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The Journal of Nutrition Feb 1958
Topics: Biological Availability; Humans; Lysine
PubMed: 13526009
DOI: 10.1093/jn/64.2.259 -
Current Drug Delivery 2019
Topics: Biological Availability; Drug Delivery Systems; Gene Transfer Techniques; Nanotechnology; Vaccines
PubMed: 31603052
DOI: 10.2174/156720181607190917091556 -
The Journal of Allergy and Clinical... 2019
Topics: Biological Availability; Epinephrine; Healthy Volunteers; Humans
PubMed: 31056449
DOI: 10.1016/j.jaip.2019.03.037 -
Archives of Biochemistry Mar 1947
Topics: Ascorbic Acid; Biological Availability; Humans; Palmitates; Palmitic Acid
PubMed: 20291025
DOI: No ID Found -
The Journal of Nutrition Jan 1952
Topics: Biological Availability; Food; Riboflavin; Vitamin A Deficiency
PubMed: 14908679
DOI: 10.1093/jn/46.1.45 -
Arzneimittel-Forschung Jul 1975The term "bioavailability" is used to describe the actual percentage of a drug released from the dosage form, which reaches the receptor site in sufficient quantity to...
The term "bioavailability" is used to describe the actual percentage of a drug released from the dosage form, which reaches the receptor site in sufficient quantity to induce a biological effect. In this connection there are many problems arising in conjunction with the formulation of the preparation, as well as through the interaction of physiological and pathological factors. Prerequisite to the bioavailability of an orally administered preparation is, firstly, the quick disintegration of the dosage form, and secondly, the release and dissolution of the active substance. No in vitro methods for the examination of these factors have as yet been evolved which would allow a reliable prediction of bioavailability in man. Animal experiments only permit limited prognoses, since numerous influential factors, such as absorption from the intestine, metabolism and metabolic rates, influence of physical and mental stress, etc., strongly dependent upon the species. Bioavailability is determined using pharmacokinetical techniques on the area affected by the dose-response curve, or a combination of these methods.
Topics: Administration, Oral; Biological Availability; Biopharmaceutics; Humans; Kinetics; Pharmaceutical Preparations
PubMed: 1242346
DOI: No ID Found -
The Journal of Nutrition Mar 1949
Topics: Biological Availability; Biological Products; Bone and Bones; Calcium; Calcium Compounds; Humans; Minerals
PubMed: 18112987
DOI: 10.1093/jn/37.3.369 -
Nature Chemistry Jul 2018
Topics: Biological Availability; Drug Discovery; Macrocyclic Compounds; Protein Interaction Maps
PubMed: 29930271
DOI: 10.1038/s41557-018-0095-7 -
Drug Development and Industrial Pharmacy May 2017
Topics: Administration, Oral; Biological Availability; Humans
PubMed: 28253737
DOI: 10.1080/03639045.2017.1290865 -
Molecules (Basel, Switzerland) Sep 2023Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations... (Review)
Review
Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance the metabolic stability, bioavailability, and protein-binding affinity of natural carbohydrates. In this review, the fluorination methods used to prepare the fluorinated carbohydrates, the effects of fluorination on the physical, chemical, and biological characteristics of natural sugars, and the biological activities of fluorinated sugars are presented.
Topics: Fluorine; Drug Discovery; Carbohydrates; Sugars; Biological Availability; Halogenation
PubMed: 37764416
DOI: 10.3390/molecules28186641