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Virulence Jan 2018Non-fermenting Gram-negative bacteria are problematic in clinical locations, being one of the most prevalent causes of nosocomial infections. Many of these... (Review)
Review
Non-fermenting Gram-negative bacteria are problematic in clinical locations, being one of the most prevalent causes of nosocomial infections. Many of these non-fermenting Gram-negative bacteria are opportunistic pathogens that affect patients that are suffering with underlying medical conditions and diseases. Brevundimonas spp., in particular Brevundimonas diminuta and Brevundimonas vesicularis, are a genus of non-fermenting Gram-negative bacteria considered of minor clinical importance. Forty-nine separate instances of infection relating to Brevundimonas spp were found in the scientific literature along with two pseudo-infections. The majority of these instances were infection with Brevundimonas vesicularis (thirty-five cases - 71%). The major condition associated with Brevundimonas spp infection was bacteraemia with seventeen individual cases/outbreaks (35%). This review identified forty-nine examples of Brevundimonas spp. infections have been discussed in the literature. These findings indicate that infection review programs should consider investigation of possible Brevundimonas spp outbreaks if these bacteria are clinically isolated in more than one patient.
Topics: Bacteremia; Caulobacteraceae; Communicable Diseases, Emerging; Disease Outbreaks; Global Health; Gram-Negative Bacterial Infections; Humans; Opportunistic Infections
PubMed: 29484917
DOI: 10.1080/21505594.2017.1419116 -
Cell Reports. Medicine Dec 2023Allergen-specific immunotherapy (AIT) has shown beneficial effects against atopic dermatitis (AD); however, the mechanisms and parameters underlying the efficacy of AIT...
Allergen-specific immunotherapy (AIT) has shown beneficial effects against atopic dermatitis (AD); however, the mechanisms and parameters underlying the efficacy of AIT remain unclear. Here, we report that the community structure and function of the oral and gut microbiota are changed in patients with AD undergoing AIT. Transplantation of fecal microbiota from patients who respond well to AIT improves AD-like dermatitis in mice. The abundance of Brevundimonas vesicularis in the gut of AD patients has been found to be positively correlated with disease severity and is decreased following AIT. Furthermore, we find that B. vesicularis from the oral cavity might ectopically colonize the gut of AD patients. In AD model mice, meanwhile, B. vesicularis promotes the skewing of the Treg/Th17 balance toward Th17 polarization and attenuates the efficacy of ovalbumin-specific immunotherapy. Our findings provide potential strategies for the optimization of AIT for AD via the modulation of the gut microbiota.
Topics: Humans; Mice; Animals; Dermatitis, Atopic; Desensitization, Immunologic; Allergens; Intestines
PubMed: 38118418
DOI: 10.1016/j.xcrm.2023.101340 -
Journal of Microbiology, Immunology,... Dec 2012Over the past 20 years, Brevundimonas vesicularis has rarely been reported as a pathogen causing human infection. The clinical manifestations of B. vesicularis...
BACKGROUND
Over the past 20 years, Brevundimonas vesicularis has rarely been reported as a pathogen causing human infection. The clinical manifestations of B. vesicularis bacteremia and its susceptibility to antibiotics has not been characterized.
METHODS
A retrospective study was conducted between 2006 and 2009 in a tertiary-care hospital in southern Taiwan.
RESULTS
A total of 22 cases of B. vesicularis bacteremia were identified during the study with 86% being community-acquired primary bloodstream infections. Of the 22 patients, 15 (68%) presented with fever, fewer comorbidities, shorter hospital stays, lower mean creatinine levels (1.10 mg/dL vs. 1.74 mg/dL), lower aspartate aminotransferase levels (29.1 IU/L vs. 79.0 IU/L), and lower alanine aminotransferase levels (16.4 IU/L vs. 67.0 IU/L) when compared to afebrile patients. Among the bacterial isolates, 90.9% were susceptible to cefpirome, imipenem and piperacillin/tazobactam while 86.4% were susceptible to gentamicin, amikacin and ciprofloxacin. However, 63.6% of the bacterial isolates were susceptible to ceftazidime, and only 59.1% were susceptible to trimethoprim-sulfamethoxazole (TMP-SMX). The 30-day mortality rate from all causes was 4.5%.
CONCLUSION
B. vesicularis is able to cause community-acquired and low-mortality primary bloodstream infections. The resistance of B. vesicularis to trimethoprim-sulfamethoxazole and ceftazidime limits the choice of available antibiotics for treatment.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacteremia; Caulobacteraceae; Ceftazidime; Child; Child, Preschool; Drug Resistance, Multiple, Bacterial; Female; Gram-Negative Bacterial Infections; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Prognosis; Retrospective Studies; Taiwan; Tertiary Care Centers; Trimethoprim, Sulfamethoxazole Drug Combination; Young Adult
PubMed: 22516745
DOI: 10.1016/j.jmii.2012.01.010 -
International Journal of Molecular... Nov 2023Drought stress is a significant threat to agricultural productivity and poses challenges to plant survival and growth. Research into microbial plant biostimulants faces...
Drought stress is a significant threat to agricultural productivity and poses challenges to plant survival and growth. Research into microbial plant biostimulants faces difficulties in understanding complicated ecological dynamics, molecular mechanisms, and specificity; to address these knowledge gaps, collaborative efforts and innovative strategies are needed. In the present study, we investigated the potential role of (S1T13) as a microbial plant biostimulant to enhance drought tolerance in . We assessed the impact of S1T13 on Col-0 wild-type (WT) and mutant plants under drought conditions. Our results revealed that the inoculation of S1T13 significantly contributed to plant vigor, with notable improvements observed in both genotypes. To elucidate the underlying mechanisms, we studied the role of ROS and their regulation by antioxidant genes and enzymes in plants inoculated with S1T13. Interestingly, the inoculation of S1T13 enhanced the activities of GSH, SOD, POD, and PPO by 33, 35, 41, and 44% in WT and 24, 22, 26, and 33% in , respectively. In addition, S1T13 upregulated the expression of antioxidant genes. This enhanced antioxidant machinery played a crucial role in neutralizing ROS and protecting plant cells from oxidative damage during drought stress. Furthermore, we investigated the impact of S1T13 on ABA and drought-stress-responsive genes. Similarly, S1T13 modulated the production of ABA and expression of , , , and by 31, 42, 37, 41, and 42% in WT and 20, 29, 27, 38, and 29% in . The improvement in plant vigor, coupled with the induction of the antioxidant system and modulation of ABA, indicates the pivotal role of S1T13 in enhancing the drought stress tolerance of the plants. Conclusively, the current study provides valuable insights for the application of multitrait S1T13 as a novel strain to improve drought stress tolerance in plants and could be added to the consortium of biofertilizers.
Topics: Arabidopsis; Antioxidants; Droughts; Reactive Oxygen Species; Stress, Physiological; Arabidopsis Proteins; Plants, Genetically Modified; Gene Expression Regulation, Plant; Abscisic Acid; Plant Proteins
PubMed: 38068913
DOI: 10.3390/ijms242316590 -
Journal of Microbiology, Immunology,... Dec 2012There are few reports of invasive infections caused by Brevundimonas vesicularis. We report two cases of B. vesicularis bacteremia confirmed by culture and 16S rRNA... (Review)
Review
There are few reports of invasive infections caused by Brevundimonas vesicularis. We report two cases of B. vesicularis bacteremia confirmed by culture and 16S rRNA sequence analysis with highly variable sensitivity to broad-spectrum antibiotics. Initial empiric therapy with anti-pseudomonal antibiotics plus trimethoprim-sulfamethoxazole for hospital-acquired B. vesicularis infections should be considered.
Topics: Adult; Aged; Anti-Bacterial Agents; Bacteremia; Caulobacteraceae; Gram-Negative Bacterial Infections; Humans; Male; Microbial Sensitivity Tests
PubMed: 22608844
DOI: 10.1016/j.jmii.2011.12.021 -
The New Microbiologica Jan 2014In 1986, we encountered the first case of Legionella micdadei pneumonia in Japan. In the follow-up study to determine the infection route of L. micdadei, we isolated...
In 1986, we encountered the first case of Legionella micdadei pneumonia in Japan. In the follow-up study to determine the infection route of L. micdadei, we isolated Brevundimonas vesicularis from the shower hose of the patient�s home. This motivated us to explore the symbiosis between B. vesicularis and Legionella in this study. B. vesicularis type strain, B. vesicularis Kobe strain, Legionella pneumophila serogroup 1 type strain, and L. micdadei Kobe strain were used. B. vesicularis was inoculated into 0.01 M phosphate buffer solution containing artificial sand, and varying concentrations of glucose at 0.1%, 0.01%, and 0.001%. Legionella was added to the cultures after ten days of incubation, and Legionella viable counts were monitored over time. After three days of incubation, Legionella counts increased approximately twofold in flasks containing 0.001% glucose, but Legionella counts decreased in both B. vesicularis inoculated and non-inoculated flasks containing higher concentrations of glucose. The counts were significantly higher in flasks inoculated with B. vesicularis than in non-inoculated flasks throughout the experiments. Under the nutrient-poor conditions, the presence of B. vesicularis was found to aid a further increase in Legionella counts. Further research is necessary to understand the symbiotic conditions most supporting the growth of L. micdadei.
Topics: Caulobacteraceae; Culture Media; Follow-Up Studies; Fresh Water; Glucose; Humans; Legionella; Legionellosis; Symbiosis
PubMed: 24531169
DOI: No ID Found -
The Canadian Journal of Hospital... 2018
PubMed: 29955194
DOI: No ID Found -
Journal of Microbiology, Immunology,... Apr 2013
Topics: Bacteremia; Caulobacteraceae; Ceftazidime; Drug Resistance, Multiple, Bacterial; Female; Gram-Negative Bacterial Infections; Humans; Male; Trimethoprim, Sulfamethoxazole Drug Combination
PubMed: 23562489
DOI: 10.1016/j.jmii.2013.02.005 -
Case Reports in Nephrology and Dialysis 2021Gram-negative peritonitis in chronic peritoneal dialysis patients is difficult to treat and may result in catheter loss. is a Gram-negative rod bacterium which rarely...
Gram-negative peritonitis in chronic peritoneal dialysis patients is difficult to treat and may result in catheter loss. is a Gram-negative rod bacterium which rarely causes infections in humans. A 41-year-old male receiving continuous cycling peritoneal dialysis for 5 months developed culture-negative peritonitis. He failed initial empiric treatment with intraperitoneal vancomycin and levofloxacin and thereafter intravenous gentamicin. resistant to levofloxacin was isolated from the peritoneal fluid 21 days after his initial symptoms. Despite treatment with intravenous ceftriaxone and oral amoxicillin-clavulanate, the infection persisted, which required removal of the peritoneal catheter in order to cure this infection. We describe the features of infection in our patient and the rarely reported additional cases.
PubMed: 34901199
DOI: 10.1159/000517140 -
Le Infezioni in Medicina Dec 2006Brevundimonas vesicularis infrequently causes human infections. We describe a case of meningitis due to Brevundimonas vesicularis, resistant to piperacillin, gentamicin...
Brevundimonas vesicularis infrequently causes human infections. We describe a case of meningitis due to Brevundimonas vesicularis, resistant to piperacillin, gentamicin and amikacin as well as to cephalosporins, aztreonam, imipenem and meropenem. The meningitis was acquired in hospital by a patient operated for astrocytoma and represents a classical hospital infection.
Topics: Adult; Cross Infection; Gram-Negative Bacterial Infections; Humans; Male; Meningitis
PubMed: 17380092
DOI: No ID Found