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Der Internist May 2022Sarcoidosis and berylliosis (chronic beryllium disease, CBD) are granulomatous diseases and are phenocopies which cannot be differentiated based on the clinical... (Review)
Review
Sarcoidosis and berylliosis (chronic beryllium disease, CBD) are granulomatous diseases and are phenocopies which cannot be differentiated based on the clinical presentation. Whereas for sarcoidosis the eliciting agent is unknown, for berylliosis an exposure to beryllium (mostly as occupational exposure) can be confirmed that therefore induces a sensitization against beryllium. The diagnosis is generally made in patients with a typical clinical presentation, the histological proof of a non-necrotizing granuloma and the exclusion of other diseases causing granulomas. In most cases, granulomas can be detected in the lungs and/or (intrathoracic) lymph nodes. The proof of sensitization to beryllium for the differential diagnosis can be performed with a so-called beryllium lymphocyte proliferation test in peripheral mononuclear blood cells or cells from a bronchoalveolar lavage. The objectives of treatment are avoidance of functional organ impairment and symptom control. Immunosuppressive therapy (initially mostly with corticosteroids) and supportive measures can prove beneficial; however, in many cases clinical observation can be sufficient because of stable disease or spontaneous resolution. In addition, further beryllium exposure must be avoided, which mostly necessitates a change of the workplace.
Topics: Berylliosis; Beryllium; Granuloma; Humans; Lung; Sarcoidosis
PubMed: 35397695
DOI: 10.1007/s00108-022-01323-x -
CMAJ : Canadian Medical Association... Dec 2023
Topics: Humans; Middle Aged; Berylliosis; Metal Workers
PubMed: 38049163
DOI: 10.1503/cmaj.221680 -
Pneumologie (Stuttgart, Germany) Feb 2007Chronic Berylliosis (CB) is an occupational disorder which needs to be considered in the diagnostic work-up of granulomatous pulmonary diseases. Germany imports... (Review)
Review
Chronic Berylliosis (CB) is an occupational disorder which needs to be considered in the diagnostic work-up of granulomatous pulmonary diseases. Germany imports increasing amounts of beryllium which causes increased occupational exposure and this fact suggests that CB is underdiagnosed. Since CB is a perfect phenocopy of sarcoidosis, it is assumed that many cases are hidden in the cohort of sarcoidosis patients. This review presents the epidemiology, pathogenesis, diagnostics, and therapy of CB.
Topics: Berylliosis; Beryllium; Diagnosis, Differential; Germany; Humans; Sarcoidosis
PubMed: 17290317
DOI: 10.1055/s-2006-954984 -
Proceedings of the Royal Society of... Mar 1955
Topics: Berylliosis; Humans; Poisoning
PubMed: 14371570
DOI: No ID Found -
British Medical Journal May 1956
Topics: Berylliosis; Humans; Poisoning
PubMed: 13316118
DOI: No ID Found -
Cutis Mar 1990
Topics: Berylliosis; Dermatitis, Occupational; Humans
PubMed: 2138073
DOI: No ID Found -
Journal of the National Medical... May 1980
Topics: Aged; Berylliosis; Biopsy; Humans; Lung; Male; Occupational Diseases; Radiography
PubMed: 7381961
DOI: No ID Found -
Archivos de Bronconeumologia Jul 2020
Topics: Berylliosis; Beryllium; Humans; Leukocyte Disorders
PubMed: 32245543
DOI: 10.1016/j.arbres.2020.03.002 -
Scientific American Aug 1958
Topics: Berylliosis; Beryllium; Humans
PubMed: 13580272
DOI: 10.1038/scientificamerican0858-27 -
Stanford Medical Bulletin Aug 1952
Topics: Berylliosis; Beryllium; Humans
PubMed: 14958532
DOI: No ID Found