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Transfusion Medicine Reviews Jan 2009Preserving cell viability and function is an essential component in the translation and delivery of existing and emerging cell-based therapeutics from the research lab... (Review)
Review
Preserving cell viability and function is an essential component in the translation and delivery of existing and emerging cell-based therapeutics from the research lab to the patient bedside. This workshop provided a summary of the advances and challenges that currently face the preservation sciences, together with a glimpse at the future applications and instrumentation that will enhance our ability to process, preserve, and store red blood cells (RBCs), platelets, and stem cells. It is clear from the presentations made during the workshop and the discussions that ensued after that, for us to overcome the challenges that face blood biopreservation, it will require a concerted effort from clinicians, scientists, and engineers from a variety of disciplines. Through this interdisciplinary research effort, significant progress will be made to improve the safety, quality, and potency of the blood products that are used in reparative medicine. As the need for effective preservation technologies will be the motivation for more concerted efforts in the biopreservation sciences, there are encouraging prospects for the future applications of biopreserved blood cells.
Topics: Blood Platelets; Blood Preservation; Education; Erythrocytes; Humans; Stem Cells
PubMed: 19056032
DOI: 10.1016/j.tmrv.2008.09.003 -
Critical Reviews in Clinical Laboratory... 1987For several decades the standard blood preservative solution consisted of citrate, dextrose, and, later, phosphate (ACD and CPD). In 1978 a new solution containing... (Review)
Review
For several decades the standard blood preservative solution consisted of citrate, dextrose, and, later, phosphate (ACD and CPD). In 1978 a new solution containing adenine (CPDA-1) was introduced to permit extension of red cell shelf life from 21 to 35 days. The success of CPDA-1 and the high percentage of blood units processed into components (estimated 87% in 1983) have stimulated a burst of research and development activity to develop improved red cell preservation systems. Most of these systems have taken the form of "additive solutions" in which the blood is drawn in CPD or CP2D and processed into components. Then the packed red cells are stored by addition of a solution customized for their preservation. This review evaluates these additive solutions in detail. Innovative systems for pH control (buffers and resins) have also been explored. Our review concludes with discussion of the safety aspects of new preservative solutions and the methodological problems of evaluating these solutions.
Topics: Blood Preservation; Erythrocytes; Humans
PubMed: 3315464
DOI: 10.3109/10408368709105883 -
The New England Journal of Medicine Mar 1978
Topics: Animals; Blood Preservation; Erythrocytes; Freezing; Hepatitis B; Humans; Pan troglodytes; Transfusion Reaction
PubMed: 628390
DOI: 10.1056/NEJM197803232981209 -
The Lancet. Haematology Dec 2016
Topics: Blood Preservation; Blood Transfusion; Humans; Practice Guidelines as Topic
PubMed: 27890071
DOI: 10.1016/S2352-3026(16)30172-7 -
Vox Sanguinis 1985
Topics: Adenine; Blood Preservation; History, 20th Century; Humans
PubMed: 3887751
DOI: 10.1111/j.1423-0410.1985.tb00190.x -
Transfusion and Apheresis Science :... Feb 2014Blood conservation, or Patient Blood Management (PBM), is a paradigm shift in transfusion practice. Recognizing the potential adverse effects associated with blood... (Review)
Review
Blood conservation, or Patient Blood Management (PBM), is a paradigm shift in transfusion practice. Recognizing the potential adverse effects associated with blood transfusion, PBM emphasises the use of alternatives to transfusion in order to minimize unnecessary or inappropriate blood transfusion. The ONTraC program is a network of transfusion coordinators in 25 Ontario hospitals with the focus of implementing PBM. The program has been highly successful in reducing transfusion rates and improving clinical outcomes, and has proven very cost-effective. This paper summarizes results of the program from its inception in 2002-2011.
Topics: Anemia; Blood Banks; Blood Preservation; Blood Transfusion; Cost-Benefit Analysis; Female; Hospitals; Humans; Male; Ontario; Perioperative Period; Time Factors; Treatment Outcome
PubMed: 24388485
DOI: 10.1016/j.transci.2013.12.010 -
Seminars in Thoracic and Cardiovascular... Oct 1990The importance of blood conservation to minimize homologous blood use after cardiac surgery is well-accepted. The most successful programs to this end are the products... (Review)
Review
The importance of blood conservation to minimize homologous blood use after cardiac surgery is well-accepted. The most successful programs to this end are the products of an integrated approach to blood conservation that begins with preoperative patient screening and carries through the postoperative period. Salvage and reinfusion of shed blood both intra- and postoperatively are important components of any such program. Other practices that help reduce blood loss and decrease the use of banked blood are also important. It is the combination of techniques and a consistent philosophy regarding the importance of blood conservation that will yield the best results. Programs that decrease the use of banked blood help today's cardiac surgeon provide safer, less costly operations for his or her patients.
Topics: Blood Banks; Blood Loss, Surgical; Blood Preservation; Blood Transfusion, Autologous; Cardiac Surgical Procedures; Humans
PubMed: 2091795
DOI: No ID Found -
Transfusion Clinique Et Biologique :... Nov 2018Blood products are issued from blood collection. Collected blood is immediately mixed with anticoagulant solutions that immediately induce chemical and/or biochemical... (Review)
Review
Blood products are issued from blood collection. Collected blood is immediately mixed with anticoagulant solutions that immediately induce chemical and/or biochemical modifications. Collected blood is then transformed into different blood products according to various steps of fabrication. All these steps induce either reversible or irreversible "preparation-related" lesions that combine with "storage-related" lesions. This short paper aims to provide an overview of the alterations that are induced by the "non-physiological" processes used to prepare blood products that are used in clinical practice.
Topics: Animals; Blood Banks; Blood Preservation; Blood Transfusion; Humans; Transfusion Reaction; Blood Banking
PubMed: 30241785
DOI: 10.1016/j.tracli.2018.08.162 -
Vox Sanguinis Jul 2014Blood banking underpins modern medical care, but blood storage, necessary for testing and inventory management, reduces the safety and efficacy of individual units of... (Review)
Review
Blood banking underpins modern medical care, but blood storage, necessary for testing and inventory management, reduces the safety and efficacy of individual units of red blood cells (RBCs). Stored RBCs are damaged by the accumulation of their own waste products, by enzymatic and oxidative injury, and by metabolically programmed cell death. These chemical activities lead to a complex RBC storage lesion that includes haemolysis, reduced in vivo recovery, energy and membrane loss, altered oxygen release, reduced adenosine tri-phosphate and nitric oxide secretion, and shedding of toxic products. These toxic products include lysophospholipids that can cause transfusion-related acute lung injury, free iron that can potentiate infections and cause inflammation, and shed microvesicles that can scavenge nitric oxide and potentiate inflammation and thrombosis. However, most of the obvious negative outcomes of RBC storage are uncommon and appear to be related to exceptionally bad units. Generally, the quality of stored RBCs is highly related to the conditions of storage, so refrigerator temperature, intact bags, residual leucocyte counts and visible haemolysis remain excellent general measures. Specific biochemical measures, such as adenosine 5'-triphosphate (ATP) and 2,3-diphosphoglycerate (DPG) concentrations, calcium and potassium content or lipid breakdown products, require specialized measures that are not widely available, involve destructive testing and generally reflect only a part of the storage lesion. This review describes a number of components of the storage lesion and their measurement and attempts to access the utility of the measures.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Blood Preservation; Erythrocytes; Hemolysis; Humans; Oxygen; Quality Control; Time Factors
PubMed: 24446817
DOI: 10.1111/vox.12130 -
Blood Transfusion = Trasfusione Del... Jul 2017Since the advent of anticoagulation and component storage of human blood products, allogeneic red blood cell transfusion has been one of the most common practices in... (Review)
Review
Since the advent of anticoagulation and component storage of human blood products, allogeneic red blood cell transfusion has been one of the most common practices in modern medicine. Efforts to reduce the biochemical effects of storage, collectively known as the red blood cell storage lesion, and prolong the storage duration have led to numerous advancements in erythrocyte storage solutions. Cryopreservation and frozen storage of red blood cells in glycerol have been successfully utilised by many civilian and military institutions worldwide. Through progressive improvements in liquid storage of erythrocytes in novel storage solutions, the logistical need for cryopreserved red blood cells in the civilian setting has diminished. A growing body of current literature is focused on the clinical consequences of packed red blood cell age. Modern cryopreservation techniques show promise as a cost-effective method to ameliorate the negative effect of the red blood cell storage lesion, while meeting the technical and logistical needs of both civilian and military medicine. This review outlines the history of red blood cell cryopreservation, the clinical impact of red cell storage, and highlights the current literature on frozen blood and its impact on modern transfusion.
Topics: Blood Preservation; Cryopreservation; Erythrocyte Transfusion; Erythrocytes; Humans
PubMed: 27643751
DOI: 10.2450/2016.0083-16