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Anais Da Academia Brasileira de Ciencias 2022The new genus Maxiclavella is proposed to accommodate Clavella simplex Castro Romero and Baeza Kuroki, 1985, which differs from Clavella species, including long and...
The new genus Maxiclavella is proposed to accommodate Clavella simplex Castro Romero and Baeza Kuroki, 1985, which differs from Clavella species, including long and narrow cephalothorax, small bulla, and simple armature of the antenna and antennule. Praeclavella nasalis, new genus and species, was found parasitizing the olfactory sacs of Isacia conceptionis. Praeclavella nasalis could be differentiated from other Clavella species by a biramous antenna with an exopod shorter than the endopod, the base of the cephalothorax with a large lobular and suborbicular projection on each side, a suborbicular bulla, mandibles without secondary teeth, and a suboval male body type. Males of both genera fit well in the Clavella-clade male type, although they differ from each other in many aspects, mainly in the position of the buccal area, which is oriented ventrally in Maxiclavella and distally in Praeclavella nasalis, and in a genital process, which is present in the latter and absent in the former. Genetic distances of mtDNA COI and 28S rDNA supported the validity of the two new genera parasitizing the same host, I. conceptionis. Also Clavella-branch (Clavellinae Wilson), a key based genera on female specimens is presented.
Topics: Animals; Blister; Copepoda; DNA, Mitochondrial; DNA, Ribosomal; Female; Male; Phylogeny; Presbytini
PubMed: 36228210
DOI: 10.1590/0001-3765202220200992 -
Acta Dermato-venereologica Jul 2020
Topics: Blister; Humans; Staphylococcal Skin Infections
PubMed: 32399573
DOI: 10.2340/00015555-3502 -
BMJ Case Reports Oct 2012
Topics: Aged; Blister; Diabetes Mellitus, Type 2; Fatal Outcome; Foot Dermatoses; Gastrointestinal Hemorrhage; Humans; Male; Multiple Organ Failure; Pulmonary Disease, Chronic Obstructive; Salmonella Infections; Salmonella enteritidis; Shock, Septic
PubMed: 23060372
DOI: 10.1136/bcr-10-2011-4923 -
Journal of Tissue Engineering and... Jun 2019Despite continuous exposure to environmental pathogens, injured mucosa within the oral cavity heals faster and almost scar free compared with skin. Saliva is thought to...
Despite continuous exposure to environmental pathogens, injured mucosa within the oral cavity heals faster and almost scar free compared with skin. Saliva is thought to be one of the main contributing factors. Saliva may possibly also stimulate skin wound healing. If so, it would provide a novel therapy for treating skin wounds, for example, burns. This study aims to investigate the therapeutic wound healing potential of human saliva in vitro. Human saliva from healthy volunteers was filter sterilized before use. Two different in vitro wound models were investigated: (a) open wounds represented by 2D skin and gingiva cultures were used to assess fibroblast and keratinocyte migration and proliferation and (b) blister wounds represented by introducing freeze blisters into organotypic reconstructed human skin and gingiva. Re-epithelialization and differentiation (keratin K10, K13, K17 expression) under the blister and inflammatory wound healing mediator secretion was assessed. Saliva-stimulated migration of skin and oral mucosa fibroblasts and keratinocytes, but only fibroblast proliferation. Topical saliva application to the blister wound on reconstructed skin did not stimulate re-epithelization because the blister wound contained a dense impenetrable dead epidermal layer. Saliva did promote an innate inflammatory response (increased CCL20, IL-6, and CXCL-8 secretion) when applied topically to the flanking viable areas of both wounded reconstructed human skin and oral mucosa without altering the skin specific keratin differentiation profile. Our results show that human saliva can stimulate oral and skin wound closure and an inflammatory response. Saliva is therefore a potential novel therapeutic for treating open skin wounds.
Topics: Blister; Cell Proliferation; Cytokines; Epithelium; Fibroblasts; Humans; Inflammation Mediators; Keratinocytes; Saliva; Skin; Wound Healing
PubMed: 30968584
DOI: 10.1002/term.2865 -
Anales de Pediatria Jan 2024
Topics: Infant; Humans; Blister; Skin Abnormalities
PubMed: 38185572
DOI: 10.1016/j.anpede.2023.12.011 -
Indian Journal of Dermatology,... 2019Lasers and light-based devices are indispensable to an aesthetic dermatology practice. The growing popularity of lasers has been matched by a sharp increase in the... (Review)
Review
Lasers and light-based devices are indispensable to an aesthetic dermatology practice. The growing popularity of lasers has been matched by a sharp increase in the incidence of complications. The Indian skin with its high melanin content is more prone to injury and careful setting of laser parameters, early detection of complications and immediate therapy are vital to avoiding permanent sequelae. We review the various complications that occur during laser procedures and their management.
Topics: Blister; Edema; Humans; Laser Therapy; Low-Level Light Therapy; Phototherapy; Postoperative Complications; Skin Pigmentation
PubMed: 30560814
DOI: 10.4103/ijdvl.IJDVL_88_17 -
Journal of Anatomy Apr 2022For rodents, hearing is essential to survival. It enables predator evasion, prey detection, and conspecific recognition; it is also likely to be constrained by the...
For rodents, hearing is essential to survival. It enables predator evasion, prey detection, and conspecific recognition; it is also likely to be constrained by the physical environment. The resulting hypothetical link between tympanic bulla morphology and ecology has never been investigated across a broad array of rodent species before. Such link may enable the determination of the ecological affinities of many fossil species only known from partial skulls. In this study, we used geometric morphometrics to quantify the shape of the auditory bulla of 197 specimens representing 91 species from 17 families of extant rodents across four different locomotory modes. We used landmarks and semi-landmarks on the ventral and lateral views of the skull to capture morphological characteristics of the bulla and external auditory meatus (EAM). Our results demonstrate an association between bullar morphology and locomotion in rodents. Bullar shape enables the correct classification of 76% of the species in our training set. Fossorial taxa, in particular, show a characteristic morphology including an asymmetric bulla with a dorsally located and laterally expanded EAM that has a small opening diameter. A phylogenetically informed flexible discriminant analysis shows a weak phylogenetic effect on tympanic morphology. There is no evidence for differences in bullar hypertrophy across locomotory categories. The application of this approach to select fossil rodents from the Oligo-Miocene shows broad agreements with prior studies and yields new locomotory inferences for 14 fossil species, including the first proposed locomotion for members of the family Florentiamyidae. Such results call for the timing of burrowing diversification in rodents to be reevaluated.
Topics: Animals; Blister; Fossils; Phylogeny; Rodentia; Skull
PubMed: 34747041
DOI: 10.1111/joa.13579 -
Journal of the American Veterinary... Mar 2022To evaluate dogs and cats undergoing total ear canal ablation with lateral bulla osteotomy (TECA-LBO), document antimicrobial choices, and determine relationships...
Effect of empirical versus definitive antimicrobial selection on postoperative complications in dogs and cats undergoing total ear canal ablation with lateral bulla osteotomy: 120 cases (2009-2019).
OBJECTIVE
To evaluate dogs and cats undergoing total ear canal ablation with lateral bulla osteotomy (TECA-LBO), document antimicrobial choices, and determine relationships associated with infection-related and neurologic postoperative complications.
ANIMALS
107 client-owned dogs and 13 client-owned cats that underwent TECA-LBO.
PROCEDURES
A retrospective analysis of medicals records of dogs and cats with TECA-LBO from 2 veterinary hospitals with postoperative data for at least 6 months was performed. All information associated with the TECA-LBO surgery including follow-up was recorded. Logistic regression analyses were performed and corrected using a false discovery rate to identify significance between antimicrobial administration and other perioperative variables and the outcomes of short- and long-term neurologic and infection-related complications, need for revision surgery, and euthanasia due to recurrence of infection-related signs.
RESULTS
Intraoperative cultures were performed in 111 animals, and 95 (85.5%) had bacterial growth, with Staphylococcus spp most commonly isolated. Revision surgeries due to infection-related signs occurred in 13 of 120 (10.8%) patients. If intraoperative bacterial cultures were positive and antimicrobials were administered within 1 month of surgery, patients were 85.8% less likely to exhibit infection-related complications, whereas patients not administered antimicrobials were 10.3 times as likely to require a revision surgery. Longer durations of postoperative antimicrobial administration were associated with revision surgery and euthanasia due to infection-related signs.
CLINICAL RELEVANCE
Administration of systemic antimicrobials within the first postoperative month may be necessary to prevent complications when intraoperative cultures exhibit bacterial growth and plays a role in the successful outcome of TECA-LBO.
Topics: Animals; Anti-Bacterial Agents; Blister; Cat Diseases; Cats; Dog Diseases; Dogs; Ear Canal; Osteotomy; Postoperative Complications; Retrospective Studies
PubMed: 35333738
DOI: 10.2460/javma.21.10.0462 -
European Journal of Medical Research Mar 2023Venomous snakebites induce tissue destruction and secondary infection; however, the optimal timing of surgical intervention for these complications remains unknown. This...
BACKGROUND
Venomous snakebites induce tissue destruction and secondary infection; however, the optimal timing of surgical intervention for these complications remains unknown. This study assessed the clinical predictors of early surgical intervention in patients with snakebites.
METHODS
This retrospective study included 63 patients (45 men and 18 women) with venomous snakebites. In addition to the snake species, the demographics, affected body parts, clinical characteristics, and ultrasound findings of the patients in the surgical (32 patients) and nonsurgical (31 patients) groups were analyzed and compared.
RESULTS
A higher incidence of acute compartment syndrome, local ecchymosis, skin necrosis, bullae, blisters, and fever was found in the surgical group than in the nonsurgical group, and ultrasound findings of the absence of Doppler flow were more frequently noted in the surgical group than in the nonsurgical group. After adjustment using a multivariate logistic regression model, only advanced age, Naja atra bite, local ecchymosis, and bulla or blister formation remained significant factors for surgical intervention. Furthermore, comparison of the outcomes of patients who received early (≤ 24 h) and late (> 24 h) surgical intervention revealed that the duration of continuous negative pressure wound therapy (6 vs. 15 days; P = 0.006), duration of hospital stay (13 vs. 26 days; P = 0.002), and duration of outpatient follow-up (15 vs. 36 days; P < 0.001) were significantly lower in patients who received early surgical intervention. The final reconstructive surgery was simple among the patients who received surgical intervention within 24 h of being bitten (P = 0.028).
CONCLUSION
In patients with snakebites, advanced age, high-risk clinical manifestations (e.g., local ecchymosis and bulla or blister formation), and Naja atra envenomation are predictors of surgical intervention within 24 h.
Topics: Snake Bites; Retrospective Studies; Blister; Antivenins; Ecchymosis; Length of Stay; Incidence; Treatment Outcome; Naja naja; Humans; Male; Adult; Middle Aged; Aged; Aged, 80 and over; Female
PubMed: 36945006
DOI: 10.1186/s40001-023-01101-x -
Revista Chilena de Pediatria Feb 2018Henoch-Schönlein purpura (HSP) or IgA Vasculitis is the most common childhood vasculitis. The classic tetrad of signs and symptoms include palpable purpura, arthralgia,...
UNLABELLED
Henoch-Schönlein purpura (HSP) or IgA Vasculitis is the most common childhood vasculitis. The classic tetrad of signs and symptoms include palpable purpura, arthralgia, abdominal pain and renal disease. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. Objec tive: To report an unusual cutaneous manifestation of HSP in children.
CASE REPORT
A 14-year-old girl complained about a 2-week painful bullous rash in both lower extremities and multiple arthral gias. There was no history of abdominal pain or urinary symptoms. In both lower extremities, there were numerous palpable purpura and hemmorrhagic bullae. In light of clinical findings, laboratory tests and skin biopsy are requested. The histopathology described intraepidermal blisters, acanthosis, spongiosis and perivascular dermal infiltrate. Direct immunofluorescence (IFD) (+) for IgA. The diagnosis of bullous HSP was made and treatment with endovenous corticosteroids was initiated. Three days after overlapping to oral corticosteroids, new ecchymotic lesions appeared in both legs. Due to the persistence of cutaneous involvement and negative control tests, azathioprine was associa ted obtaining a good response.
CONCLUSION
Although bullous lesions in HSP does not add morbidity, it is often an alarming phenomenon with multiple differential diagnoses. The anti-inflamatory effect of corticoids is likely to be beneficial in the treatment of patients with severe cutaneous involvement through inhibition of proinflammatory transcription factors and decreasing the production of the metalloproteinases.
Topics: Adolescent; Blister; Female; Humans; IgA Vasculitis
PubMed: 29664511
DOI: 10.4067/S0370-41062018000100103