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Neurology India 2022
Topics: Bone Cysts, Aneurysmal; Craniofacial Fibrous Dysplasia; Fibrous Dysplasia of Bone; Humans; Tomography, X-Ray Computed
PubMed: 35263877
DOI: 10.4103/0028-3886.338729 -
The Pan African Medical Journal 2013The aneurysmal bone cyst is a pseudotumoral lesion that can take several aspects. This is a rare lesion representing 1% of bone tumors. It appears usually during the... (Review)
Review
The aneurysmal bone cyst is a pseudotumoral lesion that can take several aspects. This is a rare lesion representing 1% of bone tumors. It appears usually during the first 30 years of life. The pathogenesis is that of a process of "dysplasia/hyperplasia", favored by a circulatory deficiency and hemorrhage within the lesion and the phenomena of osteoclasis. The objective of this work is to illustrate with analysis, the specific forms and atypical aneurysmal bone cyst which often pose a diagnostic challenge requiring radiological investigation with histological confirmation. We report eight pediatric cases of aneurysmal cysts collected over a period of 3 years, 3 boys and 5 girls. All patients had standard radiographs. MRI was performed in three patients. The diagnosis was confirmed histologically. The atypia has been in the seat: fibula (1 case), metaphyseal (2 cases), diaphyseal (4 cases) and metatarsal (1 case). Aneurysmal bone cyst is a rare benign tumor with predilection to the metaphysis of long bones. Atypical forms even fewer are dominated by the atypical seat.
Topics: Adolescent; Bone Cysts, Aneurysmal; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Male; Radiography
PubMed: 24244797
DOI: 10.11604/pamj.2013.15.111.2117 -
Turk Patoloji Dergisi 2015Bone cysts are benign lesions occurring in any bone, regardless of age. They are often asymptomatic but may cause pain, swelling, fractures, and local recurrence and may... (Comparative Study)
Comparative Study
OBJECTIVE
Bone cysts are benign lesions occurring in any bone, regardless of age. They are often asymptomatic but may cause pain, swelling, fractures, and local recurrence and may be confused with other bone lesions.
MATERIAL AND METHOD
We retrospectively re-evaluated 143 patients diagnosed with aneurysmal bone cyst (n=98, 68.5%), solitary bone cysts (n=17 11.9%), pseudocyst (n=10.7%), intraosseous ganglion (n=3, 2.1%), hydatid cyst (n=2; 1.4), epidermoid cyst (n=1, 0.7%) and cysts demonstrating "mixed" aneurysmal-solitary bone cyst histology (n=12, 8.4%), and compared them with nonparametric tests.
RESULTS
Aneurysmal bone cyst, solitary bone cysts and mixed cysts were frequently seen in the first two decades of life while the others occurred after the fourth decade. Aneurysmal bone cysts, intraosseous ganglion and pseudocysts were more common in women contrary to solitary bone cyst and mixed cysts (the female/male ratio was 1.22, 2 and 1.5 versus 0.7 and 0.5, respectively). Aneurysmal bone cyst, solitary bone cysts and "mixed" cysts were mostly seen in long bones, predominantly the femur, while epidermoid, hydatid and pseudocysts were all seen in flat bones like the vertebra, pelvis and mandible (p=0.001, chi-square). Repeat biopsies were performed in 19 cases (13.3%), 84.2% of which were aneurysmal bone cyst (5 conventional, 9 solid, 1 secondary and 1 subperiosteal) and three (15.8%) were mixed cysts (p=0.02, chi-square). Notably, some of them were located in inaccessible areas of pelvis (n=3), femur (n=3) and maxilla (n=2).
CONCLUSION
The most common and challenging intraosseous cysts are aneurysmal bone cysts, particularly the "solid" variant. The "mixed" aneurysmal-solitary bone cyst "subgroup" requires further research with larger series to be defined more thoroughly.
Topics: Adolescent; Adult; Age Factors; Aged; Biopsy; Bone Cysts; Bone Cysts, Aneurysmal; Child; Child, Preschool; Echinococcosis; Epidermal Cyst; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Predictive Value of Tests; Prognosis; Retrospective Studies; Sex Factors; Young Adult
PubMed: 25652560
DOI: 10.5146/tjpath.2014.01293 -
Pathology, Research and Practice Jan 2022We retrospectively analyzed a cohort of patients treated at our Centre with bone marrow concentrated (BMC) injection for aneurysmal bone cyst (ABC) of the spine, in...
PURPOSE
We retrospectively analyzed a cohort of patients treated at our Centre with bone marrow concentrated (BMC) injection for aneurysmal bone cyst (ABC) of the spine, in order to propose this treatment as a valid alternative for the management of ABCs.
METHODS
Fourteen patients (6 male, 8 female) were treated between June 2014 to December 2019 with BMC injection for ABC of the spine. The mean age was 15.5 years. The mean follow up was 37.4 months (range 12-60 months). The dimension of the cyst and the degree of ossification were measured by Computed Tomography (CT) scans before the treatment and during follow-up visits.
RESULTS
Six patients received a single dose of BMC, five patients received two doses and in three patients three doses of BMC were administered. The mean ossification of the cyst (expressed in Hounsfield units) increased statistically from 43.48 ± 2.36 HU to 161.71 ± 23.48 HU during follow-up time and the ossification was associated to an improvement of the clinical outcomes. The mean ossification over time was significantly higher in patients treated with a single injection compared to patients treated with multiple injections. No significant difference in ossification was found between cervical and non-cervical localization of the cyst. Moreover, the initial size of the cyst was not statistically associated with the degree of ossification during follow-up CONCLUSIONS: Results of this paper reinforce our previous evidence on the use of BMC as a valid alternative for spinal ABC management when SAE treatment is contraindicated or ineffective.
Topics: Adolescent; Adult; Bone Cysts, Aneurysmal; Child; Female; Humans; Male; Mesenchymal Stem Cell Transplantation; Retrospective Studies; Spinal Diseases; Transplantation, Autologous; Young Adult
PubMed: 34952421
DOI: 10.1016/j.prp.2021.153722 -
Dento Maxillo Facial Radiology Oct 2021To screen the radiomic features of simple bone cysts of the jaws and explore the potential application of radiomics in pre-operative diagnosis of jaw simple bone cysts.
OBJECTIVE
To screen the radiomic features of simple bone cysts of the jaws and explore the potential application of radiomics in pre-operative diagnosis of jaw simple bone cysts.
METHODS
The investigators designed and implemented a case-control study. 19 patients with simple bone cysts who were admitted to the Department of Maxillofacial Surgery, Sun Yat-sen University Affiliated Stomatology Hospital from 2013 to 2019 were included in this study. Their clinical data and cone-beam computed tomography (CBCT) images were examined. The control group consisted of patients with odontogenic keratocyst. CBCT imaging features were analyzed and compared between the patient and control groups.
RESULTS
Overall, 10,323 image features were extracted through feature analysis. A subset of 25 radiomic features obtained after feature selection were analyzed further. These 25 features were significantly different between the 2 groups ( < 0.05). The absolute value of correlation coefficient was 0.487-0.775. Gray-level co-occurrence matrix (GLCM) contrast, neighborhood gray tone difference matrix (NGTDM) contrast, and GLCM variance were the features with the highest correlation coefficients.
CONCLUSIONS
Pre-operative radiomics analysis showed the differences between simple bone cysts and odontogenic keratocysts, can help to diagnose simple bone cysts. Three specific texture features-GLCM contrast, NGTDM contrast, and GLCM variance-may be the characteristic imaging features of simple bone cysts of the jaw.
Topics: Bone Cysts; Case-Control Studies; Cone-Beam Computed Tomography; Humans; Jaw; Odontogenic Cysts
PubMed: 34233493
DOI: 10.1259/dmfr.20200384 -
Medicina (Kaunas, Lithuania) Jan 2021Calcaneal bone cysts rarely occur and most of them are known to be benign. Among them, simple bone cysts (SBCs) third most commonly occur in the calcaneus and of the... (Review)
Review
Calcaneal bone cysts rarely occur and most of them are known to be benign. Among them, simple bone cysts (SBCs) third most commonly occur in the calcaneus and of the many surgical treatment options, endoscopic curettage is recently gaining popularity among surgeons due to its advantages of minimal invasiveness and optimal visualization. As for portal placement for endoscopy, two lateral portals are considered a standard technique, but no rationale has been established for SBCs with abnormal geometry. This case report suggests an SBC with secondary aneurysmal change located outside the Ward's triangle, as well as an appropriate endoscopic approach. An 18-year-old male high school student presented with a main complaint of pain at the hind foot level for the past one year, without significant improvement from conservative treatment. An endoscopic curettage through the lesion specific two posterior portals and bone graft using allogeneic cancellous bone were performed. SBC with a secondary aneurysmal bone cyst was diagnosed on pathology. At a one-year follow-up, the patient was painless and had returned to his regular activities. Physical and radiographic examinations revealed that the lesion was completely healed without any evidence of recurrence. For calcaneal bone cysts located at the posterior aspect of the calcaneus, eccentrically medial and abnormally long anterior-posteriorly, we suggest an endoscopic procedure using lesion specific portals such as two posterior portals.
Topics: Adolescent; Bone Cysts; Calcaneus; Curettage; Endoscopy; Humans; Male; Neoplasm Recurrence, Local
PubMed: 33530595
DOI: 10.3390/medicina57020111 -
Acta Orthopaedica Et Traumatologica... Jan 2019The aim of this study was to define histopathological features of giant cell tumor of bone, especially accompanying fibrohistiocytic or aneurysmal bone cyst like...
OBJECTIVE
The aim of this study was to define histopathological features of giant cell tumor of bone, especially accompanying fibrohistiocytic or aneurysmal bone cyst like components, in the light of our institutions experience.
METHODS
A total of 120 cases (64 females and 56 males; mean age: 36.2 (12-80)) with 'GCT' diagnosed between the years 1996-2016 were included in this retrospective analysis. Cases were evaluated according to clinical features such as age, gender, localization, recurrence, metastasis and histopathological features.
RESULTS
Tumors were localized most frequently at proximal tibia and distal femur, respectively. In 11 cases areas rich in fibrohistiocytic component and in 20 cases aneurysmal bone cyst like component were observed. In 2 cases both components were present. Twenty three cases recurred. In 1 case which was primarily located at calcaneus, tumor metastasized to lung 4 years later during follow-up.
CONCLUSION
GCT can be confused with other tumor or tumor-like lesions involving giant cells. Secondary changes such as fibrohistiocytic or aneurysmal bone cyst-like components and coagulation necrosis were frequently seen in conventional giant cell tumor of bone. For tumors having prominent fibrohistiocytic and/or aneurysmal bone cyst-like components, in order to detect characteristic areas representing GCT, additional sampling is essential. Although secondary histopathological changes do not appear to affect clinical outcome, these features are important in differential diagnosis. Approximately one fifth of GCT cases show recurrence and sacrum and foot bones were the most frequent sites for recurrence.
LEVEL OF EVIDENCE
Level IV, diagnostic study.
Topics: Adult; Age Factors; Bone Cysts, Aneurysmal; Bone Neoplasms; Diagnosis, Differential; Female; Femur; Giant Cell Tumor of Bone; Humans; Male; Neoplasm Recurrence, Local; Neoplasm Staging; Orthopedic Procedures; Radiography; Retrospective Studies; Sex Factors; Tibia; Turkey
PubMed: 30392920
DOI: 10.1016/j.aott.2018.10.007 -
Osteoarthritis and Cartilage Nov 2015The aim of this study was to examine the osteoarthritis (OA)-related structural changes associated with histological synovitis in end-stage knee OA patients.
Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study.
OBJECTIVE
The aim of this study was to examine the osteoarthritis (OA)-related structural changes associated with histological synovitis in end-stage knee OA patients.
METHODS
Forty end-stage knee OA patients (female: 88%, mean age: 71.8 y) were enrolled. All participants underwent 3.0-T MRI. The structural changes, such as cartilage morphology, subchondral bone marrow lesion (BML), subchondral bone cyst (SBC), subchondral bone attrition (SBA), osteophytes, meniscal lesion and synovitis, were scored using the whole-organ MRI scoring (WORMS) method. Synovial samples were obtained from five regions of interest (ROIs) of the knee joint during total joint replacement surgery. The associations between the histological synovitis score (HSS) and WORMS or the synovial expression levels of cyclooxygenase (COX)-2, interleukin (IL)-1β, IL-6 and transforming growth factor (TGF)-β were examined using Spearman's correlation coefficient.
RESULTS
Among the seven OA-related structural changes, the BML, SBC, SBA and synovitis were significantly associated with the HSS (r = 0.33, 0.35, 0.48 and 0.36, respectively), while other morphological changes were not. Although synovial COX-2, IL-1β or IL-6 expression levels were not associated with the HSS, the synovial TGF-β expression levels were associated with the HSS.
CONCLUSION
The presence of BML, SBC and SBA was associated with histological synovitis in end-stage knee OA patients.
Topics: Aged; Bone Cysts; Bone Marrow; Bone Marrow Diseases; Cartilage, Articular; Cross-Sectional Studies; Cytokines; Female; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Male; Osteoarthritis, Knee; Synovial Fluid; Synovitis
PubMed: 26028139
DOI: 10.1016/j.joca.2015.05.017 -
Orthopaedics & Traumatology, Surgery &... Apr 2016Sclerotherapy offers an alternative to surgery for the treatment of aneurysmal bone cyst (ABC). The main objective of the present study was to assess the radiological...
INTRODUCTION
Sclerotherapy offers an alternative to surgery for the treatment of aneurysmal bone cyst (ABC). The main objective of the present study was to assess the radiological efficacy of sclerotherapy in terms of ossification on MRI. Secondary objectives were to assess clinical efficacy on pain evaluation and to analyze recurrence and complications according to type of sclerosing agent and intraoperative imaging technique.
MATERIALS AND METHODS
Between 2006 and 2014, 19 patients (7 females, 12 males, aged 3 to 17 years) with ABC treated by sclerotherapy were included. Six received Ethibloc(®), 9 Aetoxisclerol(®), 2 liquid absolute alcohol, and 2 absolute alcohol gel. Assessment used fluoroscopy in 17 cases and CT in 2. Ossification was assessed on MRI and pain on a visual analog scale and HEDEN score.
RESULTS
Ossification was complete in 11 cases (84.6%) and partial in 2 (15.4%). Eighteen patients (94.7%) were pain-free at 3 months. There was no recurrence, at a minimum 2 years' follow-up. One case of skin necrosis was observed, associated with use of liquid absolute alcohol; there was 1 case of arterial reflux of Ethibloc(®) under CT control.
DISCUSSION
Sclerotherapy enables minimally invasive treatment of lesions that are deep, difficult of access to surgery and potentially damaging. Use of absolute alcohol gel and fluoroscopic control seems to improve the risk/benefit ratio, limiting complications by vascular extravasation of the sclerosing agent, thanks to real-time visualization of diffusion. Its clinical and radiological efficacy makes sclerotherapy and alternative primary treatment choice in ABC.
LEVEL OF EVIDENCE
IV, retrospective study.
Topics: Adolescent; Bone Cysts, Aneurysmal; Child; Child, Preschool; Diatrizoate; Drug Combinations; Ethanol; Fatty Acids; Female; Fluoroscopy; Follow-Up Studies; Humans; Male; Musculoskeletal Pain; Osteogenesis; Pain Measurement; Polidocanol; Polyethylene Glycols; Propylene Glycols; Recurrence; Retrospective Studies; Sclerosing Solutions; Sclerotherapy; Treatment Outcome; Zein
PubMed: 26874446
DOI: 10.1016/j.otsr.2015.11.016 -
Veterinary Medicine and Science Mar 2022An aneurysmal bone cyst (ABC) is a rare benign lytic lesion affecting the medullary canal of long bones. It has been widely reported in human medicine, but rarely...
BACKGROUND
An aneurysmal bone cyst (ABC) is a rare benign lytic lesion affecting the medullary canal of long bones. It has been widely reported in human medicine, but rarely described in domestic animals.
OBJECTIVE
To report the surgical treatment and long term follow-up of a dog affected by ABC.
METHODS
An 8-month-old, intact female Weimaraner was presented with lameness affecting the left front limb and progressive swelling of the mid-distal radius. Survey radiographs revealed a mid-distal diaphyseal radial lesion. Fine needle aspirates, biopsy, CT scan and histopathology results supported the diagnosis of ABC. Treatment consisted of partial corticotomy of the affected radius, filling of the cystic cavity with demineralised bone matrix and autologous bone graft and stabilisation using lag screws and a neutralisation plate.
RESULTS
The long-term follow-up, at 36 post-operative months, showed no recurrence of the cyst and bone modelling. Comparing preoperative radiographs with those at 36 months, bone modelling reduced the radial area by 23.3% in the craniocaudal radiographic view and 30% in the mediolateral projection.
CONCLUSIONS
This treatment was sucessful in the case here described, with a 3 years follow-up.
Topics: Animals; Bone Cysts, Aneurysmal; Bone Transplantation; Dog Diseases; Dogs; Female; Tomography, X-Ray Computed
PubMed: 35142089
DOI: 10.1002/vms3.677