or passive participation in the histogenesis of several salivary gland tumors is a...
Myoepithelial cells are integral components of normal salivary glands. Their active or passive participation in the histogenesis of several salivary gland tumors is a debated issue. This debate notwithstanding, a rare form of salivary tumor composed entirely of myoepithelial cells exists and probably represents a monomorphic form of mixed tumor. This tumor, the myoepithelioma, occurs in most major and minor salivary tissues and is generally a biologically benign lesion.
Topics: Humans; Myoepithelioma; Salivary Gland Neoplasms; Salivary Glands
PubMed: 2996411
DOI: 10.1177/000348948509400523