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Archivos de La Sociedad Espanola de... Oct 202149-year-old man with diabetic macular edema refractory to antiangiogenics, it is decided to perform therapy with intravitreal dexamethasone implant (Ozurdex; Allergan,...
CLINICAL CASE
49-year-old man with diabetic macular edema refractory to antiangiogenics, it is decided to perform therapy with intravitreal dexamethasone implant (Ozurdex; Allergan, California, United States of America). Seven days after treatment, he showed acute endophthalmitis suggestive signs. Despite the intravitreal injection of antibiotics, the patient got worse. Vitreous sampling was repeated for Gram and cultures, and vitrectomy was performed via pars plana. The culture suggested the development of Brevibacterium species. Through an additional test, the presence of Brevibacterium casei was confirmed. Despite the treatment adjusted by antibiogram, retinal ischemia and macular atrophy was evident.
DISCUSSION
Brevibacterium casei is a Gram-positive bacterium, barely pathogenic, that mainly affects immunodepressed patients. Only two cases of endophthalmitis are described, one endogenous and the other one secondary to vegetal trauma. This is the first case of endophthalmitis, secondary to an ophthalmological procedure.
Topics: Brevibacterium; Dexamethasone; Diabetic Retinopathy; Drug Implants; Endophthalmitis; Humans; Macular Edema; Male; Middle Aged
PubMed: 34620485
DOI: 10.1016/j.oftale.2020.09.010 -
Archivos de La Sociedad Espanola de... Dec 2020A 49-year-old man with diabetic macular edema refractory to antiangiogenics was treated with intravitreal dexamethasone implant (Ozurdex; Allergan, California, USA)....
CLINICAL CASE
A 49-year-old man with diabetic macular edema refractory to antiangiogenics was treated with intravitreal dexamethasone implant (Ozurdex; Allergan, California, USA). Seven days after treatment, he showed acute endophthalmitis suggestive signs. Despite the intravitreal injection of antibiotics, the patient got worse. Vitreous sampling was repeated for Gram and cultures, and vitrectomy was performed via pars plana. The culture suggested the development of Brevibacterium species. Through an additional test, the presence of Brevibacterium casei was confirmed. Despite the treatment adjusted by antibiogram, retinal ischemia and macular atrophy was evident.
DISCUSION
Brevibacterium casei is a Gram-positive bacterium, barely pathogenic, that mainly affects immunodepressed patients. Only two cases of endophthalmitis are described, one endogenous and the other one secondary to vegetal trauma. This is the first case of Brevibacterium casei endophthalmitis, secondary to an ophthalmological procedure.
PubMed: 33281014
DOI: 10.1016/j.oftal.2020.09.007 -
Journal of Community Hospital Internal... 2022is an extremely rare organism that can lead to peritonitis in End-stage renal disease patients of peritoneal dialysis. Out of only five overall species peritonitis...
is an extremely rare organism that can lead to peritonitis in End-stage renal disease patients of peritoneal dialysis. Out of only five overall species peritonitis reported worldwide, only two of them had subspecies peritonitis detected, with both needing peritoneal dialysis catheter removal and change in dialysis modality to hemodialysis. Our patient, an elderly 63-year-old Hispanic male, was on peritoneal dialysis at home and presented with features suggestive of peritonitis. He was diagnosed subsequently with and started on broad spectrum intraperitoneal antibiotics. However, he did not need dialysis modality change and recovered fully after 3 weeks of appropriate intraperitoneal antibiotics therapy. Longer antibiotics therapy and frequent clinical follow-up plus better clinician awareness are needed to prevent this rare infection.
PubMed: 35711868
DOI: 10.55729/2000-9666.1012 -
Brazilian Journal of Microbiology :... Jun 2020Despite its low virulence potential and a commensal lifestyle as a member of the human skin microbiota, Brevibacterium casei has been increasingly reported as an...
Despite its low virulence potential and a commensal lifestyle as a member of the human skin microbiota, Brevibacterium casei has been increasingly reported as an opportunistic pathogen, especially in immunocompromised patients. Here, we present the draft genome sequence of the S51 strain isolated from a bloodstream infection. To the best of the authors' knowledge, this is the first report of the draft genome sequence of the B. casei strain isolated from the clinical infection. The strain was identified using phenotypic and molecular methods and subsequently sequenced using the next-generation sequencing. The draft whole genome was assembled de novo, automatically annotated by Rapid Annotations using Subsystems Technology (RAST) server and scrutinized to predict the presence of virulence, resistance, and stress response proteins. The genome size of the S51 strain was 3,743,532 bp and an average G+C content was 68.3%. The predicted genes included 48 genes involved in resistance to antibiotics (including vancomycin, fluoroquinolones, and beta-lactams) and toxic compounds (heavy metals), 16 genes involved in invasion and intracellular resistance (Mycobacterium virulence operons), and 94 genes involved in stress response (osmotic, oxidative stress, cold and heat shock). ResFinder has indicated the presence of a beta-lactamase, and a phenotypic analysis showed resistance to penicillin. This whole-genome NGS project for the S51strain has been deposited at EMBL/GenBank under the accession no. QNGF00000000.
Topics: Anti-Bacterial Agents; Bacteremia; Base Composition; Brevibacterium; Drug Resistance, Multiple, Bacterial; Genome, Bacterial; Gram-Positive Bacterial Infections; Humans; Sequence Analysis, DNA; Virulence; Whole Genome Sequencing
PubMed: 32067212
DOI: 10.1007/s42770-020-00236-x -
Revista Chilena de Infectologia :... Feb 2021
Topics: Actinomycetales Infections; Brevibacterium; Humans
PubMed: 33844798
DOI: 10.4067/S0716-10182021000100099 -
Enfermedades Infecciosas Y... Feb 2017
Review
Topics: Actinomycetales Infections; Anti-Bacterial Agents; Aortic Valve Stenosis; Bacteremia; Brevibacterium; Ceftriaxone; Disease Susceptibility; Drug Therapy, Combination; Emergencies; Endocarditis, Bacterial; Facial Dermatoses; Gentamicins; Humans; Levofloxacin; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Recurrence; Tetracycline; Vancomycin; Wound Infection
PubMed: 27381296
DOI: 10.1016/j.eimc.2016.05.002 -
The Brazilian Journal of Infectious... 2015Brevibacterium spp. are catalase-positive, non-spore-forming, non motile, aerobic Gram-positive rods that were considered apathogenic until a few reports of infections... (Review)
Review
Brevibacterium spp. are catalase-positive, non-spore-forming, non motile, aerobic Gram-positive rods that were considered apathogenic until a few reports of infections in immunocompromised patients had been published. To the best of our knowledge, this is the first report of B. casei catheter-related bloodstream infection in a child with acute leukemia. We aim to enhance the awareness of pediatric hematology and infectious disease specialists about this pathogen and review of the literature.
Topics: Actinomycetales Infections; Brevibacterium; Catheter-Related Infections; Child; Humans; Male; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
PubMed: 25636191
DOI: 10.1016/j.bjid.2014.09.011 -
Indian Journal of Medical Microbiology 2020Brevibacteria are a part of the normal skin flora and may be dismissed in blood cultures as contaminants. They have been reported as opportunistic pathogens in...
Brevibacteria are a part of the normal skin flora and may be dismissed in blood cultures as contaminants. They have been reported as opportunistic pathogens in immunocompromised patients. We report a catheter-related bloodstream infection with Brevibacterium casei in a 6-year-old child with aplastic anaemia. Treatment with appropriate antibiotics along with the removal of the catheter resulted in complete cure in our patient.
Topics: Anemia, Aplastic; Anti-Bacterial Agents; Bacteremia; Brevibacterium; Catheter-Related Infections; Catheters, Indwelling; Child; Gram-Positive Bacterial Infections; Humans; Immunocompromised Host; Male
PubMed: 32883940
DOI: 10.4103/ijmm.IJMM_20_292 -
Systematic and Applied Microbiology 1983DNA base compositions, DNA/DNA homologies and lipid studies were performed on some dairy and skin coryneform bacteria in an attempt to clarify their taxonomy. The...
DNA base compositions, DNA/DNA homologies and lipid studies were performed on some dairy and skin coryneform bacteria in an attempt to clarify their taxonomy. The results of the present and earlier studies (Sharpe et al., 1978) indicate the dairy and skin isolates represent two new species of the genus Brevibacterium. The isolates from cheese and milk are named Brevibacterium casei sp. nov. and those from human skin Brevibacterium epidermidis sp. nov. The type strains are NCDO 2048 (CMD1) and NCDO 2286 (D731), respectively.
PubMed: 23194737
DOI: 10.1016/S0723-2020(83)80023-X -
Brazilian Journal of Microbiology :... Dec 2020Cellular response against different heavy metal stress differs with the metal. Arsenic and chromium are heavy metals and toxic to living systems. The concentration of...
Cellular response against different heavy metal stress differs with the metal. Arsenic and chromium are heavy metals and toxic to living systems. The concentration of these metals in seawater is very low. However, due to their solubility in nature, they actively enter cells via various transport mechanisms and cause damage to the cells. Brevibacterium casei #NIOSBA88, a marine-derived, gram-positive isolate was multi-metal tolerant. Proteomic analysis of this isolate in response to arsenic and chromium resulted in the identification of total 2549 proteins, out of which 880 proteins were found to be commonly expressed at 750 mgL arsenic and 100 mgL chromium and in absence of both the metals. In contrast, 533, 212, and 270 proteins were found to be unique in the absence of any metal, 750 mgL of arsenic and 100 mgL of chromium respectively. Proteins such as antibiotic biosynthesis monooxygenase, ArsR family transcriptional regulator, cytochrome C oxidase subunit II, and thioredoxin reductase were exclusively expressed only in response to arsenic and chromium. Other proteins like superoxide dismutase, lipid hydroperoxide reductase, and thioredoxin-disulfide reductase were found to be upregulated in response to both the metals. Most of the proteins involved in the normal cell functioning were found to be downregulated. Major metabolic functions affected include amino acid metabolism, carbohydrate metabolism, translation, and energy metabolism. Peptide mass fingerprinting of Brevibacterium casei #NIOSBA88 exposed to arsenic and chromium respectively revealed the deleterious effect of these metals on the bacterium and its strategy to overcome the stress.
Topics: Arsenic; Bacterial Proteins; Brevibacterium; Chromium; Proteomics
PubMed: 32729030
DOI: 10.1007/s42770-020-00353-7