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Anesthesiology May 2024
Topics: Bupivacaine
PubMed: 38592361
DOI: 10.1097/ALN.0000000000004934 -
Anesthesiology Nov 2022
Topics: Diaphragm; Bupivacaine; Anesthetics, Local
PubMed: 36095054
DOI: 10.1097/ALN.0000000000004340 -
Anesthesiology Nov 2022
Topics: Diaphragm; Bupivacaine; Anesthetics, Local
PubMed: 36095041
DOI: 10.1097/ALN.0000000000004339 -
Oral Surgery, Oral Medicine, and Oral... Oct 1984Bupivacaine, a long-acting amide local anesthetic, is a chemical analogue of mepivacaine with high lipid-solubility and protein-binding characteristics. These properties... (Comparative Study)
Comparative Study Review
Bupivacaine, a long-acting amide local anesthetic, is a chemical analogue of mepivacaine with high lipid-solubility and protein-binding characteristics. These properties contribute to bupivacaine's greater potency and anesthetic duration as compared to other local anesthetics used in dentistry. The prolonged anesthesia it produces has been shown to limit postoperative pain following third molar extractions and endodontic procedures. Bupivacaine 0.5% with 1:200,000 epinephrine provides a safe and valuable alternative to the anesthetic agents presently available in dentistry.
Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Animals; Bupivacaine; Dose-Response Relationship, Drug; Humans; Muscles; Pain, Postoperative; Tooth Extraction
PubMed: 6387571
DOI: 10.1016/0030-4220(84)90325-6 -
Best Practice & Research. Clinical... Jun 2005Two new, long-acting local anaesthetics have been developed after the evidence of bupivacaine-related severe toxicity: levobupivacaine and ropivacaine. Both these agents... (Review)
Review
Two new, long-acting local anaesthetics have been developed after the evidence of bupivacaine-related severe toxicity: levobupivacaine and ropivacaine. Both these agents are pure left-isomers and, based on their three-dimensional structure, they have less toxic potential both on the central nervous system and on the heart. Several clinical studies have evaluated their toxicology and clinical profiles: theoretically and experimentally, some differences can be seen, but the reflections of these characteristics into clinical practice have not been evident. Evaluating randomised, controlled trials that have compared these three local anaesthetics, this chapter supports the evidence that both levobupivacaine and ropivacaine have a clinical profile similar to that of racemic bupivacaine, and that the minimal differences observed between the three agents are mainly related to the slightly different anaesthetic potency, with racemic bupivacaine>levobupivacaine>ropivacaine. However, the reduced toxic potential of the two pure left-isomers supports their use in those clinical situations in which the risk of systemic toxicity related to either overdosing or unwanted intravascular injection is high, such as during epidural or peripheral nerve blocks.
Topics: Amides; Anesthetics, Local; Bupivacaine; Humans; Levobupivacaine; Neurotoxicity Syndromes; Ropivacaine; Stereoisomerism
PubMed: 15966496
DOI: 10.1016/j.bpa.2004.12.003 -
Annales Chirurgiae Et Gynaecologiae 1984The role of bupivacaine in IVRA is controversial. It produces a reliable sensory and motor block and when used in larger doses prolonged residual analgesia is also... (Comparative Study)
Comparative Study Review
The role of bupivacaine in IVRA is controversial. It produces a reliable sensory and motor block and when used in larger doses prolonged residual analgesia is also achieved. Large series of its use without toxic complications have been presented. Yet, there are sporadic reports of severe, even fatal complications, usually as the result of a technical failure. In this article bupivacaine is compared to two other local anaesthetics commonly used in IVRA, i.e. lignocaine and prilocaine. Acidosis and hyperkaliemia are likely to increase the risk of bupivacaine toxicity. Other contributing factors include leakage under the tourniquet cuff and preexisting cardiac disease. We conclude that bupivacaine is a useful agent for IVRA assuming that the patients are carefully selected and the anaesthetist is aware of the possible risks and their prevention.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Bupivacaine; Central Nervous System Diseases; Humans; Lidocaine; Prilocaine; Risk
PubMed: 6388484
DOI: No ID Found -
Anesthesia and Analgesia 1971
Review
Topics: Analgesia; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics, Local; Bupivacaine; Chemical Phenomena; Chemistry; Chlorides; Female; Fetus; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Methods; Pregnancy; Retrospective Studies; Sensation; Time Factors
PubMed: 4939842
DOI: No ID Found -
Annals of the Royal College of Surgeons... Nov 1989
Topics: Adult; Bupivacaine; Humans; Male; Pain, Postoperative; Penis
PubMed: 2604353
DOI: No ID Found -
Der Anaesthesist May 1978
Topics: Anesthesia, Spinal; Bupivacaine; Humans
PubMed: 665968
DOI: No ID Found -
Minerva Anestesiologica Dec 2010
Comparative Study
Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Levobupivacaine; Treatment Outcome
PubMed: 21102396
DOI: No ID Found