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Science (New York, N.Y.) Dec 2009Elucidating the biogeography of bacterial communities on the human body is critical for establishing healthy baselines from which to detect differences associated with...
Elucidating the biogeography of bacterial communities on the human body is critical for establishing healthy baselines from which to detect differences associated with diseases. To obtain an integrated view of the spatial and temporal distribution of the human microbiota, we surveyed bacteria from up to 27 sites in seven to nine healthy adults on four occasions. We found that community composition was determined primarily by body habitat. Within habitats, interpersonal variability was high, whereas individuals exhibited minimal temporal variability. Several skin locations harbored more diverse communities than the gut and mouth, and skin locations differed in their community assembly patterns. These results indicate that our microbiota, although personalized, varies systematically across body habitats and time; such trends may ultimately reveal how microbiome changes cause or prevent disease.
Topics: Adult; Bacteria; Biodiversity; Cluster Analysis; DNA, Bacterial; DNA, Ribosomal; Ear Canal; Feces; Female; Genes, rRNA; Hair; Humans; Male; Metagenome; Middle Aged; Mouth; Nose; Phylogeny; Principal Component Analysis; RNA, Ribosomal, 16S; Skin; Time Factors
PubMed: 19892944
DOI: 10.1126/science.1177486 -
Journal of Educational Evaluation For... 2021This review aims to define the 4 types of the metaverse and to explain the potential and limitations of its educational applications. The metaverse roadmap categorizes... (Review)
Review
This review aims to define the 4 types of the metaverse and to explain the potential and limitations of its educational applications. The metaverse roadmap categorizes the metaverse into 4 types: augmented reality, lifelogging, mirror world, and virtual reality. An example of the application of augmented reality in medical education would be an augmented reality T-shirt that allows students to examine the inside of the human body as an anatomy lab. Furthermore, a research team in a hospital in Seoul developed a spinal surgery platform that applied augmented reality technology. The potential of the metaverse as a new educational environment is suggested to be as follows: a space for new social communication; a higher degree of freedom to create and share; and the provision of new experiences and high immersion through virtualization. Some of its limitations may be weaker social connections and the possibility of privacy impingement; the commission of various crimes due to the virtual space and anonymity of the metaverse; and maladaptation to the real world for students whose identity has not been established. The metaverse is predicted to change our daily life and economy beyond the realm of games and entertainment. The metaverse has infinite potential as a new social communication space. The following future tasks are suggested for the educational use of the metaverse: first, teachers should carefully analyze how students understand the metaverse; second, teachers should design classes for students to solve problems or perform projects cooperatively and creatively; third, educational metaverse platforms should be developed that prevent misuse of student data.
Topics: Communication; Education, Medical; Humans; Virtual Reality
PubMed: 34897242
DOI: 10.3352/jeehp.2021.18.32 -
Indian Journal of Dermatology 2017Evolutionarily, man is a terrestrial mammal, adapted to land. Aviation and now space/microgravity environment, hence, pose new challenges to our physiology. Exposure to...
Evolutionarily, man is a terrestrial mammal, adapted to land. Aviation and now space/microgravity environment, hence, pose new challenges to our physiology. Exposure to these changes affects the human body in acute and chronic settings. Since skin reflects our mental and physical well-being, any change/side effects of this environment shall be detected on the skin. Aerospace industry offers a unique environment with a blend of all possible occupational disorders, encompassing all systems of the body, particularly the skin. Aerospace dermatologists in the near future shall be called upon for their expertise as we continue to push human physiological boundaries with faster and more powerful military aircraft and look to colonize space stations and other planets. Microgravity living shall push dermatology into its next big leap-space, the final frontier. This article discusses the physiological effects of this environment on skin, effect of common dermatoses in aerospace environment, effect of microgravity on skin, and occupational hazards of this industry.
PubMed: 28216729
DOI: 10.4103/0019-5154.198051 -
Korean Journal of Family Medicine Nov 2020One-third of the global population aged 15 years and older engages in insufficient physical activities, which affects health. However, the health risks posed by...
One-third of the global population aged 15 years and older engages in insufficient physical activities, which affects health. However, the health risks posed by sedentary behaviors are not well known. The mean daily duration of sedentary behavior is 8.3 hours among the Korean population and 7.7 hours among the American adult population. Sedentary lifestyles are spreading worldwide because of a lack of available spaces for exercise, increased occupational sedentary behaviors such as office work, and the increased penetration of television and video devices. Consequently, the associated health problems are on the rise. A sedentary lifestyle affects the human body through various mechanisms. Sedentary behaviors reduce lipoprotein lipase activity, muscle glucose, protein transporter activities, impair lipid metabolism, and diminish carbohydrate metabolism. Furthermore, it decreases cardiac output and systemic blood flow while activating the sympathetic nervous system, ultimately reducing insulin sensitivity and vascular function. It also alters the insulin-like growth factor axis and the circulation levels of sex hormones, which elevates the incidence of hormone-related cancers. Increased sedentary time impairs the gravitostat, the body's weight homeostat, and weight gain, adiposity, and elevated chronic inflammation caused by sedentary behavior are risk factors for cancer. Sedentary behaviors have wide-ranging adverse impacts on the human body including increased all-cause mortality, cardiovascular disease mortality, cancer risk, and risks of metabolic disorders such as diabetes mellitus, hypertension, and dyslipidemia; musculoskeletal disorders such as arthralgia and osteoporosis; depression; and, cognitive impairment. Therefore, reducing sedentary behaviors and increasing physical activity are both important to promote public health.
PubMed: 33242381
DOI: 10.4082/kjfm.20.0165 -
Regenerative Therapy Dec 2023The human body experiences constant stimulation from Earth's gravity, and the absence of gravity leads to various impacts at the cellular and tissue levels. Simulated... (Review)
Review
The human body experiences constant stimulation from Earth's gravity, and the absence of gravity leads to various impacts at the cellular and tissue levels. Simulated microgravity (s-μg) has been employed on Earth to investigate these effects, circumventing the challenges of conducting experiments in space and providing an opportunity to understand the influence of microgravity on living organisms. Research focusing on stem cells and utilizing s-μg has enhanced our understanding of how microgravity affects stem cell morphology, migration, proliferation, and differentiation. Studies have used systems such as rotating wall vessels, random positioning machines, and clinostats. By uncovering the mechanisms underlying the observed changes in these studies, there is potential to identify therapeutic targets that regulate stem cell function and explore a range of applications, including stem cell-based regenerative medicine. This review will focus on the features of each device designed to simulate microgravity on Earth, as well as the stem cell experiments performed with those devices.
PubMed: 37662695
DOI: 10.1016/j.reth.2023.08.001 -
Nanomaterials (Basel, Switzerland) Oct 2022Space represents one of the most dangerous environments for humans, which can be affected by high stress levels. This can lead to severe physiological problems, such as... (Review)
Review
Space represents one of the most dangerous environments for humans, which can be affected by high stress levels. This can lead to severe physiological problems, such as headaches, gastrointestinal disorders, anxiety, hypertension, depression, and coronary heart diseases. During a stress condition, the human body produces specific hormones, such as dopamine, adrenaline, noradrenaline, and cortisol. In particular, the control of cortisol levels can be related to the stress level of an astronaut, particularly during a long-term space mission. The common analytical methods (HPLC, GC-MS) cannot be used in an extreme environment, such as a space station, due to the steric hindrance of the instruments and the absence of gravity. For these reasons, the development of smart sensing devices with a and fast analytical protocol can be extremely useful for space applications. This review summarizes the recent (from 2011) miniaturized sensoristic devices based on nanomaterials (gold and carbon nanoparticles, nanotubes, nanowires, nano-electrodes), which allow rapid and real-time analyses of cortisol levels in biological samples (such as saliva, urine, sweat, and plasma), to monitor the health conditions of humans under extreme stress conditions.
PubMed: 36364563
DOI: 10.3390/nano12213790