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Indian Journal of Gastroenterology :... Jun 2020Health research is essential for improving global health, health equity, and economic development. There are vast differences in the disease burden, research budget... (Review)
Review
Health research is essential for improving global health, health equity, and economic development. There are vast differences in the disease burden, research budget allocation, and scientific publications between the developed and the low-middle-income countries, which are the homes of 85% of the world's population. There are multiple challenges, as well as opportunities for health research in developing countries. One of the primary reasons for reduced research output from the developing countries is the lack of research capacity. Many developing countries are striving to build their research capacity. They are trying to understand their needs and goals to solve their fundamental health problems, but the opportunity for research education and training remains low. The first joint research meeting of the Bangladesh Gastroenterology Society and the British Society of Gastroenterology took place in February 2020 at the Bangabandhu Sheikh Mujib Medical University in Dhaka, Bangladesh, aimed at providing an overview of medical research for young, aspiring medical researchers. This review article provides an outline of the research day and covers a number of useful topics. This review aims to provide a basic guide for early career researchers, both within the field of gastroenterology and, more generally, to all spheres of medical research.
Topics: Bangladesh; Biomedical Research; Developing Countries; Gastroenterology; Humans; Neoplasms
PubMed: 32607962
DOI: 10.1007/s12664-020-01056-5 -
Nature Neuroscience Dec 2013
Topics: Biomedical Research; Cooperative Behavior; Government Regulation; Humans; Italy
PubMed: 24270267
DOI: 10.1038/nn.3595 -
Medicina Clinica Aug 2018
Topics: Animals; Biomedical Research; Biostatistics; Cell Line; Humans; Peer Review, Research; Reproducibility of Results; Translational Research, Biomedical
PubMed: 29496238
DOI: 10.1016/j.medcli.2017.12.013 -
Nigerian Journal of Clinical Practice Dec 2015Unregulated biomedical research has previously caused untold suffering to humankind. History is full of examples of abuse of animal and human subjects for research.... (Review)
Review
Unregulated biomedical research has previously caused untold suffering to humankind. History is full of examples of abuse of animal and human subjects for research. Several codes and instruments have been formulated to regulate biomedical research. In Kenya, the Science, Technology and Innovation Act, 2014, together with the Constitution of Kenya, 2010, provide a fairly robust legal framework. Possible challenges include capacity building, overlap of functions of institutions, monitoring and evaluation, scientific/technological advances, intellectual property rights, funding for research, and dispute resolution. It is hoped that the new legislation will adequately address these challenges.
Topics: Animals; Bioethics; Biomedical Research; Humans; Kenya; Technology
PubMed: 26620619
DOI: 10.4103/1119-3077.170819 -
Protein Science : a Publication of the... Jan 2018The Protein Data Bank (PDB) is one of two archival resources for experimental data central to biomedical research and education worldwide (the other key Primary Data... (Review)
Review
The Protein Data Bank (PDB) is one of two archival resources for experimental data central to biomedical research and education worldwide (the other key Primary Data Archive in biology being the International Nucleotide Sequence Database Collaboration). The PDB currently houses >134,000 atomic level biomolecular structures determined by crystallography, NMR spectroscopy, and 3D electron microscopy. It was established in 1971 as the first open-access, digital-data resource in biology, and is managed by the Worldwide Protein Data Bank partnership (wwPDB; wwpdb.org). US PDB operations are conducted by the RCSB Protein Data Bank (RCSB PDB; RCSB.org; Rutgers University and UC San Diego) and funded by NSF, NIH, and DoE. The RCSB PDB serves as the global Archive Keeper for the wwPDB. During calendar 2016, >591 million structure data files were downloaded from the PDB by Data Consumers working in every sovereign nation recognized by the United Nations. During this same period, the RCSB PDB processed >5300 new atomic level biomolecular structures plus experimental data and metadata coming into the archive from Data Depositors working in the Americas and Oceania. In addition, RCSB PDB served >1 million RCSB.org users worldwide with PDB data integrated with ∼40 external data resources providing rich structural views of fundamental biology, biomedicine, and energy sciences, and >600,000 PDB101.rcsb.org educational website users around the globe. RCSB PDB resources are described in detail together with metrics documenting the impact of access to PDB data on basic and applied research, clinical medicine, education, and the economy.
Topics: Biomedical Research; Databases, Protein; Humans
PubMed: 29067736
DOI: 10.1002/pro.3331 -
Semergen Mar 2019Studies of research with human beings, their biological specimens, or their personal data in the field of biomedicine have been subject to regulation since the middle of... (Review)
Review
Studies of research with human beings, their biological specimens, or their personal data in the field of biomedicine have been subject to regulation since the middle of the last century. Initially a regulation based on recommendations such as the Nuremberg Code, the Belmont Report or the first versions of the Declaration of Helsinki. All of them documents in which the principles (autonomy, beneficence, non-maleficence, and justice) were conceptualized, and that all researchers had to follow in the development of their research. This first phase is known as a period of self-regulation, because it is considered that the researchers themselves could, by following these recommendations, carry out their investigations without further control. Subsequently, it went through a clearly regulatory period in which the premises of these recommendations were progressively incorporated into the legal system of the different countries, and with this, arose the external control of the investigation by the administrations and other bodies, such as the Research Ethics Committees. The purpose of this article is to serve as a guide to professionals whose main activity is care in the field of Primary Care and who, in turn, are interested in initiating research studies to respond to uncertainties in the context of their daily activity that may arise.
Topics: Biomedical Research; Guidelines as Topic; Humans
PubMed: 30541705
DOI: 10.1016/j.semerg.2018.06.005 -
Nature Medicine Nov 2023The coproduction of health research represents an important advance in the realm of participatory methodologies, which have evolved over the past five decades. This... (Review)
Review
The coproduction of health research represents an important advance in the realm of participatory methodologies, which have evolved over the past five decades. This transition to a collaborative approach emphasizes shared control between academic researchers and their partners, fostering a more balanced influence on the research process. This shift not only enhances the quality of the research and the evidence generated, but also increases the likelihood of successful implementation. For Indigenous peoples, coproduced research represents a critical development, enabling a shift from being mere 'subjects' of research to being active controllers of the process-including addressing the extractive and oppressive practices of the past. In this Review, we explore how research coproduction with Indigenous peoples is evolving. An 'Indigenous turn' embraces the concept of shared control while also considering the principles of reciprocity, the incommensurability of Western and Indigenous knowledge systems, divergent ethical standards, strategic and political differences, and the broader impact of processes and outcomes. To illustrate these ideas, we present examples involving New Zealand's Māori communities and offer recommendations for further progress.
Topics: Humans; Indigenous Peoples; Maori People; Biomedical Research; Patient Participation
PubMed: 37946057
DOI: 10.1038/s41591-023-02588-x -
Journal of the College of Physicians... Sep 2011
Topics: Biomedical Research; Humans; Mentors; Organizational Culture; Pakistan
PubMed: 21914404
DOI: No ID Found -
Nursing Standard (Royal College of... Jul 2015This article which forms part of the research series addresses scientific rigour in quantitative research. It explores the basis and use of quantitative research and the... (Review)
Review
This article which forms part of the research series addresses scientific rigour in quantitative research. It explores the basis and use of quantitative research and the nature of scientific rigour. It examines how the reader may determine whether quantitative research results are accurate, the questions that should be asked to determine accuracy and the checklists that may be used in this process. Quantitative research has advantages in nursing, since it can provide numerical data to help answer questions encountered in everyday practice.
Topics: Biomedical Research; Humans
PubMed: 26198528
DOI: 10.7748/ns.29.47.43.e8820 -
Cancer Control : Journal of the Moffitt... 2019
Topics: Biomedical Research; Forecasting; Humans; Neoplasms; Vietnam
PubMed: 31343929
DOI: 10.1177/1073274819866556