-
Der Anaesthesist Sep 1998
-
Schweizerische Rundschau Fur Medizin... Nov 1992
Topics: Asthma; Bronchial Hyperreactivity; Drug Therapy, Combination; Humans
PubMed: 1439415
DOI: No ID Found -
Orvosi Hetilap Apr 2017It is increasingly recognized that the bronchial asthma is a heterogeneous entity, encompassing a variety of different phenotypes. The identification of specific...
It is increasingly recognized that the bronchial asthma is a heterogeneous entity, encompassing a variety of different phenotypes. The identification of specific phenotypes is the key to develop more effective personalised treatment. The earliest attempt to phenotype asthma was proposed classifying into extrinsic and intrinsic subtypes. Clinical asthma is mainly divided into allergic (atopic) and non-allergic (non-atopic) asthma. Other phenotypes are based on trigger factors. Later the phenotyping based on the predominant cellular nature of inflammation: It can be divided into eosinophilic and non-eosinohilic. The non-eosinophilic asthma may be neutrophilic, combined, and paucigranulocytic. The discovery of Ig E represented a major breakthrough in asthma research. Ig E is an immunglobulin that plays a central role in pathomechanisms. Later identify with novel immune phenotypes: T-helper-2 high and T-helper-2 low subtypes. Neutrophilic asthma is mostly dependent of T-helper-17 cell induced mechanisms. The cluster analysis have been used increasingly to identify phenotypes. New data have been identified molecular pathways. However phenotyping of asthma is complex because of the overlap of the various phenotypes. The limitations of the studies need future research. Biomarkers e.g. levels of eosinophils in blood and sputum, exhaled nitric oxide fraction, serum immunglobulin E, serum periostin identify different asthma phenotypes. Orv. Hetil., 2017, 158(13), 491-498.
Topics: Asthma; Eosinophils; Granulocytes; Humans; Inflammation; Leukocyte Count; Lymphocyte Count; Macrophages; Neutrophils; Phenotype
PubMed: 28929787
DOI: 10.1556/650.2017.30702 -
Dermatologie (Heidelberg, Germany) Mar 2024This article reports the case of a 30-year-old female patient who suffered for many years from initially unspecific symptoms, such as recurrent, nonallergic and...
This article reports the case of a 30-year-old female patient who suffered for many years from initially unspecific symptoms, such as recurrent, nonallergic and noninfectious sinusitis, late-onset bronchial asthma and pronounced lymphadenopathy; however, the correct diagnosis of eosinophilic granulomatosis with polyangiitis (EGPA) could only be made by histological investigations after the appearance of skin symptoms. The EGPA is a severe systemic disease which, if left untreated, can cause multiple organ damage and even be fatal. With adequate treatment the disease is mild in more than 90% of cases and patients can even completely recover. By making the correct diagnosis, the patient could be successfully treated and the risk of late manifestations and subsequent damage with a potentially fatal outcome was reduced.
PubMed: 38502363
DOI: 10.1007/s00105-024-05323-w -
Recenti Progressi in Medicina Dec 1963
-
Giornale Di Medicina Militare 1964
Topics: Adenoma; Bronchial Neoplasms; Bronchiectasis; Bronchography; Diagnosis, Differential; Humans; Lung Neoplasms; Pathology; Tuberculosis; Tuberculosis, Pulmonary
PubMed: 14164391
DOI: No ID Found -
Medizinische Monatsschrift Fur... Sep 1988
Review
Topics: Asthma; Bronchial Provocation Tests; Diagnosis, Differential; Humans
PubMed: 3067063
DOI: No ID Found -
Medizinische Klinik Jul 1954
Topics: Asthma; Humans
PubMed: 13202957
DOI: No ID Found -
Minerva Medica Dec 1952
Topics: Adenoma; Bronchi; Humans; Lung Neoplasms; Neoplasms
PubMed: 13046225
DOI: No ID Found -
Praxis Jun 1949
Topics: Asthma; Humans
PubMed: 18146385
DOI: No ID Found