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Molecules (Basel, Switzerland) Mar 2022Molecular dynamics (MD) simulations have led to great advances in many scientific disciplines, such as chemical physics, materials science, and biophysics [...].
Molecular dynamics (MD) simulations have led to great advances in many scientific disciplines, such as chemical physics, materials science, and biophysics [...].
Topics: Biophysics; Molecular Dynamics Simulation
PubMed: 35408504
DOI: 10.3390/molecules27072105 -
Annual Review of Biophysics May 2023Mitochondria are involved in multiple cellular tasks, such as ATP synthesis, metabolism, metabolite and ion transport, regulation of apoptosis, inflammation, signaling,... (Review)
Review
Mitochondria are involved in multiple cellular tasks, such as ATP synthesis, metabolism, metabolite and ion transport, regulation of apoptosis, inflammation, signaling, and inheritance of mitochondrial DNA. The majority of the correct functioning of mitochondria is based on the large electrochemical proton gradient, whose component, the inner mitochondrial membrane potential, is strictly controlled by ion transport through mitochondrial membranes. Consequently, mitochondrial function is critically dependent on ion homeostasis, the disturbance of which leads to abnormal cell functions. Therefore, the discovery of mitochondrial ion channels influencing ion permeability through the membrane has defined a new dimension of the function of ion channels in different cell types, mainly linked to the important tasks that mitochondrial ion channels perform in cell life and death. This review summarizes studies on animal mitochondrial ion channels with special focus on their biophysical properties, molecular identity, and regulation. Additionally, the potential of mitochondrial ion channels as therapeutic targets for several diseases is briefly discussed.
Topics: Animals; Mitochondria; Ion Channels; Signal Transduction; Biophysics
PubMed: 37159294
DOI: 10.1146/annurev-biophys-092622-094853 -
IISE Transactions on Occupational... 2022OCCUPATIONAL APPLICATIONSHeavy deadlifting is used as a screening tool or training protocol for recruitment and retention in physically-demanding occupations, especially... (Review)
Review
OCCUPATIONAL APPLICATIONSHeavy deadlifting is used as a screening tool or training protocol for recruitment and retention in physically-demanding occupations, especially in the military. Spinal loads experienced during heavy deadlifts, particularly shearing forces, are well above recommended thresholds for lumbar spine injury in occupational settings. Although members of the noted occupation likely have stronger musculoskeletal systems compared to the general population, experiencing shearing forces that are 2 to 4 times larger than the threshold of injury, particularly under repetitive deadlift, may transform a screening tool or training protocol to an occupationally-harmful physical activity.
Topics: Biomechanical Phenomena; Biophysics; Humans; Spine
PubMed: 34875981
DOI: No ID Found -
Biochimica Et Biophysica Acta.... Feb 2022
Topics: Biophysics; History, 20th Century; History, 21st Century; Humans
PubMed: 34856128
DOI: 10.1016/j.bbamem.2021.183827 -
Science (New York, N.Y.) Apr 2021Measuring the dynamics of neural processing across time scales requires following the spiking of thousands of individual neurons over milliseconds and months. To address...
Measuring the dynamics of neural processing across time scales requires following the spiking of thousands of individual neurons over milliseconds and months. To address this need, we introduce the Neuropixels 2.0 probe together with newly designed analysis algorithms. The probe has more than 5000 sites and is miniaturized to facilitate chronic implants in small mammals and recording during unrestrained behavior. High-quality recordings over long time scales were reliably obtained in mice and rats in six laboratories. Improved site density and arrangement combined with newly created data processing methods enable automatic post hoc correction for brain movements, allowing recording from the same neurons for more than 2 months. These probes and algorithms enable stable recordings from thousands of sites during free behavior, even in small animals such as mice.
Topics: Action Potentials; Algorithms; Animals; Brain; Electrodes, Implanted; Electrophysiology; Male; Mice; Mice, Inbred C57BL; Microelectrodes; Miniaturization; Neurons; Rats
PubMed: 33859006
DOI: 10.1126/science.abf4588 -
Developmental Cell Jan 2021
Topics: Animals; Biophysics; Humans; Mechanotransduction, Cellular; Models, Biological
PubMed: 33497619
DOI: 10.1016/j.devcel.2021.01.004 -
Developmental Cell Jan 2021Mechanical forces are integral to development-from the earliest stages of embryogenesis to the construction and differentiation of complex organs. Advances in imaging... (Review)
Review
Mechanical forces are integral to development-from the earliest stages of embryogenesis to the construction and differentiation of complex organs. Advances in imaging and biophysical tools have allowed us to delve into the developmental mechanobiology of increasingly complex organs and organisms. Here, we focus on recent work that highlights the diversity and importance of mechanical influences during morphogenesis. Developing tissues experience intrinsic mechanical signals from active forces and changes to tissue mechanical properties as well as extrinsic mechanical signals, including constraint and compression, pressure, and shear forces. Finally, we suggest promising avenues for future work in this rapidly expanding field.
Topics: Animals; Biomechanical Phenomena; Biophysics; Cell Differentiation; Embryonic Development; Humans; Mechanotransduction, Cellular; Morphogenesis; Signal Transduction
PubMed: 33321105
DOI: 10.1016/j.devcel.2020.11.025 -
Biochimica Et Biophysica Acta.... Jan 2020
Topics: Biophysics; Cell Membrane; Membrane Proteins
PubMed: 31810503
DOI: 10.1016/j.bbamem.2019.183116 -
Biophysical Journal Oct 2022
Topics: Biophysical Phenomena; Biophysics; Humans; Neoplasms
PubMed: 36152633
DOI: 10.1016/j.bpj.2022.09.017 -
Frontiers in Immunology 2021
Topics: Animals; Biophysical Phenomena; Biophysics; Humans; Immunity, Cellular; Membranes; Signal Transduction
PubMed: 34630421
DOI: 10.3389/fimmu.2021.740373